| Deler fremragende | 54,084,378 shares |
| Insideraktier | 21.708.704 shares |
| Insider ejerskab | 40,14 % |
| Total Insiders | 60 |
Insider-stemningsscore
Insider Sentiment Score viser, at virksomhederne bliver købt af virksomheders insidere.
Det er resultatet af en sofistikeret, multi-faktor kvantitativ model, der identificerer virksomheder med de højeste niveauer af insider-akkumulering. Scoringsmodellen bruger en kombination af nettoantallet af insidere, der har købt de foregående 90 dage, det samlede antal aktier købt som en procentdel af float og det samlede antal aktier ejet af insidere. Tallet går fra 0 til 100, hvor højere tal indikerer et højere niveau af akkumulering for sine jævnaldrende, og 50 er gennemsnittet.
Opdateringsfrekvens: Dagligt
Se Insiders Top Picks, som giver en liste over virksomheder med den højeste insider-akkumulering.
Officers sentiment score
Officer Sentiment Score finder virksomheder, der bliver købt af Corporate Officers.
Per definition er Corporate Officers Corporate Insiders, men i modsætning til nogle af de andre Insiders (10 % aktionærer og bestyrelsesmedlemmer), arbejder officerer for virksomheden på daglig basis, og de bruger deres egne penge, når de handler . (10 % aktionærer og bestyrelsesmedlemmer er ofte fondsforvaltere, der administrerer andres penge.) Som sådan er insiderhandler foretaget af embedsmænd meget mere betydningsfulde og bør behandles passende.
Ligesom Insider Sentiment Score er Officer Sentiment Score resultatet af en sofistikeret, multi-faktor kvantitativ model, der identificerer virksomheder med de højeste niveauer af officerakkumulering.
Opdateringsfrekvens: Dagligt
Se Insiders Top Picks, som giver en liste over virksomheder med højeste insider-stemning.
Nøgle Insider Metrics
Dette kort viser, hvordan virksomheden rangerer langs forskellige insider-metrics. Percentilrangen viser, hvordan denne virksomhed sammenligner sig med andre virksomheder på de amerikanske markeder. Højere placeringer er tegn på bedre situationer.
For eksempel er det generelt accepteret, at insider-køb er en positiv indikator, så virksomheder med flere insider-køb vil rangere højere end virksomheder med mindre insider-køb (eller endda insider-salg).
Insiderhandelsdiagram
Protara Therapeutics, Inc. insiderhandler er vist i følgende diagram. Insidere er embedsmænd, direktører eller betydelige investorer i en virksomhed. Generelt er det generelt ulovligt for insidere at foretage handler i deres virksomheder baseret på væsentlige, ikke-offentlige oplysninger. Dette betyder ikke, at det er ulovligt for dem at handle i deres egne virksomheder. De skal dog rapportere alle handler til SEC via en formular 4.
Insiderliste og lønsomhedsmålinger
Denne tabel viser listen over kendte insidere og genereres automatisk fra arkiveringer, der er videregivet til SEC. Ud over navnene, den seneste titel og direktør, officer eller 10 % ejerbetegnelse giver vi de seneste offentliggjorte besiddelser. Derudover giver vi, når det er muligt, den historiske handelspræstation for insideren. Den historiske handelspræstation er et vægtet gennemsnit af præstationen af faktiske købstransaktioner på det åbne marked foretaget af insideren. For mere information om, hvordan dette beregnes, se dette YouTube-webinar.
See our leaderboard of most profitable insider traders.
| Insider | Gennemsnitlig fortjeneste (%) | Aktier Ejet |
Dele Justeret |
|---|---|---|---|
| LLP Abingworth - | 2.144.517 | 2.144.517 | |
| Luke M Beshar Director - [D] | 198.000 | 198.000 | |
| Garen G Bohlin Director - [D] | 53.312 | 53.312 | |
| Jathin Bandari Chief Medical Officer - [O] | 56.704 | 56.704 | |
|
Hubert Birner
Director, 10% Owner -
[D]
|
12.700 | ||
| Scott Braunstein Director - [D] | 26.500 | 26.500 | |
| Steven Keith Burke SVP and Chief Medical Officer - [O] | 26.332 | 26.332 | |
| William Conkling Chief Commercial Officer - [O] | 76.000 | 76.000 | |
| Scott A Canute | 12.700 | ||
| Julio Casoy Chief Medical Officer - [O] | 45.500 | 45.500 | |
|
Management Co Deerfield
10% Owner -
|
12.700 | 0 | |
| Deerfield Partners, L.p. Director - [D] | 0 | 0 | |
| Blaine Davis Chief Financial Officer - [O] | 20.662 | 20.662 | |
| Deerfield International Master Fund, L.P. Director - [D] | 0 | 0 | |
|
Deerfield Mgmt III, L.P.
10% Owner -
|
1.311.766 | 1.311.766 | |
| Deerfield Mgmt IV, L.P. Director - [D] | 1.311.766 | 1.311.766 | |
|
Deerfield Mgmt L.P.
10% Owner -
|
0 | 0 | |
|
Deerfield Private Design Fund III, L.P.
10% Owner -
|
1.311.766 | 1.311.766 | |
| Deerfield Private Design Fund IV, L.P. Director - [D] | 1.311.766 | 1.311.766 | |
|
Deerfield Special Situations Fund, L.P.
10% Owner -
|
1.311.766 | 1.311.766 |
| Insider | Gennemsnitlig fortjeneste (%) | Aktier Ejet |
Dele Justeret |
|---|---|---|---|
|
Deerfield Special Situations International Master Fund, L.P.
10% Owner -
|
170.371 | 170.371 | |
| George Arthur Eldridge, Sr VP, CFO, Treasr, Asst Secy - [O] | 29.132 | 29.132 | |
| Patrick Fabbio Chief Financial Officer - [O] | 64.115 | 64.115 | |
|
Stefan Fischer
10% Owner -
|
500 | 1.943.059 | |
| Barry P Flannelly | 26.250 | ||
| James E Flynn Director - [D] | 0 | 0 | |
|
John Gordon Freund
10% Owner -
|
2.175.882 | 2.175.882 | |
| Hannah Fry VP, Controller - [O] | 42.723 | 42.723 | |
| Roger Garceau Director - [D] | 33.000 | 33.000 | |
|
Alexandra Goll
10% Owner -
|
1.943.059 | 1.943.059 | |
| Daniel Philip Gottlieb VP Corporate Development - [O] | 244 | 244 | |
| Paul J Hastings Director - [D] | 13.272 | 13.272 | |
| Timothy Haines - | 2.144.517 | 2.144.517 | |
| Bradley J Hartman | 70.000 | ||
|
Yasunori Kaneko
10% Owner -
|
1.432.930 | 1.432.930 | |
| Stuart A Kingsley | 12.700 | ||
|
Dmitry Kobyzev
Director, 10% Owner -
[D]
|
1.165.344 | 1.165.344 | |
| Matthew Paul Kowalsky VP, Legal and Secretary - [O] | 29.479 | 29.479 | |
| Jonathan S Leff Director - [D] | 0 | 0 | |
| Richard S Levy Director - [D] | 51.000 | 51.000 |
| Insider | Gennemsnitlig fortjeneste (%) | Aktier Ejet |
Dele Justeret |
|---|---|---|---|
| Randall Marshall - | 585.600 | 585.600 | |
| Timothy P Noyes President and CEO, Director - [D] [O] | 0 | 0 | |
| Leonardo Viana Nicacio Chief Medical Officer - [O] | 78.181 | 78.181 | |
| Brendan O'Leary Director - [D] | 1.387.198 | 1.387.198 | |
| Martin Sebastian Olivo Chief Medical Officer - [O] | 14.344 | 14.344 | |
|
Opaleye Management Inc.
10% Owner -
|
45.000 | 45.000 | |
|
Opaleye, L.P.
10% Owner -
|
2.208.472 | 2.208.472 | |
| Gregory D Phelps | 6.666 | ||
|
Pharmstandard International S.A.
10% Owner -
|
1.165.344 | 1.165.344 | |
|
Joint Stock Co Pharmstandard Public
10% Owner -
|
1.165.344 | 1.165.344 | |
| Gregory Sargen Director - [D] | 31.000 | 31.000 | |
|
Helmut Schuhsler
10% Owner -
|
500 | 1.943.059 | |
| Jesse Shefferman CEO and President, Director - [D] [O] | 1.021.832 | 1.021.832 | |
|
Skyline Venture Management IV, LLC
10% Owner -
|
1.432.930 | 1.432.930 | |
|
Skyline Venture Partners Qualified Purchaser Fund IV L P
10% Owner -
|
1.432.930 | 1.432.930 | |
| Michael Edward Solomon Director - [D] | 26.500 | 26.500 | |
|
TVM Life Science Ventures VI GmbH & Co KG
10% Owner -
|
1.943.059 | 1.943.059 | |
|
TVM Life Science Ventures VI LP
10% Owner -
|
500 | 1.943.059 | |
| Toner E. Scott Senior VP of Commercial - [O] | 23.357 | 23.357 | |
| Jacqueline Zummo Chief R&D Officer - [O] | 94.827 | 94.827 |
Report errors via our new Insider Auditing Tool
Track Records af insiderkøb - Kortsigtet profitanalyse
I dette afsnit analyserer vi rentabiliteten af ethvert uplanlagt insiderkøb i åbent marked foretaget i TARA / Protara Therapeutics, Inc.. Denne analyse hjælper med at forstå, om insideren konsekvent genererer unormale afkast og er værd at følge. Denne analyse er for et år efter hver handel, og resultaterne er teoretiske .
Følgende tabel viser de seneste køb på det åbne marked, der ikke var en del af en automatisk handelsplan.
Justeret pris er den split-justerede pris. Adjusted Shares er de split-justerede aktier.
Track Records af insidersalg - Kortsigtet tabsanalyse
I dette afsnit analyserer vi den kortsigtede undgåelse af tab af ethvert uplanlagt insidersalg på åbent marked, der foretages i TARA / Protara Therapeutics, Inc.. Et konsekvent mønster af tabsforebyggelse kan tyde på, at fremtidige salgstransaktioner kan forudsige prisfald. Denne analyse er for et år efter hver handel, og resultaterne er teoretiske .
Følgende tabel viser de seneste salg på det åbne marked, der ikke var en del af en automatisk handelsplan.
Justeret pris er den split-justerede pris. Adjusted Shares er de split-justerede aktier.
Transaktionshistorik
Klik på linkikonet for at se den fulde transaktionshistorik. Transaktioner, der rapporteres som en del af en automatisk handelsplan 10b5-1, vil have et X i kolonnen markeret 10b-5.
| Fil Dato |
Handle Dato |
Form | Insider | Ticker | Sikkerhedstitel | Kode | Direkte | Dyrke motion Pris |
Enhed Pris |
Enheder Ændret |
Værdi Ændret (1K) |
Tilbage Muligheder |
Tilbage Aktier |
|
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2026-04-09 | 2026-04-08 | 4 | Zummo Jacqueline | TARA | Common Stock | D | 5,4000 | -1.134 | -6 | 94.827 | ||||
| 2026-04-02 | 2026-04-01 | 4 | Zummo Jacqueline | TARA | Common Stock | D | 5,2600 | -22.598 | -119 | 95.961 | ||||
| 2026-01-27 | 2026-01-26 | 4 | Zummo Jacqueline | TARA | Common Stock | D | 6,6700 | -3.724 | -25 | 118.559 | ||||
| 2026-01-27 | 2026-01-26 | 4 | Shefferman Jesse | TARA | Common Stock | D | 6,6700 | -8.732 | -58 | 1.021.832 | ||||
| 2026-01-27 | 2026-01-26 | 4 | Fabbio Patrick | TARA | Common Stock | D | 6,6700 | -3.261 | -22 | 64.115 | ||||
| 2026-01-27 | 2026-01-26 | 4 | Fry Hannah | TARA | Common Stock | D | 6,6700 | -1.457 | -10 | 42.723 | ||||
| 2026-01-22 | 2026-01-20 | 4 | Zummo Jacqueline | TARA | Common Stock | D | 5,6000 | -6.578 | -37 | 122.283 | ||||
| 2026-01-22 | 2026-01-20 | 4 | Fry Hannah | TARA | Common Stock | D | 5,6000 | -2.132 | -12 | 44.180 | ||||
| 2026-01-22 | 2026-01-20 | 4 | Fabbio Patrick | TARA | Common Stock | D | 5,6000 | -3.063 | -17 | 67.376 | ||||
| 2026-01-22 | 2026-01-20 | 4 | Shefferman Jesse | TARA | Common Stock | D | 5,6000 | -16.322 | -91 | 1.030.564 | ||||
| 2026-01-21 | 2026-01-16 | 4 | CONKLING WILLIAM | TARA | Common Stock | D | 26.000 | 76.000 | ||||||
| 2026-01-21 | 2026-01-16 | 4 | Shefferman Jesse | TARA | Common Stock | D | 87.000 | 1.046.886 | ||||||
| 2026-01-21 | 2026-01-16 | 4 | Zummo Jacqueline | TARA | Common Stock | D | 30.000 | 128.861 | ||||||
| 2026-01-21 | 2026-01-16 | 4 | Nicacio Leonardo Viana | TARA | Common Stock | D | 26.000 | 78.181 | ||||||
| 2026-01-21 | 2026-01-16 | 4 | Fry Hannah | TARA | Common Stock | D | 9.500 | 46.312 | ||||||
| 2026-01-21 | 2026-01-16 | 4 | Fabbio Patrick | TARA | Common Stock | D | 28.000 | 70.439 | ||||||
| 2025-07-07 | 2025-06-24 | 4 | Shefferman Jesse | TARA | Common Stock | D | -300.000 | 659.886 | ||||||
| 2025-06-30 | 2025-06-27 | 4 | Shefferman Jesse | TARA | Common Stock | D | -3.367 | 959.886 | ||||||
| 2025-06-30 | 2025-06-27 | 4 | Shefferman Jesse | TARA | Common Stock | D | -10.200 | 963.253 | ||||||
| 2025-06-30 | 2025-06-26 | 4 | Shefferman Jesse | TARA | Common Stock | D | -3.400 | 973.453 | ||||||
| 2025-06-30 | 2025-06-26 | 4 | Shefferman Jesse | TARA | Common Stock | D | -1.700 | 976.853 | ||||||
| 2025-06-04 | 2025-06-02 | 4 | CONKLING WILLIAM | TARA | Common Stock | D | 50.000 | 50.000 | ||||||
| 2025-05-19 | 2025-05-14 | 4/A | Levy Richard S | TARA | Common Stock | D | 3,1900 | 20.000 | 64 | 51.000 | ||||
| 2025-05-16 | 2025-05-14 | 4 | Levy Richard S | TARA | Common Stock | D | 3,1900 | 20.000 | 64 | 51.000 | ||||
| 2025-04-17 | 2025-04-15 | 4 | Nicacio Leonardo Viana | TARA | Common Stock | D | 50.000 | 52.181 | ||||||
| 2025-04-17 | 3 | Nicacio Leonardo Viana | TARA | Common Stock | D | 2.181 | ||||||||
| 2025-03-28 | 2025-03-26 | 4 | Zummo Jacqueline | TARA | Common Stock | D | 4,5300 | -21.224 | -96 | 98.861 | ||||
| 2025-01-28 | 2025-01-24 | 4 | Zummo Jacqueline | TARA | Common Stock | D | 24.500 | 126.639 | ||||||
| 2025-01-28 | 2025-01-24 | 4 | Shefferman Jesse | TARA | Common Stock | D | 65.000 | 994.022 | ||||||
| 2025-01-28 | 2025-01-24 | 4 | Fabbio Patrick | TARA | Common Stock | D | 23.500 | 45.500 | ||||||
| 2025-01-28 | 2025-01-24 | 4 | Fry Hannah | TARA | Common Stock | D | 9.500 | 38.942 | ||||||
| 2025-01-23 | 2025-01-21 | 4 | Zummo Jacqueline | TARA | Common Stock | D | 4,7600 | -6.554 | -31 | 95.585 | ||||
| 2025-01-23 | 2025-01-21 | 4 | Fry Hannah | TARA | Common Stock | D | 4,7600 | -2.130 | -10 | 27.312 | ||||
| 2025-01-23 | 2025-01-21 | 4 | Fabbio Patrick | TARA | Common Stock | D | 4,7600 | -3.061 | -15 | 18.939 | ||||
| 2025-01-23 | 2025-01-21 | 4 | Shefferman Jesse | TARA | Common Stock | D | 4,7600 | -15.469 | -74 | 913.553 | ||||
| 2025-01-07 | 2025-01-03 | 4 | Fry Hannah | TARA | Common Stock | D | 6,1400 | -394 | -2 | 29.442 | ||||
| 2025-01-07 | 2025-01-03 | 4 | Zummo Jacqueline | TARA | Common Stock | D | 6,1400 | -2.157 | -13 | 102.139 | ||||
| 2025-01-07 | 2025-01-03 | 4 | Shefferman Jesse | TARA | Common Stock | D | 6,1400 | -6.479 | -40 | 929.022 | ||||
| 2024-09-12 | 2024-09-12 | 4 | Opaleye Management Inc. By Managed account | TARA | Common Stock, par value $0.001 per share | I | 1,7089 | -6.500 | -11 | 45.000 | ||||
| 2024-09-12 | 2024-09-12 | 4 | Opaleye Management Inc. By Opaleye, L.P. | TARA | Common Stock, par value $0.001 per share | I | 1,7089 | -119.801 | -205 | 1.944.134 | ||||
| 2024-09-12 | 2024-09-11 | 4 | Opaleye Management Inc. By Managed account | TARA | Common Stock, par value $0.001 per share | I | 1,7141 | -1.600 | -3 | 51.500 | ||||
| 2024-09-12 | 2024-09-11 | 4 | Opaleye Management Inc. By Opaleye, L.P. | TARA | Common Stock, par value $0.001 per share | I | 1,7141 | -31.000 | -53 | 2.063.935 | ||||
| 2024-09-10 | 2024-09-10 | 4 | Opaleye Management Inc. By Managed account | TARA | Common Stock, par value $0.001 per share | I | 1,7690 | -1.500 | -3 | 53.100 | ||||
| 2024-09-10 | 2024-09-10 | 4 | Opaleye Management Inc. By Opaleye, L.P. | TARA | Common Stock, par value $0.001 per share | I | 1,7690 | -24.000 | -42 | 2.094.935 | ||||
| 2024-09-10 | 2024-09-09 | 4 | Opaleye Management Inc. By Managed account | TARA | Common Stock, par value $0.001 per share | I | 1,8947 | -1.900 | -4 | 54.600 | ||||
| 2024-09-10 | 2024-09-09 | 4 | Opaleye Management Inc. By Opaleye, L.P. | TARA | Common Stock, par value $0.001 per share | I | 1,8947 | -34.592 | -66 | 2.118.935 | ||||
| 2024-08-30 | 2024-08-28 | 4 | Shefferman Jesse | TARA | Common Stock | D | -3.300 | 935.501 | ||||||
| 2024-08-30 | 2024-08-28 | 4 | Shefferman Jesse | TARA | Common Stock | D | -5.263 | 938.801 | ||||||
| 2024-07-18 | 2024-07-16 | 4 | Opaleye Management Inc. By Managed account | TARA | Common Stock, par value $0.001 per share | I | 2,4419 | -3.500 | -9 | 56.500 | ||||
| 2024-07-18 | 2024-07-16 | 4 | Opaleye Management Inc. By Opaleye, L.P. | TARA | Common Stock, par value $0.001 per share | I | 2,4419 | -7.896 | -19 | 2.153.527 | ||||
| 2024-07-11 | 2024-07-11 | 4 | Opaleye Management Inc. By Managed account | TARA | Common Stock, par value $0.001 per share | I | 2,4034 | -15.000 | -36 | 60.000 | ||||
| 2024-07-11 | 2024-07-11 | 4 | Opaleye Management Inc. By Opaleye, L.P. | TARA | Common Stock, par value $0.001 per share | I | 2,4034 | -32.993 | -79 | 2.161.423 | ||||
| 2024-07-11 | 2024-07-10 | 4 | Opaleye Management Inc. By Managed account | TARA | Common Stock, par value $0.001 per share | I | 2,3080 | -5.000 | -12 | 75.000 | ||||
| 2024-07-11 | 2024-07-10 | 4 | Opaleye Management Inc. By Opaleye, L.P. | TARA | Common Stock, par value $0.001 per share | I | 2,3080 | -13.061 | -30 | 2.194.416 | ||||
| 2024-07-11 | 2024-07-09 | 4 | Opaleye Management Inc. By Managed account | TARA | Common Stock, par value $0.001 per share | I | 2,2138 | -2.500 | -6 | 80.000 | ||||
| 2024-07-11 | 2024-07-09 | 4 | Opaleye Management Inc. By Opaleye, L.P. | TARA | Common Stock, par value $0.001 per share | I | 2,2138 | -5.997 | -13 | 2.207.477 | ||||
| 2024-07-03 | 2024-07-01 | 4 | Opaleye Management Inc. By Managed account | TARA | Common Stock, par value $0.001 per share | I | 2,1233 | -2.500 | -5 | 87.500 | ||||
| 2024-07-03 | 2024-07-01 | 4 | Opaleye Management Inc. By Opaleye, L.P. | TARA | Common Stock, par value $0.001 per share | I | 2,1233 | -5.788 | -12 | 2.213.474 | ||||
| 2024-06-28 | 2024-06-28 | 4 | Opaleye Management Inc. By Managed account | TARA | Common Stock, par value $0.001 per share | I | 2,0748 | -5.000 | -10 | 85.000 | ||||
| 2024-06-28 | 2024-06-28 | 4 | Opaleye Management Inc. By Opaleye, L.P. | TARA | Common Stock, par value $0.001 per share | I | 2,0748 | -12.994 | -27 | 2.219.262 | ||||
| 2024-06-28 | 2024-06-27 | 4 | Opaleye Management Inc. By Managed account | TARA | Common Stock, par value $0.001 per share | I | 2,2581 | -12.471 | -28 | 90.000 | ||||
| 2024-06-28 | 2024-06-27 | 4 | Opaleye Management Inc. By Opaleye, L.P. | TARA | Common Stock, par value $0.001 per share | I | 2,2581 | -34.103 | -77 | 2.232.256 | ||||
| 2024-06-27 | 2024-06-25 | 4 | Opaleye Management Inc. By Managed account | TARA | Common Stock, par value $0.001 per share | I | 2,2581 | -6.225 | -14 | 102.471 | ||||
| 2024-06-27 | 2024-06-25 | 4 | Opaleye Management Inc. By Opaleye, L.P. | TARA | Common Stock, par value $0.001 per share | I | 2,2581 | -6.500 | -15 | 2.266.359 | ||||
| 2024-05-31 | 2024-05-31 | 4 | Opaleye Management Inc. By Managed account | TARA | Common Stock, par value $0.001 per share | I | 2,9009 | -5.824 | -17 | 108.696 | ||||
| 2024-05-31 | 2024-05-30 | 4 | Opaleye Management Inc. By Managed account | TARA | Common Stock, par value $0.001 per share | I | 2,9375 | -9.230 | -27 | 114.520 | ||||
| 2024-05-23 | 2024-05-22 | 4 | Opaleye Management Inc. By Managed account | TARA | Common Stock, par value $0.001 per share | I | 3,0021 | -500 | -2 | 123.750 | ||||
| 2024-05-23 | 2024-05-22 | 4 | Opaleye Management Inc. By Managed account | TARA | Common Stock, par value $0.001 per share | I | 3,0210 | -9.300 | -28 | 2.272.859 | ||||
| 2024-05-23 | 2024-05-21 | 4 | Opaleye Management Inc. By Managed account | TARA | Common Stock, par value $0.001 per share | I | 3,0557 | -1.800 | -6 | 124.250 | ||||
| 2024-05-23 | 2024-05-21 | 4 | Opaleye Management Inc. By Opaleye, L.P. | TARA | Common Stock, par value $0.001 per share | I | 3,0557 | -31.200 | -95 | 2.282.159 | ||||
| 2024-05-17 | 2024-05-17 | 4 | Opaleye Management Inc. By Managed account | TARA | Common Stock, par value $0.001 per share | I | 3,0606 | -1.200 | -4 | 126.050 | ||||
| 2024-05-17 | 2024-05-17 | 4 | Opaleye Management Inc. By Managed account | TARA | Common Stock, par value $0.001 per share | I | 3,3281 | -2.750 | -9 | 127.250 | ||||
| 2024-05-17 | 2024-05-17 | 4 | Opaleye Management Inc. By Opaleye, L.P. | TARA | Common Stock, par value $0.001 per share | I | 3,0606 | -19.685 | -60 | 2.313.359 | ||||
| 2024-05-17 | 2024-05-17 | 4 | Opaleye Management Inc. By Opaleye, L.P. | TARA | Common Stock, par value $0.001 per share | I | 3,3281 | -47.250 | -157 | 2.333.044 | ||||
| 2024-05-10 | 2024-05-10 | 4 | Opaleye Management Inc. By Opaleye, L.P. | TARA | Common Stock, par value $0.001 per share | I | 3,1142 | -151.700 | -472 | 2.380.294 | ||||
| 2024-05-10 | 2024-05-09 | 4 | Opaleye Management Inc. By Opaleye, L.P. | TARA | Common Stock, par value $0.001 per share | I | 3,0891 | -30.600 | -95 | 2.531.994 | ||||
| 2024-01-23 | 2024-01-19 | 4 | Fry Hannah | TARA | Common Stock | D | 1,9100 | -904 | -2 | 29.836 | ||||
| 2024-01-23 | 2024-01-19 | 4 | Fry Hannah | TARA | Common Stock | D | 8.000 | 30.740 | ||||||
| 2024-01-23 | 2024-01-19 | 4 | Fabbio Patrick | TARA | Common Stock | D | 22.000 | 22.000 | ||||||
| 2024-01-23 | 2024-01-19 | 4 | Zummo Jacqueline | TARA | Common Stock | D | 1,9100 | -3.049 | -6 | 104.296 | ||||
| 2024-01-23 | 2024-01-19 | 4 | Zummo Jacqueline | TARA | Common Stock | D | 23.000 | 107.345 | ||||||
| 2024-01-23 | 2024-01-19 | 4 | Bandari Jathin | TARA | Common Stock | D | 1,9100 | -2.879 | -5 | 56.704 | ||||
| 2024-01-23 | 2024-01-19 | 4 | Bandari Jathin | TARA | Common Stock | D | 23.000 | 59.583 | ||||||
| 2024-01-23 | 2024-01-19 | 4 | Shefferman Jesse | TARA | Common Stock | D | 1,9100 | -7.803 | -15 | 944.064 | ||||
| 2024-01-23 | 2024-01-19 | 4 | Shefferman Jesse | TARA | Common Stock | D | 59.000 | 951.867 | ||||||
| 2024-01-12 | 2024-01-10 | 4 | Bandari Jathin | TARA | Common Stock | D | 2,3900 | -1.877 | -4 | 36.583 | ||||
| 2024-01-12 | 2024-01-10 | 4 | Zummo Jacqueline | TARA | Common Stock | D | 2,3900 | -5.229 | -12 | 84.345 | ||||
| 2024-01-12 | 2024-01-10 | 4 | Shefferman Jesse | TARA | Common Stock | D | 2,3900 | -5.746 | -14 | 892.867 | ||||
| 2024-01-05 | 2024-01-03 | 4 | Zummo Jacqueline | TARA | Common Stock | D | 2,1700 | -1.899 | -4 | 89.574 | ||||
| 2024-01-05 | 2024-01-03 | 4 | Shefferman Jesse | TARA | Common Stock | D | 2,1700 | -5.840 | -13 | 898.613 | ||||
| 2024-01-05 | 2024-01-03 | 4 | Fry Hannah | TARA | Common Stock | D | 2,1700 | -324 | -1 | 22.740 | ||||
| 2023-07-18 | 2023-07-17 | 4 | Fry Hannah | TARA | Common Stock | D | 2,5600 | -10.075 | -26 | 23.064 | ||||
| 2023-07-05 | 2023-07-03 | 4 | Bandari Jathin | TARA | Common Stock | D | 2,4600 | -682 | -2 | 38.460 | ||||
| 2023-06-27 | 2023-06-27 | 4 | Shefferman Jesse | TARA | Common Stock | D | -7.420 | 904.453 | ||||||
| 2023-06-27 | 2023-06-23 | 4 | Shefferman Jesse | TARA | Common Stock | D | -1.890 | 911.873 | ||||||
| 2023-02-10 | 2022-06-27 | 5 | Shefferman Jesse | TARA | Common Stock | D | -4.519 | 913.763 | ||||||
| 2023-01-20 | 2023-01-19 | 4 | Bandari Jathin | TARA | Common Stock | D | 20.700 | 39.142 | ||||||
| 2023-01-20 | 2023-01-19 | 4 | Zummo Jacqueline | TARA | Common Stock | D | 19.900 | 91.473 | ||||||
| 2023-01-20 | 2023-01-19 | 4 | Fry Hannah | TARA | Common Stock | D | 5.900 | 33.139 | ||||||
| 2023-01-20 | 2023-01-19 | 4 | Shefferman Jesse | TARA | Common Stock | D | 51.300 | 918.282 | ||||||
| 2023-01-11 | 2023-01-10 | 4 | Zummo Jacqueline | TARA | Common Stock | D | 3,0000 | -5.225 | -16 | 71.573 | ||||
| 2023-01-11 | 2023-01-10 | 4 | Bandari Jathin | TARA | Common Stock | D | 3,0000 | -1.876 | -6 | 18.442 | ||||
| 2023-01-11 | 2023-01-10 | 4 | Shefferman Jesse | TARA | Common Stock | D | 3,0000 | -5.855 | -18 | 866.982 | ||||
| 2023-01-04 | 2023-01-03 | 4 | Zummo Jacqueline | TARA | Common Stock | D | 2,8000 | -2.159 | -6 | 76.798 | ||||
| 2023-01-04 | 2023-01-03 | 4 | Shefferman Jesse | TARA | Common Stock | D | 2,8000 | -6.604 | -18 | 872.837 | ||||
| 2023-01-04 | 2023-01-03 | 4 | Fry Hannah | TARA | Common Stock | D | 2,8000 | -361 | -1 | 27.239 | ||||
| 2022-12-30 | 2022-12-30 | 4 | Opaleye Management Inc. By Managed Account | TARA | Common Stock, par value $0.001 per share | I | 2,7111 | 2.300 | 6 | 130.000 | ||||
| 2022-12-30 | 2022-12-30 | 4 | Opaleye Management Inc. By Opaleye, L.P. | TARA | Common Stock, par value $0.001 per share | I | 2,7111 | 13.173 | 36 | 2.562.594 | ||||
| 2022-09-15 | 2022-09-15 | 4 | Opaleye Management Inc. By Managed Account | TARA | Common Stock, par value $0.001 per share | I | 3,8000 | 2.300 | 9 | 132.300 | ||||
| 2022-09-15 | 2022-09-15 | 4 | Opaleye Management Inc. By Opaleye, L.P. | TARA | Common Stock, par value $0.001 per share | I | 3,8000 | 5.000 | 19 | 2.575.777 | ||||
| 2022-09-15 | 2022-09-14 | 4 | Opaleye Management Inc. By Managed Account | TARA | Common Stock, par value $0.001 per share | I | 3,9800 | 2.500 | 10 | 130.000 | ||||
| 2022-09-15 | 2022-09-14 | 4 | Opaleye Management Inc. By Opaleye, L.P. | TARA | Common Stock, par value $0.001 per share | I | 3,9800 | 14.100 | 56 | 2.570.777 | ||||
| 2022-08-15 | 2022-08-11 | 4 | Shefferman Jesse | TARA | Common Stock | D | 3,8400 | 9.065 | 35 | 879.441 | ||||
| 2022-07-19 | 2022-07-15 | 4 | Davis Blaine | TARA | Common Stock | D | 3,1300 | -5.081 | -16 | 20.662 | ||||
| 2022-07-19 | 2022-07-16 | 4 | Fry Hannah | TARA | Common Stock | D | 25.000 | 27.600 | ||||||
| 2022-07-19 | 3 | Fry Hannah | TARA | Common Stock | D | 2.600 | ||||||||
| 2022-07-05 | 2022-06-30 | 4 | BESHAR LUKE M | TARA | Common Stock | D | 3,1000 | 10.000 | 31 | 198.000 | ||||
| 2022-07-05 | 2022-07-01 | 4 | Bandari Jathin | TARA | Common Stock | D | 3,2200 | -682 | -2 | 20.318 | ||||
| 2022-04-15 | 2022-04-08 | 4/A | Opaleye Management Inc. By Managed Account | TARA | Common Stock, par value $0.001 per share | I | 4,7958 | 2.469 | 12 | 127.500 | ||||
| 2022-04-15 | 2022-04-08 | 4/A | Opaleye Management Inc. By Opaleye, L.P. | TARA | Common Stock, par value $0.001 per share | I | 4,7958 | 5.322 | 26 | 2.556.667 | ||||
| 2022-04-15 | 2022-04-07 | 4/A | Opaleye Management Inc. By Managed Account | TARA | Common Stock, par value $0.001 per share | I | 4,7432 | 1.000 | 5 | 125.031 | ||||
| 2022-04-15 | 2022-04-07 | 4/A | Opaleye Management Inc. By Opaleye, L.P. | TARA | Common Stock, par value $0.001 per share | I | 4,7432 | 1.345 | 6 | 2.551.345 | ||||
| 2022-04-08 | 2022-04-08 | 4 | Opaleye Management Inc. By Managed Account | TARA | Common Stock, par value $0.001 per share | I | 4,7958 | 2.469 | 12 | 128 | ||||
| 2022-04-08 | 2022-04-08 | 4 | Opaleye Management Inc. By Opaleye, L.P. | TARA | Common Stock, par value $0.001 per share | I | 4,7958 | 5.322 | 26 | 2.556.667 | ||||
| 2022-04-08 | 2022-04-07 | 4 | Opaleye Management Inc. By Managed Account | TARA | Common Stock, par value $0.001 per share | I | 4,7432 | 1.000 | 5 | 125.031 | ||||
| 2022-04-08 | 2022-04-07 | 4 | Opaleye Management Inc. By Opaleye, L.P. | TARA | Common Stock, par value $0.001 per share | I | 4,7432 | 1.345 | 6 | 2.551.345 | ||||
| 2022-03-16 | 2022-03-14 | 4 | BESHAR LUKE M | TARA | Common Stock | D | 4,2500 | 10.000 | 42 | 188.000 | ||||
| 2022-03-14 | 2022-03-10 | 4 | BESHAR LUKE M | TARA | Common Stock | D | 4,4555 | 10.000 | 45 | 178.000 | ||||
| 2022-02-11 | 2021-06-29 | 5 | Shefferman Jesse | TARA | Common Stock | D | -513 | 870.376 | ||||||
| 2022-02-11 | 2021-06-29 | 5 | Shefferman Jesse | TARA | Common Stock | D | -1.536 | 870.889 | ||||||
| 2022-01-31 | 2022-01-28 | 4 | Opaleye Management Inc. By Managed Account | TARA | Common Stock, par value $0.001 per share | I | 4,9632 | 4.031 | 20 | 124.031 | ||||
| 2022-01-31 | 2022-01-28 | 4 | Opaleye Management Inc. By Opaleye, L.P. | TARA | Common Stock, par value $0.001 per share | I | 4,9632 | 20.000 | 99 | 2.550.000 | ||||
| 2022-01-12 | 2022-01-10 | 4 | Zummo Jacqueline | TARA | Common Stock | D | 6,2700 | -4.603 | -29 | 78.957 | ||||
| 2022-01-12 | 2022-01-10 | 4 | Shefferman Jesse | TARA | Common Stock | D | 6,2700 | -5.080 | -32 | 872.425 | ||||
| 2022-01-12 | 2022-01-10 | 4 | Bandari Jathin | TARA | Stock Option (Right to Buy) | D | 6,27 | 81.000 | 81.000 | |||||
| 2022-01-12 | 2022-01-10 | 4 | Bandari Jathin | TARA | Common Stock | D | 13.500 | 13.500 | ||||||
| 2022-01-12 | 3 | Bandari Jathin | TARA | Common Stock | D | 7.500 | ||||||||
| 2022-01-05 | 2022-01-03 | 4 | Shefferman Jesse | TARA | Stock Option (Right to Buy) | D | 6,90 | 253.500 | 253.500 | |||||
| 2022-01-05 | 2022-01-03 | 4 | Shefferman Jesse | TARA | Common Stock | D | 42.300 | 877.505 | ||||||
| 2022-01-05 | 2022-01-03 | 4 | Zummo Jacqueline | TARA | Stock Option (Right to Buy) | D | 6,90 | 84.800 | 84.800 | |||||
| 2022-01-05 | 2022-01-03 | 4 | Zummo Jacqueline | TARA | Common Stock | D | 14.100 | 83.560 | ||||||
| 2022-01-05 | 2022-01-03 | 4 | Davis Blaine | TARA | Stock Option (Right to Buy) | D | 6,90 | 84.800 | 84.800 | |||||
| 2022-01-05 | 2022-01-03 | 4 | Davis Blaine | TARA | Common Stock | D | 14.100 | 15.581 | ||||||
| 2021-12-29 | 2021-12-29 | 4 | Opaleye Management Inc. By Managed Account | TARA | Common Stock, par value $0.001 per share | I | 6,9795 | 4.500 | 31 | 120.000 | ||||
| 2021-12-29 | 2021-12-28 | 4 | Opaleye Management Inc. By Managed Account | TARA | Common Stock, par value $0.001 per share | I | 6,3588 | 5.500 | 35 | 115.500 | ||||
| 2021-12-29 | 2021-12-28 | 4 | Opaleye Management Inc. By Opaleye, L.P. | TARA | Common Stock, par value $0.001 per share | I | 6,3588 | 1.591 | 10 | 2.530.000 | ||||
| 2021-12-27 | 2021-12-27 | 4 | Opaleye Management Inc. By Managed Account | TARA | Common Stock, par value $0.001 per share | I | 6,5317 | 5.000 | 33 | 110.000 | ||||
| 2021-12-27 | 2021-12-27 | 4 | Opaleye Management Inc. By Opaleye, L.P. | TARA | Common Stock, par value $0.001 per share | I | 6,5317 | 31.700 | 207 | 2.528.409 | ||||
| 2021-12-27 | 2021-12-23 | 4 | Opaleye Management Inc. By Managed Account | TARA | Common Stock, par value $0.001 per share | I | 6,6000 | 800 | 5 | 105.000 | ||||
| 2021-12-27 | 2021-12-23 | 4 | Opaleye Management Inc. By Opaleye, L.P. | TARA | Common Stock, par value $0.001 per share | I | 6,6000 | 500 | 3 | 2.496.709 | ||||
| 2021-12-22 | 2021-12-20 | 4 | Opaleye Management Inc. By Opaleye, L.P. | TARA | Common Stock, par value $0.001 per share | I | 6,4900 | 703 | 5 | 2.496.209 | ||||
| 2021-12-20 | 2021-12-17 | 4 | Opaleye Management Inc. By Managed Account | TARA | Common Stock, par value $0.001 per share | I | 6,6000 | 490 | 3 | 104.200 | ||||
| 2021-12-20 | 2021-12-17 | 4 | Opaleye Management Inc. By Opaleye, L.P. | TARA | Common Stock, par value $0.001 per share | I | 6,6000 | 2.300 | 15 | 2.495.506 | ||||
| 2021-12-20 | 2021-12-16 | 4 | Opaleye Management Inc. By Managed Account | TARA | Common Stock, par value $0.001 per share | I | 6,4108 | 1.063 | 7 | 103.710 | ||||
| 2021-12-20 | 2021-12-16 | 4 | Opaleye Management Inc. By Opaleye, L.P. | TARA | Common Stock, par value $0.001 per share | I | 6,4108 | 6.500 | 42 | 2.493.206 | ||||
| 2021-11-19 | 2021-11-18 | 4 | Opaleye Management Inc. By Managed Account | TARA | Common Stock, par value $0.001 per share | I | 6,9795 | 1.000 | 7 | 102.647 | ||||
| 2021-11-19 | 2021-11-18 | 4 | Opaleye Management Inc. By Opaleye, L.P. | TARA | Common Stock, par value $0.001 per share | I | 6,9795 | 14.206 | 99 | 2.486.706 | ||||
| 2021-11-19 | 2021-11-17 | 4 | Opaleye Management Inc. By Managed Account | TARA | Common Stock, par value $0.001 per share | I | 6,9800 | 1.090 | 8 | 101.647 | ||||
| 2021-11-19 | 2021-11-17 | 4 | Opaleye Management Inc. By Opaleye, L.P. | TARA | Common Stock, par value $0.001 per share | I | 6,9800 | 8.028 | 56 | 2.472.500 | ||||
| 2021-11-08 | 2021-11-04 | 4 | Opaleye Management Inc. By Managed Account | TARA | Common Stock, par value $0.001 per share | I | 6,5000 | 557 | 4 | 100.557 | ||||
| 2021-11-08 | 2021-11-04 | 4 | Opaleye Management Inc. By Opaleye, L.P. | TARA | Common Stock, par value $0.001 per share | I | 6,5000 | 6.000 | 39 | 2.464.472 | ||||
| 2021-06-14 | 2021-06-10 | 4 | Olivo Martin Sebastian | TARA | Common Stock | D | 10,1300 | 4.934 | 50 | 14.344 | ||||
| 2021-06-14 | 2021-06-10 | 4 | Olivo Martin Sebastian | TARA | Common Stock | D | 10,0800 | 4.959 | 50 | 9.410 | ||||
| 2021-06-10 | 2021-06-09 | 4 | Huang Jane | TARA | Stock Option (Right to Buy) | D | 10,51 | 10.000 | 10.000 | |||||
| 2021-06-10 | 2021-06-09 | 4 | Huang Jane | TARA | Stock Option (Right to Buy) | D | 10,51 | 20.000 | 20.000 | |||||
| 2021-06-10 | 2021-06-09 | 4 | Flannelly Barry P | TARA | Stock Option (Right to Buy) | D | 10,51 | 10.000 | 10.000 | |||||
| 2021-06-10 | 2021-06-09 | 4 | Smith Cynthia | TARA | Stock Option (Right to Buy) | D | 10,51 | 10.000 | 10.000 | |||||
| 2021-06-10 | 2021-06-09 | 4 | Levy Richard S | TARA | Stock Option (Right to Buy) | D | 10,51 | 10.000 | 10.000 | |||||
| 2021-06-10 | 2021-06-09 | 4 | Solomon Michael Edward | TARA | Stock Option (Right to Buy) | D | 10,51 | 10.000 | 10.000 | |||||
| 2021-06-10 | 2021-06-09 | 4 | SARGEN GREGORY | TARA | Stock Option (Right to Buy) | D | 10,51 | 10.000 | 10.000 | |||||
| 2021-06-10 | 2021-06-09 | 4 | GARCEAU ROGER | TARA | Stock Option (Right to Buy) | D | 10,51 | 10.000 | 10.000 | |||||
| 2021-06-10 | 2021-06-09 | 4 | BESHAR LUKE M | TARA | Stock Option (Right to Buy) | D | 10,51 | 10.000 | 10.000 | |||||
| 2021-04-20 | 2021-04-19 | 4 | Olivo Martin Sebastian | TARA | Stock Option (Right to Buy) | D | 15,30 | 120.000 | 120.000 | |||||
| 2021-04-20 | 3 | Olivo Martin Sebastian | TARA | Common Stock | D | 4.451 | ||||||||
| 2021-02-01 | 2021-01-29 | 4 | Smith Cynthia | TARA | Stock Option (Right to Buy) | D | 17,98 | 3.750 | 21.750 | |||||
| 2021-02-01 | 2021-01-29 | 4 | Smith Cynthia | TARA | Stock Option (Right to Buy) | D | 17,98 | 18.000 | 18.000 | |||||
| 2021-01-21 | 2021-01-19 | 4 | Davis Blaine | TARA | Stock Option (Right to Buy) | D | 19,82 | 75.000 | 75.000 | |||||
| 2021-01-21 | 2021-01-19 | 4 | Zummo Jacqueline | TARA | Stock Option (Right to Buy) | D | 19,82 | 75.000 | 75.000 | |||||
| 2021-01-21 | 2021-01-19 | 4 | Shefferman Jesse | TARA | Stock Option (Right to Buy) | D | 19,82 | 202.000 | 202.000 | |||||
| 2021-01-13 | 2021-01-11 | 4 | Zummo Jacqueline | TARA | Common Stock | D | 21,1600 | -4.653 | -98 | 69.460 | ||||
| 2021-01-13 | 2021-01-11 | 4 | Shefferman Jesse | TARA | Common Stock | D | 21,1600 | -5.069 | -107 | 835.205 | ||||
| 2020-10-02 | 2020-09-30 | 4 | Opaleye Management Inc. By Opaleye, L.P. | TARA | Common Stock, par value $0.001 per share | I | 16,0000 | 50.000 | 800 | 2.458.472 | ||||
| 2020-09-25 | 2020-09-24 | 4 | Opaleye Management Inc. By Opaleye, L.P. | "TARA" | Common Stock, par value $0.001 per share | I | 16,8700 | 200.000 | 3.374 | 2.408.472 | ||||
| 2020-09-25 | 2020-09-24 | 4 | Opaleye Management Inc. By Managed Account | "TARA" | Common Stock, par value $0.001 per share | I | 16,8700 | 100.000 | 1.687 | 100.000 | ||||
| 2020-09-23 | 2020-09-22 | 4 | Davis Blaine | TARA | Common Stock | D | 16,9060 | 1.481 | 25 | 1.481 | ||||
| 2020-09-15 | 2020-09-14 | 4 | Marshall Randall | TARA | Common Stock | D | 20,0000 | -474 | -9 | 585.600 | ||||
| 2020-09-15 | 2020-09-14 | 4 | Marshall Randall | TARA | Common Stock | D | 19,2600 | -2.080 | -40 | 586.074 | ||||
| 2020-09-14 | 2020-09-10 | 4 | Marshall Randall | TARA | Common Stock | D | 18,0000 | -239 | -4 | 588.154 | ||||
| 2020-09-10 | 2020-09-09 | 4 | Marshall Randall | TARA | Common Stock | D | 19,2700 | -4.913 | -95 | 588.393 | ||||
| 2020-09-10 | 2020-09-09 | 4 | Marshall Randall | TARA | Common Stock | D | 18,1000 | -5.309 | -96 | 593.306 | ||||
| 2020-09-10 | 2020-09-08 | 4 | Marshall Randall | TARA | Common Stock | D | 18,9400 | -3.108 | -59 | 598.615 | ||||
| 2020-09-04 | 2020-09-03 | 4 | Marshall Randall | TARA | Common Stock | D | 20,1900 | -52 | -1 | 601.723 | ||||
| 2020-09-04 | 2020-09-02 | 4 | Marshall Randall | TARA | Common Stock | D | 20,6800 | -207 | -4 | 601.775 | ||||
| 2020-09-01 | 2020-08-28 | 4 | Marshall Randall | TARA | Common Stock | D | 22,0900 | -771 | -17 | 601.982 | ||||
| 2020-08-28 | 2020-08-27 | 4 | Marshall Randall | TARA | Common Stock | D | 22,3700 | -616 | -14 | 602.753 | ||||
| 2020-08-28 | 2020-08-26 | 4 | Marshall Randall | TARA | Common Stock | D | 22,4000 | -1.418 | -32 | 603.369 | ||||
| 2020-08-26 | 2020-08-25 | 4 | Marshall Randall | TARA | Common Stock | D | 22,7300 | -2.461 | -56 | 604.787 | ||||
| 2020-08-26 | 2020-08-24 | 4 | Marshall Randall | TARA | Common Stock | D | 23,1600 | -974 | -23 | 607.248 | ||||
| 2020-08-24 | 2020-08-20 | 4 | Marshall Randall | TARA | Common Stock | D | 24,1830 | -510 | -12 | 608.222 | ||||
| 2020-08-20 | 2020-08-18 | 4 | Marshall Randall | TARA | Common Stock | D | 25,1900 | -200 | -5 | 608.732 | ||||
| 2020-08-18 | 2020-08-17 | 4 | Marshall Randall | TARA | Common Stock | D | 25,1100 | -1.548 | -39 | 608.932 | ||||
| 2020-08-18 | 2020-08-14 | 4 | Marshall Randall | TARA | Common Stock | D | 25,0900 | -700 | -18 | 610.480 | ||||
| 2020-07-31 | 2020-07-30 | 4 | Marshall Randall | TARA | Common Stock | D | 26,1400 | -1.317 | -34 | 611.180 | ||||
| 2020-07-31 | 2020-07-29 | 4 | Marshall Randall | TARA | Common Stock | D | 28,4500 | -100 | -3 | 612.497 | ||||
| 2020-07-31 | 2020-07-29 | 4 | Marshall Randall | TARA | Common Stock | D | 27,2800 | -600 | -16 | 612.597 | ||||
| 2020-07-31 | 2020-07-29 | 4 | Marshall Randall | TARA | Common Stock | D | 26,0300 | -1.816 | -47 | 613.197 | ||||
| 2020-07-29 | 2020-07-28 | 4 | Marshall Randall | TARA | Common Stock | D | 35,4500 | -600 | -21 | 615.013 | ||||
| 2020-07-29 | 2020-07-28 | 4 | Marshall Randall | TARA | Common Stock | D | 33,7900 | -1.650 | -56 | 615.613 | ||||
| 2020-07-29 | 2020-07-28 | 4 | Marshall Randall | TARA | Common Stock | D | 33,0900 | -1.200 | -40 | 617.263 | ||||
| 2020-07-29 | 2020-07-28 | 4 | Marshall Randall | TARA | Common Stock | D | 31,5300 | -3.493 | -110 | 618.463 | ||||
| 2020-07-29 | 2020-07-28 | 4 | Marshall Randall | TARA | Common Stock | D | 30,4200 | -14.243 | -433 | 621.956 | ||||
| 2020-07-29 | 2020-07-28 | 4 | Marshall Randall | TARA | Common Stock | D | 28,6300 | -1.811 | -52 | 636.199 | ||||
| 2020-07-29 | 2020-07-28 | 4 | Marshall Randall | TARA | Common Stock | D | 26,8500 | -2.600 | -70 | 638.010 | ||||
| 2020-07-29 | 2020-07-27 | 4 | Marshall Randall | TARA | Common Stock | D | 26,0800 | -338 | -9 | 640.610 | ||||
| 2020-07-27 | 2020-07-23 | 4 | Flannelly Barry P | TARA | Stock Option (Right to Buy) | D | 26,70 | 8.250 | 26.250 | |||||
| 2020-07-27 | 2020-07-23 | 4 | Flannelly Barry P | TARA | Stock Option (Right to Buy) | D | 26,70 | 18.000 | 18.000 | |||||
| 2020-07-27 | 2020-07-24 | 4 | Marshall Randall | TARA | Common Stock | D | 26,0000 | -300 | -8 | 640.948 | ||||
| 2020-07-27 | 2020-07-23 | 4 | Marshall Randall | TARA | Common Stock | D | 27,2900 | -93 | -3 | 641.248 | ||||
| 2020-07-27 | 2020-07-23 | 4 | Marshall Randall | TARA | Common Stock | D | 26,5800 | -1.950 | -52 | 641.341 | ||||
| 2020-07-23 | 2020-07-22 | 4 | Marshall Randall | TARA | Common Stock | D | 27,4450 | -75 | -2 | 643.291 | ||||
| 2020-07-23 | 2020-07-22 | 4 | Marshall Randall | TARA | Common Stock | D | 26,6900 | -1.297 | -35 | 643.366 | ||||
| 2020-07-23 | 2020-07-21 | 4 | Marshall Randall | TARA | Common Stock | D | 26,5600 | -223 | -6 | 644.663 | ||||
| 2020-07-21 | 2020-07-20 | 4 | Marshall Randall | TARA | Common Stock | D | 27,6800 | -472 | -13 | 644.886 | ||||
| 2020-07-21 | 2020-07-20 | 4 | Marshall Randall | TARA | Common Stock | D | 26,7000 | -2.257 | -60 | 645.358 | ||||
| 2020-07-21 | 2020-07-17 | 4 | Marshall Randall | TARA | Common Stock | D | 26,6600 | -1.601 | -43 | 647.615 | ||||
| 2020-07-14 | 2020-07-13 | 4 | Marshall Randall | TARA | Common Stock | D | 27,1300 | -2.145 | -58 | 649.216 | ||||
| 2020-07-14 | 2020-07-10 | 4 | Marshall Randall | TARA | Common Stock | D | 27,4100 | -2.659 | -73 | 651.361 | ||||
| 2020-07-13 | 2020-07-10 | 4 | Shefferman Jesse | TARA | Stock Option (Right to Buy) | D | 27,42 | 111.250 | 111.250 | |||||
| 2020-06-11 | 2020-01-09 | 4/A | BESHAR LUKE M | TARA | Stock Option (Right to Buy) | D | 9,18 | 6.676 | 6.676 | |||||
| 2020-06-11 | 2020-01-09 | 4/A | BESHAR LUKE M | TARA | Stock Option (Right to Buy) | D | 9,18 | 12.399 | 12.399 | |||||
| 2020-06-11 | 2020-01-09 | 4/A | Braunstein Scott | TARA | Stock Option (Right to Buy) | D | 9,18 | 15.641 | 15.641 | |||||
| 2020-06-11 | 2020-01-09 | 4/A | Braunstein Scott | TARA | Stock Option (Right to Buy) | D | 9,18 | 16.214 | 16.214 | |||||
| 2020-06-11 | 2020-01-09 | 4/A | Braunstein Scott | TARA | Stock Option (Right to Buy) | D | 9,18 | 2.861 | 2.861 | |||||
| 2020-06-11 | 2020-01-09 | 4/A | GARCEAU ROGER | TARA | Stock Option (Right to Buy) | D | 9,18 | 12.399 | 12.399 | |||||
| 2020-06-11 | 2020-01-10 | 4/A | Solomon Michael Edward | TARA | Common Stock | D | 26.500 | 26.500 | ||||||
| 2020-06-11 | 2020-01-09 | 4/A | Solomon Michael Edward | TARA | Stock Option (Right to Buy) | D | 9,18 | 6.676 | 6.676 | |||||
| 2020-06-11 | 2020-01-09 | 4/A | Solomon Michael Edward | TARA | Stock Option (Right to Buy) | D | 9,18 | 2.861 | 2.861 | |||||
| 2020-06-11 | 2020-06-09 | 4 | Solomon Michael Edward | TARA | Stock Option (Right to Buy) | D | 35,00 | 9.000 | 9.000 | |||||
| 2020-06-11 | 2020-06-09 | 4 | SARGEN GREGORY | TARA | Stock Option (Right to Buy) | D | 35,00 | 9.000 | 9.000 | |||||
| 2020-06-11 | 2020-06-09 | 4 | Levy Richard S | TARA | Stock Option (Right to Buy) | D | 35,00 | 9.000 | 9.000 | |||||
| 2020-06-11 | 2020-06-09 | 4 | Braunstein Scott | TARA | Stock Option (Right to Buy) | D | 35,00 | 9.000 | 9.000 | |||||
| 2020-06-11 | 2020-06-09 | 4 | GARCEAU ROGER | TARA | Stock Option (Right to Buy) | D | 35,00 | 9.000 | 9.000 | |||||
| 2020-06-11 | 2020-06-09 | 4 | BESHAR LUKE M | TARA | Stock Option (Right to Buy) | D | 35,00 | 9.000 | 9.000 | |||||
| 2020-02-18 | 2020-01-10 | 4/A | Shefferman Jesse | TARA | Stock Option (Right to Buy) | D | 30,00 | 111.250 | 111.250 | |||||
| 2020-02-11 | 2020-02-11 | 4 | Davis Blaine | TARA | Stock Option (Right to Buy) | D | 37,30 | 94.000 | 94.000 | |||||
| 2020-01-13 | 2020-01-10 | 4 | Zummo Jacqueline | TARA | Common Stock | D | 45.500 | 74.113 | ||||||
| 2020-01-13 | 2020-01-09 | 4 | Zummo Jacqueline | TARA | Stock Option (Right to Buy) | D | 9,18 | 9.537 | 9.537 | |||||
| 2020-01-13 | 2020-01-09 | 4 | Zummo Jacqueline | TARA | Stock Option (Right to Buy) | D | 9,18 | 9.537 | 9.537 | |||||
| 2020-01-13 | 2020-01-09 | 4 | Zummo Jacqueline | TARA | Stock Option (Right to Buy) | D | 9,18 | 19.075 | 19.075 | |||||
| 2020-01-13 | 2020-01-09 | 4 | Zummo Jacqueline | TARA | Common Stock | D | 28.613 | 28.613 | ||||||
| 2020-01-13 | 2020-01-10 | 4 | Levy Richard S | TARA | Common Stock | D | 31.000 | 31.000 | ||||||
| 2020-01-13 | 2020-01-10 | 4 | Solomon Michael Edward | TARA | Common Stock | D | 26.500 | 26.500 | ||||||
| 2020-01-13 | 2020-01-09 | 4 | Solomon Michael Edward | TARA | Stock Option (Right to Buy) | D | 9,18 | 10.491 | 10.491 | |||||
| 2020-01-13 | 2020-01-09 | 4 | Solomon Michael Edward | TARA | Stock Option (Right to Buy) | D | 9,18 | 6.676 | 6.676 | |||||
| 2020-01-13 | 2020-01-09 | 4 | Solomon Michael Edward | TARA | Stock Option (Right to Buy) | D | 9,18 | 2.861 | 2.861 | |||||
| 2020-01-13 | 2020-01-09 | 4 | Solomon Michael Edward | TARA | Stock Option (Right to Buy) | D | 9,18 | 9.537 | 9.537 | |||||
| 2020-01-13 | 2020-01-10 | 4 | GARCEAU ROGER | TARA | Common Stock | D | 33.000 | 33.000 | ||||||
| 2020-01-13 | 2020-01-09 | 4 | GARCEAU ROGER | TARA | Stock Option (Right to Buy) | D | 9,18 | 10.491 | 10.491 | |||||
| 2020-01-13 | 2020-01-09 | 4 | GARCEAU ROGER | TARA | Stock Option (Right to Buy) | D | 9,18 | 12.399 | 12.399 | |||||
| 2020-01-13 | 2020-01-10 | 4 | SARGEN GREGORY | TARA | Common Stock | D | 31.000 | 31.000 | ||||||
| 2020-01-13 | 2020-01-10 | 4 | Braunstein Scott | TARA | Common Stock | D | 26.500 | 26.500 | ||||||
| 2020-01-13 | 2020-01-09 | 4 | Braunstein Scott | TARA | Stock Option (Right to Buy) | D | 9,18 | 15.737 | 15.737 | |||||
| 2020-01-13 | 2020-01-09 | 4 | Braunstein Scott | TARA | Stock Option (Right to Buy) | D | 9,18 | 6.676 | 6.676 | |||||
| 2020-01-13 | 2020-01-09 | 4 | Braunstein Scott | TARA | Stock Option (Right to Buy) | D | 9,18 | 9.537 | 9.537 | |||||
| 2020-01-13 | 2020-01-09 | 4 | Braunstein Scott | TARA | Stock Option (Right to Buy) | D | 9,18 | 9.537 | 9.537 | |||||
| 2020-01-13 | 2020-01-09 | 4 | Braunstein Scott | TARA | Stock Option (Right to Buy) | D | 9,18 | 2.861 | 2.861 | |||||
| 2020-01-13 | 2020-01-10 | 4 | Shefferman Jesse | TARA | Stock Option (Right to Buy) | D | 31,50 | 111.250 | 111.250 | |||||
| 2020-01-13 | 2020-01-10 | 4 | Shefferman Jesse | TARA | Common Stock | D | 50.000 | 840.274 | ||||||
| 2020-01-13 | 2020-01-09 | 4 | Shefferman Jesse | TARA | Common Stock | D | 790.274 | 790.274 | ||||||
| 2020-01-13 | 2020-01-09 | 4 | Marshall Randall | TARA | Common Stock | D | 654.020 | 654.020 | ||||||
| 2020-01-13 | 2020-01-10 | 4 | Casoy Julio | TARA | Common Stock | D | 45.500 | 45.500 | ||||||
| 2020-01-13 | 2020-01-09 | 4 | Casoy Julio | TARA | Stock Option (Right to Buy) | D | 9,18 | 38.151 | 38.151 | |||||
| 2020-01-13 | 3 | Opaleye, L.P. | TARA | Common Stock | D | 9.206 | ||||||||
| 2020-01-13 | 3 | Opaleye, L.P. | TARA | Common Stock | D | 9.206 | ||||||||
| 2020-01-13 | 3 | Opaleye, L.P. | TARA | Common Stock | D | 9.206 | ||||||||
| 2020-01-13 | 2020-01-09 | 4 | Opaleye, L.P. | TARA | Common Stock | D | 7,0100 | 1.426.234 | 9.998 | 2.208.472 | ||||
| 2020-01-13 | 2020-01-09 | 4 | Opaleye, L.P. | TARA | Common Stock | D | 777.635 | 782.238 | ||||||
| 2020-01-13 | 2020-01-10 | 4 | BESHAR LUKE M | TARA | Common Stock | D | 168.000 | 168.000 | ||||||
| 2020-01-13 | 2020-01-09 | 4 | BESHAR LUKE M | TARA | Stock Option (Right to Buy) | D | 9,18 | 10.491 | 10.491 | |||||
| 2020-01-13 | 2020-01-09 | 4 | BESHAR LUKE M | TARA | Stock Option (Right to Buy) | D | 9,18 | 6.676 | 6.676 | |||||
| 2020-01-13 | 2020-01-09 | 4 | BESHAR LUKE M | TARA | Stock Option (Right to Buy) | D | 9,18 | 12.399 | 12.399 | |||||
| 2019-11-14 | 2019-11-12 | 4 | Abingworth LLP | PRTO | Series A Convertible Preferred Stock | I | 0,99 | -126 | 2.400 | |||||
| 2019-11-14 | 2019-11-12 | 4 | Abingworth LLP | PRTO | Common Stock, $0.001 par value | I | 0,9949 | 126.645 | 126 | 2.144.517 | ||||
| 2019-11-14 | 2019-11-12 | 4 | Haines Timothy By Abingworth Bioventures VI, LP | PRTO | Series A Convertible Preferred Stock | I | 0,99 | -126 | 2.400 | |||||
| 2019-11-14 | 2019-11-12 | 4 | Haines Timothy By Abingworth Bioventures VI, LP | PRTO | Common Stock, $0.001 par value | I | 0,9949 | 126.645 | 126 | 2.144.517 | ||||
| 2019-11-12 | 2019-11-08 | 4 | Freund John Gordon | PRTO | Series A Convertible Preferred Stock | I | 0,99 | -700 | 354 | |||||
| 2019-11-12 | 2019-11-08 | 4 | Freund John Gordon | PRTO | Common Stock | D | 0,9949 | 703.588 | 700 | 2.175.882 | ||||
| 2019-03-18 | 2019-03-15 | 4 | Burke Steven Keith | PRTO | Common Stock | I | 7.333 | 26.332 | ||||||
| 2019-03-18 | 2019-03-15 | 4 | Burke Steven Keith | PRTO | Common Stock | I | 7.333 | 26.332 | ||||||
| 2019-03-18 | 2019-03-15 | 4 | Burke Steven Keith | PRTO | Common Stock | D | -7.333 | 101.917 | ||||||
| 2019-03-18 | 2019-03-15 | 4 | Burke Steven Keith | PRTO | Common Stock | D | -7.333 | 101.917 | ||||||
| 2019-03-18 | 2019-03-15 | 4 | Burke Steven Keith | PRTO | Common Stock | D | -7.334 | 116.584 | ||||||
| 2019-02-04 | 2019-01-31 | 4 | NOYES TIMOTHY P | PRTO | Stock Option (Right to Buy) | D | 2,70 | 350.000 | 350.000 | |||||
| 2019-01-23 | 2019-01-18 | 4 | Burke Steven Keith | PRTO | Stock Option (Right to Buy) | D | 2,64 | 145.000 | 145.000 | |||||
| 2019-01-23 | 2019-01-18 | 4 | Eldridge, George Arthur | PRTO | Stock Option (Right to Buy) | D | 2,64 | 145.000 | 145.000 | |||||
| 2019-01-23 | 2019-01-18 | 4 | Hartman Bradley J | PRTO | Stock Option (Right to Buy) | D | 2,64 | 70.000 | 70.000 | |||||
| 2019-01-23 | 2019-01-18 | 4 | Kowalsky Matthew Paul | PRTO | Stock Option (Right to Buy) | D | 2,64 | 60.000 | 60.000 | |||||
| 2019-01-23 | 2019-01-18 | 4 | Toner E. Scott | PRTO | Stock Option (Right to Buy) | D | 2,64 | 60.000 | 60.000 | |||||
| 2019-01-23 | 2019-01-18 | 4 | Gottlieb Daniel Philip | PRTO | Stock Option (Right to Buy) | D | 2,64 | 60.000 | 60.000 | |||||
| 2019-01-03 | 2018-12-31 | 4 | Burke Steven Keith | PRTO | Common Stock | D | 1,9300 | 2.448 | 5 | 123.917 | ||||
| 2019-01-03 | 2018-12-31 | 4 | Eldridge, George Arthur | PRTO | Common Stock | D | 1,9300 | 2.448 | 5 | 29.132 | ||||
| 2019-01-03 | 2018-12-31 | 4 | Kowalsky Matthew Paul | PRTO | Common Stock | D | 1,9300 | 2.448 | 5 | 29.479 | ||||
| 2019-01-03 | 2018-12-31 | 4 | Toner E. Scott | PRTO | Common Stock | D | 1,9300 | 4.117 | 8 | 23.357 | ||||
| 2018-08-02 | 2018-08-01 | 4 | Hartman Bradley J | PRTO | Stock Option (Right to Buy) | D | 2,12 | 150.000 | 150.000 | |||||
| 2018-07-03 | 2018-06-29 | 4 | Burke Steven Keith | PRTO | Common Stock | D | 1,6150 | -10.000 | -16 | 121.469 | ||||
| 2018-07-03 | 2018-06-29 | 4 | Eldridge, George Arthur | PRTO | Common Stock | D | 1,6150 | 10.000 | 16 | 26.684 | ||||
| 2018-07-03 | 2018-06-29 | 4 | Kowalsky Matthew Paul | PRTO | Common Stock | D | 1,6150 | 10.000 | 16 | 27.031 | ||||
| 2018-07-03 | 2018-06-29 | 4 | Toner E. Scott | PRTO | Common Stock | D | 1,6150 | 4.856 | 8 | 19.240 | ||||
| 2018-06-12 | 2018-06-08 | 4 | Flynn James E Through Deerfield Management Company, L.P. | PRTO | Stock Option (Right to Buy) | I | 2,50 | 12.700 | 12.700 | |||||
| 2018-06-12 | 2018-06-08 | 4 | LEFF JONATHAN S | PRTO | Stock Option (Right to Buy) | D | 2,50 | 12.700 | 12.700 | |||||
| 2018-06-11 | 2018-06-08 | 4 | Abingworth LLP By affiliate | PRTO | Stock Option (Right to Buy) | I | 2,50 | 12.700 | 12.700 | |||||
| 2018-06-11 | 2018-06-08 | 4 | Birner Hubert | PRTO | Stock Option (Right to Buy) | D | 2,50 | 12.700 | 12.700 | |||||
| 2018-06-11 | 2018-06-08 | 4 | BOHLIN GAREN G | PRTO | Stock Option (Right to Buy) | D | 2,50 | 12.700 | 12.700 | |||||
| 2018-06-11 | 2018-06-08 | 4 | Canute Scott A | PRTO | Stock Option (Right to Buy) | D | 2,50 | 12.700 | 12.700 | |||||
| 2018-06-11 | 2018-06-08 | 4 | Freund John Gordon | PRTO | Stock Option (Right to Buy) | D | 2,50 | 12.700 | 12.700 | |||||
| 2018-06-11 | 2018-06-08 | 4 | Haines Timothy | PRTO | Stock Option (Right to Buy) | D | 2,50 | 12.700 | 12.700 | |||||
| 2018-06-11 | 2018-06-08 | 4 | HASTINGS PAUL J | PRTO | Stock Option (Right to Buy) | D | 2,50 | 12.700 | 12.700 | |||||
| 2018-06-11 | 2018-06-08 | 4 | Kingsley Stuart A | PRTO | Stock Option (Right to Buy) | D | 2,50 | 12.700 | 12.700 | |||||
| 2018-02-20 | 2018-02-16 | 4 | NOYES TIMOTHY P | PRTO | Common Stock | D | 2,1100 | -2.997 | -6 | 0 | ||||
| 2018-02-16 | 2018-02-15 | 4 | NOYES TIMOTHY P | PRTO | Common Stock | D | 2,1520 | -2.245 | -5 | 2.997 | ||||
| 2018-02-16 | 2018-02-14 | 4 | NOYES TIMOTHY P | PRTO | Common Stock | D | 2,2000 | -3.500 | -8 | 5.242 | ||||
| 2018-02-09 | 2018-02-08 | 4 | NOYES TIMOTHY P | PRTO | Stock Option (Right to Buy) | D | 2,15 | 500.000 | 500.000 | |||||
| 2018-01-18 | 2018-01-17 | 4 | Burke Steven Keith | PRTO | Stock Option (Right to Buy) | D | 2,85 | 200.000 | 200.000 | |||||
| 2018-01-18 | 2018-01-17 | 4 | Eldridge, George Arthur | PRTO | Stock Option (Right to Buy) | D | 2,85 | 200.000 | 200.000 | |||||
| 2018-01-18 | 2018-01-17 | 4 | Gottlieb Daniel Philip | PRTO | Stock Option (Right to Buy) | D | 2,85 | 110.000 | 110.000 | |||||
| 2018-01-18 | 2018-01-17 | 4 | Kowalsky Matthew Paul | PRTO | Stock Option (Right to Buy) | D | 2,85 | 110.000 | 110.000 | |||||
| 2018-01-18 | 2018-01-17 | 4 | Toner E. Scott | PRTO | Stock Option (Right to Buy) | D | 2,85 | 110.000 | 110.000 | |||||
| 2018-01-17 | 2018-01-16 | 4 | NOYES TIMOTHY P | PRTO | Common Stock | D | 2,3570 | -10.000 | -24 | 8.742 | ||||
| 2018-01-03 | 2017-12-29 | 4 | Burke Steven Keith | PRTO | Common Stock | D | 1,2960 | -3.934 | -5 | 111.469 | ||||
| 2018-01-03 | 2017-12-29 | 4 | Eldridge, George Arthur | PRTO | Common Stock | D | 1,2960 | 3.934 | 5 | 16.684 | ||||
| 2018-01-03 | 2017-12-29 | 4 | Kowalsky Matthew Paul | PRTO | Common Stock | D | 1,2960 | 3.934 | 5 | 17.031 | ||||
| 2018-01-03 | 2017-12-29 | 4 | Toner E. Scott | PRTO | Common Stock | D | 1,2960 | 5.531 | 7 | 14.384 | ||||
| 2017-12-18 | 2017-12-15 | 4 | Burke Steven Keith | PRTO | Common Stock | I | 3.333 | 11.666 | ||||||
| 2017-12-18 | 2017-12-15 | 4 | Burke Steven Keith | PRTO | Common Stock | I | 3.333 | 11.666 | ||||||
| 2017-12-18 | 2017-12-15 | 4 | Burke Steven Keith | PRTO | Common Stock | D | -3.333 | 107.535 | ||||||
| 2017-12-18 | 2017-12-15 | 4 | Burke Steven Keith | PRTO | Common Stock | D | -3.333 | 107.535 | ||||||
| 2017-12-18 | 2017-12-15 | 4 | Burke Steven Keith | PRTO | Common Stock | D | -3.334 | 114.201 | ||||||
| 2017-12-18 | 2017-12-15 | 4 | Burke Steven Keith | PRTO | Common Stock | D | 1,8800 | 12.000 | 23 | 117.535 | ||||
| 2017-12-15 | 2017-12-14 | 4 | NOYES TIMOTHY P | PRTO | Common Stock | D | 1,8540 | -10.000 | -19 | 18.742 | ||||
| 2017-12-04 | 2017-11-30 | 4 | Flynn James E Through Deerfield International Master Fund, L.P. | PRTO | Common Stock | I | 1,7500 | -110.557 | -193 | 0 | ||||
| 2017-12-04 | 2017-11-30 | 4 | Flynn James E Through Deerfield Partners, L.P. | PRTO | Common Stock | I | 1,7500 | 110.557 | 193 | 197.424 | ||||
| 2017-11-16 | 2017-11-15 | 4 | NOYES TIMOTHY P | PRTO | Common Stock | D | 1,7020 | -5.650 | -10 | 28.742 | ||||
| 2017-11-16 | 2017-11-14 | 4 | NOYES TIMOTHY P | PRTO | Common Stock | D | 1,6870 | -4.350 | -7 | 34.392 | ||||
| 2017-11-14 | 2017-11-14 | 4 | BOHLIN GAREN G | PRTO | Common Stock | D | 1,8890 | 3.812 | 7 | 53.312 | ||||
| 2017-11-14 | 2017-11-13 | 4 | BOHLIN GAREN G | PRTO | Common Stock | D | 1,9180 | 25.700 | 49 | 49.500 | ||||
| 2017-11-14 | 2017-11-10 | 4 | BOHLIN GAREN G | PRTO | Common Stock | D | 1,9630 | 23.800 | 47 | 23.800 | ||||
| 2017-11-14 | 2017-11-14 | 4 | Eldridge, George Arthur As custodian for child's UTMA account | PRTO | Common Stock | I | 1,6900 | 295 | 0 | 1.545 | ||||
| 2017-10-17 | 2017-10-16 | 4 | NOYES TIMOTHY P | PRTO | Common Stock | D | 2,3120 | -10.000 | -23 | 38.742 | ||||
| 2017-09-18 | 2017-09-15 | 4 | NOYES TIMOTHY P | PRTO | Common Stock | D | 1,4790 | -5.146 | -8 | 48.742 | ||||
| 2017-09-18 | 2017-09-14 | 4 | NOYES TIMOTHY P | PRTO | Common Stock | D | 1,4540 | -4.854 | -7 | 53.888 | ||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield Private Design Fund III, L.P. | PRTO | Common Stock | I | 2.102.698 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield Special Situations Fund, L.P. | PRTO | Common Stock | I | 1.374.575 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield International Master Fund, L.P. | PRTO | Common Stock | I | 1.335.456 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield Private Design Fund III, L.P. | PRTO | Common Stock | I | 2.102.698 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield Special Situations Fund, L.P. | PRTO | Common Stock | I | 1.374.575 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield International Master Fund, L.P. | PRTO | Common Stock | I | 1.335.456 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield Partners, L.P. | PRTO | Common Stock | I | 1.311.766 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield Special Situations Fund, L.P. | PRTO | Common Stock | I | 1.374.575 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield International Master Fund, L.P. | PRTO | Common Stock | I | 1.335.456 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield Private Design Fund III, L.P. | PRTO | Common Stock | I | 2.102.698 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield Private Design Fund III, L.P. | PRTO | Common Stock | I | 2.102.698 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield Special Situations Fund, L.P. | PRTO | Common Stock | I | 1.374.575 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield International Master Fund, L.P. | PRTO | Common Stock | I | 1.335.456 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield Partners, L.P. | PRTO | Common Stock | I | 1.311.766 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield Private Design Fund III, L.P. | PRTO | Common Stock | I | 2.102.698 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield International Master Fund, L.P. | PRTO | Common Stock | I | 1.335.456 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield Partners, L.P. | PRTO | Common Stock | I | 1.311.766 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield Private Design Fund III, L.P. | PRTO | Common Stock | I | 2.102.698 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield Private Design Fund III, L.P. | PRTO | Common Stock | I | 2.102.698 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield International Master Fund, L.P. | PRTO | Common Stock | I | 1.335.456 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield Partners, L.P. | PRTO | Common Stock | I | 1.311.766 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield Private Design Fund III, L.P. | PRTO | Common Stock | I | 2.102.698 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield Partners, L.P. | PRTO | Common Stock | I | 1.311.766 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield Partners, L.P. | PRTO | Common Stock | I | 1.311.766 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield Private Design Fund III, L.P. | PRTO | Common Stock | I | 2.102.698 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield Special Situations Fund, L.P. | PRTO | Common Stock | I | 1.374.575 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield International Master Fund, L.P. | PRTO | Common Stock | I | 1.335.456 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield Partners, L.P. | PRTO | Common Stock | I | 1.311.766 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield International Master Fund, L.P. | PRTO | Common Stock | I | 1.335.456 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield International Master Fund, L.P. | PRTO | Common Stock | I | 1.335.456 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield Private Design Fund III, L.P. | PRTO | Common Stock | I | 2.102.698 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield Special Situations Fund, L.P. | PRTO | Common Stock | I | 1.374.575 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield International Master Fund, L.P. | PRTO | Common Stock | I | 1.335.456 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield Partners, L.P. | PRTO | Common Stock | I | 1.311.766 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield Private Design Fund III, L.P. | PRTO | Common Stock | I | 2.102.698 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield Special Situations Fund, L.P. | PRTO | Common Stock | I | 1.374.575 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield Partners, L.P. | PRTO | Common Stock | I | 1.311.766 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield Special Situations Fund, L.P. | PRTO | Common Stock | I | 1.374.575 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield Special Situations Fund, L.P. | PRTO | Common Stock | I | 1.374.575 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield Partners, L.P. | PRTO | Common Stock | I | 1.311.766 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield International Master Fund, L.P. | PRTO | Common Stock | I | 1.335.456 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield Special Situations Fund, L.P. | PRTO | Common Stock | I | 1.374.575 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield Special Situations Fund, L.P. | PRTO | Common Stock | I | 1.374.575 | ||||||||
| 2017-08-04 | 3 | Flynn James E Through Deerfield Partners, L.P. | PRTO | Common Stock | I | 1.311.766 | ||||||||
| 2017-08-04 | 3 | LEFF JONATHAN S | PRTO | Common Stock | D | 0 | ||||||||
| 2017-08-04 | 2017-08-02 | 4 | Flynn James E Through Deerfield Management Company, L.P. | PRTO | Stock Option (Right to Buy) | I | 1,30 | 13.333 | 13.333 | |||||
| 2017-08-04 | 2017-08-02 | 4 | LEFF JONATHAN S | PRTO | Stock Option (Right to Buy) | D | 1,30 | 13.333 | 13.333 | |||||
| 2017-07-05 | 2017-06-30 | 4 | Burke Steven Keith | PRTO | Common Stock | D | 1,2960 | -10.000 | -13 | 105.535 | ||||
| 2017-07-05 | 2017-06-30 | 4 | Eldridge, George Arthur | PRTO | Common Stock | D | 1,2960 | 10.000 | 13 | 12.750 | ||||
| 2017-07-05 | 2017-06-30 | 4 | Kowalsky Matthew Paul | PRTO | Common Stock | D | 1,2960 | 10.000 | 13 | 13.097 | ||||
| 2017-07-05 | 2017-06-30 | 4 | Toner E. Scott | PRTO | Common Stock | D | 1,2960 | -8.718 | -11 | 8.853 | ||||
| 2017-06-30 | 2017-06-22 | 4/A | TVM Life Science Ventures VI GmbH & Co KG | PRTO | Series A Convertible Preferred Stock | D | 0,99 | 1.000,0000 | 372 | 372 | 500 | |||
| 2017-06-26 | 2017-06-22 | 4 | TVM Life Science Ventures VI GmbH & Co KG | PRTO | Series A Convertible Preferred Stock | D | 0,99 | 1.000,0000 | 128 | 128 | 500 | |||
| 2017-06-26 | 2017-06-22 | 4 | TVM Life Science Ventures VI GmbH & Co KG | PRTO | Series A Convertible Preferred Stock | D | 0,99 | 1.000,0000 | 372 | 372 | 500 | |||
| 2017-06-26 | 2017-06-22 | 4 | Freund John Gordon By Skyline Venture Partners | PRTO | Series A Convertible Preferred Stock | I | 0,99 | 1.000,0000 | 1.054 | 1.054 | 1.054 | |||
| 2017-06-26 | 2017-06-22 | 4 | Haines Timothy By Abingworth Bioventures VI, LP | PRTO | Series A Convertible Preferred Stock | I | 0,99 | 1.000,0000 | 2.526 | 2.526 | 2.526 | |||
| 2017-06-26 | 2017-06-22 | 4 | Abingworth LLP | PRTO | Series A Convertible Preferred Stock | I | 0,99 | 1.000,0000 | 2.526 | 2.526 | 2.526 | |||
| 2017-06-21 | 2017-06-20 | 4 | Canute Scott A | PRTO | Stock Option (Right to Buy) | D | 1,30 | 6.666 | 6.666 | |||||
| 2017-06-21 | 2017-06-20 | 4 | HASTINGS PAUL J | PRTO | Stock Option (Right to Buy) | D | 1,30 | 6.666 | 6.666 | |||||
| 2017-06-21 | 2017-06-20 | 4 | Kingsley Stuart A | PRTO | Stock Option (Right to Buy) | D | 1,30 | 6.666 | 6.666 | |||||
| 2017-06-21 | 2017-06-20 | 4 | Abingworth LLP By affiliate | PRTO | Stock Option (Right to Buy) | I | 1,30 | 6.666 | 6.666 | |||||
| 2017-06-21 | 2017-06-20 | 4 | Birner Hubert | PRTO | Stock Option (Right to Buy) | D | 1,30 | 6.666 | 6.666 | |||||
| 2017-06-21 | 2017-06-20 | 4 | Freund John Gordon | PRTO | Stock Option (Right to Buy) | D | 1,30 | 6.666 | 6.666 | |||||
| 2017-06-21 | 2017-06-20 | 4 | Haines Timothy | PRTO | Stock Option (Right to Buy) | D | 1,30 | 6.666 | 6.666 | |||||
| 2017-06-21 | 2017-06-20 | 4 | BOHLIN GAREN G | PRTO | Stock Option (Right to Buy) | D | 1,30 | 6.666 | 6.666 | |||||
| 2017-05-05 | 3 | Kowalsky Matthew Paul | PRTO | Common Stock, $0.001 par value | D | 6.194 | ||||||||
| 2017-05-05 | 3 | Kowalsky Matthew Paul | PRTO | Common Stock, $0.001 par value | D | 6.194 | ||||||||
| 2017-03-13 | 2017-03-10 | 4 | Burke Steven Keith | PRTO | Stock Option (Right to Buy) | D | 1,27 | -57.934 | 0 | |||||
| 2017-03-13 | 2017-03-10 | 4 | Burke Steven Keith | PRTO | Stock Option (Right to Buy) | D | 2,38 | -12.287 | 0 | |||||
| 2017-03-13 | 2017-03-10 | 4 | Burke Steven Keith | PRTO | Common Stock | D | 1,2700 | 57.934 | 74 | 95.535 | ||||
| 2017-03-13 | 2017-03-10 | 4 | Burke Steven Keith | PRTO | Common Stock | D | 2,3800 | 12.287 | 29 | 37.601 | ||||
| 2017-01-26 | 2017-01-24 | 4 | NOYES TIMOTHY P | PRTO | Stock Option (Right to Buy) | D | 2,05 | 122.838 | 122.838 | |||||
| 2017-01-26 | 2017-01-24 | 4 | Gottlieb Daniel Philip | PRTO | Stock Option (Right to Buy) | D | 2,05 | 29.215 | 29.215 | |||||
| 2017-01-26 | 2017-01-24 | 4 | Burke Steven Keith | PRTO | Stock Option (Right to Buy) | D | 2,05 | 53.119 | 53.119 | |||||
| 2017-01-26 | 2017-01-24 | 4 | Eldridge, George Arthur | PRTO | Stock Option (Right to Buy) | D | 2,05 | 53.119 | 53.119 | |||||
| 2017-01-26 | 2017-01-24 | 4 | Toner E. Scott | PRTO | Stock Option (Right to Buy) | D | 2,05 | 73.039 | 73.039 | |||||
| 2016-12-06 | 2016-12-02 | 4 | Burke Steven Keith | PRTO | Common Stock | I | 2.500 | 5.000 | ||||||
| 2016-12-06 | 2016-12-02 | 4 | Burke Steven Keith | PRTO | Common Stock | I | 2.500 | 5.000 | ||||||
| 2016-12-06 | 2016-12-02 | 4 | Burke Steven Keith | PRTO | Common Stock | D | -2.500 | 25.314 | ||||||
| 2016-12-06 | 2016-12-02 | 4 | Burke Steven Keith | PRTO | Common Stock | D | -2.500 | 25.314 | ||||||
| 2016-12-06 | 2016-12-02 | 4 | Burke Steven Keith | PRTO | Common Stock | D | -2.500 | 25.314 | ||||||
| 2016-10-20 | 3 | HASTINGS PAUL J | PRTO | Common Stock, $0.001 par value | I | 13.272 | ||||||||
| 2016-10-20 | 3 | HASTINGS PAUL J | PRTO | Common Stock, $0.001 par value | I | 13.272 | ||||||||
| 2016-10-20 | 2016-10-18 | 4 | HASTINGS PAUL J | PRTO | Stock Option (Right to Buy) | D | 9,00 | 13.333 | 13.333 | |||||
| 2016-09-01 | 2016-08-31 | 4 | Toner E. Scott | PRTO | Common Stock | D | -50 | 135 | ||||||
| 2016-06-15 | 2016-06-09 | 4 | Birner Hubert | PRTO | Stock Option (Right to Buy) | D | 5,90 | 6.666 | 6.666 | |||||
| 2016-06-14 | 2016-06-09 | 4 | Canute Scott A | PRTO | Stock Option (Right to Buy) | D | 5,90 | 6.666 | 6.666 | |||||
| 2016-06-14 | 2016-06-09 | 4 | BOHLIN GAREN G | PRTO | Stock Option (Right to Buy) | D | 5,90 | 6.666 | 6.666 | |||||
| 2016-06-14 | 2016-06-09 | 4 | Freund John Gordon | PRTO | Stock Option (Right to Buy) | D | 5,90 | 6.666 | 6.666 | |||||
| 2016-06-14 | 2016-06-09 | 4 | Kingsley Stuart A | PRTO | Stock Option (Right to Buy) | D | 5,90 | 6.666 | 6.666 | |||||
| 2016-06-14 | 2016-06-09 | 4 | Abingworth LLP By affiliate | PRTO | Stock Option (Right to Buy) | I | 5,90 | 6.666 | 6.666 | |||||
| 2016-06-14 | 2016-06-09 | 4 | O'Leary Brendan | PRTO | Stock Option (Right to Buy) | D | 5,90 | 6.666 | 6.666 | |||||
| 2016-06-14 | 2016-06-09 | 4 | Haines Timothy | PRTO | Stock Option (Right to Buy) | D | 5,90 | 6.666 | 6.666 | |||||
| 2016-06-07 | 2016-06-06 | 4 | Eldridge, George Arthur As custodian for child's UTMA account | PRTO | Common Stock | I | 5,7800 | 400 | 2 | 400 | ||||
| 2016-06-07 | 2016-06-06 | 4 | Eldridge, George Arthur As custodian for child's UTMA account | PRTO | Common Stock | I | 5,7760 | 425 | 2 | 425 | ||||
| 2016-06-07 | 2016-06-06 | 4 | Eldridge, George Arthur As custodian for child's UTMA account | PRTO | Common Stock | I | 5,7600 | 425 | 2 | 425 | ||||
| 2016-06-07 | 2016-06-06 | 4 | Eldridge, George Arthur | PRTO | Common Stock | D | 5,7800 | 2.750 | 16 | 2.750 | ||||
| 2016-04-13 | 2016-04-12 | 4 | NOYES TIMOTHY P | PRTO | Stock Option (Right to Buy) | D | 1,91 | -58.742 | 0 | |||||
| 2016-04-13 | 2016-04-12 | 4 | NOYES TIMOTHY P | PRTO | Common Stock | D | 1,9100 | 58.742 | 112 | 58.742 | ||||
| 2016-01-05 | 2015-12-31 | 4 | Toner E. Scott | PRTO | Common Stock | D | 13,1800 | 185 | 2 | 185 | ||||
| 2016-01-05 | 2015-12-31 | 4 | Gottlieb Daniel Philip | PRTO | Common Stock | D | 13,1800 | 244 | 3 | 244 | ||||
| 2016-01-05 | 2016-01-04 | 4 | NOYES TIMOTHY P | PRTO | Stock Option (Right to Buy) | D | 1,91 | -5.000 | 58.742 | |||||
| 2016-01-05 | 2016-01-04 | 4 | NOYES TIMOTHY P | PRTO | Common Stock | D | 13,8800 | -5.000 | -69 | 0 | ||||
| 2016-01-05 | 2016-01-04 | 4 | NOYES TIMOTHY P | PRTO | Common Stock | D | 1,9100 | 5.000 | 10 | 5.000 | ||||
| 2015-12-10 | 2015-12-08 | 4 | Toner E. Scott | PRTO | Stock Option (Right to Buy) | D | 14,70 | -22.000 | 22.000 | |||||
| 2015-12-10 | 2015-12-08 | 4 | NOYES TIMOTHY P | PRTO | Stock Option (Right to Buy) | D | 14,70 | -125.000 | 125.000 | |||||
| 2015-12-10 | 2015-12-08 | 4 | Gottlieb Daniel Philip | PRTO | Stock Option (Right to Buy) | D | 14,70 | -22.000 | 22.000 | |||||
| 2015-12-10 | 2015-12-08 | 4 | Eldridge, George Arthur | PRTO | Stock Option (Right to Buy) | D | 14,70 | -33.000 | 33.000 | |||||
| 2015-12-10 | 2015-12-08 | 4 | Burke Steven Keith | PRTO | Stock Option (Right to Buy) | D | 14,70 | -57.000 | 57.000 | |||||
| 2015-12-02 | 2015-12-01 | 4 | NOYES TIMOTHY P | PRTO | Stock Option (Right to Buy) | D | 1,91 | -5.000 | 63.742 | |||||
| 2015-12-02 | 2015-12-01 | 4 | NOYES TIMOTHY P | PRTO | Common Stock | D | 14,9700 | -5.000 | -75 | 0 | ||||
| 2015-12-02 | 2015-12-01 | 4 | NOYES TIMOTHY P | PRTO | Common Stock | D | 1,9100 | 5.000 | 10 | 5.000 | ||||
| 2015-11-03 | 2015-11-02 | 4 | NOYES TIMOTHY P | PRTO | Stock Option (Right to Buy) | D | 1,91 | -5.000 | 68.742 | |||||
| 2015-11-03 | 2015-11-02 | 4 | NOYES TIMOTHY P | PRTO | Common Stock | D | 13,5000 | -5.000 | -68 | 0 | ||||
| 2015-11-03 | 2015-11-02 | 4 | NOYES TIMOTHY P | PRTO | Common Stock | D | 1,9100 | 5.000 | 10 | 5.000 | ||||
| 2015-10-19 | 2015-10-16 | 4 | Kingsley Stuart A | PRTO | Stock Option (Right to Buy) | D | 15,21 | 13.333 | 13.333 | |||||
| 2015-10-02 | 2015-10-01 | 4 | NOYES TIMOTHY P | PRTO | Stock Option (Right to Buy) | D | 1,91 | -5.000 | 73.742 | |||||
| 2015-10-02 | 2015-10-01 | 4 | NOYES TIMOTHY P | PRTO | Common Stock | D | 13,3300 | -5.000 | -67 | 0 | ||||
| 2015-10-02 | 2015-10-01 | 4 | NOYES TIMOTHY P | PRTO | Common Stock | D | 1,9100 | 5.000 | 10 | 5.000 | ||||
| 2015-09-10 | 2015-09-08 | 4 | NOYES TIMOTHY P | PRTO | Stock Option (Right to Buy) | D | 1,91 | -5.000 | 78.742 | |||||
| 2015-09-10 | 2015-09-08 | 4 | NOYES TIMOTHY P | PRTO | Common Stock | D | 13,5500 | -5.000 | -68 | 0 | ||||
| 2015-09-10 | 2015-09-08 | 4 | NOYES TIMOTHY P | PRTO | Common Stock | D | 1,9100 | 5.000 | 10 | 5.000 | ||||
| 2015-07-23 | 2015-07-21 | 4 | Canute Scott A | PRTO | Stock Option (Right to Buy) | D | 18,25 | 13.333 | 13.333 | |||||
| 2015-07-08 | 2015-06-30 | 4 | Burke Steven Keith | PRTO | Common Stock | D | 8,8400 | 2.403 | 21 | 32.814 | ||||
| 2015-07-08 | 2015-07-07 | 4 | Gottlieb Daniel Philip | PRTO | Common Stock | D | 16,8600 | -1.965 | -33 | 0 | ||||
| 2015-07-08 | 2015-06-30 | 4 | Gottlieb Daniel Philip | PRTO | Common Stock | D | 8,8400 | 1.965 | 17 | 1.965 | ||||
| 2015-06-03 | 2015-06-02 | 4 | BOHLIN GAREN G | PRTO | Stock Option (Right to Buy) | D | 17,59 | 6.666 | 6.666 | |||||
| 2015-06-03 | 2015-06-02 | 4 | Freund John Gordon | PRTO | Stock Option (Right to Buy) | D | 17,59 | 6.666 | 6.666 | |||||
| 2015-06-03 | 2015-06-02 | 4 | PHELPS GREGORY D | PRTO | Stock Option (Right to Buy) | D | 17,59 | 6.666 | 6.666 | |||||
| 2015-06-03 | 2015-06-02 | 4 | Abingworth LLP By affiliate | PRTO | Stock Option (Right to Buy) | I | 17,59 | 6.666 | 6.666 | |||||
| 2015-06-03 | 2015-06-02 | 4 | Birner Hubert | PRTO | Stock Option (Right to Buy) | D | 17,59 | 6.666 | 6.666 | |||||
| 2015-06-03 | 2015-06-02 | 4 | O'Leary Brendan | PRTO | Stock Option (Right to Buy) | D | 17,59 | 6.666 | 6.666 | |||||
| 2015-06-03 | 2015-06-02 | 4 | Haines Timothy | PRTO | Stock Option (Right to Buy) | D | 17,59 | 6.666 | 6.666 | |||||
| 2015-06-03 | 2015-06-02 | 4 | Kobyzev Dmitry | PRTO | Stock Option (Right to Buy) | D | 17,59 | 6.666 | 6.666 | |||||
| 2015-06-03 | 2015-06-02 | 4 | Toner E. Scott | PRTO | Stock Option (Right to Buy) | D | 17,59 | 50.000 | 50.000 | |||||
| 2015-01-08 | 2015-01-07 | 4 | Gottlieb Daniel Philip | PRTO | Stock Option (Right to Buy) | D | 10,61 | 26.699 | 26.699 | |||||
| 2015-01-08 | 2015-01-07 | 4 | Eldridge, George Arthur | PRTO | Stock Option (Right to Buy) | D | 10,61 | 53.808 | 53.808 | |||||
| 2015-01-08 | 2015-01-07 | 4 | NOYES TIMOTHY P | PRTO | Stock Option (Right to Buy) | D | 10,61 | 134.333 | 134.333 | |||||
| 2015-01-08 | 2015-01-07 | 4 | Burke Steven Keith | PRTO | Stock Option (Right to Buy) | D | 10,61 | 69.813 | 69.813 | |||||
| 2014-10-30 | 2014-10-27 | 4 | Birner Hubert By TVM Life Science Ventures VI, L.P. | PRTO | Option (Right to Purchase) | I | -451.276 | 0 | ||||||
| 2014-10-30 | 2014-10-27 | 4 | Birner Hubert By TVM Life Science Ventures VI GmbH & Co. KG | PRTO | Option (Right to Purchase) | I | -1.316.683 | 0 | ||||||
| 2014-10-30 | 2014-10-27 | 4 | Birner Hubert By TVM Life Science Ventures VI, L.P. | PRTO | Warrants (Right to Buy) | I | 4,60 | -39.932 | 0 | |||||
| 2014-10-30 | 2014-10-27 | 4 | Birner Hubert By TVM Life Science Ventures VI GmbH & Co. KG | PRTO | Warrants (Right to Buy) | I | 4,60 | -116.511 | 0 | |||||
| 2014-10-30 | 2014-10-27 | 4 | Birner Hubert By TVM Life Science Ventures VI, L.P. | PRTO | Series D Convertible Preferred Stock | I | -1.277.663 | 0 | ||||||
| 2014-10-30 | 2014-10-27 | 4 | Birner Hubert By TVM Life Science Ventures VI GmbH & Co. KG | PRTO | Series D Convertible Preferred Stock | I | -3.727.823 | 0 | ||||||
| 2014-10-30 | 2014-10-27 | 4 | Birner Hubert By TVM Life Science Ventures VI, L.P. | PRTO | Series C Convertible Preferred Stock | I | -799.043 | 0 | ||||||
| 2014-10-30 | 2014-10-27 | 4 | Birner Hubert By TVM Life Science Ventures VI GmbH & Co. KG | PRTO | Series C Convertible Preferred Stock | I | -2.331.391 | 0 | ||||||
| 2014-10-30 | 2014-10-27 | 4 | Birner Hubert By TVM Life Science Ventures VI, L.P. | PRTO | Series B Convertible Preferred Stock | I | -835.121 | 0 | ||||||
| 2014-10-30 | 2014-10-27 | 4 | Birner Hubert By TVM Life Science Ventures VI GmbH & Co. KG | PRTO | Series B Convertible Preferred Stock | I | -2.436.618 | 0 | ||||||
| 2014-10-30 | 2014-10-27 | 4 | Birner Hubert By TVM Life Science Ventures VI, L.P. | PRTO | Series A-1 Convertible Preferred Stock | I | -717.260 | 0 | ||||||
| 2014-10-30 | 2014-10-27 | 4 | Birner Hubert By TVM Life Science Ventures VI GmbH & Co. KG | PRTO | Series A-1 Convertible Preferred Stock | I | -2.092.735 | 0 | ||||||
| 2014-10-30 | 2014-10-27 | 4 | Birner Hubert By TVM Life Science Ventures VI, L.P. | PRTO | Series A Convertible Preferred Stock | I | -1.531.518 | 0 | ||||||
| 2014-10-30 | 2014-10-27 | 4 | Birner Hubert By TVM Life Science Ventures VI GmbH & Co. KG | PRTO | Series A Convertible Preferred Stock | I | -4.468.482 | 0 | ||||||
| 2014-10-30 | 2014-10-27 | 4 | Birner Hubert By TVM Life Science Ventures VI, L.P.(3) | PRTO | Common Stock | I | 4,6023 | 39.932 | 184 | 1.943.059 | ||||
| 2014-10-30 | 2014-10-27 | 4 | Birner Hubert By TVM Life Science Ventures VI GmbH & Co. KG | PRTO | Common Stock | I | 4,6023 | 116.511 | 536 | 1.903.127 | ||||
| 2014-10-30 | 2014-10-27 | 4 | Birner Hubert By TVM Life Science Ventures VI, L.P. | PRTO | Common Stock | I | 379.462 | 1.786.616 | ||||||
| 2014-10-30 | 2014-10-27 | 4 | Birner Hubert By TVM Life Science Ventures VI GmbH & Co. KG | PRTO | Common Stock | I | 1.107.154 | 1.407.154 | ||||||
| 2014-10-30 | 2014-10-27 | 4 | Birner Hubert By TVM Life Science Ventures VI, L.P. | PRTO | Common Stock | I | 10,0000 | 76.590 | 766 | 300.000 | ||||
| 2014-10-30 | 2014-10-27 | 4 | Birner Hubert By TVM Life Science Ventures VI GmbH & Co. KG | PRTO | Common Stock | I | 10,0000 | 223.410 | 2.234 | 223.410 | ||||
| 2014-10-30 | 2014-10-27 | 4 | TVM Life Science Ventures VI GmbH & Co KG By TVM Life Science Ventures VI, L.P. | PRTO | Option (Right to Purchase) | I | -451.276 | 0 | ||||||
| 2014-10-30 | 2014-10-27 | 4 | TVM Life Science Ventures VI GmbH & Co KG | PRTO | Option (Right to Purchase) | D | -1.316.683 | 0 | ||||||
| 2014-10-30 | 2014-10-27 | 4 | TVM Life Science Ventures VI GmbH & Co KG By TVM Life Science Ventures VI, L.P. | PRTO | Warrants (Right to Buy) | I | 4,60 | -39.932 | 0 | |||||
| 2014-10-30 | 2014-10-27 | 4 | TVM Life Science Ventures VI GmbH & Co KG | PRTO | Warrants (Right to Buy) | D | 4,60 | -116.511 | 0 | |||||
| 2014-10-30 | 2014-10-27 | 4 | TVM Life Science Ventures VI GmbH & Co KG By TVM Life Science Ventures VI, L.P. | PRTO | Series D Convertible Preferred Stock | I | -1.277.663 | 0 | ||||||
| 2014-10-30 | 2014-10-27 | 4 | TVM Life Science Ventures VI GmbH & Co KG | PRTO | Series D Convertible Preferred Stock | D | -3.727.823 | 0 | ||||||
| 2014-10-30 | 2014-10-27 | 4 | TVM Life Science Ventures VI GmbH & Co KG By TVM Life Science Ventures VI, L.P. | PRTO | Series C Convertible Preferred Stock | I | -799.043 | 0 | ||||||
| 2014-10-30 | 2014-10-27 | 4 | TVM Life Science Ventures VI GmbH & Co KG | PRTO | Series C Convertible Preferred Stock | D | -2.331.391 | 0 | ||||||
| 2014-10-30 | 2014-10-27 | 4 | TVM Life Science Ventures VI GmbH & Co KG By TVM Life Science Ventures VI, L.P. | PRTO | Series B Convertible Preferred Stock | I | -835.121 | 0 | ||||||
| 2014-10-30 | 2014-10-27 | 4 | TVM Life Science Ventures VI GmbH & Co KG | PRTO | Series B Convertible Preferred Stock | D | -2.436.618 | 0 | ||||||
| 2014-10-30 | 2014-10-27 | 4 | TVM Life Science Ventures VI GmbH & Co KG By TVM Life Science Ventures VI, L.P. | PRTO | Series A-1 Convertible Preferred Stock | I | -717.260 | 0 | ||||||
| 2014-10-30 | 2014-10-27 | 4 | TVM Life Science Ventures VI GmbH & Co KG | PRTO | Series A-1 Convertible Preferred Stock | D | -2.092.735 | 0 | ||||||
| 2014-10-30 | 2014-10-27 | 4 | TVM Life Science Ventures VI GmbH & Co KG By TVM Life Science Ventures VI, L.P. | PRTO | Series A Convertible Preferred Stock | I | -1.531.518 | 0 | ||||||
| 2014-10-30 | 2014-10-27 | 4 | TVM Life Science Ventures VI GmbH & Co KG | PRTO | Series A Convertible Preferred Stock | D | -4.468.482 | 0 | ||||||
| 2014-10-30 | 2014-10-27 | 4 | TVM Life Science Ventures VI GmbH & Co KG By TVM Life Science Ventures VI, L.P. | PRTO | Common Stock | I | 4,6023 | 39.932 | 184 | 1.943.059 | ||||
| 2014-10-30 | 2014-10-27 | 4 | TVM Life Science Ventures VI GmbH & Co KG | PRTO | Common Stock | D | 4,6023 | 116.511 | 536 | 1.903.127 | ||||
| 2014-10-30 | 2014-10-27 | 4 | TVM Life Science Ventures VI GmbH & Co KG By TVM Life Science Ventures VI, L.P. | PRTO | Common Stock | I | 379.462 | 1.786.616 | ||||||
| 2014-10-30 | 2014-10-27 | 4 | TVM Life Science Ventures VI GmbH & Co KG | PRTO | Common Stock | D | 1.107.154 | 1.407.154 | ||||||
| 2014-10-30 | 2014-10-27 | 4 | TVM Life Science Ventures VI GmbH & Co KG By TVM Life Science Ventures VI, L.P. | PRTO | Common Stock | I | 10,0000 | 76.590 | 766 | 300.000 | ||||
| 2014-10-30 | 2014-10-27 | 4 | TVM Life Science Ventures VI GmbH & Co KG | PRTO | Common Stock | D | 10,0000 | 223.410 | 2.234 | 223.410 | ||||
| 2014-10-29 | 3/A | Burke Steven Keith | PRTO | Common Stock | D | 30.411 | ||||||||
| 2014-10-29 | 2014-10-27 | 4 | Freund John Gordon By Skyline Venture Partners Qualified Purchaser Fund IV, L.P. | PRTO | Option (Right to Purchase) | I | -1.389.064 | 0 | ||||||
| 2014-10-29 | 2014-10-27 | 4 | Freund John Gordon By Skyline Venture Partners Qualified Purchaser Fund IV, L.P. | PRTO | Warrants (Right to Buy) | I | 4,60 | -121.760 | 0 | |||||
| 2014-10-29 | 2014-10-27 | 4 | Freund John Gordon By Skyline Venture Partners Qualified Purchaser Fund IV, L.P. | PRTO | Series D Convertible Preferred Stock | I | -3.932.747 | 0 | ||||||
| 2014-10-29 | 2014-10-27 | 4 | Freund John Gordon By Skyline Venture Partners Qualified Purchaser Fund IV, L.P. | PRTO | Series C Convertible Preferred Stock | I | -2.436.437 | 0 | ||||||
| 2014-10-29 | 2014-10-27 | 4 | Freund John Gordon By Skyline Venture Partners Qualified Purchaser Fund IV, L.P. | PRTO | Series B Convertible Preferred Stock | I | -2.173.913 | 0 | ||||||
| 2014-10-29 | 2014-10-27 | 4 | Freund John Gordon By Skyline Venture Partners Qualified Purchaser Fund IV, L.P. | PRTO | Series A-1 Convertible Preferred Stock | I | -2.341.664 | 0 | ||||||
| 2014-10-29 | 2014-10-27 | 4 | Freund John Gordon By Skyline Venture Partners Qualified Purchaser Fund IV, L.P. | PRTO | Series A Convertible Preferred Stock | I | -5.000.000 | 0 | ||||||
| 2014-10-29 | 2014-10-27 | 4 | Freund John Gordon By Skyline Venture Partners Qualified Purchaser Fund IV, L.P. | PRTO | Common Stock | I | 10,0000 | -56.038 | -560 | 1.432.930 | ||||
| 2014-10-29 | 2014-10-27 | 4 | Freund John Gordon By Skyline Venture Partners Qualified Purchaser Fund IV, L.P. | PRTO | Common Stock | I | 4,6023 | 121.760 | 560 | 1.488.968 | ||||
| 2014-10-29 | 2014-10-27 | 4 | Freund John Gordon By Skyline Venture Partners Qualified Purchaser Fund IV, L.P. | PRTO | Common Stock | I | 1.167.208 | 1.367.208 | ||||||
| 2014-10-29 | 2014-10-27 | 4 | Freund John Gordon By Skyline Venture Partners Qualified Purchaser Fund IV, L.P. | PRTO | Common Stock | I | 10,0000 | 200.000 | 2.000 | 200.000 | ||||
| 2014-10-29 | 2014-10-27 | 4 | Skyline Venture Partners Qualified Purchaser Fund IV L P | PRTO | Option (Right to Purchase) | D | -1.389.064 | 0 | ||||||
| 2014-10-29 | 2014-10-27 | 4 | Skyline Venture Partners Qualified Purchaser Fund IV L P | PRTO | Warrants (Right to Buy) | D | 4,60 | -121.760 | 0 | |||||
| 2014-10-29 | 2014-10-27 | 4 | Skyline Venture Partners Qualified Purchaser Fund IV L P | PRTO | Series D Convertible Preferred Stock | D | -3.932.747 | 0 | ||||||
| 2014-10-29 | 2014-10-27 | 4 | Skyline Venture Partners Qualified Purchaser Fund IV L P | PRTO | Series C Convertible Preferred Stock | D | -2.436.437 | 0 | ||||||
| 2014-10-29 | 2014-10-27 | 4 | Skyline Venture Partners Qualified Purchaser Fund IV L P | PRTO | Series B Convertible Preferred Stock | D | -2.173.913 | 0 | ||||||
| 2014-10-29 | 2014-10-27 | 4 | Skyline Venture Partners Qualified Purchaser Fund IV L P | PRTO | Series A-1 Convertible Preferred Stock | D | -2.341.664 | 0 | ||||||
| 2014-10-29 | 2014-10-27 | 4 | Skyline Venture Partners Qualified Purchaser Fund IV L P | PRTO | Series A Convertible Preferred Stock | D | -5.000.000 | 0 | ||||||
| 2014-10-29 | 2014-10-27 | 4 | Skyline Venture Partners Qualified Purchaser Fund IV L P | PRTO | Common Stock | D | 10,0000 | -56.038 | -560 | 1.432.930 | ||||
| 2014-10-29 | 2014-10-27 | 4 | Skyline Venture Partners Qualified Purchaser Fund IV L P | PRTO | Common Stock | D | 4,6023 | 121.760 | 560 | 1.488.968 | ||||
| 2014-10-29 | 2014-10-27 | 4 | Skyline Venture Partners Qualified Purchaser Fund IV L P | PRTO | Common Stock | D | 1.167.208 | 1.367.208 | ||||||
| 2014-10-29 | 2014-10-27 | 4 | Skyline Venture Partners Qualified Purchaser Fund IV L P | PRTO | Common Stock | D | 10,0000 | 200.000 | 2.000 | 200.000 | ||||
| 2014-10-29 | 2014-10-27 | 4 | Abingworth LLP See Note | PRTO | Option (Right to Purchase) | I | -12.835.264 | 0 | ||||||
| 2014-10-29 | 2014-10-27 | 4 | Abingworth LLP See Note | PRTO | Series D Convertible Preferred Stock | I | -16.044.081 | 0 | ||||||
| 2014-10-29 | 2014-10-27 | 4 | Abingworth LLP See Note | PRTO | Common Stock | I | 1.067.872 | 2.017.872 | ||||||
| 2014-10-29 | 2014-10-27 | 4 | Abingworth LLP See Note | PRTO | Common Stock | I | 10,0000 | 950.000 | 9.500 | 950.000 | ||||
| 2014-10-29 | 2014-10-27 | 4 | O'Leary Brendan | PRTO | Common Stock Warrants | I | -1.965.454 | 0 | ||||||
| 2014-10-29 | 2014-10-27 | 4 | O'Leary Brendan | PRTO | Series D Convertible Preferred Stock | I | -4.000.070 | 0 | ||||||
| 2014-10-29 | 2014-10-27 | 4 | O'Leary Brendan | PRTO | Series C Convertible Preferred Stock | I | -2.478.183 | 0 | ||||||
| 2014-10-29 | 2014-10-27 | 4 | O'Leary Brendan | PRTO | Series B Convertible Preferred Stock | I | -2.336.956 | 0 | ||||||
| 2014-10-29 | 2014-10-27 | 4 | O'Leary Brendan | PRTO | Series A-1 Convertible Preferred Stock | I | -2.341.664 | 0 | ||||||
| 2014-10-29 | 2014-10-27 | 4 | O'Leary Brendan | PRTO | Series A Convertible Preferred Stock | I | -5.000.000 | 0 | ||||||
| 2014-10-29 | 2014-10-27 | 4 | O'Leary Brendan | PRTO | Common Stock | I | 10,0000 | 83.170 | 832 | 1.387.198 | ||||
| 2014-10-29 | 2014-10-27 | 4 | O'Leary Brendan | PRTO | Common Stock | I | 123.846 | 1.304.028 | ||||||
| 2014-10-29 | 2014-10-27 | 4 | O'Leary Brendan | PRTO | Common Stock | I | 252.052 | 1.180.182 | ||||||
| 2014-10-29 | 2014-10-27 | 4 | O'Leary Brendan | PRTO | Common Stock | I | 192.070 | 928.130 | ||||||
| 2014-10-29 | 2014-10-27 | 4 | O'Leary Brendan | PRTO | Common Stock | I | 181.125 | 736.060 | ||||||
| 2014-10-29 | 2014-10-27 | 4 | O'Leary Brendan | PRTO | Common Stock | I | 180.014 | 554.935 | ||||||
| 2014-10-29 | 2014-10-27 | 4 | O'Leary Brendan | PRTO | Common Stock | I | 374.921 | 374.921 | ||||||
| 2014-10-29 | 2014-10-27 | 4 | Haines Timothy By Abingworth Bioventures VI, LP | PRTO | Option (Right to Purchase) | I | -12.835.264 | 0 | ||||||
| 2014-10-29 | 2014-10-27 | 4 | Haines Timothy By Abingworth Bioventures VI, LP | PRTO | Series D Convertible Preferred Stock | I | -16.044.081 | 0 | ||||||
| 2014-10-29 | 2014-10-27 | 4 | Haines Timothy By Abingworth Bioventures VI, LP | PRTO | Common Stock | I | 1.067.872 | 2.017.872 | ||||||
| 2014-10-29 | 2014-10-27 | 4 | Haines Timothy By Abingworth Bioventures VI, LP | PRTO | Common Stock | I | 10,0000 | 950.000 | 9.500 | 950.000 | ||||
| 2014-10-29 | 2014-10-27 | 4 | Pharmstandard International S.A. | PRTO | Option (Right to Purchase) | D | -6.795.140 | 0 | ||||||
| 2014-10-29 | 2014-10-27 | 4 | Pharmstandard International S.A. | PRTO | Series D Convertible Preferred Stock | D | -8.493.925 | 0 | ||||||
| 2014-10-29 | 2014-10-27 | 4 | Pharmstandard International S.A. | PRTO | Common Stock | D | 565.344 | 1.165.344 | ||||||
| 2014-10-29 | 2014-10-27 | 4 | Pharmstandard International S.A. | PRTO | Common Stock | D | 10,0000 | 600.000 | 6.000 | 600.000 | ||||
| 2014-10-29 | 2014-10-27 | 4 | Kobyzev Dmitry By Pharmstandard International S.A | PRTO | Option (Right to Purchase) | I | -6.795.140 | 0 | ||||||
| 2014-10-29 | 2014-10-27 | 4 | Kobyzev Dmitry By Pharmstandard International S.A | PRTO | Series D Convertible Preferred Stock | I | -8.493.925 | 0 | ||||||
| 2014-10-29 | 2014-10-27 | 4 | Kobyzev Dmitry By Pharmstandard International S.A | PRTO | Common Stock | I | 565.344 | 1.165.344 | ||||||
| 2014-10-29 | 2014-10-27 | 4 | Kobyzev Dmitry By Pharmstandard International S.A | PRTO | Common Stock | I | 10,0000 | 600.000 | 6.000 | 600.000 | ||||
| 2014-10-27 | 2014-10-27 | 4 | Flynn James E Through Deerfield Special Situations International Master Fund, L.P. | PRTO | Series D Purchase Right | I | -838.067 | 0 | ||||||
| 2014-10-27 | 2014-10-27 | 4 | Flynn James E Through Deerfield Special Situations Fund, L.P. | PRTO | Series D Purchase Right | I | -1.049.472 | 0 | ||||||
| 2014-10-27 | 2014-10-27 | 4 | Flynn James E Through Deerfield Private Design Fund III, L.P. | PRTO | Series D Purchase Right | I | -4.907.601 | 0 | ||||||
| 2014-10-27 | 2014-10-27 | 4 | Flynn James E Through Deerfield Special Situations International Master Fund, L.P. | PRTO | Series D Preferred Stock | I | -1.047.584 | 0 | ||||||
| 2014-10-27 | 2014-10-27 | 4 | Flynn James E Through Deerfield Special Situations Fund, L.P. | PRTO | Series D Preferred Stock | I | -1.311.840 | 0 | ||||||
| 2014-10-27 | 2014-10-27 | 4 | Flynn James E Through Deerfield Private Design Fund III, L.P. | PRTO | Series D Preferred Stock | I | -6.134.501 | 0 | ||||||
| 2014-10-27 | 2014-10-27 | 4 | Flynn James E Through Deerfield Special Situations International Master Fund, L.P. | PRTO | Common Stock | I | 10,0000 | 45 | 0 | 170.371 | ||||
| 2014-10-27 | 2014-10-27 | 4 | Flynn James E Through Deerfield Special Situations Fund, L.P. | PRTO | Common Stock | I | 10,0000 | 55 | 1 | 208.345 | ||||
| 2014-10-27 | 2014-10-27 | 4 | Flynn James E Through Deerfield Special Situations International Master Fund, L.P. | PRTO | Common Stock | I | 10,0000 | 272 | 3 | 170.326 | ||||
| 2014-10-27 | 2014-10-27 | 4 | Flynn James E Through Deerfield Special Situations Fund, L.P. | PRTO | Common Stock | I | 10,0000 | 328 | 3 | 208.290 | ||||
| 2014-10-27 | 2014-10-27 | 4 | Flynn James E Through Deerfield Special Situations International Master Fund, L.P. | PRTO | Common Stock | I | 10,0000 | 12.819 | 128 | 170.054 | ||||
| 2014-10-27 | 2014-10-27 | 4 | Flynn James E Through Deerfield Special Situations Fund, L.P. | PRTO | Common Stock | I | 10,0000 | 15.417 | 154 | 207.962 | ||||
| 2014-10-27 | 2014-10-27 | 4 | Flynn James E Through Deerfield Special Situations International Master Fund, L.P. | PRTO | Common Stock | I | 10,0000 | 5.801 | 58 | 157.235 | ||||
| 2014-10-27 | 2014-10-27 | 4 | Flynn James E Through Deerfield Special Situations Fund, L.P. | PRTO | Common Stock | I | 10,0000 | 6.976 | 70 | 192.545 | ||||
| 2014-10-27 | 2014-10-27 | 4 | Flynn James E Through Deerfield Special Situations International Master Fund, L.P. | PRTO | Common Stock | I | 10,0000 | 81.949 | 819 | 151.434 | ||||
| 2014-10-27 | 2014-10-27 | 4 | Flynn James E Through Deerfield Special Situations Fund, L.P. | PRTO | Common Stock | I | 10,0000 | 98.556 | 986 | 185.569 | ||||
| 2014-10-27 | 2014-10-27 | 4 | Flynn James E Through Deerfield Private Design Fund III, L.P. | PRTO | Common Stock | I | 10,0000 | 469.495 | 4.695 | 876.391 | ||||
| 2014-10-27 | 2014-10-27 | 4 | Flynn James E Through Deerfield Special Situations International Master Fund, L.P. | PRTO | Common Stock | I | 69.485 | 69.485 | ||||||
| 2014-10-27 | 2014-10-27 | 4 | Flynn James E Through Deerfield Special Situations Fund, L.P. | PRTO | Common Stock | I | 87.013 | 87.013 | ||||||
| 2014-10-27 | 2014-10-27 | 4 | Flynn James E Through Deerfield Private Design Fund III, L.P. | PRTO | Common Stock | I | 406.896 | 406.896 |
P
Åbent marked eller privat køb af ikke-afledte eller afledte værdipapirer
S
Åbent marked eller privat salg af ikke-afledte eller afledte værdipapirer
A
Tildeling, tildeling eller anden erhvervelse af værdipapirer fra virksomheden (såsom en option)
C
Konvertering af derivat
D
Salg eller overførsel af værdipapirer tilbage til virksomheden
F
Betaling af udnyttelseskurs eller skatteforpligtelse ved brug af en del af værdipapirer modtaget fra selskabet
G
Gave af værdipapirer af eller til insideren
K
Aktieswaps og lignende sikringstransaktioner
M
Udnyttelse eller konvertering af afledt værdipapir modtaget fra virksomheden (såsom en option)
V
En transaktion rapporteret frivilligt på formular 4
J
Andet (ledsaget af en fodnote, der beskriver transaktionen)
