| Insideraktier | 6.872.638 shares |
Insider-stemningsscore
Insider Sentiment Score viser, at virksomhederne bliver købt af virksomheders insidere.
Det er resultatet af en sofistikeret, multi-faktor kvantitativ model, der identificerer virksomheder med de højeste niveauer af insider-akkumulering. Scoringsmodellen bruger en kombination af nettoantallet af insidere, der har købt de foregående 90 dage, det samlede antal aktier købt som en procentdel af float og det samlede antal aktier ejet af insidere. Tallet går fra 0 til 100, hvor højere tal indikerer et højere niveau af akkumulering for sine jævnaldrende, og 50 er gennemsnittet.
Opdateringsfrekvens: Dagligt
Se Insiders Top Picks, som giver en liste over virksomheder med den højeste insider-akkumulering.
Officers sentiment score
Officer Sentiment Score finder virksomheder, der bliver købt af Corporate Officers.
Per definition er Corporate Officers Corporate Insiders, men i modsætning til nogle af de andre Insiders (10 % aktionærer og bestyrelsesmedlemmer), arbejder officerer for virksomheden på daglig basis, og de bruger deres egne penge, når de handler . (10 % aktionærer og bestyrelsesmedlemmer er ofte fondsforvaltere, der administrerer andres penge.) Som sådan er insiderhandler foretaget af embedsmænd meget mere betydningsfulde og bør behandles passende.
Ligesom Insider Sentiment Score er Officer Sentiment Score resultatet af en sofistikeret, multi-faktor kvantitativ model, der identificerer virksomheder med de højeste niveauer af officerakkumulering.
Opdateringsfrekvens: Dagligt
Se Insiders Top Picks, som giver en liste over virksomheder med højeste insider-stemning.
Nøgle Insider Metrics
Dette kort viser, hvordan virksomheden rangerer langs forskellige insider-metrics. Percentilrangen viser, hvordan denne virksomhed sammenligner sig med andre virksomheder på de amerikanske markeder. Højere placeringer er tegn på bedre situationer.
For eksempel er det generelt accepteret, at insider-køb er en positiv indikator, så virksomheder med flere insider-køb vil rangere højere end virksomheder med mindre insider-køb (eller endda insider-salg).
Netto antal insidere, der køber (rang)
N/A
Netto antal insidere, der køber, er det samlede antal insiders, der køber minus det samlede antal insiders, der har solgt inden for de sidste 90 dage. Percentilrangen vises her (spænder fra 0 til 100%).
Procent af float købt af insidere (rangering)
N/A
Procent af float købt af insidere er det samlede antal aktier købt af insidere minus det samlede antal aktier solgt af insidere inden for de sidste 90 dage, divideret med den samlede float og ganget med 100.
Insiderhandelsdiagram
Regulus Therapeutics Inc. insiderhandler er vist i følgende diagram. Insidere er embedsmænd, direktører eller betydelige investorer i en virksomhed. Generelt er det generelt ulovligt for insidere at foretage handler i deres virksomheder baseret på væsentlige, ikke-offentlige oplysninger. Dette betyder ikke, at det er ulovligt for dem at handle i deres egne virksomheder. De skal dog rapportere alle handler til SEC via en formular 4.
Insiderliste og lønsomhedsmålinger
Denne tabel viser listen over kendte insidere og genereres automatisk fra arkiveringer, der er videregivet til SEC. Ud over navnene, den seneste titel og direktør, officer eller 10 % ejerbetegnelse giver vi de seneste offentliggjorte besiddelser. Derudover giver vi, når det er muligt, den historiske handelspræstation for insideren. Den historiske handelspræstation er et vægtet gennemsnit af præstationen af faktiske købstransaktioner på det åbne marked foretaget af insideren. For mere information om, hvordan dette beregnes, se dette YouTube-webinar.
See our leaderboard of most profitable insider traders.
| Insider | Gennemsnitlig fortjeneste (%) | Aktier Ejet |
Dele Justeret |
|---|
Report errors via our new Insider Auditing Tool
Track Records af insiderkøb - Kortsigtet profitanalyse
I dette afsnit analyserer vi rentabiliteten af ethvert uplanlagt insiderkøb i åbent marked foretaget i RGLS / Regulus Therapeutics Inc.. Denne analyse hjælper med at forstå, om insideren konsekvent genererer unormale afkast og er værd at følge. Denne analyse er for et år efter hver handel, og resultaterne er teoretiske .
Følgende tabel viser de seneste køb på det åbne marked, der ikke var en del af en automatisk handelsplan.
Justeret pris er den split-justerede pris. Adjusted Shares er de split-justerede aktier.
Track Records af insidersalg - Kortsigtet tabsanalyse
I dette afsnit analyserer vi den kortsigtede undgåelse af tab af ethvert uplanlagt insidersalg på åbent marked, der foretages i RGLS / Regulus Therapeutics Inc.. Et konsekvent mønster af tabsforebyggelse kan tyde på, at fremtidige salgstransaktioner kan forudsige prisfald. Denne analyse er for et år efter hver handel, og resultaterne er teoretiske .
Følgende tabel viser de seneste salg på det åbne marked, der ikke var en del af en automatisk handelsplan.
Justeret pris er den split-justerede pris. Adjusted Shares er de split-justerede aktier.
Transaktionshistorik
Klik på linkikonet for at se den fulde transaktionshistorik. Transaktioner, der rapporteres som en del af en automatisk handelsplan 10b5-1, vil have et X i kolonnen markeret 10b-5.
| Fil Dato |
Handle Dato |
Form | Insider | Ticker | Sikkerhedstitel | Kode | Direkte | Dyrke motion Pris |
Enhed Pris |
Enheder Ændret |
Værdi Ændret (1K) |
Tilbage Muligheder |
Tilbage Aktier |
|
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2025-06-27 | 2025-06-25 | 4 | RASTETTER WILLIAM H By The Rastetter Family Trust | RGLS | Common Stock | I | -57.292 | 0 | ||||||
| 2025-06-27 | 2025-06-25 | 4 | RASTETTER WILLIAM H By The Rastetter Family Trust | RGLS | Common Stock | I | -44.264 | 57.292 | ||||||
| 2025-06-27 | 2025-06-25 | 4 | Witz Pascale | RGLS | Common Stock | D | -67.233 | 0 | ||||||
| 2025-06-27 | 2025-06-25 | 4 | PAPADOPOULOS STELIOS | RGLS | Common Stock | D | -64.635 | 0 | ||||||
| 2025-06-27 | 2025-06-25 | 4 | PAPADOPOULOS STELIOS | RGLS | Common Stock | D | -976.253 | 64.635 | ||||||
| 2025-06-27 | 2025-06-25 | 4 | Rosen Hugh | RGLS | Common Stock | D | -57.292 | 0 | ||||||
| 2025-06-27 | 2025-06-25 | 4 | Rosen Hugh | RGLS | Common Stock | D | -6.979 | 57.292 | ||||||
| 2025-06-27 | 2025-06-25 | 4 | Aker Christopher Ray | RGLS | Common Stock | D | -83.125 | 0 | ||||||
| 2025-06-27 | 2025-06-25 | 4 | Aker Christopher Ray | RGLS | Common Stock | D | -60.796 | 83.125 | ||||||
| 2025-06-27 | 2025-06-25 | 4 | Klassen Preston | RGLS | Common Stock | D | -115.555 | 0 | ||||||
| 2025-06-27 | 2025-06-25 | 4 | Hagan Joseph P | RGLS | Common Stock | D | -571.558 | 0 | ||||||
| 2025-06-27 | 2025-06-25 | 4 | BALTIMORE DAVID | RGLS | Common Stock | D | -57.292 | 0 | ||||||
| 2025-06-27 | 2025-06-25 | 4 | BALTIMORE DAVID By Spouse | RGLS | Common Stock | I | -57.292 | 0 | ||||||
| 2025-06-27 | 2025-06-25 | 4 | BALTIMORE DAVID By Spouse | RGLS | Common Stock | I | -5.208 | 57.292 | ||||||
| 2025-06-27 | 2025-06-25 | 4 | BALTIMORE DAVID | RGLS | Common Stock | D | -27.377 | 57.292 | ||||||
| 2025-06-27 | 2025-06-25 | 4 | Nunn Jason Raleigh | RGLS | Common Stock | D | -62.500 | 0 | ||||||
| 2025-06-27 | 2025-06-25 | 4 | Huang Alice Shih-hou | RGLS | Common Stock | D | -57.292 | 0 | ||||||
| 2025-06-27 | 2025-06-25 | 4 | Huang Alice Shih-hou By Spouse | RGLS | Common Stock | I | -57.292 | 0 | ||||||
| 2025-06-27 | 2025-06-25 | 4 | Huang Alice Shih-hou By Spouse | RGLS | Common Stock | I | -27.377 | 57.292 | ||||||
| 2025-06-27 | 2025-06-25 | 4 | Huang Alice Shih-hou | RGLS | Common Stock | D | -5.208 | 57.292 | ||||||
| 2025-06-27 | 2025-06-25 | 4 | Collier Kathryn J | RGLS | Common Stock | D | -75.565 | 0 | ||||||
| 2025-06-27 | 2025-06-25 | 4 | CALSADA CRISPINA | RGLS | Common Stock | D | -140.228 | 0 | ||||||
| 2025-06-18 | 2025-06-17 | 4 | Collier Kathryn J | RGLS | Common Stock | D | 8,8000 | 2.325 | 20 | 62.915 | ||||
| 2025-06-18 | 2025-06-17 | 4 | Collier Kathryn J | RGLS | Common Stock | D | 9,9000 | 2.604 | 26 | 65.240 | ||||
| 2025-06-18 | 2025-06-16 | 4 | Collier Kathryn J | RGLS | Common Stock | D | 9,9000 | 1.396 | 14 | 67.844 | ||||
| 2025-06-04 | 2025-06-03 | 4 | Klassen Preston | RGLS | Common Stock | D | 7,9877 | 12.000 | 96 | 48.055 | ||||
| 2025-04-30 | 2025-04-30 | 4 | Nunn Jason Raleigh | RGLS | Common Stock | D | 62.500 | 62.500 | ||||||
| 2025-04-30 | 2025-04-30 | 4 | Collier Kathryn J | RGLS | Common Stock | D | 62.500 | 69.240 | ||||||
| 2025-04-30 | 2025-04-30 | 4 | Witz Pascale | RGLS | Common Stock | D | 62.500 | 67.233 | ||||||
| 2025-04-30 | 2025-04-30 | 4 | Huang Alice Shih-hou | RGLS | Common Stock | D | 62.500 | 84.669 | ||||||
| 2025-04-30 | 2025-04-30 | 4 | Huang Alice Shih-hou By Spouse | RGLS | Common Stock | I | 62.500 | 84.669 | ||||||
| 2025-04-30 | 2025-04-30 | 4 | BALTIMORE DAVID | RGLS | Common Stock | D | 62.500 | 62.500 | ||||||
| 2025-04-30 | 2025-04-30 | 4 | BALTIMORE DAVID By Spouse | RGLS | Common Stock | I | 62.500 | 62.500 | ||||||
| 2025-04-30 | 2025-04-30 | 4 | PAPADOPOULOS STELIOS | RGLS | Common Stock | D | 62.500 | 1.040.888 | ||||||
| 2025-04-30 | 2025-04-30 | 4 | RASTETTER WILLIAM H The Rastetter Family Trust | RGLS | Common Stock | I | 62.500 | 101.556 | ||||||
| 2025-04-30 | 2025-04-30 | 4 | Rosen Hugh | RGLS | Common Stock | D | 62.500 | 64.271 | ||||||
| 2025-01-31 | 2025-01-30 | 4 | BALTIMORE DAVID | RGLS | Common Stock | D | 1,0600 | 19.610 | 21 | 22.169 | ||||
| 2025-01-31 | 2025-01-30 | 4 | Hagan Joseph P | RGLS | Common Stock | D | 1,0852 | 50.000 | 54 | 260.808 | ||||
| 2025-01-15 | 2025-01-13 | 4 | Klassen Preston | RGLS | Common Stock | D | 1,2632 | -31.445 | -40 | 36.055 | ||||
| 2025-01-15 | 2025-01-14 | 4 | CALSADA CRISPINA | RGLS | Common Stock | D | 1,2632 | -5.088 | -6 | 45.478 | ||||
| 2025-01-15 | 2025-01-13 | 4 | CALSADA CRISPINA | RGLS | Common Stock | D | 1,2632 | -38.716 | -49 | 50.566 | ||||
| 2025-01-15 | 2025-01-14 | 4 | Hagan Joseph P | RGLS | Common Stock | D | 1,2632 | -11.764 | -15 | 210.808 | ||||
| 2025-01-15 | 2025-01-13 | 4 | Hagan Joseph P | RGLS | Common Stock | D | 1,2632 | -115.290 | -146 | 222.572 | ||||
| 2025-01-15 | 2025-01-14 | 4 | Aker Christopher Ray | RGLS | Common Stock | D | 1,2632 | -5.088 | -6 | 49.546 | ||||
| 2025-01-15 | 2025-01-13 | 4 | Aker Christopher Ray | RGLS | Common Stock | D | 1,2632 | -38.547 | -49 | 54.634 | ||||
| 2025-01-10 | 2025-01-09 | 4 | CALSADA CRISPINA | RGLS | Common Stock | D | 1,3000 | 21.000 | 27 | 89.282 | ||||
| 2025-01-10 | 2025-01-09 | 4 | CALSADA CRISPINA | RGLS | Common Stock | D | 1,3600 | 62.500 | 85 | 68.282 | ||||
| 2025-01-10 | 2025-01-09 | 4 | Hagan Joseph P | RGLS | Common Stock | D | 1,3000 | 62.000 | 81 | 337.862 | ||||
| 2025-01-10 | 2025-01-09 | 4 | Hagan Joseph P | RGLS | Common Stock | D | 1,3600 | 218.750 | 298 | 275.862 | ||||
| 2025-01-10 | 2025-01-09 | 4 | Klassen Preston | RGLS | Common Stock | D | 1,3000 | 30.000 | 39 | 67.500 | ||||
| 2025-01-10 | 2025-01-09 | 4 | Klassen Preston | RGLS | Common Stock | D | 1,3600 | 37.500 | 51 | 37.500 | ||||
| 2025-01-10 | 2025-01-09 | 4 | Aker Christopher Ray | RGLS | Common Stock | D | 1,3000 | 17.500 | 23 | 93.181 | ||||
| 2025-01-10 | 2025-01-09 | 4 | Aker Christopher Ray | RGLS | Common Stock | D | 1,3600 | 66.625 | 91 | 75.681 | ||||
| 2024-07-29 | 2024-07-25 | 4 | Collier Kathryn J | RGLS | Common Stock | D | 1,8200 | 4.000 | 7 | 6.740 | ||||
| 2024-03-15 | 2024-03-14 | 4 | PAPADOPOULOS STELIOS | RGLS | Common Stock | D | 1,6000 | 250.000 | 400 | 978.388 | ||||
| 2024-01-18 | 2024-01-18 | 4 | CALSADA CRISPINA | RGLS | Common Stock | D | 1,1906 | -5.468 | -7 | 5.782 | ||||
| 2024-01-18 | 2024-01-18 | 4 | Aker Christopher Ray | RGLS | Common Stock | D | 1,1906 | -5.468 | -7 | 10.056 | ||||
| 2024-01-18 | 2024-01-18 | 4 | Hagan Joseph P | RGLS | Common Stock | D | 1,1906 | -14.580 | -17 | 57.112 | ||||
| 2024-01-17 | 2024-01-12 | 4 | Hagan Joseph P | RGLS | Common Stock | D | 30.000 | 71.692 | ||||||
| 2024-01-17 | 2024-01-12 | 4 | CALSADA CRISPINA | RGLS | Common Stock | D | 11.250 | 11.250 | ||||||
| 2024-01-17 | 2024-01-12 | 4 | Aker Christopher Ray | RGLS | Common Stock | D | 11.250 | 15.524 | ||||||
| 2023-04-14 | 2023-04-13 | 4 | PAPADOPOULOS STELIOS | RGLS | Common Stock | D | 0,9001 | 222.198 | 200 | 728.388 | ||||
| 2022-05-11 | 2022-05-10 | 4 | Hagan Joseph P | RGLS | Stock Option (Right to Buy) | D | 1,31 | 300.000 | 300.000 | |||||
| 2022-05-11 | 2022-05-10 | 4 | CALSADA CRISPINA | RGLS | Stock Option (Right to Buy) | D | 1,31 | 50.000 | 50.000 | |||||
| 2022-05-11 | 2022-05-09 | 4 | Aker Christopher Ray | RGLS | Stock Option (Right to Buy) | D | 1,31 | 70.000 | 70.000 | |||||
| 2022-03-01 | 2022-03-01 | 4 | Drygin Denis | RGLS | Common Stock | D | 0,2300 | 76.686 | 18 | 100.000 | ||||
| 2022-02-07 | 2022-02-04 | 4 | Drygin Denis | RGLS | Common Stock | D | 0,2300 | 23.314 | 5 | 23.314 | ||||
| 2022-01-26 | 2022-01-26 | 4 | Hagan Joseph P | RGLS | Common Stock | D | 0,2152 | 100.000 | 22 | 417.006 | ||||
| 2022-01-26 | 2022-01-12 | 4 | Hagan Joseph P | RGLS | Stock Option (Right to Buy) | D | 0,26 | 1.600.000 | 1.600.000 | |||||
| 2022-01-26 | 2022-01-12 | 4 | Drygin Denis | RGLS | Stock Option (Right to Buy) | D | 0,26 | 400.000 | 400.000 | |||||
| 2022-01-26 | 2022-01-12 | 4 | CALSADA CRISPINA | RGLS | Stock Option (Right to Buy) | D | 0,26 | 480.000 | 480.000 | |||||
| 2022-01-26 | 2022-01-12 | 4 | Aker Christopher Ray | RGLS | Stock Option (Right to Buy) | D | 0,26 | 480.000 | 480.000 | |||||
| 2021-12-01 | 2021-11-30 | 4 | PAPADOPOULOS STELIOS | RGLS | Common Stock | D | 0,3600 | 2.222.222 | 800 | 5.061.929 | ||||
| 2021-06-15 | 2021-06-14 | 4 | Simeonidis Simos | RGLS | Stock Option (Right to Buy) | D | 0,99 | 40.000 | 40.000 | |||||
| 2021-06-15 | 2021-06-14 | 4 | Witz Pascale | RGLS | Stock Option (Right to Buy) | D | 0,99 | 40.000 | 40.000 | |||||
| 2021-06-15 | 2021-06-14 | 4 | Rosen Hugh | RGLS | Stock Option (Right to Buy) | D | 0,99 | 40.000 | 40.000 | |||||
| 2021-06-15 | 2021-06-14 | 4 | RASTETTER WILLIAM H | RGLS | Stock Option (Right to Buy) | D | 0,99 | 40.000 | 40.000 | |||||
| 2021-06-15 | 2021-06-14 | 4 | Nunn Jason Raleigh | RGLS | Stock Option (Right to Buy) | D | 0,99 | 40.000 | 40.000 | |||||
| 2021-06-15 | 2021-06-14 | 4 | PAPADOPOULOS STELIOS | RGLS | Stock Option (Right to Buy) | D | 0,99 | 40.000 | 40.000 | |||||
| 2021-06-15 | 2021-06-14 | 4 | Huang Alice Shih-hou | RGLS | Stock Option (Right to Buy) | D | 0,99 | 40.000 | 40.000 | |||||
| 2021-06-15 | 2021-06-14 | 4 | Collier Kathryn J | RGLS | Stock Option (Right to Buy) | D | 0,99 | 40.000 | 40.000 | |||||
| 2021-06-15 | 2021-06-14 | 4 | BALTIMORE DAVID | RGLS | Stock Option (Right to Buy) | D | 0,99 | 40.000 | 40.000 | |||||
| 2021-05-17 | 2021-05-17 | 4 | Hagan Joseph P | RGLS | Common Stock | D | 0,8900 | -4.186 | -4 | 316.292 | ||||
| 2021-05-17 | 2021-05-17 | 4 | Aker Christopher Ray | RGLS | Common Stock | D | 0,8900 | -860 | -1 | 41.754 | ||||
| 2021-04-16 | 2021-04-14 | 4 | Hagan Joseph P PACIFIC PREMIER TRUST OBO JOSEPH P. HAGAN IRA | RGLS | Class A-2 Convertible Preferred Stock | I | 7.585 | 0 | ||||||
| 2021-04-16 | 2021-04-14 | 4 | Hagan Joseph P | RGLS | Common Stock | D | 75.850 | 320.478 | ||||||
| 2021-04-16 | 2021-02-16 | 4/A | Hagan Joseph P | RGLS | Common Stock | D | 1,7200 | -4.144 | -7 | 244.628 | ||||
| 2021-02-17 | 2021-02-16 | 4 | Hagan Joseph P | RGLS | Common Stock | D | 1,7200 | -4.144 | -7 | 485.756 | ||||
| 2021-02-17 | 2021-02-16 | 4 | Aker Christopher Ray | RGLS | Common Stock | D | 1,7200 | -828 | -1 | 42.614 | ||||
| 2021-02-05 | 2021-02-04 | 4 | Hagan Joseph P | RGLS | Stock Option (Right to Buy) | D | 1,59 | 600.000 | 600.000 | |||||
| 2021-02-05 | 2021-02-04 | 4 | Drygin Denis | RGLS | Stock Option (Right to Buy) | D | 1,59 | 120.000 | 120.000 | |||||
| 2021-02-05 | 2021-02-04 | 4 | Aker Christopher Ray | RGLS | Stock Option (Right to Buy) | D | 1,59 | 180.000 | 180.000 | |||||
| 2021-02-05 | 2021-02-04 | 4 | CALSADA CRISPINA | RGLS | Stock Option (Right to Buy) | D | 1,59 | 150.000 | 150.000 | |||||
| 2021-01-27 | 2021-01-26 | 4 | Huang Alice Shih-hou | RGLS | Stock Option (Right to Buy) | D | 1,55 | 80.000 | 80.000 | |||||
| 2021-01-27 | 3 | Huang Alice Shih-hou By Spouse | RGLS | Common Stock | I | 25.604 | ||||||||
| 2021-01-27 | 2020-12-04 | 4/A | PAPADOPOULOS STELIOS | RGLS | Common Stock | D | 0,6301 | 793.528 | 500 | 2.839.707 | ||||
| 2020-12-07 | 2020-12-04 | 4 | Sonsini Peter W. See Note 2 | RGLS | Class A-3 Convertible Preferred Stock | I | 6,2200 | 258.707 | 1.609 | 258.707 | ||||
| 2020-12-07 | 2020-12-04 | 4 | Sonsini Peter W. See Note 2 | RGLS | Common Stock Purchase Warrant (right to buy) | I | 0,75 | 0,1250 | 5.239.254 | 655 | 5.239.254 | |||
| 2020-12-07 | 2020-12-04 | 4 | Sonsini Peter W. See Note 2 | RGLS | Common Stock | I | 0,6220 | 4.398.602 | 2.736 | 6.451.056 | ||||
| 2020-12-07 | 2020-12-04 | 4 | Walker Paul Edward See Note 2 | RGLS | Class A-3 Convertible Preferred Stock | I | 6,2200 | 258.707 | 1.609 | 258.707 | ||||
| 2020-12-07 | 2020-12-04 | 4 | Walker Paul Edward See Note 2 | RGLS | Common Stock Purchase Warrant (right to buy) | I | 0,75 | 0,1250 | 5.239.254 | 655 | 5.239.254 | |||
| 2020-12-07 | 2020-12-04 | 4 | Walker Paul Edward See Note 2 | RGLS | Common Stock | I | 0,6220 | 4.398.602 | 2.736 | 6.451.056 | ||||
| 2020-12-07 | 2020-12-04 | 4 | BASKETT FOREST See Note 2 | RGLS | Class A-3 Convertible Preferred Stock | I | 6,2200 | 258.707 | 1.609 | 258.707 | ||||
| 2020-12-07 | 2020-12-04 | 4 | BASKETT FOREST See Note 2 | RGLS | Common Stock Purchase Warrant (right to buy) | I | 0,75 | 0,1250 | 5.239.254 | 655 | 5.239.254 | |||
| 2020-12-07 | 2020-12-04 | 4 | BASKETT FOREST See Note 2 | RGLS | Common Stock | I | 0,6220 | 4.398.602 | 2.736 | 6.451.056 | ||||
| 2020-12-07 | 2020-12-04 | 4 | Behbahani Ali See Note 2 | RGLS | Class A-3 Convertible Preferred Stock | I | 6,2200 | 258.707 | 1.609 | 258.707 | ||||
| 2020-12-07 | 2020-12-04 | 4 | Behbahani Ali See Note 2 | RGLS | Common Stock Purchase Warrant (right to buy) | I | 0,75 | 0,1250 | 5.239.254 | 655 | 5.239.254 | |||
| 2020-12-07 | 2020-12-04 | 4 | Behbahani Ali See Note 2 | RGLS | Common Stock | I | 0,6220 | 4.398.602 | 2.736 | 6.451.056 | ||||
| 2020-12-07 | 2020-12-04 | 4 | Chang Carmen See Note 2 | RGLS | Class A-3 Convertible Preferred Stock | I | 6,2200 | 258.707 | 1.609 | 258.707 | ||||
| 2020-12-07 | 2020-12-04 | 4 | Chang Carmen See Note 2 | RGLS | Common Stock Purchase Warrant (right to buy) | I | 0,75 | 0,1250 | 5.239.254 | 655 | 5.239.254 | |||
| 2020-12-07 | 2020-12-04 | 4 | Chang Carmen See Note 2 | RGLS | Common Stock | I | 0,6220 | 4.398.602 | 2.736 | 6.451.056 | ||||
| 2020-12-07 | 2020-12-04 | 4 | Florence Anthony A. Jr. See Note 2 | RGLS | Class A-3 Convertible Preferred Stock | I | 6,2200 | 258.707 | 1.609 | 258.707 | ||||
| 2020-12-07 | 2020-12-04 | 4 | Florence Anthony A. Jr. See Note 2 | RGLS | Common Stock Purchase Warrant (right to buy) | I | 0,75 | 0,1250 | 5.239.254 | 655 | 5.239.254 | |||
| 2020-12-07 | 2020-12-04 | 4 | Florence Anthony A. Jr. See Note 2 | RGLS | Common Stock | I | 0,6220 | 4.398.602 | 2.736 | 6.451.056 | ||||
| 2020-12-07 | 2020-12-04 | 4 | Makhzoumi Mohamad See Note 2 | RGLS | Class A-3 Convertible Preferred Stock | I | 6,2200 | 258.707 | 1.609 | 258.707 | ||||
| 2020-12-07 | 2020-12-04 | 4 | Makhzoumi Mohamad See Note 2 | RGLS | Common Stock Purchase Warrant (right to buy) | I | 0,75 | 0,1250 | 5.239.254 | 655 | 5.239.254 | |||
| 2020-12-07 | 2020-12-04 | 4 | Makhzoumi Mohamad See Note 2 | RGLS | Common Stock | I | 0,6220 | 4.398.602 | 2.736 | 6.451.056 | ||||
| 2020-12-07 | 2020-12-04 | 4 | MAKOWER JOSHUA See Note 2 | RGLS | Class A-3 Convertible Preferred Stock | I | 6,2200 | 258.707 | 1.609 | 258.707 | ||||
| 2020-12-07 | 2020-12-04 | 4 | MAKOWER JOSHUA See Note 2 | RGLS | Common Stock Purchase Warrant (right to buy) | I | 0,75 | 0,1250 | 5.239.254 | 655 | 5.239.254 | |||
| 2020-12-07 | 2020-12-04 | 4 | MAKOWER JOSHUA See Note 2 | RGLS | Common Stock | I | 0,6220 | 4.398.602 | 2.736 | 6.451.056 | ||||
| 2020-12-07 | 2020-12-04 | 4 | SANDELL SCOTT D See Note 2 | RGLS | Class A-3 Convertible Preferred Stock | I | 6,2200 | 258.707 | 1.609 | 258.707 | ||||
| 2020-12-07 | 2020-12-04 | 4 | SANDELL SCOTT D See Note 2 | RGLS | Common Stock Purchase Warrant (right to buy) | I | 0,75 | 0,1250 | 5.239.254 | 655 | 5.239.254 | |||
| 2020-12-07 | 2020-12-04 | 4 | SANDELL SCOTT D See Note 2 | RGLS | Common Stock | I | 0,6220 | 4.398.602 | 2.736 | 6.451.056 | ||||
| 2020-12-07 | 2020-12-04 | 4 | Growth Equity Opportunities V, LLC | RGLS | Class A-3 Convertible Preferred Stock | D | 6,2200 | 258.707 | 1.609 | 258.707 | ||||
| 2020-12-07 | 2020-12-04 | 4 | Growth Equity Opportunities V, LLC | RGLS | Common Stock Purchase Warrant (right to buy) | D | 0,75 | 0,1250 | 5.239.254 | 655 | 5.239.254 | |||
| 2020-12-07 | 2020-12-04 | 4 | Growth Equity Opportunities V, LLC | RGLS | Common Stock | D | 0,6220 | 4.398.602 | 2.736 | 6.451.056 | ||||
| 2020-12-07 | 2020-12-04 | 4 | PAPADOPOULOS STELIOS | RGLS | Common Stock Purchase Warrant (Right to Buy) | D | 0,75 | 0,1250 | 595.146 | 74 | 595.146 | |||
| 2020-12-07 | 2020-12-04 | 4 | PAPADOPOULOS STELIOS | RGLS | Common Stock | D | 0,6301 | 793.528 | 500 | 1.986.729 | ||||
| 2020-12-07 | 2020-12-04 | 4 | Hagan Joseph P Securities purchased through an affiliated investment entity | RGLS | Common Stock Purchase Warrant (Right to Buy) | I | 0,75 | 0,1250 | 29.760 | 4 | 29.760 | |||
| 2020-12-07 | 2020-12-04 | 4 | Hagan Joseph P Securities purchased through an affiliated investment entity | RGLS | Common Stock | I | 0,6301 | 39.680 | 25 | 225.674 | ||||
| 2020-11-18 | 2020-11-16 | 4 | Aker Christopher Ray | RGLS | Common Stock | D | 0,5211 | -876 | -0 | 25.762 | ||||
| 2020-11-18 | 2020-11-16 | 4 | Hagan Joseph P | RGLS | Common Stock | D | 0,5211 | -6.094 | -3 | 215.994 | ||||
| 2020-08-17 | 2020-08-14 | 4 | Hagan Joseph P | RGLS | Common Stock | D | 0,6049 | -4.245 | -3 | 222.088 | ||||
| 2020-08-17 | 2020-08-14 | 4 | Aker Christopher Ray | RGLS | Common Stock | D | 0,6050 | -872 | -1 | 26.638 | ||||
| 2020-08-05 | 2020-03-03 | 4 | Drygin Denis | RGLS | Stock Option (Right to Buy) | D | 0,69 | 300.000 | 300.000 | |||||
| 2020-06-19 | 2020-06-17 | 4 | BALTIMORE DAVID | RGLS | Stock Option (Right to Buy) | D | 0,88 | 23.250 | 23.250 | |||||
| 2020-06-19 | 2020-06-17 | 4 | Collier Kathryn J | RGLS | Stock Option (Right to Buy) | D | 0,88 | 23.250 | 23.250 | |||||
| 2020-06-19 | 2020-06-17 | 4 | Nunn Jason Raleigh | RGLS | Stock Option (Right to Buy) | D | 0,88 | 23.250 | 23.250 | |||||
| 2020-06-19 | 2020-06-17 | 4 | PAPADOPOULOS STELIOS | RGLS | Stock Option (Right to Buy) | D | 0,88 | 23.250 | 23.250 | |||||
| 2020-06-19 | 2020-06-17 | 4 | RASTETTER WILLIAM H THE RASTETTER FAMILY TRUST DTD 9-2-2010 | RGLS | Stock Option (Right to Buy) | I | 0,88 | 23.250 | 23.250 | |||||
| 2020-06-19 | 2020-06-17 | 4 | Rosen Hugh | RGLS | Stock Option (Right to Buy) | D | 0,88 | 23.250 | 23.250 | |||||
| 2020-06-19 | 2020-06-17 | 4 | Simeonidis Simos | RGLS | Stock Option (Right to Buy) | D | 0,88 | 23.250 | 23.250 | |||||
| 2020-06-19 | 2020-06-17 | 4 | Witz Pascale | RGLS | Stock Option (Right to Buy) | D | 0,88 | 23.250 | 23.250 | |||||
| 2020-05-18 | 2020-05-15 | 4 | Aker Christopher Ray | RGLS | Common Stock | D | 0,6268 | -909 | -1 | 27.510 | ||||
| 2020-05-18 | 2020-05-15 | 4 | Hagan Joseph P | RGLS | Common Stock | D | 0,6267 | -4.426 | -3 | 226.333 | ||||
| 2020-05-08 | 3 | Sarissa Capital Master Fund II LP | RGLS | Common Stock | D | 152.712 | ||||||||
| 2020-05-08 | 3 | Sarissa Capital Master Fund II LP | RGLS | Common Stock | D | 152.712 | ||||||||
| 2020-05-08 | 3 | Sarissa Capital Master Fund II LP | RGLS | Common Stock | D | 152.712 | ||||||||
| 2020-05-08 | 2020-04-01 | 4 | Sarissa Capital Offshore Master Fund LP | RGLS | Warrants to Purchase Common Stock | D | 0,67 | -53.113 | 2.627.037 | |||||
| 2020-05-08 | 2020-04-01 | 4 | Sarissa Capital Offshore Master Fund LP | RGLS | Warrants to Purchase Common Stock | D | 1,08 | -23.243 | 1.149.649 | |||||
| 2020-05-08 | 2020-04-01 | 4 | Sarissa Capital Offshore Master Fund LP | RGLS | Class A-2 Convertible Preferred Stock | D | -5.311 | 262.704 | ||||||
| 2020-02-19 | 2020-02-18 | 4 | Hagan Joseph P | RGLS | Common Stock | D | 0,8304 | -4.324 | -4 | 230.759 | ||||
| 2020-02-19 | 2020-02-18 | 4 | Aker Christopher Ray | RGLS | Common Stock | D | 0,8305 | -888 | -1 | 28.419 | ||||
| 2020-02-04 | 2020-02-03 | 4 | RASTETTER WILLIAM H The Rastetter Family Trust dtd 9-2-2010 | RGLS | Class A-2 Convertible Preferred Stock | I | -22.594 | 0 | ||||||
| 2020-02-04 | 2020-02-03 | 4 | RASTETTER WILLIAM H The Rastetter Family Trust dtd 9-2-2010 | RGLS | Common Stock | I | 225.940 | 390.584 | ||||||
| 2020-02-04 | 2020-02-03 | 4 | PAPADOPOULOS STELIOS | RGLS | Class A-2 Convertible Preferred Stock | D | -84.632 | 0 | ||||||
| 2020-02-04 | 2020-02-03 | 4 | PAPADOPOULOS STELIOS | RGLS | Common Stock | D | 846.320 | 2.039.521 | ||||||
| 2020-01-24 | 2020-01-22 | 4 | Aker Christopher Ray | RGLS | Stock Option (Right to Buy) | D | 1,31 | 210.000 | 210.000 | |||||
| 2020-01-24 | 2020-01-22 | 4 | CALSADA CRISPINA | RGLS | Stock Option (Right to Buy) | D | 1,31 | 150.000 | 150.000 | |||||
| 2020-01-24 | 2020-01-22 | 4 | Hagan Joseph P | RGLS | Stock Option (Right to Buy) | D | 1,31 | 900.000 | 900.000 | |||||
| 2020-01-03 | 2019-12-24 | 4 | DENNER ALEXANDER J See Footnotes | RGLS | Warrants to Purchase Common Stock | I | 6,66 | 4.231.620 | 6.083.471 | |||||
| 2020-01-03 | 2019-12-24 | 4 | DENNER ALEXANDER J See Footnotes | RGLS | Class A-2 Convertible Preferred Stock | I | 0,67 | 423.162 | 423.162 | |||||
| 2020-01-03 | 2020-01-02 | 4 | Aker Christopher Ray | RGLS | Common Stock | D | 0,9667 | -2.239 | -2 | 29.307 | ||||
| 2020-01-03 | 2020-01-02 | 4 | Hagan Joseph P | RGLS | Common Stock | D | 0,9667 | -8.345 | -8 | 235.083 | ||||
| 2019-12-26 | 2019-12-24 | 4 | SANDELL SCOTT D See Note 1 | RGLS | Class A-2 Convertible Preferred Stock | I | 6,6600 | 900.900 | 6.000 | 900.900 | ||||
| 2019-12-26 | 2019-12-24 | 4 | SANDELL SCOTT D See Note 1 | RGLS | Common Stock Purchase Warrant (Right to Buy) | I | 0,67 | 0,1250 | 9.009.000 | 1.126 | 9.009.000 | |||
| 2019-12-26 | 2019-12-24 | 4 | Sonsini Peter W. See Note 1 | RGLS | Class A-2 Convertible Preferred Stock | I | 6,6600 | 900.900 | 6.000 | 900.900 | ||||
| 2019-12-26 | 2019-12-24 | 4 | Sonsini Peter W. See Note 1 | RGLS | Common Stock Purchase Warrant (Right to Buy) | I | 0,67 | 0,1250 | 9.009.000 | 1.126 | 9.009.000 | |||
| 2019-12-26 | 2019-12-24 | 4 | Walker Paul Edward See Note 1 | RGLS | Class A-2 Convertible Preferred Stock | I | 6,6600 | 900.900 | 6.000 | 900.900 | ||||
| 2019-12-26 | 2019-12-24 | 4 | Walker Paul Edward See Note 1 | RGLS | Common Stock Purchase Warrant (Right to Buy) | I | 0,67 | 0,1250 | 9.009.000 | 1.126 | 9.009.000 | |||
| 2019-12-26 | 2019-12-24 | 4 | Growth Equity Opportunities V, LLC | RGLS | Class A-2 Convertible Preferred Stock | D | 6,6600 | 900.900 | 6.000 | 900.900 | ||||
| 2019-12-26 | 2019-12-24 | 4 | Growth Equity Opportunities V, LLC | RGLS | Common Stock Purchase Warrant (Right to Buy) | D | 0,67 | 0,1250 | 9.009.000 | 1.126 | 9.009.000 | |||
| 2019-12-26 | 2019-12-24 | 4 | BARRIS PETER J See Note 1 | RGLS | Class A-2 Convertible Preferred Stock | I | 6,6600 | 900.900 | 6.000 | 900.900 | ||||
| 2019-12-26 | 2019-12-24 | 4 | BARRIS PETER J See Note 1 | RGLS | Common Stock Purchase Warrant (Right to Buy) | I | 0,67 | 0,1250 | 9.009.000 | 1.126 | 9.009.000 | |||
| 2019-12-26 | 2019-12-24 | 4 | BASKETT FOREST See Note 1 | RGLS | Class A-2 Convertible Preferred Stock | I | 6,6600 | 900.900 | 6.000 | 900.900 | ||||
| 2019-12-26 | 2019-12-24 | 4 | BASKETT FOREST See Note 1 | RGLS | Common Stock Purchase Warrant (Right to Buy) | I | 0,67 | 0,1250 | 9.009.000 | 1.126 | 9.009.000 | |||
| 2019-12-26 | 2019-12-24 | 4 | Behbahani Ali See Note 1 | RGLS | Class A-2 Convertible Preferred Stock | I | 6,6600 | 900.900 | 6.000 | 900.900 | ||||
| 2019-12-26 | 2019-12-24 | 4 | Behbahani Ali See Note 1 | RGLS | Common Stock Purchase Warrant (Right to Buy) | I | 0,67 | 0,1250 | 9.009.000 | 1.126 | 9.009.000 | |||
| 2019-12-26 | 2019-12-24 | 4 | Chang Carmen See Note 1 | RGLS | Class A-2 Convertible Preferred Stock | I | 6,6600 | 900.900 | 6.000 | 900.900 | ||||
| 2019-12-26 | 2019-12-24 | 4 | Chang Carmen See Note 1 | RGLS | Common Stock Purchase Warrant (Right to Buy) | I | 0,67 | 0,1250 | 9.009.000 | 1.126 | 9.009.000 | |||
| 2019-12-26 | 2019-12-24 | 4 | Florence Anthony A. Jr. See Note 1 | RGLS | Class A-2 Convertible Preferred Stock | I | 6,6600 | 900.900 | 6.000 | 900.900 | ||||
| 2019-12-26 | 2019-12-24 | 4 | Florence Anthony A. Jr. See Note 1 | RGLS | Common Stock Purchase Warrant (Right to Buy) | I | 0,67 | 0,1250 | 9.009.000 | 1.126 | 9.009.000 | |||
| 2019-12-26 | 2019-12-24 | 4 | Makhzoumi Mohamad See Note 1 | RGLS | Class A-2 Convertible Preferred Stock | I | 6,6600 | 900.900 | 6.000 | 900.900 | ||||
| 2019-12-26 | 2019-12-24 | 4 | Makhzoumi Mohamad See Note 1 | RGLS | Common Stock Purchase Warrant (Right to Buy) | I | 0,67 | 0,1250 | 9.009.000 | 1.126 | 9.009.000 | |||
| 2019-12-26 | 2019-12-24 | 4 | MAKOWER JOSHUA See Note 1 | RGLS | Class A-2 Convertible Preferred Stock | I | 6,6600 | 900.900 | 6.000 | 900.900 | ||||
| 2019-12-26 | 2019-12-24 | 4 | MAKOWER JOSHUA See Note 1 | RGLS | Common Stock Purchase Warrant (Right to Buy) | I | 0,67 | 0,1250 | 9.009.000 | 1.126 | 9.009.000 | |||
| 2019-12-26 | 2019-12-24 | 4 | MOTT DAVID M See Note 1 | RGLS | Class A-2 Convertible Preferred Stock | I | 6,6600 | 900.900 | 6.000 | 900.900 | ||||
| 2019-12-26 | 2019-12-24 | 4 | MOTT DAVID M See Note 1 | RGLS | Common Stock Purchase Warrant (Right to Buy) | I | 0,67 | 0,1250 | 9.009.000 | 1.126 | 9.009.000 | |||
| 2019-12-26 | 2019-12-24 | 4 | Hagan Joseph P PENSCO TRUST CO OBO JOSEPH HAGAN IRA | RGLS | Common Stock Purchase Warrant (Right to Buy) | I | 0,67 | 0,1250 | 75.850 | 9 | 75.850 | |||
| 2019-12-26 | 2019-12-24 | 4 | Hagan Joseph P PENSCO TRUST CO OBO JOSEPH HAGAN IRA | RGLS | Class A-2 Convertible Preferred Stock | I | 6,6600 | 7.585 | 51 | 7.585 | ||||
| 2019-12-26 | 2019-12-24 | 4 | RASTETTER WILLIAM H THE RASTETTER FAMILY TRUST DTD 9-2-2010 | RGLS | Common Stock Purchase Warrant (Right to Buy) | I | 0,67 | 0,1250 | 225.940 | 28 | 225.940 | |||
| 2019-12-26 | 2019-12-24 | 4 | RASTETTER WILLIAM H THE RASTETTER FAMILY TRUST DTD 9-2-2010 | RGLS | Class A-2 Convertible Preferred Stock | I | 6,6600 | 22.594 | 150 | 22.594 | ||||
| 2019-12-26 | 2019-12-24 | 4 | Witz Pascale | RGLS | Common Stock Purchase Warrant (Right to Buy) | D | 0,67 | 0,1250 | 67.700 | 8 | 67.700 | |||
| 2019-12-26 | 2019-12-24 | 4 | Witz Pascale | RGLS | Class A-2 Convertible Preferred Stock | D | 6,6600 | 6.770 | 45 | 6.770 | ||||
| 2019-12-26 | 2019-12-24 | 4 | PAPADOPOULOS STELIOS | RGLS | Common Stock Purchase Warrant (Right to Buy) | D | 0,67 | 0,1250 | 846.320 | 106 | 846.320 | |||
| 2019-12-26 | 2019-12-24 | 4 | PAPADOPOULOS STELIOS | RGLS | Class A-2 Convertible Preferred Stock | D | 6,6600 | 84.632 | 564 | 84.632 | ||||
| 2019-11-15 | 2019-11-14 | 4 | Hagan Joseph P | RGLS | Common Stock | D | 0,6400 | -5.838 | -4 | 243.428 | ||||
| 2019-11-15 | 2019-11-14 | 4 | Aker Christopher Ray | RGLS | Common Stock | D | 0,6400 | -833 | -1 | 31.546 | ||||
| 2019-10-15 | 2019-10-10 | 4 | Aker Christopher Ray | RGLS | Stock Option (Right to Buy) | D | 0,64 | 335.000 | 335.000 | |||||
| 2019-10-15 | 2019-10-10 | 4 | BALTIMORE DAVID | RGLS | Stock Option (Right to Buy) | D | 0,64 | 46.500 | 46.500 | |||||
| 2019-10-15 | 2019-10-10 | 4 | CALSADA CRISPINA | RGLS | Stock Option (Right to Buy) | D | 0,64 | 210.000 | 210.000 | |||||
| 2019-10-15 | 2019-10-10 | 4 | Collier Kathryn J | RGLS | Stock Option (Right to Buy) | D | 0,64 | 46.500 | 46.500 | |||||
| 2019-10-15 | 2019-10-10 | 4 | Hagan Joseph P | RGLS | Stock Option (Right to Buy) | D | 0,64 | 1.000.000 | 1.000.000 | |||||
| 2019-10-15 | 2019-10-10 | 4 | Nunn Jason Raleigh | RGLS | Stock Option (Right to Buy) | D | 0,64 | 46.500 | 46.500 | |||||
| 2019-10-15 | 2019-10-10 | 4 | PAPADOPOULOS STELIOS | RGLS | Stock Option (Right to Buy) | D | 0,64 | 46.500 | 46.500 | |||||
| 2019-10-15 | 2019-10-10 | 4 | RASTETTER WILLIAM H THE RASTETTER FAMILY TRUST DTD 9-2-2010 | RGLS | Stock Option (Right to Buy) | I | 0,64 | 46.500 | 46.500 | |||||
| 2019-10-15 | 2019-10-10 | 4 | Rosen Hugh | RGLS | Stock Option (Right to Buy) | D | 0,64 | 46.500 | 46.500 | |||||
| 2019-10-15 | 2019-10-10 | 4 | Simeonidis Simos | RGLS | Stock Option (Right to Buy) | D | 0,64 | 46.500 | 46.500 | |||||
| 2019-10-15 | 2019-10-10 | 4 | Witz Pascale | RGLS | Stock Option (Right to Buy) | D | 0,64 | 46.500 | 46.500 | |||||
| 2019-10-02 | 2019-10-01 | 4 | Hagan Joseph P | RGLS | Common Stock | D | 0,6827 | -8.743 | -6 | 249.266 | ||||
| 2019-10-02 | 2019-10-01 | 4 | Aker Christopher Ray | RGLS | Common Stock | D | 0,6827 | -2.346 | -2 | 32.379 | ||||
| 2019-09-03 | 2019-08-30 | 4 | CALSADA CRISPINA | RGLS | Stock Option (Right to Buy) | D | 0,62 | 100.000 | 100.000 | |||||
| 2019-08-16 | 2019-08-15 | 4 | Aker Christopher Ray | RGLS | Common Stock | D | 0,5506 | -899 | -0 | 34.725 | ||||
| 2019-08-16 | 2019-08-15 | 4 | Hagan Joseph P | RGLS | Common Stock | D | 0,5506 | -4.375 | -2 | 258.009 | ||||
| 2019-07-02 | 2019-07-01 | 4 | Chevallard Daniel R. | RGLS | Common Stock | D | 1,3115 | -2.669 | -4 | 77.870 | ||||
| 2019-07-02 | 2019-07-01 | 4 | Aker Christopher Ray | RGLS | Common Stock | D | 1,3115 | -2.225 | -3 | 35.624 | ||||
| 2019-07-02 | 2019-07-01 | 4 | Hagan Joseph P | RGLS | Common Stock | D | 1,3115 | -5.783 | -8 | 262.384 | ||||
| 2019-06-11 | 3 | Simeonidis Simos By Sarissa Capital | RGLS | Common Stock | I | 3.703.702 | ||||||||
| 2019-06-11 | 3 | Simeonidis Simos By Sarissa Capital | RGLS | Common Stock | I | 3.703.702 | ||||||||
| 2019-06-11 | 3 | Simeonidis Simos By Sarissa Capital | RGLS | Common Stock | I | 3.703.702 | ||||||||
| 2019-05-21 | 2019-05-07 | 4/A | Hagan Joseph P | RGLS | Common Stock Purchase Warrant (Right to Buy) | D | 1,08 | 0,1250 | 33.194 | 4 | 33.194 | |||
| 2019-05-21 | 2019-05-07 | 4/A | Hagan Joseph P | RGLS | Common Stock | D | 1,0800 | 33.194 | 36 | 64.542 | ||||
| 2019-05-21 | 2019-05-07 | 4/A | Witz Pascale | RGLS | Common Stock Purchase Warrant (Right to Buy) | D | 1,08 | 0,1250 | 29.630 | 4 | 29.630 | |||
| 2019-05-21 | 2019-05-07 | 4/A | Witz Pascale | RGLS | Common Stock | D | 1,0800 | 29.630 | 32 | 37.849 | ||||
| 2019-05-21 | 2019-05-07 | 4/A | RASTETTER WILLIAM H The Rastetter Family Trust DTD 9-2-2010 | RGLS | Common Stock Purchase Warrant (Right to Buy) | I | 1,08 | 0,1250 | 92.889 | 12 | 92.889 | |||
| 2019-05-21 | 2019-05-07 | 4/A | RASTETTER WILLIAM H The Rastetter Family Trust DTD 9-2-2010 | RGLS | Common Stock | I | 1,0800 | 92.889 | 100 | 154.223 | ||||
| 2019-05-21 | 2019-05-07 | 4/A | PAPADOPOULOS STELIOS | RGLS | Common Stock Purchase Warrant (Right to Buy) | D | 1,08 | 0,1250 | 370.370 | 46 | 370.370 | |||
| 2019-05-21 | 2019-05-07 | 4/A | PAPADOPOULOS STELIOS | RGLS | Common Stock | D | 1,0800 | 370.370 | 400 | 1.189.872 | ||||
| 2019-05-17 | 3 | Sarissa Capital Offshore Master Fund LP See Footnotes | RGLS | Common Stock | I | 3.703.702 | ||||||||
| 2019-05-17 | 3 | Sarissa Capital Offshore Master Fund LP See Footnotes | RGLS | Common Stock | I | 3.703.702 | ||||||||
| 2019-05-17 | 3 | Sarissa Capital Offshore Master Fund LP See Footnotes | RGLS | Common Stock | I | 3.703.702 | ||||||||
| 2019-05-17 | 3 | Sarissa Capital Offshore Master Fund LP See Footnotes | RGLS | Common Stock | I | 3.703.702 | ||||||||
| 2019-05-17 | 3 | Sarissa Capital Offshore Master Fund LP See Footnotes | RGLS | Common Stock | I | 3.703.702 | ||||||||
| 2019-05-17 | 3 | Sarissa Capital Offshore Master Fund LP See Footnotes | RGLS | Common Stock | I | 3.703.702 | ||||||||
| 2019-05-17 | 3 | Sarissa Capital Offshore Master Fund LP See Footnotes | RGLS | Common Stock | I | 3.703.702 | ||||||||
| 2019-05-16 | 2019-05-14 | 4/A | Chevallard Daniel R. | RGLS | Stock Option (Right to Buy) | D | 0,95 | 8.000 | 8.000 | |||||
| 2019-05-16 | 2019-05-15 | 4 | Aker Christopher Ray | RGLS | Common Stock | D | 1,4095 | -6.950 | -10 | 59.309 | ||||
| 2019-05-16 | 2019-05-14 | 4 | Aker Christopher Ray | RGLS | Stock Option (Right to Buy) | D | 0,95 | 7.500 | 7.500 | |||||
| 2019-05-16 | 2019-05-14 | 4 | Aker Christopher Ray | RGLS | Common Stock | D | 38.512 | 66.259 | ||||||
| 2019-05-16 | 2019-05-15 | 4 | Chevallard Daniel R. | RGLS | Common Stock | D | 1,4089 | -10.000 | -14 | 80.539 | ||||
| 2019-05-16 | 2019-05-14 | 4 | Chevallard Daniel R. | RGLS | Stock Option (Right to Buy) | D | 0,95 | 8.000 | 7.500 | |||||
| 2019-05-16 | 2019-05-14 | 4 | Chevallard Daniel R. | RGLS | Common Stock | D | 55.414 | 90.539 | ||||||
| 2019-05-16 | 2019-05-16 | 4 | Hagan Joseph P | RGLS | Common Stock | D | 1,2189 | -39.352 | -48 | 268.167 | ||||
| 2019-05-16 | 2019-05-14 | 4 | Hagan Joseph P | RGLS | Stock Option (Right to Buy) | D | 0,95 | 10.000 | 10.000 | |||||
| 2019-05-16 | 2019-05-14 | 4 | Hagan Joseph P | RGLS | Common Stock | D | 188.385 | 307.519 | ||||||
| 2019-05-10 | 2019-05-07 | 4/A | Walker Paul Edward See Note 2 | RGLS | Class A-1 Convertible Preferred Stock | I | 10,8000 | 256.700 | 2.772 | 256.700 | ||||
| 2019-05-10 | 2019-05-07 | 4/A | Walker Paul Edward See Note 2 | RGLS | Common Stock Purchase Warrant (Right to Buy) | I | 1,08 | 0,1250 | 3.703.704 | 463 | 3.703.704 | |||
| 2019-05-10 | 2019-05-07 | 4/A | Walker Paul Edward See Note 2 | RGLS | Common Stock | I | 1,0800 | 1.136.704 | 1.228 | 2.052.454 | ||||
| 2019-05-09 | 2019-05-07 | 4 | Growth Equity Opportunities V, LLC | RGLS | Class A-1 Convertible Preferred Stock | D | 10,8000 | 256.700 | 2.772 | 256.700 | ||||
| 2019-05-09 | 2019-05-07 | 4 | Growth Equity Opportunities V, LLC | RGLS | Common Stock Purchase Warrant (Right to Buy) | D | 1,08 | 0,1250 | 3.703.704 | 463 | 3.703.704 | |||
| 2019-05-09 | 2019-05-07 | 4 | Growth Equity Opportunities V, LLC | RGLS | Common Stock | D | 1,0800 | 1.136.704 | 1.228 | 2.052.454 | ||||
| 2019-05-09 | 2019-05-07 | 4 | BARRIS PETER J See Note 2 | RGLS | Class A-1 Convertible Preferred Stock | I | 10,8000 | 256.700 | 2.772 | 256.700 | ||||
| 2019-05-09 | 2019-05-07 | 4 | BARRIS PETER J See Note 2 | RGLS | Common Stock Purchase Warrant (Right to Buy) | I | 1,08 | 0,1250 | 3.703.704 | 463 | 3.703.704 | |||
| 2019-05-09 | 2019-05-07 | 4 | BARRIS PETER J See Note 2 | RGLS | Common Stock | I | 1,0800 | 1.136.704 | 1.228 | 2.052.454 | ||||
| 2019-05-09 | 2019-05-07 | 4 | BASKETT FOREST See Note 2 | RGLS | Class A-1 Convertible Preferred Stock | I | 10,8000 | 256.700 | 2.772 | 256.700 | ||||
| 2019-05-09 | 2019-05-07 | 4 | BASKETT FOREST See Note 2 | RGLS | Common Stock Purchase Warrant (Right to Buy) | I | 1,08 | 0,1250 | 3.703.704 | 463 | 3.703.704 | |||
| 2019-05-09 | 2019-05-07 | 4 | BASKETT FOREST See Note 2 | RGLS | Common Stock | I | 1,0800 | 1.136.704 | 1.228 | 2.052.454 | ||||
| 2019-05-09 | 2019-05-07 | 4 | Behbahani Ali See Note 2 | RGLS | Class A-1 Convertible Preferred Stock | I | 10,8000 | 256.700 | 2.772 | 256.700 | ||||
| 2019-05-09 | 2019-05-07 | 4 | Behbahani Ali See Note 2 | RGLS | Common Stock Purchase Warrant (Right to Buy) | I | 1,08 | 0,1250 | 3.703.704 | 463 | 3.703.704 | |||
| 2019-05-09 | 2019-05-07 | 4 | Behbahani Ali See Note 2 | RGLS | Common Stock | I | 1,0800 | 1.136.704 | 1.228 | 2.052.454 | ||||
| 2019-05-09 | 2019-05-07 | 4 | Chang Carmen See Note 2 | RGLS | Class A-1 Convertible Preferred Stock | I | 10,8000 | 256.700 | 2.772 | 256.700 | ||||
| 2019-05-09 | 2019-05-07 | 4 | Chang Carmen See Note 2 | RGLS | Common Stock Purchase Warrant (Right to Buy) | I | 1,08 | 0,1250 | 3.703.704 | 463 | 3.703.704 | |||
| 2019-05-09 | 2019-05-07 | 4 | Chang Carmen See Note 2 | RGLS | Common Stock | I | 1,0800 | 1.136.704 | 1.228 | 2.052.454 | ||||
| 2019-05-09 | 2019-05-07 | 4 | Florence Anthony A. Jr. See Note 2 | RGLS | Class A-1 Convertible Preferred Stock | I | 10,8000 | 256.700 | 2.772 | 256.700 | ||||
| 2019-05-09 | 2019-05-07 | 4 | Florence Anthony A. Jr. See Note 2 | RGLS | Common Stock Purchase Warrant (Right to Buy) | I | 1,08 | 0,1250 | 3.703.704 | 463 | 3.703.704 | |||
| 2019-05-09 | 2019-05-07 | 4 | Florence Anthony A. Jr. See Note 2 | RGLS | Common Stock | I | 1,0800 | 1.136.704 | 1.228 | 2.052.454 | ||||
| 2019-05-09 | 2019-05-07 | 4 | Makhzoumi Mohamad See Note 2 | RGLS | Class A-1 Convertible Preferred Stock | I | 10,8000 | 256.700 | 2.772 | 256.700 | ||||
| 2019-05-09 | 2019-05-07 | 4 | Makhzoumi Mohamad See Note 2 | RGLS | Common Stock Purchase Warrant (Right to Buy) | I | 1,08 | 0,1250 | 3.703.704 | 463 | 3.703.704 | |||
| 2019-05-09 | 2019-05-07 | 4 | Makhzoumi Mohamad See Note 2 | RGLS | Common Stock | I | 1,0800 | 1.136.704 | 1.228 | 2.052.454 | ||||
| 2019-05-09 | 2019-05-07 | 4 | MAKOWER JOSHUA See Note 2 | RGLS | Class A-1 Convertible Preferred Stock | I | 10,8000 | 256.700 | 2.772 | 256.700 | ||||
| 2019-05-09 | 2019-05-07 | 4 | MAKOWER JOSHUA See Note 2 | RGLS | Common Stock Purchase Warrant (Right to Buy) | I | 1,08 | 0,1250 | 3.703.704 | 463 | 3.703.704 | |||
| 2019-05-09 | 2019-05-07 | 4 | MAKOWER JOSHUA See Note 2 | RGLS | Common Stock | I | 1,0800 | 1.136.704 | 1.228 | 2.052.454 | ||||
| 2019-05-09 | 2019-05-07 | 4 | MOTT DAVID M See Note 2 | RGLS | Class A-1 Convertible Preferred Stock | I | 10,8000 | 256.700 | 2.772 | 256.700 | ||||
| 2019-05-09 | 2019-05-07 | 4 | MOTT DAVID M See Note 2 | RGLS | Common Stock Purchase Warrant (Right to Buy) | I | 1,08 | 0,1250 | 3.703.704 | 463 | 3.703.704 | |||
| 2019-05-09 | 2019-05-07 | 4 | MOTT DAVID M See Note 2 | RGLS | Common Stock | I | 1,0800 | 1.136.704 | 1.228 | 2.052.454 | ||||
| 2019-05-09 | 2019-05-07 | 4 | SANDELL SCOTT D See Note 2 | RGLS | Class A-1 Convertible Preferred Stock | I | 10,8000 | 256.700 | 2.772 | 256.700 | ||||
| 2019-05-09 | 2019-05-07 | 4 | SANDELL SCOTT D See Note 2 | RGLS | Common Stock Purchase Warrant (Right to Buy) | I | 1,08 | 0,1250 | 3.703.704 | 463 | 3.703.704 | |||
| 2019-05-09 | 2019-05-07 | 4 | SANDELL SCOTT D See Note 2 | RGLS | Common Stock | I | 1,0800 | 1.136.704 | 1.228 | 2.052.454 | ||||
| 2019-05-09 | 2019-05-07 | 4 | Sonsini Peter W. See Note 2 | RGLS | Class A-1 Convertible Preferred Stock | I | 10,8000 | 256.700 | 2.772 | 256.700 | ||||
| 2019-05-09 | 2019-05-07 | 4 | Sonsini Peter W. See Note 2 | RGLS | Common Stock Purchase Warrant (Right to Buy) | I | 1,08 | 0,1250 | 3.703.704 | 463 | 3.703.704 | |||
| 2019-05-09 | 2019-05-07 | 4 | Sonsini Peter W. See Note 2 | RGLS | Common Stock | I | 1,0800 | 1.136.704 | 1.228 | 2.052.454 | ||||
| 2019-05-09 | 2019-05-07 | 4 | Walker Paul Edward See Note 2 | RGLS | Class A-1 Convertible Preferred Stock | I | 10,8000 | 256.700 | 2.772 | 256.700 | ||||
| 2019-05-09 | 2019-05-07 | 4 | Walker Paul Edward See Note 2 | RGLS | Common Stock Purchase Warrant (Right to Buy) | I | 1,08 | 0,1250 | 3.703.704 | 463 | 3.703.704 | |||
| 2019-05-09 | 2019-05-07 | 4 | Walker Paul Edward See Note 2 | RGLS | Common Stock | I | 1,0800 | 1.136.704 | 1.228 | 2.052.454 | ||||
| 2019-05-08 | 2019-05-07 | 4 | PAPADOPOULOS STELIOS | RGLS | Common Stock Purchase Warrant (Right to Buy) | D | 1,08 | 0,1250 | 370.370 | 46 | 370.370 | |||
| 2019-05-08 | 2019-05-07 | 4 | PAPADOPOULOS STELIOS | RGLS | Common Stock | D | 1,0800 | 370.370 | 400 | 1.189.872 | ||||
| 2019-05-08 | 2019-05-07 | 4 | RASTETTER WILLIAM H THE RASTETTER FAMILY TRUST DTD 09-02-2010 | RGLS | Common Stock Purchase Warrant (Right to Buy) | I | 1,08 | 0,1250 | 92.889 | 12 | 92.889 | |||
| 2019-05-08 | 2019-05-07 | 4 | RASTETTER WILLIAM H THE RASTETTER FAMILY TRUST DTD 9-2-2010 | RGLS | Common Stock | I | 1,0800 | 92.889 | 100 | 154.223 | ||||
| 2019-05-08 | 2019-05-07 | 4 | Witz Pascale | RGLS | Common Stock Purchase Warrant (Right to Buy) | D | 1,08 | 0,1250 | 29.630 | 4 | 29.630 | |||
| 2019-05-08 | 2019-05-07 | 4 | Witz Pascale | RGLS | Common Stock | D | 1,0800 | 29.630 | 32 | 37.849 | ||||
| 2019-05-08 | 2019-05-07 | 4 | Hagan Joseph P | RGLS | Common Stock Purchase Warrant (Right to Buy) | D | 1,08 | 0,1250 | 33.194 | 4 | 33.194 | |||
| 2019-05-08 | 2019-05-07 | 4 | Hagan Joseph P | RGLS | Common Stock | D | 1,0800 | 33.194 | 36 | 64.542 | ||||
| 2019-04-03 | 2019-04-01 | 4 | Hagan Joseph P | RGLS | Common Stock | D | 0,9810 | -5.842 | -6 | 31.348 | ||||
| 2019-04-03 | 2019-04-01 | 4 | Aker Christopher Ray | RGLS | Common Stock | D | 0,9812 | -2.710 | -3 | 6.287 | ||||
| 2019-04-03 | 2019-04-01 | 4 | Chevallard Daniel R. | RGLS | Common Stock | D | 0,9814 | -3.253 | -3 | 9.372 | ||||
| 2019-02-06 | 2019-02-05 | 4 | Aker Christopher Ray | RGLS | Stock Option (Right to Buy) | D | 0,95 | 25.000 | 25.000 | |||||
| 2019-02-06 | 2019-02-05 | 4 | Aker Christopher Ray | RGLS | Common Stock | D | 25.000 | 27.747 | ||||||
| 2019-02-06 | 2019-02-05 | 4 | Chevallard Daniel R. | RGLS | Stock Option (Right to Buy) | D | 0,95 | 30.000 | 30.000 | |||||
| 2019-02-06 | 2019-02-05 | 4 | Chevallard Daniel R. | RGLS | Common Stock | D | 0,9500 | 30.000 | 28 | 34.578 | ||||
| 2019-02-06 | 2019-02-05 | 4 | Hagan Joseph P | RGLS | Stock Option (Right to Buy) | D | 0,95 | 65.000 | 65.000 | |||||
| 2019-02-06 | 2019-02-05 | 4 | Hagan Joseph P | RGLS | Common Stock | D | 0,9500 | 65.000 | 62 | 84.148 | ||||
| 2019-02-06 | 2019-02-05 | 4 | WRIGHT TIMOTHY MICHAEL | RGLS | Stock Option (Right to Buy) | D | 0,95 | 40.000 | 40.000 | |||||
| 2019-02-06 | 2019-02-05 | 4 | WRIGHT TIMOTHY MICHAEL | RGLS | Common Stock | D | 0,9500 | 40.000 | 38 | 62.893 | ||||
| 2019-01-02 | 3 | Aker Christopher Ray | RGLS | Common Stock | D | 5.494 | ||||||||
| 2019-01-02 | 3 | Aker Christopher Ray | RGLS | Common Stock | D | 5.494 | ||||||||
| 2019-01-02 | 3 | Aker Christopher Ray | RGLS | Common Stock | D | 5.494 | ||||||||
| 2019-01-02 | 2018-12-28 | 4 | PAPADOPOULOS STELIOS | RGLS | Common Stock | D | 1,0914 | 50.000 | 55 | 835.073 | ||||
| 2018-12-28 | 2018-12-27 | 4 | PAPADOPOULOS STELIOS | RGLS | Common Stock | D | 1,0401 | 26.401 | 27 | 785.073 | ||||
| 2018-12-28 | 2018-12-26 | 4 | PAPADOPOULOS STELIOS | RGLS | Common Stock | D | 0,9542 | 90.000 | 86 | 758.672 | ||||
| 2018-11-21 | 2018-11-12 | 4 | PAPADOPOULOS STELIOS | RGLS | Stock Option (Right to Buy) | D | 8,76 | -4.583 | 0 | |||||
| 2018-11-21 | 2018-11-12 | 4 | PAPADOPOULOS STELIOS | RGLS | Stock Option (Right to Buy) | D | 8,52 | -6.250 | 0 | |||||
| 2018-11-21 | 2018-11-12 | 4 | PAPADOPOULOS STELIOS | RGLS | Stock Option (Right to Buy) | D | 17,40 | -2.500 | 0 | |||||
| 2018-11-21 | 2018-11-12 | 4 | PAPADOPOULOS STELIOS | RGLS | Stock Option (Right to Buy) | D | 74,40 | -3.051 | 0 | |||||
| 2018-11-21 | 2018-11-12 | 4 | PAPADOPOULOS STELIOS | RGLS | Stock Option (Right to Buy) | D | 111,84 | -1.458 | 0 | |||||
| 2018-11-21 | 2018-11-12 | 4 | PAPADOPOULOS STELIOS | RGLS | Stock Option (Right to Buy) | D | 120,24 | -1.458 | 0 | |||||
| 2018-11-21 | 2018-11-12 | 4 | PAPADOPOULOS STELIOS | RGLS | Stock Option (Right to Buy) | D | 74,64 | -1.458 | 0 | |||||
| 2018-11-21 | 2018-11-12 | 4 | PAPADOPOULOS STELIOS | RGLS | Stock Option (Right to Buy) | D | 31,92 | -152 | 0 | |||||
| 2018-11-21 | 2018-11-12 | 4 | PAPADOPOULOS STELIOS | RGLS | Common Stock | D | 20.910 | 168.672 | ||||||
| 2018-11-19 | 2018-11-16 | 4 | Collier Kathryn J | RGLS | Common Stock | D | 1,4100 | 7.100 | 10 | 27.596 | ||||
| 2018-11-19 | 2018-11-16 | 4 | PAPADOPOULOS STELIOS | RGLS | Common Stock | D | 1,3849 | 300.000 | 415 | 668.672 | ||||
| 2018-11-19 | 2018-11-15 | 4 | PAPADOPOULOS STELIOS | RGLS | Common Stock | D | 1,3254 | 200.000 | 265 | 368.672 | ||||
| 2018-11-13 | 2018-11-12 | 4 | Witz Pascale | RGLS | Stock Option (Right to Buy) | D | 8,76 | -4.583 | 0 | |||||
| 2018-11-13 | 2018-11-12 | 4 | Witz Pascale | RGLS | Stock Option (Right to Buy) | D | 8,52 | -6.250 | 0 | |||||
| 2018-11-13 | 2018-11-12 | 4 | Witz Pascale | RGLS | Stock Option (Right to Buy) | D | 17,40 | -5.000 | 0 | |||||
| 2018-11-13 | 2018-11-12 | 4 | Witz Pascale | RGLS | Common Stock | D | 15.833 | 19.625 | ||||||
| 2018-11-13 | 2018-11-12 | 4 | Rosen Hugh | RGLS | Stock Option (Right to Buy) | D | 8,76 | -4.583 | 0 | |||||
| 2018-11-13 | 2018-11-12 | 4 | Rosen Hugh | RGLS | Stock Option (Right to Buy) | D | 8,52 | -6.250 | 0 | |||||
| 2018-11-13 | 2018-11-12 | 4 | Rosen Hugh | RGLS | Stock Option (Right to Buy) | D | 17,40 | -2.500 | 0 | |||||
| 2018-11-13 | 2018-11-12 | 4 | Rosen Hugh | RGLS | Stock Option (Right to Buy) | D | 74,40 | -5.912 | 0 | |||||
| 2018-11-13 | 2018-11-12 | 4 | Rosen Hugh | RGLS | Common Stock | D | 19.245 | 22.756 | ||||||
| 2018-11-13 | 2018-11-12 | 4 | RASTETTER WILLIAM H William H. Rastetter TTEE, Marisa Rastetter TTEE 9-2-2010 FBO Rastetter Family Trus | RGLS | Stock Option (Right to Buy) | I | 8,76 | -4.583 | 0 | |||||
| 2018-11-13 | 2018-11-12 | 4 | RASTETTER WILLIAM H William H. Rastetter TTEE, Marisa Rastetter TTEE 9-2-2010 FBO Rastetter Family Trus | RGLS | Stock Option (Right to Buy) | I | 8,52 | -6.250 | 0 | |||||
| 2018-11-13 | 2018-11-12 | 4 | RASTETTER WILLIAM H William H. Rastetter TTEE, Marisa Rastetter TTEE 9-2-2010 FBO Rastetter Family Trus | RGLS | Stock Option (Right to Buy) | I | 17,40 | -2.500 | 0 | |||||
| 2018-11-13 | 2018-11-12 | 4 | RASTETTER WILLIAM H William H. Rastetter TTEE, Marisa Rastetter TTEE 9-2-2010 FBO Rastetter Family Trus | RGLS | Stock Option (Right to Buy) | I | 92,04 | -2.500 | 0 | |||||
| 2018-11-13 | 2018-11-12 | 4 | RASTETTER WILLIAM H William H. Rastetter TTEE, Marisa Rastetter TTEE 9-2-2010 FBO Rastetter Family Trus | RGLS | Stock Option (Right to Buy) | I | 74,40 | -3.051 | 0 | |||||
| 2018-11-13 | 2018-11-12 | 4 | RASTETTER WILLIAM H William H. Rastetter TTEE, Marisa Rastetter TTEE 9-2-2010 FBO Rastetter Family Trus | RGLS | Stock Option (Right to Buy) | I | 120,24 | -1.458 | 0 | |||||
| 2018-11-13 | 2018-11-12 | 4 | RASTETTER WILLIAM H William H. Rastetter TTEE, Marisa Rastetter TTEE 9-2-2010 FBO Rastetter Family Trus | RGLS | Stock Option (Right to Buy) | I | 111,84 | -1.458 | 0 | |||||
| 2018-11-13 | 2018-11-12 | 4 | RASTETTER WILLIAM H William H. Rastetter TTEE, Marisa Rastetter TTEE 9-2-2010 FBO Rastetter Family Trus | RGLS | Stock Option (Right to Buy) | I | 74,64 | -1.458 | 0 | |||||
| 2018-11-13 | 2018-11-12 | 4 | RASTETTER WILLIAM H William H. Rastetter TTEE, Marisa Rastetter TTEE 9-2-2010 FBO Rastetter Family Trust | RGLS | Common Stock | I | 23.258 | 79.672 | ||||||
| 2018-11-13 | 2018-11-12 | 4 | Collier Kathryn J | RGLS | Stock Option (Right to Buy) | D | 8,67 | -4.583 | 0 | |||||
| 2018-11-13 | 2018-11-12 | 4 | Collier Kathryn J | RGLS | Stock Option (Right to Buy) | D | 8,52 | -3.125 | 0 | |||||
| 2018-11-13 | 2018-11-12 | 4 | Collier Kathryn J | RGLS | Stock Option (Right to Buy) | D | 9,45 | -9.166 | 0 | |||||
| 2018-11-13 | 2018-11-12 | 4 | Collier Kathryn J | RGLS | Common Stock | D | 16.874 | 20.496 | ||||||
| 2018-11-13 | 2018-11-12 | 4 | BALTIMORE DAVID | RGLS | Stock Option (Right to Buy) | D | 8,76 | -4.583 | 0 | |||||
| 2018-11-13 | 2018-11-12 | 4 | BALTIMORE DAVID | RGLS | Stock Option (Right to Buy) | D | 8,52 | -6.250 | 0 | |||||
| 2018-11-13 | 2018-11-12 | 4 | BALTIMORE DAVID | RGLS | Stock Option (Right to Buy) | D | 17,40 | -2.500 | 0 | |||||
| 2018-11-13 | 2018-11-12 | 4 | BALTIMORE DAVID | RGLS | Stock Option (Right to Buy) | D | 74,40 | -3.051 | 0 | |||||
| 2018-11-13 | 2018-11-12 | 4 | BALTIMORE DAVID | RGLS | Stock Option (Right to Buy) | D | 120,24 | -1.458 | 0 | |||||
| 2018-11-13 | 2018-11-12 | 4 | BALTIMORE DAVID | RGLS | Stock Option (Right to Buy) | D | 4,56 | -1.458 | 0 | |||||
| 2018-11-13 | 2018-11-12 | 4 | BALTIMORE DAVID | RGLS | Stock Option (Right to Buy) | D | 74,64 | -416 | 0 | |||||
| 2018-11-13 | 2018-11-12 | 4 | BALTIMORE DAVID | RGLS | Stock Option (Right to Buy) | D | 111,84 | -416 | 0 | |||||
| 2018-11-13 | 2018-11-12 | 4 | BALTIMORE DAVID | RGLS | Stock Option (Right to Buy) | D | 74,64 | -1.458 | 0 | |||||
| 2018-11-13 | 2018-11-12 | 4 | BALTIMORE DAVID | RGLS | Stock Option (Right to Buy) | D | 111,84 | -1.458 | 0 | |||||
| 2018-11-13 | 2018-11-12 | 4 | BALTIMORE DAVID | RGLS | Stock Option (Right to Buy) | D | 31,92 | -1.458 | 0 | |||||
| 2018-11-13 | 2018-11-12 | 4 | BALTIMORE DAVID | RGLS | Stock Option (Right to Buy) | D | 4,56 | -625 | 0 | |||||
| 2018-11-13 | 2018-11-12 | 4 | BALTIMORE DAVID | RGLS | Stock Option (Right to Buy) | D | 31,92 | -625 | 0 | |||||
| 2018-11-13 | 2018-11-12 | 4 | BALTIMORE DAVID | RGLS | Stock Option (Right to Buy) | D | 20,88 | -1.458 | 0 | |||||
| 2018-11-13 | 2018-11-12 | 4 | BALTIMORE DAVID | RGLS | Stock Option (Right to Buy) | D | 20,88 | -625 | 0 | |||||
| 2018-11-13 | 2018-11-12 | 4 | BALTIMORE DAVID | RGLS | Stock Option (Right to Buy) | D | 4,56 | -1.875 | 0 | |||||
| 2018-11-13 | 2018-11-12 | 4 | BALTIMORE DAVID | RGLS | Stock Option (Right to Buy) | D | 4,56 | -10.625 | 0 | |||||
| 2018-11-13 | 2018-11-12 | 4 | BALTIMORE DAVID | RGLS | Common Stock | D | 40.339 | 44.131 | ||||||
| 2018-07-17 | 3 | Behbahani Ali See Note 1 | RGLS | Common Stock | I | 21.978.020 | ||||||||
| 2018-07-17 | 3 | Behbahani Ali See Note 1 | RGLS | Common Stock | I | 21.978.020 | ||||||||
| 2018-07-17 | 3 | Behbahani Ali See Note 1 | RGLS | Common Stock | I | 21.978.020 | ||||||||
| 2018-07-17 | 3 | Chang Carmen See Note 1 | RGLS | Common Stock | I | 21.978.020 | ||||||||
| 2018-07-17 | 3 | Chang Carmen See Note 1 | RGLS | Common Stock | I | 21.978.020 | ||||||||
| 2018-07-17 | 3 | Chang Carmen See Note 1 | RGLS | Common Stock | I | 21.978.020 | ||||||||
| 2018-06-05 | 2018-06-05 | 4 | Collier Kathryn J | RGLS | Common Stock | D | 0,7400 | 7.695 | 6 | 7.695 | ||||
| 2018-06-05 | 2018-06-01 | 4 | Collier Kathryn J | RGLS | Stock Option (Right to Buy) | D | 0,73 | 55.000 | 55.000 | |||||
| 2018-06-05 | 2018-06-01 | 4 | BALTIMORE DAVID | RGLS | Stock Option (Right to Buy) | D | 0,73 | 55.000 | 55.000 | |||||
| 2018-06-05 | 2018-06-01 | 4 | PAPADOPOULOS STELIOS | RGLS | Stock Option (Right to Buy) | D | 0,73 | 55.000 | 55.000 | |||||
| 2018-06-05 | 2018-06-01 | 4 | RASTETTER WILLIAM H Rastetter Family Trust dated 9-2-2010 | RGLS | Stock Option (Right to Buy) | I | 0,73 | 55.000 | 55.000 | |||||
| 2018-06-05 | 2018-06-01 | 4 | Rosen Hugh | RGLS | Stock Option (Right to Buy) | D | 0,73 | 55.000 | 55.000 | |||||
| 2018-06-05 | 2018-06-01 | 4 | Witz Pascale | RGLS | Stock Option (Right to Buy) | D | 0,73 | 55.000 | 55.000 | |||||
| 2018-05-21 | 2018-05-17 | 4 | Deeg Mark Albert | RGLS | Common Stock (Right to Buy) | D | 0,71 | 100.000 | 100.000 | |||||
| 2018-05-21 | 2018-05-17 | 4 | Hagan Joseph P | RGLS | Stock Option (Right to Buy) | D | 0,71 | 725.000 | 725.000 | |||||
| 2018-05-21 | 2018-05-17 | 4 | PAPADOPOULOS STELIOS | RGLS | Stock Option (Right to Buy) | D | 0,71 | 75.000 | 75.000 | |||||
| 2018-05-21 | 2018-05-17 | 4 | RASTETTER WILLIAM H Rastetter Family Trust dated 9-2-2010 | RGLS | Stock Option (Right to Buy) | I | 0,71 | 75.000 | 75.000 | |||||
| 2018-05-21 | 2018-05-17 | 4 | Rosen Hugh | RGLS | Stock Option (Right to Buy) | D | 0,71 | 75.000 | 75.000 | |||||
| 2018-05-21 | 2018-05-17 | 4 | Witz Pascale | RGLS | Stock Option (Right to Buy) | D | 0,71 | 75.000 | 75.000 | |||||
| 2018-05-21 | 2018-05-17 | 4 | WRIGHT TIMOTHY MICHAEL | RGLS | Stock Option (Right to Buy) | D | 0,71 | 350.000 | 350.000 | |||||
| 2018-05-21 | 2018-05-17 | 4 | BALTIMORE DAVID | RGLS | Stock Option (Right to Buy) | D | 0,71 | 75.000 | 75.000 | |||||
| 2018-05-21 | 2018-05-17 | 4 | Chevallard Daniel R. | RGLS | Stock Option (Right to Buy) | D | 0,71 | 250.000 | 250.000 | |||||
| 2018-05-21 | 2018-05-17 | 4 | Collier Kathryn J | RGLS | Stock Option (Right to Buy) | D | 0,71 | 37.500 | 37.500 | |||||
| 2018-04-17 | 2018-04-14 | 4 | Collier Kathryn J | RGLS | Stock Option (Right to Buy) | D | 0,64 | 110.000 | 110.000 | |||||
| 2018-04-17 | 2018-04-14 | 4 | Collier Kathryn J | RGLS | Common Stock | D | 0,6400 | 60.234 | 39 | 60.234 | ||||
| 2018-01-05 | 2018-01-05 | 4 | Chevallard Daniel R. | RGLS | Stock Option (Right to Buy) | D | 1,24 | 350.000 | 350.000 | |||||
| 2018-01-05 | 2018-01-05 | 4 | Deeg Mark Albert | RGLS | Stock Option (Right to Buy) | D | 1,24 | 175.000 | 175.000 | |||||
| 2018-01-05 | 2018-01-05 | 4 | WRIGHT TIMOTHY MICHAEL | RGLS | Stock Option (Right to Buy) | D | 1,24 | 500.000 | 500.000 | |||||
| 2018-01-05 | 2018-01-05 | 4 | Hagan Joseph P | RGLS | Stock Option (Right to Buy) | D | 1,24 | 1.000.000 | 1.000.000 | |||||
| 2017-12-06 | 2017-12-04 | 4 | Witz Pascale | RGLS | Common Stock | D | 0,8900 | 60.674 | 54 | 60.674 | ||||
| 2017-12-06 | 2017-12-04 | 4 | Rosen Hugh | RGLS | Common Stock | D | 0,8900 | 56.179 | 50 | 56.179 | ||||
| 2017-12-06 | 2017-12-04 | 4 | PAPADOPOULOS STELIOS | RGLS | Common Stock | D | 0,8900 | 96.629 | 86 | 1.797.306 | ||||
| 2017-12-06 | 2017-12-04 | 4 | FOLETTA MARK G | RGLS | Common Stock | D | 0,8900 | 71.910 | 64 | 81.910 | ||||
| 2017-12-06 | 2017-12-04 | 4 | BALTIMORE DAVID | RGLS | Common Stock | D | 0,8900 | 60.674 | 54 | 60.674 | ||||
| 2017-12-06 | 2017-12-04 | 4 | RASTETTER WILLIAM H WILLIAM H RASTETTER TTEE INVESTMENT 2002 TRUST U/A DTD 11/11/2002 | RGLS | Common Stock | I | 0,8900 | 69.662 | 62 | 694.387 | ||||
| 2017-12-05 | 2017-12-04 | 4 | WRIGHT TIMOTHY MICHAEL | RGLS | Stock Option (Right to Buy) | D | 3,30 | 100.000 | 100.000 | |||||
| 2017-11-27 | 3 | BVF PARTNERS L P/IL | RGLS | Common Stock, $0.001 par value per share | D | 17.248.837 | ||||||||
| 2017-11-27 | 3 | BVF PARTNERS L P/IL | RGLS | Common Stock, $0.001 par value per share | D | 17.248.837 | ||||||||
| 2017-11-27 | 3 | BVF PARTNERS L P/IL | RGLS | Common Stock, $0.001 par value per share | D | 15.027.176 | ||||||||
| 2017-11-27 | 3 | BVF PARTNERS L P/IL | RGLS | Common Stock, $0.001 par value per share | D | 12.158.047 | ||||||||
| 2017-11-27 | 3 | BVF PARTNERS L P/IL | RGLS | Common Stock, $0.001 par value per share | D | 17.248.837 | ||||||||
| 2017-11-27 | 3 | BVF PARTNERS L P/IL | RGLS | Common Stock, $0.001 par value per share | D | 15.027.176 | ||||||||
| 2017-11-27 | 3 | BVF PARTNERS L P/IL | RGLS | Common Stock, $0.001 par value per share | D | 12.158.047 | ||||||||
| 2017-11-27 | 3 | BVF PARTNERS L P/IL | RGLS | Common Stock, $0.001 par value per share | D | 17.248.837 | ||||||||
| 2017-11-27 | 3 | BVF PARTNERS L P/IL | RGLS | Common Stock, $0.001 par value per share | D | 15.027.176 | ||||||||
| 2017-11-27 | 3 | BVF PARTNERS L P/IL | RGLS | Common Stock, $0.001 par value per share | D | 12.158.047 | ||||||||
| 2017-11-27 | 3 | BVF PARTNERS L P/IL | RGLS | Common Stock, $0.001 par value per share | D | 17.248.837 | ||||||||
| 2017-11-27 | 3 | BVF PARTNERS L P/IL | RGLS | Common Stock, $0.001 par value per share | D | 15.027.176 | ||||||||
| 2017-11-27 | 3 | BVF PARTNERS L P/IL | RGLS | Common Stock, $0.001 par value per share | D | 12.158.047 | ||||||||
| 2017-11-27 | 3 | BVF PARTNERS L P/IL | RGLS | Common Stock, $0.001 par value per share | D | 15.027.176 | ||||||||
| 2017-11-27 | 3 | BVF PARTNERS L P/IL | RGLS | Common Stock, $0.001 par value per share | D | 12.158.047 | ||||||||
| 2017-11-27 | 3 | BVF PARTNERS L P/IL | RGLS | Common Stock, $0.001 par value per share | D | 17.248.837 | ||||||||
| 2017-11-27 | 3 | BVF PARTNERS L P/IL | RGLS | Common Stock, $0.001 par value per share | D | 15.027.176 | ||||||||
| 2017-11-27 | 3 | BVF PARTNERS L P/IL | RGLS | Common Stock, $0.001 par value per share | D | 12.158.047 | ||||||||
| 2017-11-27 | 3 | BVF PARTNERS L P/IL | RGLS | Common Stock, $0.001 par value per share | D | 17.248.837 | ||||||||
| 2017-11-27 | 3 | BVF PARTNERS L P/IL | RGLS | Common Stock, $0.001 par value per share | D | 15.027.176 | ||||||||
| 2017-11-27 | 3 | BVF PARTNERS L P/IL | RGLS | Common Stock, $0.001 par value per share | D | 12.158.047 | ||||||||
| 2017-11-27 | 3 | BVF PARTNERS L P/IL | RGLS | Common Stock, $0.001 par value per share | D | 17.248.837 | ||||||||
| 2017-11-27 | 3 | BVF PARTNERS L P/IL | RGLS | Common Stock, $0.001 par value per share | D | 15.027.176 | ||||||||
| 2017-11-27 | 3 | BVF PARTNERS L P/IL | RGLS | Common Stock, $0.001 par value per share | D | 12.158.047 | ||||||||
| 2017-07-31 | 3 | Growth Equity Opportunities V, LLC | RGLS | Common Stock | D | 21.978.020 | ||||||||
| 2017-07-31 | 3 | Growth Equity Opportunities V, LLC | RGLS | Common Stock | D | 21.978.020 | ||||||||
| 2017-07-31 | 3 | Growth Equity Opportunities V, LLC | RGLS | Common Stock | D | 21.978.020 | ||||||||
| 2017-07-31 | 3 | Growth Equity Opportunities V, LLC | RGLS | Common Stock | D | 21.978.020 | ||||||||
| 2017-07-31 | 3 | Growth Equity Opportunities V, LLC | RGLS | Common Stock | D | 21.978.020 | ||||||||
| 2017-07-31 | 3 | Sonsini Peter W. See Note 1 | RGLS | Common Stock | I | 21.978.020 | ||||||||
| 2017-07-31 | 3 | Sonsini Peter W. See Note 1 | RGLS | Common Stock | I | 21.978.020 | ||||||||
| 2017-07-31 | 3 | Viswanathan Ravi See Note 1 | RGLS | Common Stock | I | 21.978.020 | ||||||||
| 2017-07-31 | 3 | Viswanathan Ravi See Note 1 | RGLS | Common Stock | I | 21.978.020 | ||||||||
| 2017-07-31 | 3 | SANDELL SCOTT D See Note 1 | RGLS | Common Stock | I | 21.978.020 | ||||||||
| 2017-07-31 | 3 | SANDELL SCOTT D See Note 1 | RGLS | Common Stock | I | 21.978.020 | ||||||||
| 2017-07-31 | 3 | MOTT DAVID M See Note 1 | RGLS | Common Stock | I | 21.978.020 | ||||||||
| 2017-07-31 | 3 | MOTT DAVID M See Note 1 | RGLS | Common Stock | I | 21.978.020 | ||||||||
| 2017-07-31 | 3 | Puttagunta Chetan See Note 1 | RGLS | Common Stock | I | 21.978.020 | ||||||||
| 2017-07-31 | 3 | Puttagunta Chetan See Note 1 | RGLS | Common Stock | I | 21.978.020 | ||||||||
| 2017-07-31 | 3 | Sakoda Jon See Note 1 | RGLS | Common Stock | I | 21.978.020 | ||||||||
| 2017-07-31 | 3 | Sakoda Jon See Note 1 | RGLS | Common Stock | I | 21.978.020 | ||||||||
| 2017-07-31 | 3 | BASKETT FOREST See Note 1 | RGLS | Common Stock | I | 21.978.020 | ||||||||
| 2017-07-31 | 3 | BASKETT FOREST See Note 1 | RGLS | Common Stock | I | 21.978.020 | ||||||||
| 2017-07-31 | 3 | Florence Anthony A. Jr. See Note 1 | RGLS | Common Stock | I | 21.978.020 | ||||||||
| 2017-07-31 | 3 | Florence Anthony A. Jr. See Note 1 | RGLS | Common Stock | I | 21.978.020 | ||||||||
| 2017-07-31 | 3 | BARRIS PETER J See Note 1 | RGLS | Common Stock | I | 21.978.020 | ||||||||
| 2017-07-31 | 3 | BARRIS PETER J See Note 1 | RGLS | Common Stock | I | 21.978.020 | ||||||||
| 2017-07-31 | 3 | Makhzoumi Mohamad See Note 1 | RGLS | Common Stock | I | 21.978.020 | ||||||||
| 2017-07-31 | 3 | Makhzoumi Mohamad See Note 1 | RGLS | Common Stock | I | 21.978.020 | ||||||||
| 2017-07-31 | 3 | MAKOWER JOSHUA See Note 1 | RGLS | Common Stock | I | 21.978.020 | ||||||||
| 2017-07-31 | 3 | MAKOWER JOSHUA See Note 1 | RGLS | Common Stock | I | 21.978.020 | ||||||||
| 2017-07-25 | 2017-07-25 | 4 | RASTETTER WILLIAM H WILLIAM H RASTETTER TTEE INVESTMENT 2002 TRUST U/A DTD 11/11/2002 | RGLS | Common Stock | I | 0,9100 | 274.725 | 250 | 624.625 | ||||
| 2017-07-25 | 2017-07-25 | 4 | WRIGHT TIMOTHY MICHAEL | RGLS | Common Stock | D | 0,9100 | 274.725 | 250 | 274.725 | ||||
| 2017-07-25 | 2017-07-25 | 4 | PAPADOPOULOS STELIOS | RGLS | Common Stock | D | 0,9100 | 1.000.000 | 910 | 1.770.677 | ||||
| 2017-07-25 | 2017-07-25 | 4 | Chevallard Daniel R. | RGLS | Common Stock | D | 0,9100 | 54.945 | 50 | 59.415 | ||||
| 2017-07-25 | 2017-07-25 | 4 | Hagan Joseph P | RGLS | Common Stock | D | 0,9100 | 219.780 | 200 | 241.297 | ||||
| 2017-06-23 | 2017-06-22 | 4 | Deeg Mark Albert | RGLS | Stock Option (Right to Buy) | D | 0,99 | 100.000 | 100.000 | |||||
| 2017-06-02 | 2017-06-01 | 4 | Witz Pascale | RGLS | Stock Option (Right to Buy) | D | 1,45 | 60.000 | 60.000 | |||||
| 2017-06-02 | 2017-06-01 | 4 | BALTIMORE DAVID | RGLS | Common Stock (Option to Buy) | D | 1,45 | 30.000 | 30.000 | |||||
| 2017-06-02 | 2017-06-01 | 4 | FOLETTA MARK G | RGLS | Stock Option (Right to Buy) | D | 1,45 | 30.000 | 30.000 | |||||
| 2017-06-02 | 2017-06-01 | 4 | PAPADOPOULOS STELIOS | RGLS | Stock Option (Right to Buy) | D | 1,45 | 30.000 | 30.000 | |||||
| 2017-06-02 | 2017-06-01 | 4 | RASTETTER WILLIAM H | RGLS | Stock Option (Right to Buy) | D | 1,45 | 30.000 | 30.000 | |||||
| 2017-06-02 | 2017-06-01 | 4 | Rosen Hugh | RGLS | Stock Option (Right to Buy) | D | 1,45 | 30.000 | 30.000 | |||||
| 2017-05-12 | 2017-05-10 | 4 | Chevallard Daniel R. | RGLS | Stock Option (Right to Buy) | D | 1,65 | 100.000 | 100.000 | |||||
| 2017-05-10 | 3 | Chevallard Daniel R. | RGLS | Common Stock | D | 8.940 | ||||||||
| 2017-05-10 | 3 | Chevallard Daniel R. | RGLS | Common Stock | D | 8.940 | ||||||||
| 2017-05-08 | 2017-05-04 | 4 | Hagan Joseph P | RGLS | Stock Option (Right to Buy) | D | 1,70 | 750.000 | 750.000 | |||||
| 2017-05-08 | 2017-05-04 | 4 | WRIGHT TIMOTHY MICHAEL | RGLS | Stock Option (Right to Buy) | D | 1,70 | 350.000 | 350.000 | |||||
| 2017-03-23 | 2017-03-22 | 4 | PAPADOPOULOS STELIOS | RGLS | Common Stock | D | 1,2270 | 300.000 | 368 | 700.677 | ||||
| 2017-03-23 | 2017-03-21 | 4 | PAPADOPOULOS STELIOS | RGLS | Common Stock | D | 1,1990 | 200.000 | 240 | 400.677 | ||||
| 2017-03-07 | 2017-03-07 | 4 | RASTETTER WILLIAM H WILLIAM H RASTETTER TTEE INVESTMENT TRUST 2002 TRUST BOARDS U/A DATED 11/11/2002 | RGLS | Common Stock | I | 1,1500 | 250.000 | 288 | 350.000 | ||||
| 2017-02-23 | 2017-02-15 | 4 | Hagan Joseph P | RGLS | Stock Option (Right to Buy) | D | 1,20 | 160.000 | 160.000 | |||||
| 2017-02-23 | 2017-02-15 | 4 | GRINT PAUL C | RGLS | Stock Option (Right to Buy) | D | 1,20 | 410.000 | 410.000 | |||||
| 2017-02-23 | 2017-02-15 | 4 | WRIGHT TIMOTHY MICHAEL | RGLS | Stock Option (Right to Buy) | D | 1,20 | 32.412 | 32.412 | |||||
| 2017-02-01 | 2017-01-30 | 4 | GRINT PAUL C | RGLS | Stock Option (Right to Buy) | D | 6,35 | 130.000 | 130.000 | |||||
| 2017-02-01 | 2017-01-30 | 4 | Hagan Joseph P | RGLS | Stock Option (Right to Buy) | D | 5,77 | 30.000 | 30.000 | |||||
| 2016-10-07 | 2016-10-05 | 4 | GRINT PAUL C | RGLS | Stock Option (Right to Buy) | D | 3,52 | 186.640 | 186.640 | |||||
| 2016-10-07 | 2016-10-05 | 4 | Hagan Joseph P | RGLS | Stock Option (Right to Buy) | D | 3,52 | 59.625 | 59.625 | |||||
| 2016-10-05 | 2016-10-03 | 4 | WRIGHT TIMOTHY MICHAEL | RGLS | Stock Option (Right to Buy) | D | 3,30 | 450.000 | 450.000 | |||||
| 2016-06-03 | 2016-06-02 | 4 | BALTIMORE DAVID | RGLS | Stock Option (Right to Buy) | D | 6,20 | 36.620 | 36.620 | |||||
| 2016-06-03 | 2016-06-02 | 4 | FOLETTA MARK G | RGLS | Stock Option (Right to Buy) | D | 6,20 | 36.620 | 36.620 | |||||
| 2016-06-03 | 2016-06-02 | 4 | PAPADOPOULOS STELIOS | RGLS | Stock Option (Right to Buy) | D | 6,20 | 36.620 | 36.620 | |||||
| 2016-06-03 | 2016-06-02 | 4 | RASTETTER WILLIAM H | RGLS | Stock Option (Right to Buy) | D | 6,20 | 36.620 | 36.620 | |||||
| 2016-06-03 | 2016-06-02 | 4 | WILLIAMS DOUGLAS E | RGLS | Stock Option (Right to Buy) | D | 6,20 | 36.620 | 36.620 | |||||
| 2016-06-03 | 2016-06-02 | 4 | Rosen Hugh | RGLS | Stock Option (Right to Buy) | D | 6,20 | 70.952 | 70.952 | |||||
| 2016-03-07 | 2016-03-03 | 4 | Hagan Joseph P | RGLS | Common Stock | D | 7,1900 | 10.000 | 72 | 10.000 | ||||
| 2016-02-24 | 2016-02-23 | 4 | ALNYLAM PHARMACEUTICALS, INC. | RGLS | Common Stock | D | 7,1800 | -1.000.000 | -7.180 | 4.896.716 | ||||
| 2016-02-05 | 2016-02-04 | 4 | GRINT PAUL C | RGLS | Stock Option (Right to Buy) | D | 6,35 | 265.000 | 265.000 | |||||
| 2016-01-06 | 2016-01-04 | 4 | Hagan Joseph P | RGLS | Stock Option (Right to Buy) | D | 8,57 | 420.000 | 420.000 | |||||
| 2016-01-06 | 2015-12-16 | 4 | GRINT PAUL C | RGLS | Stock Option (Right to Buy) | D | 7,58 | 30.000 | 30.000 | |||||
| 2015-08-13 | 2015-08-13 | 4 | FOLETTA MARK G | RGLS | Common Stock | D | 7,6405 | 10.000 | 76 | 10.000 | ||||
| 2015-08-07 | 2015-08-07 | 4 | PAPADOPOULOS STELIOS | RGLS | Stock Option (Right to Buy) | D | 2,66 | -15.677 | 1.823 | |||||
| 2015-08-07 | 2015-08-07 | 4 | PAPADOPOULOS STELIOS | RGLS | Stock Option (Right to Buy) | D | 1,74 | -17.500 | 0 | |||||
| 2015-08-07 | 2015-08-07 | 4 | PAPADOPOULOS STELIOS | RGLS | Stock Option (Right to Buy) | D | 0,38 | -17.500 | 0 | |||||
| 2015-08-07 | 2015-08-07 | 4 | PAPADOPOULOS STELIOS | RGLS | Common Stock | D | 2,6600 | 15.677 | 42 | 200.677 | ||||
| 2015-08-07 | 2015-08-07 | 4 | PAPADOPOULOS STELIOS | RGLS | Common Stock | D | 1,7400 | 17.500 | 30 | 185.000 | ||||
| 2015-08-07 | 2015-08-07 | 4 | PAPADOPOULOS STELIOS | RGLS | Common Stock | D | 0,3800 | 17.500 | 7 | 167.500 | ||||
| 2015-07-21 | 2015-07-21 | 4 | RASTETTER WILLIAM H William H. Rastetter TTEE Investment 2002 Trust Boards U/A dated 11/11/2002 | RGLS | Common Stock | I | 10,1935 | 61.235 | 624 | 100.000 | ||||
| 2015-07-21 | 2015-07-20 | 4 | RASTETTER WILLIAM H William H. Rastetter TTEE Investment 2002 Trust Boards U/A dated 11/11/2002 | RGLS | Common Stock | I | 10,1323 | 38.765 | 393 | 38.765 | ||||
| 2015-07-17 | 2015-07-17 | 4 | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 10,2140 | -111.000 | -1.134 | 5.173.172 | ||||
| 2015-07-17 | 2015-07-16 | 4 | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 10,7866 | -167.000 | -1.801 | 5.284.172 | ||||
| 2015-07-17 | 2015-07-15 | 4 | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 10,7620 | -65.133 | -701 | 5.451.172 | ||||
| 2015-07-02 | 2015-06-30 | 4 | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 10,7948 | -13.248 | -143 | 5.516.305 | ||||
| 2015-07-02 | 2015-06-23 | 4 | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 13.248 | 5.529.553 | ||||||
| 2015-06-26 | 2015-06-10 | 4 | WILLIAMS DOUGLAS E | RGLS | Stock Option (Right to Buy) | D | 10,02 | 17.500 | 17.500 | |||||
| 2015-06-26 | 2015-06-10 | 4 | CARTER BRUCE L A | RGLS | Stock Option (Right to Buy) | D | 10,02 | 17.500 | 17.500 | |||||
| 2015-06-26 | 2015-06-10 | 4 | BALTIMORE DAVID | RGLS | Stock Option (Right to Buy) | D | 10,02 | 17.500 | 17.500 | |||||
| 2015-06-26 | 2015-06-10 | 4 | CARTER BRUCE L A | RGLS | Stock Option (Right to Buy) | D | 10,02 | 17.500 | 17.500 | |||||
| 2015-06-26 | 2015-06-10 | 4 | RASTETTER WILLIAM H | RGLS | Stock Option (Right to Buy) | D | 10,02 | 17.500 | 17.500 | |||||
| 2015-06-26 | 2015-06-10 | 4 | FOLETTA MARK G | RGLS | Stock Option (Right to Buy) | D | 10,02 | 17.500 | 17.500 | |||||
| 2015-06-26 | 2015-06-10 | 4 | PAPADOPOULOS STELIOS | RGLS | Stock Option (Right to Buy) | D | 10,02 | 17.500 | 17.500 | |||||
| 2015-06-26 | 2015-06-25 | 4 | GRINT PAUL C | RGLS | Stock Option (Right to Buy) | D | 10,22 | 500.000 | 500.000 | |||||
| 2015-04-21 | 2015-04-21 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Stock Option (Right to Buy) | D | 0,38 | -60.000 | 8.287 | |||||
| 2015-04-21 | 2015-04-21 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Common Stock | D | 17,7330 | -60.000 | -1.064 | 3.705 | ||||
| 2015-04-21 | 2015-04-21 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Common Stock | D | 0,3800 | 60.000 | 23 | 63.705 | ||||
| 2015-04-21 | 2015-04-20 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Stock Option (Right to Buy) | D | 0,38 | -66.071 | 68.287 | |||||
| 2015-04-21 | 2015-04-20 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Common Stock | D | 16,8533 | -66.071 | -1.114 | 3.705 | ||||
| 2015-04-21 | 2015-04-20 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Common Stock | D | 0,3800 | 66.071 | 25 | 69.776 | ||||
| 2015-04-21 | 2015-04-17 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Stock Option (Right to Buy) | D | 0,38 | -73.929 | 134.358 | |||||
| 2015-04-21 | 2015-04-17 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Common Stock | D | 16,9352 | -73.929 | -1.252 | 3.705 | ||||
| 2015-04-21 | 2015-04-17 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Common Stock | D | 0,3800 | 73.929 | 28 | 77.634 | ||||
| 2015-04-14 | 2015-04-13 | 4 | CARTER BRUCE L A | RGLS | Stock Option (Right to Buy) | D | 4,78 | -20.000 | 10.000 | |||||
| 2015-04-14 | 2015-04-13 | 4 | CARTER BRUCE L A | RGLS | Common Stock | D | 17,6582 | -20.000 | -353 | 0 | ||||
| 2015-04-14 | 2015-04-13 | 4 | CARTER BRUCE L A | RGLS | Common Stock | D | 4,7800 | 20.000 | 96 | 20.000 | ||||
| 2015-03-05 | 2015-03-05 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Stock Option (Right to Buy) | D | 0,38 | -89.230 | 208.287 | |||||
| 2015-03-05 | 2015-03-05 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Common Stock | D | 20,8143 | -23.616 | -492 | 2.466 | ||||
| 2015-03-05 | 2015-03-05 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Common Stock | D | 20,0645 | -65.614 | -1.317 | 26.082 | ||||
| 2015-03-05 | 2015-03-05 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Common Stock | D | 0,3800 | 89.230 | 34 | 91.696 | ||||
| 2015-03-03 | 2015-02-27 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Stock Option (Right to Buy) | D | 0,38 | -70 | 297.517 | |||||
| 2015-03-03 | 2015-02-27 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Common Stock | D | 19,5000 | -70 | -1 | 2.466 | ||||
| 2015-03-03 | 2015-02-27 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Common Stock | D | 0,3800 | 70 | 0 | 2.536 | ||||
| 2015-02-03 | 2015-02-02 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Stock Option (Right to Buy) | D | 0,38 | -2.400 | 297.587 | |||||
| 2015-02-03 | 2015-02-02 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Common Stock | D | 19,7667 | -2.400 | -47 | 2.466 | ||||
| 2015-02-03 | 2015-02-02 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Common Stock | D | 0,3800 | 2.400 | 1 | 4.866 | ||||
| 2015-02-03 | 2015-01-30 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Stock Option (Right to Buy) | D | 0,38 | -3.300 | 299.987 | |||||
| 2015-02-03 | 2015-01-30 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Common Stock | D | 19,5004 | -3.300 | -64 | 2.466 | ||||
| 2015-02-03 | 2015-01-30 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Common Stock | D | 0,3800 | 3.300 | 1 | 5.766 | ||||
| 2015-01-30 | 2015-01-28 | 4 | Gibson Neil W | RGLS | Common Stock | D | 18,6589 | -8.655 | -161 | 0 | ||||
| 2015-01-30 | 2015-01-28 | 4 | Gibson Neil W | RGLS | Common Stock | D | 17,9804 | -71.345 | -1.283 | 8.655 | ||||
| 2015-01-30 | 2015-01-29 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Stock Option (Right to Buy) | D | 0,38 | -60.000 | 303.287 | |||||
| 2015-01-30 | 2015-01-29 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Common Stock | D | 18,4019 | -26.227 | -483 | 2.466 | ||||
| 2015-01-30 | 2015-01-29 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Common Stock | D | 17,7659 | -33.773 | -600 | 28.693 | ||||
| 2015-01-30 | 2015-01-29 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Common Stock | D | 0,3800 | 60.000 | 23 | 62.466 | ||||
| 2015-01-30 | 2015-01-28 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Stock Option (Right to Buy) | D | 0,38 | -85.000 | 363.287 | |||||
| 2015-01-30 | 2015-01-28 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Common Stock | D | 18,6851 | -12.989 | -243 | 2.466 | ||||
| 2015-01-30 | 2015-01-28 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Common Stock | D | 17,9669 | -72.011 | -1.294 | 15.455 | ||||
| 2015-01-30 | 2015-01-28 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Common Stock | D | 0,3800 | 85.000 | 32 | 87.466 | ||||
| 2014-12-15 | 2014-12-12 | 4 | PAPADOPOULOS STELIOS | RGLS | Stock Option (Right to Buy) | D | 0,38 | -150.000 | 0 | |||||
| 2014-12-15 | 2014-12-12 | 4 | PAPADOPOULOS STELIOS | RGLS | Common Stock | D | 0,3800 | 150.000 | 57 | 150.000 | ||||
| 2014-12-04 | 2014-12-02 | 4 | Szekeres David Leslie | RGLS | Stock Option (Right to Buy) | D | 17,76 | 81.101 | 81.101 | |||||
| 2014-12-04 | 2014-12-02 | 4 | Gibson Neil W | RGLS | Stock Option (Right to Buy) | D | 17,76 | 90.378 | 90.378 | |||||
| 2014-12-04 | 2014-12-02 | 4 | GRINT PAUL C | RGLS | Stock Option (Right to Buy) | D | 17,76 | 50.870 | 50.870 | |||||
| 2014-12-04 | 2014-12-02 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Stock Option (Right to Buy) | D | 17,76 | 231.634 | 231.634 | |||||
| 2014-12-01 | 2014-11-28 | 4 | Gibson Neil W | RGLS | Stock Option (Right to Buy) | D | 1,74 | -2.500 | 111.500 | |||||
| 2014-12-01 | 2014-11-28 | 4 | Gibson Neil W | RGLS | Common Stock | D | 19,6300 | -1.500 | -29 | 80.000 | ||||
| 2014-12-01 | 2014-11-28 | 4 | Gibson Neil W | RGLS | Common Stock | D | 18,8000 | -1.000 | -19 | 81.500 | ||||
| 2014-12-01 | 2014-11-28 | 4 | Gibson Neil W | RGLS | Common Stock | D | 1,7400 | 2.500 | 4 | 82.500 | ||||
| 2014-11-14 | 2014-11-12 | 4 | ASTRAZENECA PLC | RGLS | COMMON STOCK | I | 17,0000 | -2.000.000 | -34.000 | 4.250.000 | ||||
| 2014-11-05 | 2014-11-03 | 4 | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 15,9375 | -1.279.411 | -20.391 | 5.516.305 | ||||
| 2014-10-31 | 2014-10-29 | 4 | Gibson Neil W | RGLS | Stock Option (Right to Buy) | D | 1,74 | -2.500 | 114.000 | |||||
| 2014-10-31 | 2014-10-29 | 4 | Gibson Neil W | RGLS | Common Stock | D | 20,4100 | -200 | -4 | 80.000 | ||||
| 2014-10-31 | 2014-10-29 | 4 | Gibson Neil W | RGLS | Common Stock | D | 19,6700 | -1.200 | -24 | 80.200 | ||||
| 2014-10-31 | 2014-10-29 | 4 | Gibson Neil W | RGLS | Common Stock | D | 18,6800 | -1.100 | -21 | 81.400 | ||||
| 2014-10-31 | 2014-10-29 | 4 | Gibson Neil W | RGLS | Common Stock | D | 1,7400 | 2.500 | 4 | 82.500 | ||||
| 2014-10-31 | 2014-10-29 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Stock Option (Right to Buy) | D | 0,38 | -3.505 | 448.287 | |||||
| 2014-10-31 | 2014-10-29 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Common Stock | D | 20,4100 | -100 | -2 | 2.466 | ||||
| 2014-10-31 | 2014-10-29 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Common Stock | D | 19,7800 | -2.005 | -40 | 2.566 | ||||
| 2014-10-31 | 2014-10-29 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Common Stock | D | 18,6600 | -1.400 | -26 | 4.571 | ||||
| 2014-10-31 | 2014-10-29 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Common Stock | D | 0,3800 | 3.505 | 1 | 5.971 | ||||
| 2014-10-28 | 2014-10-24 | 4/A | ALNYLAM PHARMACEUTICALS, INC. | RGLS | Common Stock | D | 16,2922 | -446 | -7 | 5.896.716 | ||||
| 2014-10-28 | 2014-10-24 | 4/A | ALNYLAM PHARMACEUTICALS, INC. | RGLS | Common Stock | D | 15,5014 | -350 | -5 | 5.897.162 | ||||
| 2014-10-28 | 2014-10-24 | 4/A | ALNYLAM PHARMACEUTICALS, INC. | RGLS | Common Stock | D | 14,6277 | -1.054 | -15 | 5.897.512 | ||||
| 2014-10-28 | 2014-10-23 | 4/A | ALNYLAM PHARMACEUTICALS, INC. | RGLS | Common Stock | D | 15,4500 | -50 | -1 | 5.898.566 | ||||
| 2014-10-28 | 2014-10-23 | 4/A | ALNYLAM PHARMACEUTICALS, INC. | RGLS | Common Stock | D | 14,8956 | -450 | -7 | 5.898.616 | ||||
| 2014-10-28 | 2014-10-23 | 4/A | ALNYLAM PHARMACEUTICALS, INC. | RGLS | Common Stock | D | 13,9390 | -1.200 | -17 | 5.899.066 | ||||
| 2014-10-28 | 2014-10-22 | 4/A | ALNYLAM PHARMACEUTICALS, INC. | RGLS | Common Stock | D | 17,1100 | -175 | -3 | 5.900.266 | ||||
| 2014-10-28 | 2014-10-22 | 4/A | ALNYLAM PHARMACEUTICALS, INC. | RGLS | Common Stock | D | 16,5881 | -11.376 | -189 | 5.900.441 | ||||
| 2014-10-28 | 2014-10-22 | 4/A | ALNYLAM PHARMACEUTICALS, INC. | RGLS | Common Stock | D | 14,6707 | -15.156 | -222 | 5.911.817 | ||||
| 2014-10-28 | 2014-10-22 | 4/A | ALNYLAM PHARMACEUTICALS, INC. | RGLS | Common Stock | D | 13,9112 | -57.753 | -803 | 5.926.973 | ||||
| 2014-10-28 | 2014-10-22 | 4/A | ALNYLAM PHARMACEUTICALS, INC. | RGLS | Common Stock | D | 12,8309 | -15.791 | -203 | 5.984.726 | ||||
| 2014-10-28 | 2014-10-22 | 4/A | ALNYLAM PHARMACEUTICALS, INC. | RGLS | Common Stock | D | 12,1792 | -9.283 | -113 | 6.000.517 | ||||
| 2014-10-28 | 2014-10-24 | 4/A | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 16,2922 | -446 | -7 | 6.795.716 | ||||
| 2014-10-28 | 2014-10-24 | 4/A | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 15,5014 | -350 | -5 | 6.796.162 | ||||
| 2014-10-28 | 2014-10-24 | 4/A | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 14,6277 | -1.054 | -15 | 6.796.512 | ||||
| 2014-10-28 | 2014-10-23 | 4/A | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 15,4500 | -50 | -1 | 6.797.566 | ||||
| 2014-10-28 | 2014-10-23 | 4/A | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 14,8956 | -450 | -7 | 6.797.616 | ||||
| 2014-10-28 | 2014-10-23 | 4/A | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 13,9390 | -1.200 | -17 | 6.798.066 | ||||
| 2014-10-28 | 2014-10-22 | 4/A | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 17,1100 | -175 | -3 | 6.799.266 | ||||
| 2014-10-28 | 2014-10-22 | 4/A | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 16,5881 | -11.376 | -189 | 6.799.441 | ||||
| 2014-10-28 | 2014-10-22 | 4/A | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 14,6707 | -15.156 | -222 | 6.810.817 | ||||
| 2014-10-28 | 2014-10-22 | 4/A | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 13,9112 | -57.753 | -803 | 6.825.973 | ||||
| 2014-10-28 | 2014-10-22 | 4/A | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 12,8309 | -15.791 | -203 | 6.883.726 | ||||
| 2014-10-28 | 2014-10-22 | 4/A | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 12,1792 | -9.283 | -113 | 6.899.517 | ||||
| 2014-10-24 | 2014-10-24 | 4 | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 15,1943 | -1.850 | -28 | 6.795.716 | ||||
| 2014-10-24 | 2014-10-23 | 4 | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 14,2367 | -1.700 | -24 | 6.797.566 | ||||
| 2014-10-24 | 2014-10-22 | 4 | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 13,9968 | -109.534 | -1.533 | 6.799.266 | ||||
| 2014-10-24 | 2014-10-24 | 4 | ALNYLAM PHARMACEUTICALS, INC. | RGLS | Common Stock | D | 15,1943 | -1.850 | -28 | 5.896.716 | ||||
| 2014-10-24 | 2014-10-23 | 4 | ALNYLAM PHARMACEUTICALS, INC. | RGLS | Common Stock | D | 14,2367 | -1.700 | -24 | 5.898.566 | ||||
| 2014-10-24 | 2014-10-22 | 4 | ALNYLAM PHARMACEUTICALS, INC. | RGLS | Common Stock | D | 13,9968 | -109.534 | -1.533 | 5.900.266 | ||||
| 2014-10-24 | 2014-10-22 | 4 | Gibson Neil W | RGLS | Stock Option (Right to Buy) | D | 1,74 | -3.300 | 116.500 | |||||
| 2014-10-24 | 2014-10-22 | 4 | Gibson Neil W | RGLS | Common Stock | D | 14,4376 | -3.300 | -48 | 80.000 | ||||
| 2014-10-24 | 2014-10-22 | 4 | Gibson Neil W | RGLS | Common Stock | D | 1,7400 | 3.300 | 6 | 83.300 | ||||
| 2014-10-22 | 2014-10-20 | 4 | Gibson Neil W | RGLS | Stock Option (Right to Buy) | D | 6,13 | 40.000 | 40.000 | |||||
| 2014-10-22 | 2014-10-20 | 4 | Szekeres David Leslie | RGLS | Stock Option (Right to Buy) | D | 8,51 | 40.000 | 40.000 | |||||
| 2014-10-22 | 2014-10-20 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Stock Option (Right to Buy) | D | 6,13 | 88.000 | 88.000 | |||||
| 2014-10-22 | 2014-10-20 | 4 | GRINT PAUL C | RGLS | Stock Option (Right to Buy) | D | 7,58 | 40.000 | 40.000 | |||||
| 2014-10-21 | 2014-10-20 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Stock Option (Right to Buy) | D | 0,38 | -300 | 451.792 | |||||
| 2014-10-21 | 2014-10-20 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Common Stock | D | 7,0000 | -300 | -2 | 2.466 | ||||
| 2014-10-21 | 2014-10-20 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Common Stock | D | 0,3800 | 300 | 0 | 2.766 | ||||
| 2014-10-21 | 2014-10-17 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Stock Option (Right to Buy) | D | 0,38 | -400 | 452.092 | |||||
| 2014-10-21 | 2014-10-17 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Common Stock | D | 7,0400 | -400 | -3 | 2.466 | ||||
| 2014-10-21 | 2014-10-17 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Common Stock | D | 0,3800 | 400 | 0 | 2.866 | ||||
| 2014-10-17 | 2014-10-17 | 4 | ALNYLAM PHARMACEUTICALS, INC. | RGLS | Common Stock | D | 6,7903 | -3.000 | -20 | 6.009.800 | ||||
| 2014-10-17 | 2014-10-16 | 4 | ALNYLAM PHARMACEUTICALS, INC. | RGLS | Common Stock | D | 6,7605 | -4.800 | -32 | 6.012.800 | ||||
| 2014-10-17 | 2014-10-15 | 4 | ALNYLAM PHARMACEUTICALS, INC. | RGLS | Common Stock | D | 6,6714 | -4.300 | -29 | 6.017.600 | ||||
| 2014-10-17 | 2014-10-17 | 4 | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 6,7903 | -3.000 | -20 | 6.908.800 | ||||
| 2014-10-17 | 2014-10-16 | 4 | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 6,7605 | -4.800 | -32 | 6.911.800 | ||||
| 2014-10-17 | 2014-10-15 | 4 | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 6,6714 | -4.300 | -29 | 6.916.600 | ||||
| 2014-10-14 | 2014-10-14 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Stock Option (Right to Buy) | D | 0,38 | -400 | 452.492 | |||||
| 2014-10-14 | 2014-10-14 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Common Stock | D | 7,0000 | -400 | -3 | 2.466 | ||||
| 2014-10-14 | 2014-10-14 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Common Stock | D | 0,3800 | 400 | 0 | 2.866 | ||||
| 2014-10-14 | 2014-10-09 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Stock Option (Right to Buy) | D | 0,38 | -105 | 452.892 | |||||
| 2014-10-14 | 2014-10-09 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Common Stock | D | 7,0000 | -105 | -1 | 2.466 | ||||
| 2014-10-14 | 2014-10-09 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Common Stock | D | 0,3800 | 105 | 0 | 2.571 | ||||
| 2014-10-10 | 2014-10-10 | 4 | ALNYLAM PHARMACEUTICALS, INC. | RGLS | Common Stock | D | 6,4063 | -2.000 | -13 | 6.021.900 | ||||
| 2014-10-10 | 2014-10-09 | 4 | ALNYLAM PHARMACEUTICALS, INC. | RGLS | Common Stock | D | 6,5764 | -4.750 | -31 | 6.023.900 | ||||
| 2014-10-10 | 2014-10-08 | 4 | ALNYLAM PHARMACEUTICALS, INC. | RGLS | Common Stock | D | 6,6326 | -3.300 | -22 | 6.028.650 | ||||
| 2014-10-10 | 2014-10-10 | 4 | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 6,4063 | -2.000 | -13 | 6.920.900 | ||||
| 2014-10-10 | 2014-10-09 | 4 | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 6,5764 | -4.750 | -31 | 6.922.900 | ||||
| 2014-10-10 | 2014-10-08 | 4 | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 6,6326 | -3.300 | -22 | 6.927.650 | ||||
| 2014-10-03 | 2014-10-03 | 4 | ALNYLAM PHARMACEUTICALS, INC. | RGLS | Common Stock | D | 6,8751 | -3.300 | -23 | 6.031.950 | ||||
| 2014-10-03 | 2014-10-02 | 4 | ALNYLAM PHARMACEUTICALS, INC. | RGLS | Common Stock | D | 6,6407 | -3.750 | -25 | 6.035.250 | ||||
| 2014-10-03 | 2014-10-01 | 4 | ALNYLAM PHARMACEUTICALS, INC. | RGLS | Common Stock | D | 6,7103 | -3.250 | -22 | 6.039.000 | ||||
| 2014-10-03 | 2014-10-03 | 4 | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 6,8751 | -3.300 | -23 | 6.930.950 | ||||
| 2014-10-03 | 2014-10-02 | 4 | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 6,6407 | -3.750 | -25 | 6.934.250 | ||||
| 2014-10-03 | 2014-10-01 | 4 | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 6,7103 | -3.250 | -22 | 6.938.000 | ||||
| 2014-10-02 | 2014-09-30 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Stock Option (Right to Buy) | D | 0,38 | -2.300 | 452.997 | |||||
| 2014-10-02 | 2014-09-30 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Common Stock | D | 7,0163 | -2.300 | -16 | 2.466 | ||||
| 2014-10-02 | 2014-09-30 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Common Stock | D | 0,3800 | 2.300 | 1 | 4.766 | ||||
| 2014-09-26 | 2014-09-26 | 4 | ALNYLAM PHARMACEUTICALS, INC. | RGLS | Common Stock | D | 7,0393 | -2.500 | -18 | 6.042.250 | ||||
| 2014-09-26 | 2014-09-25 | 4 | ALNYLAM PHARMACEUTICALS, INC. | RGLS | Common Stock | D | 7,1160 | -2.500 | -18 | 6.044.750 | ||||
| 2014-09-26 | 2014-09-24 | 4 | ALNYLAM PHARMACEUTICALS, INC. | RGLS | Common Stock | D | 7,1942 | -3.750 | -27 | 6.047.250 | ||||
| 2014-09-26 | 2014-09-26 | 4 | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 7,0393 | -2.500 | -18 | 6.941.250 | ||||
| 2014-09-26 | 2014-09-25 | 4 | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 7,1160 | -2.500 | -18 | 6.943.750 | ||||
| 2014-09-26 | 2014-09-24 | 4 | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 7,1942 | -3.750 | -27 | 6.946.250 | ||||
| 2014-09-19 | 2014-09-19 | 4 | ALNYLAM PHARMACEUTICALS, INC. | RGLS | Common Stock | D | 7,2163 | -4.100 | -30 | 6.051.000 | ||||
| 2014-09-19 | 2014-09-18 | 4 | ALNYLAM PHARMACEUTICALS, INC. | RGLS | Common Stock | D | 7,3984 | -1.500 | -11 | 6.055.100 | ||||
| 2014-09-19 | 2014-09-17 | 4 | ALNYLAM PHARMACEUTICALS, INC. | RGLS | Common Stock | D | 7,4331 | -2.100 | -16 | 6.056.600 | ||||
| 2014-09-19 | 2014-09-19 | 4 | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 7,2163 | -4.100 | -30 | 6.950.000 | ||||
| 2014-09-19 | 2014-09-18 | 4 | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 7,3984 | -1.500 | -11 | 6.954.100 | ||||
| 2014-09-19 | 2014-09-17 | 4 | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 7,4331 | -2.100 | -16 | 6.955.600 | ||||
| 2014-09-15 | 2014-09-12 | 4 | Gibson Neil W | RGLS | Stock Option (Right to Buy) | D | 1,74 | -2.200 | 119.800 | |||||
| 2014-09-15 | 2014-09-12 | 4 | Gibson Neil W | RGLS | Common Stock | D | 8,0075 | -2.200 | -18 | 80.000 | ||||
| 2014-09-15 | 2014-09-12 | 4 | Gibson Neil W | RGLS | Common Stock | D | 1,7400 | 2.200 | 4 | 82.200 | ||||
| 2014-09-15 | 2014-09-11 | 4 | Gibson Neil W | RGLS | Stock Option (Right to Buy) | D | 1,74 | -2.000 | 122.000 | |||||
| 2014-09-15 | 2014-09-11 | 4 | Gibson Neil W | RGLS | Common Stock | D | 8,0050 | -2.000 | -16 | 80.000 | ||||
| 2014-09-15 | 2014-09-11 | 4 | Gibson Neil W | RGLS | Common Stock | D | 1,7400 | 2.000 | 3 | 82.000 | ||||
| 2014-09-12 | 2014-09-12 | 4 | ALNYLAM PHARMACEUTICALS, INC. | RGLS | Common Stock | D | 7,9602 | -3.500 | -28 | 6.058.700 | ||||
| 2014-09-12 | 2014-09-11 | 4 | ALNYLAM PHARMACEUTICALS, INC. | RGLS | Common Stock | D | 7,8341 | -3.400 | -27 | 6.062.200 | ||||
| 2014-09-12 | 2014-09-10 | 4 | ALNYLAM PHARMACEUTICALS, INC. | RGLS | Common Stock | D | 7,6996 | -2.000 | -15 | 6.065.600 | ||||
| 2014-09-12 | 2014-09-12 | 4 | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 7,9602 | -3.500 | -28 | 6.957.700 | ||||
| 2014-09-12 | 2014-09-11 | 4 | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 7,8341 | -3.400 | -27 | 6.961.200 | ||||
| 2014-09-12 | 2014-09-10 | 4 | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 7,6996 | -2.000 | -15 | 6.964.600 | ||||
| 2014-09-05 | 2014-09-05 | 4 | ALNYLAM PHARMACEUTICALS, INC. | RGLS | Common Stock | D | 7,0727 | -2.400 | -17 | 6.067.600 | ||||
| 2014-09-05 | 2014-09-04 | 4 | ALNYLAM PHARMACEUTICALS, INC. | RGLS | Common Stock | D | 7,1094 | -6.000 | -43 | 6.070.000 | ||||
| 2014-09-05 | 2014-09-03 | 4 | ALNYLAM PHARMACEUTICALS, INC. | RGLS | Common Stock | D | 6,9519 | -1.650 | -11 | 6.076.000 | ||||
| 2014-09-05 | 2014-09-05 | 4 | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 7,0727 | -2.400 | -17 | 6.966.600 | ||||
| 2014-09-05 | 2014-09-04 | 4 | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 7,1094 | -6.000 | -43 | 6.969.000 | ||||
| 2014-09-05 | 2014-09-03 | 4 | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 6,9519 | -1.650 | -11 | 6.975.000 | ||||
| 2014-08-29 | 2014-08-28 | 4 | XANTHOPOULOS KLEANTHIS G | "RGLS" | Stock Option (Right to Buy) | D | 0,38 | -3.505 | 455.297 | |||||
| 2014-08-29 | 2014-08-28 | 4 | XANTHOPOULOS KLEANTHIS G | "RGLS" | Common Stock | D | 7,0626 | -3.505 | -25 | 0 | ||||
| 2014-08-29 | 2014-08-28 | 4 | XANTHOPOULOS KLEANTHIS G | "RGLS" | Common Stock | D | 0,3800 | 3.505 | 1 | 3.505 | ||||
| 2014-08-29 | 2014-08-29 | 4 | ALNYLAM PHARMACEUTICALS, INC. | "RGLS" | Common Stock | D | 6,8360 | -1.500 | -10 | 6.077.650 | ||||
| 2014-08-29 | 2014-08-28 | 4 | ALNYLAM PHARMACEUTICALS, INC. | "RGLS" | Common Stock | D | 6,9604 | -2.000 | -14 | 6.079.150 | ||||
| 2014-08-29 | 2014-08-27 | 4 | ALNYLAM PHARMACEUTICALS, INC. | "RGLS" | Common Stock | D | 7,2143 | -1.500 | -11 | 6.081.150 | ||||
| 2014-08-29 | 2014-08-29 | 4 | ISIS PHARMACEUTICALS INC | "RGLS" | Common Stock | D | 6,8360 | -1.500 | -10 | 6.976.650 | ||||
| 2014-08-29 | 2014-08-28 | 4 | ISIS PHARMACEUTICALS INC | "RGLS" | Common Stock | D | 6,9604 | -2.000 | -14 | 6.978.150 | ||||
| 2014-08-29 | 2014-08-27 | 4 | ISIS PHARMACEUTICALS INC | "RGLS" | Common Stock | D | 7,2143 | -1.500 | -11 | 6.980.150 | ||||
| 2014-08-22 | 2014-08-22 | 4 | ALNYLAM PHARMACEUTICALS, INC. | "RGLS" | Common Stock | D | 6,7510 | -5.250 | -35 | 6.082.650 | ||||
| 2014-08-22 | 2014-08-21 | 4 | ALNYLAM PHARMACEUTICALS, INC. | "RGLS" | Common Stock | D | 6,8889 | -2.500 | -17 | 6.087.900 | ||||
| 2014-08-22 | 2014-08-20 | 4 | ALNYLAM PHARMACEUTICALS, INC. | "RGLS" | Common Stock | D | 7,1412 | -3.000 | -21 | 6.090.400 | ||||
| 2014-08-22 | 2014-08-22 | 4 | ISIS PHARMACEUTICALS INC | "RGLS" | Common Stock | D | 6,7510 | -5.250 | -35 | 6.981.650 | ||||
| 2014-08-22 | 2014-08-21 | 4 | ISIS PHARMACEUTICALS INC | "RGLS" | Common Stock | D | 6,8889 | -2.500 | -17 | 6.986.900 | ||||
| 2014-08-22 | 2014-08-20 | 4 | ISIS PHARMACEUTICALS INC | "RGLS" | Common Stock | D | 7,1412 | -3.000 | -21 | 6.989.400 | ||||
| 2014-08-15 | 2014-08-15 | 4 | ALNYLAM PHARMACEUTICALS, INC. | "RGLS" | Common Stock | D | 6,9761 | -1.450 | -10 | 6.093.400 | ||||
| 2014-08-15 | 2014-08-14 | 4 | ALNYLAM PHARMACEUTICALS, INC. | "RGLS" | Common Stock | D | 7,0423 | -1.750 | -12 | 6.094.850 | ||||
| 2014-08-15 | 2014-08-13 | 4 | ALNYLAM PHARMACEUTICALS, INC. | "RGLS" | Common Stock | D | 7,0167 | -2.250 | -16 | 6.096.600 | ||||
| 2014-08-15 | 2014-08-15 | 4 | ISIS PHARMACEUTICALS INC | "RGLS" | Common Stock | D | 6,9761 | -1.450 | -10 | 6.992.400 | ||||
| 2014-08-15 | 2014-08-14 | 4 | ISIS PHARMACEUTICALS INC | "RGLS" | Common Stock | D | 7,0423 | -1.750 | -12 | 6.993.850 | ||||
| 2014-08-15 | 2014-08-13 | 4 | ISIS PHARMACEUTICALS INC | "RGLS" | Common Stock | D | 7,0167 | -2.250 | -16 | 6.995.600 | ||||
| 2014-08-08 | 2014-08-08 | 4 | ALNYLAM PHARMACEUTICALS, INC. | "RGLS" | Common Stock | D | 6,8014 | -1.850 | -13 | 6.098.850 | ||||
| 2014-08-08 | 2014-08-07 | 4 | ALNYLAM PHARMACEUTICALS, INC. | "RGLS" | Common Stock | D | 6,6623 | -2.600 | -17 | 6.100.700 | ||||
| 2014-08-08 | 2014-08-06 | 4 | ALNYLAM PHARMACEUTICALS, INC. | "RGLS" | Common Stock | D | 7,0794 | -3.150 | -22 | 6.103.300 | ||||
| 2014-08-08 | 2014-08-08 | 4 | ISIS PHARMACEUTICALS INC | "RGLS" | Common Stock | D | 6,8014 | -1.850 | -13 | 6.997.850 | ||||
| 2014-08-08 | 2014-08-07 | 4 | ISIS PHARMACEUTICALS INC | "RGLS" | Common Stock | D | 6,6623 | -2.600 | -17 | 6.999.700 | ||||
| 2014-08-08 | 2014-08-06 | 4 | ISIS PHARMACEUTICALS INC | "RGLS" | Common Stock | D | 7,0794 | -3.150 | -22 | 7.002.300 | ||||
| 2014-08-07 | 2014-08-05 | 4 | XANTHOPOULOS KLEANTHIS G | "RGLS" | Stock Option (Right to Buy) | D | 0,38 | -3.505 | 458.802 | |||||
| 2014-08-07 | 2014-08-05 | 4 | XANTHOPOULOS KLEANTHIS G | "RGLS" | Common Stock | D | 7,0583 | -3.505 | -25 | 0 | ||||
| 2014-08-07 | 2014-08-05 | 4 | XANTHOPOULOS KLEANTHIS G | "RGLS" | Common Stock | D | 0,3800 | 3.505 | 1 | 3.505 | ||||
| 2014-08-01 | 2014-08-01 | 4 | ALNYLAM PHARMACEUTICALS, INC. | "RGLS" | Common Stock | D | 6,2125 | -2.600 | -16 | 6.106.450 | ||||
| 2014-08-01 | 2014-07-31 | 4 | ALNYLAM PHARMACEUTICALS, INC. | "RGLS" | Common Stock | D | 6,4198 | -1.750 | -11 | 6.109.050 | ||||
| 2014-08-01 | 2014-07-30 | 4 | ALNYLAM PHARMACEUTICALS, INC. | "RGLS" | Common Stock | D | 6,6021 | -1.000 | -7 | 6.110.800 | ||||
| 2014-08-01 | 2014-08-01 | 4 | ISIS PHARMACEUTICALS INC | "RGLS" | Common Stock | D | 6,2125 | -2.600 | -16 | 7.005.450 | ||||
| 2014-08-01 | 2014-07-31 | 4 | ISIS PHARMACEUTICALS INC | "RGLS" | Common Stock | D | 6,4198 | -1.750 | -11 | 7.008.050 | ||||
| 2014-08-01 | 2014-07-30 | 4 | ISIS PHARMACEUTICALS INC | "RGLS" | Common Stock | D | 6,6021 | -1.000 | -7 | 7.009.800 | ||||
| 2014-07-25 | 2014-07-25 | 4 | ALNYLAM PHARMACEUTICALS, INC. | "RGLS" | Common Stock | D | 6,5509 | -1.700 | -11 | 6.111.800 | ||||
| 2014-07-25 | 2014-07-24 | 4 | ALNYLAM PHARMACEUTICALS, INC. | "RGLS" | Common Stock | D | 6,8097 | -1.850 | -13 | 6.113.500 | ||||
| 2014-07-25 | 2014-07-23 | 4 | ALNYLAM PHARMACEUTICALS, INC. | "RGLS" | Common Stock | D | 6,8835 | -1.700 | -12 | 6.115.350 | ||||
| 2014-07-25 | 2014-07-25 | 4 | ISIS PHARMACEUTICALS INC | "RGLS" | Common Stock | D | 6,5509 | -1.700 | -11 | 7.010.800 | ||||
| 2014-07-25 | 2014-07-24 | 4 | ISIS PHARMACEUTICALS INC | "RGLS" | Common Stock | D | 6,8097 | -1.850 | -13 | 7.012.500 | ||||
| 2014-07-25 | 2014-07-23 | 4 | ISIS PHARMACEUTICALS INC | "RGLS" | Common Stock | D | 6,8835 | -1.700 | -12 | 7.014.350 | ||||
| 2014-07-18 | 2014-07-18 | 4 | ALNYLAM PHARMACEUTICALS, INC. | "RGLS" | Common Stock | D | 6,8002 | -5.000 | -34 | 6.117.050 | ||||
| 2014-07-18 | 2014-07-17 | 4 | ALNYLAM PHARMACEUTICALS, INC. | "RGLS" | Common Stock | D | 6,5812 | -5.000 | -33 | 6.122.050 | ||||
| 2014-07-18 | 2014-07-16 | 4 | ALNYLAM PHARMACEUTICALS, INC. | "RGLS" | Common Stock | D | 6,5881 | -3.500 | -23 | 6.127.050 | ||||
| 2014-07-18 | 2014-07-18 | 4 | ISIS PHARMACEUTICALS INC | "RGLS" | Common Stock | D | 6,8002 | -5.000 | -34 | 7.016.050 | ||||
| 2014-07-18 | 2014-07-17 | 4 | ISIS PHARMACEUTICALS INC | "RGLS" | Common Stock | D | 6,5812 | -5.000 | -33 | 7.021.050 | ||||
| 2014-07-18 | 2014-07-16 | 4 | ISIS PHARMACEUTICALS INC | "RGLS" | Common Stock | D | 6,5881 | -3.500 | -23 | 7.026.050 | ||||
| 2014-07-11 | 2014-07-11 | 4 | ALNYLAM PHARMACEUTICALS, INC. | "RGLS" | Common Stock | D | 6,4797 | -1.750 | -11 | 6.130.550 | ||||
| 2014-07-11 | 2014-07-10 | 4 | ALNYLAM PHARMACEUTICALS, INC. | "RGLS" | Common Stock | D | 6,6908 | -4.500 | -30 | 6.132.300 | ||||
| 2014-07-11 | 2014-07-09 | 4 | ALNYLAM PHARMACEUTICALS, INC. | "RGLS" | Common Stock | D | 7,0824 | -1.800 | -13 | 6.136.800 | ||||
| 2014-07-11 | 2014-07-11 | 4 | ISIS PHARMACEUTICALS INC | "RGLS" | Common Stock | D | 6,4797 | -1.750 | -11 | 7.029.550 | ||||
| 2014-07-11 | 2014-07-10 | 4 | ISIS PHARMACEUTICALS INC | "RGLS" | Common Stock | D | 6,6908 | -4.500 | -30 | 7.031.300 | ||||
| 2014-07-11 | 2014-07-09 | 4 | ISIS PHARMACEUTICALS INC | "RGLS" | Common Stock | D | 7,0824 | -1.800 | -13 | 7.035.800 | ||||
| 2014-07-07 | 2014-07-03 | 4 | ALNYLAM PHARMACEUTICALS, INC. | "RGLS" | Common Stock | D | 8,0653 | -1.200 | -10 | 6.138.600 | ||||
| 2014-07-07 | 2014-07-02 | 4 | ALNYLAM PHARMACEUTICALS, INC. | "RGLS" | Common Stock | D | 8,0680 | -3.100 | -25 | 6.139.800 | ||||
| 2014-07-07 | 2014-07-03 | 4 | ISIS PHARMACEUTICALS INC | "RGLS" | Common Stock | D | 8,0653 | -1.200 | -10 | 7.037.600 | ||||
| 2014-07-07 | 2014-07-02 | 4 | ISIS PHARMACEUTICALS INC | "RGLS" | Common Stock | D | 8,0680 | -3.100 | -25 | 7.038.800 | ||||
| 2014-07-02 | 2014-07-01 | 4 | XANTHOPOULOS KLEANTHIS G | "RGLS" | Stock Option (Right to Buy) | D | 0,38 | -3.505 | 462.307 | |||||
| 2014-07-02 | 2014-07-01 | 4 | XANTHOPOULOS KLEANTHIS G | "RGLS" | Common Stock | D | 8,1100 | -3.505 | -28 | 0 | ||||
| 2014-07-02 | 2014-07-01 | 4 | XANTHOPOULOS KLEANTHIS G | "RGLS" | Common Stock | D | 0,3800 | 3.505 | 1 | 3.505 | ||||
| 2014-07-02 | 2014-07-01 | 4 | Gibson Neil W | "RGLS" | Stock Option (Right to Buy) | D | 1,74 | -2.500 | 124.000 | |||||
| 2014-07-02 | 2014-07-01 | 4 | Gibson Neil W | "RGLS" | Common Stock | D | 8,1040 | -2.500 | -20 | 80.000 | ||||
| 2014-07-02 | 2014-07-01 | 4 | Gibson Neil W | "RGLS" | Common Stock | D | 1,7400 | 2.500 | 4 | 82.500 | ||||
| 2014-06-27 | 2014-06-27 | 4 | ALNYLAM PHARMACEUTICALS, INC. | "RGLS" | Common Stock | D | 7,9146 | -3.150 | -25 | 6.142.900 | ||||
| 2014-06-27 | 2014-06-26 | 4 | ALNYLAM PHARMACEUTICALS, INC. | "RGLS" | Common Stock | D | 7,8870 | -1.700 | -13 | 6.146.050 | ||||
| 2014-06-27 | 2014-06-25 | 4 | ALNYLAM PHARMACEUTICALS, INC. | "RGLS" | Common Stock | D | 7,8421 | -2.750 | -22 | 6.147.750 | ||||
| 2014-06-27 | 2014-06-27 | 4 | ISIS PHARMACEUTICALS INC | "RGLS" | Common Stock | D | 7,9146 | -3.150 | -25 | 7.041.900 | ||||
| 2014-06-27 | 2014-06-26 | 4 | ISIS PHARMACEUTICALS INC | "RGLS" | Common Stock | D | 7,8870 | -1.700 | -13 | 7.045.050 | ||||
| 2014-06-27 | 2014-06-25 | 4 | ISIS PHARMACEUTICALS INC | "RGLS" | Common Stock | D | 7,8421 | -2.750 | -22 | 7.046.750 | ||||
| 2014-06-18 | 2014-03-06 | 4/A | Gibson Neil W | "RGLS" | Stock Option (Right to Buy) | D | 1,74 | -2.500 | 91 | |||||
| 2014-06-18 | 2014-04-09 | 4/A | Gibson Neil W | "RGLS" | Stock Option (Right to Buy) | D | 1,74 | -2.409 | 131.500 | |||||
| 2014-06-18 | 2014-04-09 | 4/A | Gibson Neil W | "RGLS" | Stock Option (Right to Buy) | D | 1,74 | -91 | 0 | |||||
| 2014-06-18 | 2014-06-16 | 4 | GRINT PAUL C | "RGLS" | Employee Stock Option (Right to Buy) | D | 7,58 | 250.000 | 250.000 | |||||
| 2014-06-18 | 2014-06-17 | 4 | Gibson Neil W | "RGLS" | Stock Option (Right to Buy) | D | 1,74 | -5.000 | 126.500 | |||||
| 2014-06-18 | 2014-06-17 | 4 | Gibson Neil W | "RGLS" | Common Stock | D | 8,0454 | -5.000 | -40 | 80.000 | ||||
| 2014-06-18 | 2014-06-17 | 4 | Gibson Neil W | "RGLS" | Common Stock | D | 1,7400 | 5.000 | 9 | 85.000 | ||||
| 2014-06-09 | 2014-06-09 | 4 | XANTHOPOULOS KLEANTHIS G | "RGLS" | Stock Option (Right to Buy) | D | 0,38 | -3.505 | 465.812 | |||||
| 2014-06-09 | 2014-06-09 | 4 | XANTHOPOULOS KLEANTHIS G | "RGLS" | Common Stock | D | 7,1376 | -3.505 | -25 | 0 | ||||
| 2014-06-09 | 2014-06-09 | 4 | XANTHOPOULOS KLEANTHIS G | "RGLS" | Common Stock | D | 0,3800 | 3.505 | 1 | 3.505 | ||||
| 2014-05-29 | 2014-05-29 | 4 | XANTHOPOULOS KLEANTHIS G | "RGLS" | Stock Option (Right to Buy) | D | 0,38 | -887 | 469.317 | |||||
| 2014-05-29 | 2014-05-29 | 4 | XANTHOPOULOS KLEANTHIS G | "RGLS" | Common Stock | D | 7,0000 | -887 | -6 | 0 | ||||
| 2014-05-29 | 2014-05-29 | 4 | XANTHOPOULOS KLEANTHIS G | "RGLS" | Common Stock | D | 0,3800 | 887 | 0 | 887 | ||||
| 2014-05-29 | 2014-05-28 | 4 | XANTHOPOULOS KLEANTHIS G | "RGLS" | Stock Option (Right to Buy) | D | 0,38 | -875 | 470.204 | |||||
| 2014-05-29 | 2014-05-28 | 4 | XANTHOPOULOS KLEANTHIS G | "RGLS" | Common Stock | D | 7,0011 | -875 | -6 | 0 | ||||
| 2014-05-29 | 2014-05-28 | 4 | XANTHOPOULOS KLEANTHIS G | "RGLS" | Common Stock | D | 0,3800 | 875 | 0 | 875 | ||||
| 2014-05-29 | 2014-05-27 | 4 | XANTHOPOULOS KLEANTHIS G | "RGLS" | Stock Option (Right to Buy) | D | 0,38 | -1.743 | 471.079 | |||||
| 2014-05-29 | 2014-05-27 | 4 | XANTHOPOULOS KLEANTHIS G | "RGLS" | Common Stock | D | 7,0011 | -1.743 | -12 | 0 | ||||
| 2014-05-29 | 2014-05-27 | 4 | XANTHOPOULOS KLEANTHIS G | "RGLS" | Common Stock | D | 0,3800 | 1.743 | 1 | 1.743 | ||||
| 2014-05-22 | 2014-05-22 | 4 | CARTER BRUCE L A | "RGLS" | Stock Option (Right to Buy) | D | 6,22 | 17.500 | 17.500 | |||||
| 2014-05-22 | 2014-05-22 | 4 | BALTIMORE DAVID | "RGLS" | Stock Option (Right to Buy) | D | 6,22 | 5.000 | 5.000 | |||||
| 2014-05-22 | 2014-05-22 | 4 | BALTIMORE DAVID | "RGLS" | Stock Option (Right to Buy) | D | 6,22 | 17.500 | 17.500 | |||||
| 2014-05-22 | 2014-05-22 | 4 | PAPADOPOULOS STELIOS | "RGLS" | Stock Option (Right to Buy) | D | 6,22 | 17.500 | 17.500 | |||||
| 2014-05-22 | 2014-05-22 | 4 | FOLETTA MARK G | "RGLS" | Stock Option (Right to Buy) | D | 6,22 | 17.500 | 17.500 | |||||
| 2014-05-22 | 2014-05-22 | 4 | RASTETTER WILLIAM H | "RGLS" | Stock Option (Right to Buy) | D | 6,22 | 17.500 | 17.500 | |||||
| 2014-05-22 | 2014-05-22 | 4 | WILLIAMS DOUGLAS E | "RGLS" | Stock Option (Right to Buy) | D | 6,22 | 17.500 | 17.500 | |||||
| 2014-04-10 | 2014-04-09 | 4 | Gibson Neil W | "RGLS" | Stock Option (Right to Buy) | D | 1,74 | -2.500 | 42.591 | |||||
| 2014-04-10 | 2014-04-09 | 4 | Gibson Neil W | "RGLS" | Common Stock | D | 8,1085 | -2.500 | -20 | 80.000 | ||||
| 2014-04-10 | 2014-04-09 | 4 | Gibson Neil W | "RGLS" | Common Stock | D | 1,7400 | 2.500 | 4 | 82.500 | ||||
| 2014-04-09 | 2014-04-08 | 4 | XANTHOPOULOS KLEANTHIS G | "RGLS" | Stock Option (Right to Buy) | D | 0,38 | -3.505 | 472.822 | |||||
| 2014-04-09 | 2014-03-06 | 4 | XANTHOPOULOS KLEANTHIS G By the Xanthopoulos Family Trust dated September 30, 2011 | "RGLS" | Common Stock | I | 7,5957 | -3.505 | -27 | 80.216 | ||||
| 2014-04-09 | 2014-03-06 | 4 | XANTHOPOULOS KLEANTHIS G By the Xanthopoulos Family Trust dated September 30, 2011 | "RGLS" | Common Stock | I | 0,3800 | 3.505 | 1 | 83.721 | ||||
| 2014-03-07 | 2014-03-06 | 4 | XANTHOPOULOS KLEANTHIS G | "RGLS" | Stock Option (Right to Buy) | D | 0,38 | -3.505 | 476.327 | |||||
| 2014-03-07 | 2014-03-06 | 4 | XANTHOPOULOS KLEANTHIS G By the Xanthopoulos Family Trust dated September 30, 2011 | "RGLS" | Common Stock | I | 11,3490 | -3.505 | -40 | 80.216 | ||||
| 2014-03-07 | 2014-03-06 | 4 | XANTHOPOULOS KLEANTHIS G By the Xanthopoulos Family Trust dated September 30, 2011 | "RGLS" | Common Stock | I | 0,3800 | 3.505 | 1 | 83.721 | ||||
| 2014-03-07 | 2014-03-06 | 4 | Gibson Neil W | "RGLS" | Stock Option (Right to Buy) | D | 1,74 | -2.500 | 45.091 | |||||
| 2014-03-07 | 2014-03-06 | 4 | Gibson Neil W | "RGLS" | Common Stock | D | 11,3714 | -2.500 | -28 | 80.000 | ||||
| 2014-03-07 | 2014-03-06 | 4 | Gibson Neil W | "RGLS" | Common Stock | D | 1,7400 | 2.500 | 4 | 82.500 | ||||
| 2014-02-07 | 2014-02-05 | 4 | XANTHOPOULOS KLEANTHIS G | "RGLS" | Stock Option (Right to Buy) | D | 0,38 | -3.505 | 479.832 | |||||
| 2014-02-07 | 2014-02-05 | 4 | XANTHOPOULOS KLEANTHIS G By the Xanthopoulos Family Trust dated September 30, 2011 | "RGLS" | Common Stock | I | 8,3987 | -3.505 | -29 | 80.216 | ||||
| 2014-02-07 | 2014-02-05 | 4 | XANTHOPOULOS KLEANTHIS G By the Xanthopoulos Family Trust dated September 30, 2011 | "RGLS" | Common Stock | I | 0,3800 | 3.505 | 1 | 83.721 | ||||
| 2014-02-07 | 2014-02-06 | 4 | Gibson Neil W | "RGLS" | Stock Option (Right to Buy) | D | 1,74 | -45.000 | 2.591 | |||||
| 2014-02-07 | 2014-02-06 | 4 | Gibson Neil W | "RGLS" | Common Stock | D | 1,7400 | 45.000 | 78 | 80.000 | ||||
| 2014-02-07 | 2014-02-05 | 4 | Gibson Neil W | "RGLS" | Stock Option (Right to Buy) | D | 1,74 | -2.500 | 47.591 | |||||
| 2014-02-07 | 2014-02-05 | 4 | Gibson Neil W | "RGLS" | Common Stock | D | 8,3832 | -17.500 | -147 | 35.000 | ||||
| 2014-02-07 | 2014-02-05 | 4 | Gibson Neil W | "RGLS" | Common Stock | D | 1,7400 | 2.500 | 4 | 52.500 | ||||
| 2014-02-05 | 2014-02-04 | 4 | Sanofi | RGLS | Common stock, $ 0.001 par value- | I | 7,6700 | 1.303.780 | 10.000 | 5.053.779 | ||||
| 2014-01-23 | 2014-01-21 | 4 | Gibson Neil W | RGLS | Stock Option (Right to Buy) | D | 2,66 | -4.421 | 701 | |||||
| 2014-01-23 | 2014-01-21 | 4 | Gibson Neil W | RGLS | Common Stock | D | 8,0896 | -4.421 | -36 | 50.000 | ||||
| 2014-01-23 | 2014-01-21 | 4 | Gibson Neil W | RGLS | Common Stock | D | 2,6600 | 4.421 | 12 | 54.421 | ||||
| 2014-01-21 | 2014-01-17 | 4 | Gibson Neil W | RGLS | Stock Option (Right to Buy) | D | 2,66 | -2.079 | 5.122 | |||||
| 2014-01-21 | 2014-01-17 | 4 | Gibson Neil W | RGLS | Stock Option (Right to Buy) | D | 1,74 | -2.400 | 50.091 | |||||
| 2014-01-21 | 2014-01-17 | 4 | Gibson Neil W | RGLS | Common Stock | D | 8,1477 | -4.479 | -36 | 50.000 | ||||
| 2014-01-21 | 2014-01-17 | 4 | Gibson Neil W | RGLS | Common Stock | D | 2,6600 | 2.079 | 6 | 54.479 | ||||
| 2014-01-21 | 2014-01-17 | 4 | Gibson Neil W | RGLS | Common Stock | D | 1,7400 | 2.400 | 4 | 52.400 | ||||
| 2014-01-17 | 2014-01-16 | 4 | Gibson Neil W | RGLS | Stock Option (Right to Buy) | D | 1,74 | -1.100 | 52.491 | |||||
| 2014-01-17 | 2014-01-16 | 4 | Gibson Neil W | RGLS | Common Stock | D | 8,0336 | -1.100 | -9 | 50.000 | ||||
| 2014-01-17 | 2014-01-16 | 4 | Gibson Neil W | RGLS | Common Stock | D | 1,7400 | 1.100 | 2 | 51.100 | ||||
| 2014-01-02 | 2014-01-02 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Stock Option (Right to Buy) | D | 0,38 | -3.505 | 483.337 | |||||
| 2014-01-02 | 2014-01-02 | 4 | XANTHOPOULOS KLEANTHIS G By the Xanthopoulos Family Trust dated September 30, 2011 | RGLS | Common Stock | I | 7,2492 | -3.505 | -25 | 80.216 | ||||
| 2014-01-02 | 2014-01-02 | 4 | XANTHOPOULOS KLEANTHIS G By the Xanthopoulos Family Trust dated September 30, 2011 | RGLS | Common Stock | I | 0,3800 | 3.505 | 1 | 83.721 | ||||
| 2013-12-16 | 2013-12-16 | 4 | XANTHOPOULOS KLEANTHIS G By the Xanthopoulos Family Trust dated September 30, 2011 | RGLS | Common Stock | I | -2.000 | 80.216 | ||||||
| 2013-12-16 | 2013-12-12 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Stock Option (Right to Buy) | D | 6,13 | 220.000 | 220.000 | |||||
| 2013-12-16 | 2013-12-12 | 4 | Gibson Neil W | RGLS | Stock Option (Right to Buy) | D | 6,13 | 100.000 | 100.000 | |||||
| 2013-06-10 | 2013-06-10 | 4 | BALTIMORE DAVID | RGLS | Stock Option (Right to Buy) | D | 9,32 | 5.000 | 5.000 | |||||
| 2013-06-10 | 2013-06-10 | 4 | BALTIMORE DAVID | RGLS | Stock Option (Right to Buy) | D | 9,32 | 17.500 | 17.500 | |||||
| 2013-06-10 | 2013-06-10 | 4 | RASTETTER WILLIAM H | RGLS | Stock Option (Right to Buy) | D | 9,32 | 17.500 | 17.500 | |||||
| 2013-06-10 | 2013-06-10 | 4 | PAPADOPOULOS STELIOS | RGLS | Stock Option (Right to Buy) | D | 9,32 | 17.500 | 17.500 | |||||
| 2013-06-10 | 2013-06-10 | 4 | WILLIAMS DOUGLAS E | RGLS | Stock Option (Right to Buy) | D | 9,32 | 17.500 | 17.500 | |||||
| 2013-06-10 | 2013-06-10 | 4 | FOLETTA MARK G | RGLS | Stock Option (Right to Buy) | D | 9,32 | 17.500 | 17.500 | |||||
| 2013-06-10 | 2013-06-10 | 4 | CARTER BRUCE L A | RGLS | Stock Option (Right to Buy) | D | 9,32 | 17.500 | 17.500 | |||||
| 2013-04-01 | 3 | RASTETTER WILLIAM H | RGLS | Common Stock | D | 0 | ||||||||
| 2013-04-01 | 2013-04-01 | 4 | RASTETTER WILLIAM H | RGLS | Stock Option (Right to Buy) | D | 7,67 | 30.000 | 30.000 | |||||
| 2013-02-14 | 2013-02-04 | 4 | Gibson Neil W | RGLS | Stock Option (Right to Buy) | D | 1,74 | 50.000 | 133.909 | |||||
| 2013-02-14 | 2013-02-04 | 4 | Gibson Neil W | RGLS | Common Stock | D | 1,7400 | 50.000 | 87 | 50.000 | ||||
| 2013-01-31 | 3 | FOLETTA MARK G | RGLS | Common Stock | D | 0 | ||||||||
| 2013-01-31 | 2013-01-30 | 4 | FOLETTA MARK G | RGLS | Stock Option (Right to Buy) | D | 5,98 | 30.000 | 30.000 | |||||
| 2012-12-13 | 2012-12-11 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Stock Option (Right to Buy) | D | 4,44 | 150.000 | 150.000 | |||||
| 2012-12-13 | 2012-12-11 | 4 | Gibson Neil W | RGLS | Stock Option (Right to Buy) | D | 4,44 | 112.500 | 112.500 | |||||
| 2012-12-13 | 2012-12-11 | 4 | Menzel Garry E | RGLS | Stock Option (Right to Buy) | D | 4,44 | 75.000 | 75.000 | |||||
| 2012-11-08 | 3 | WILLIAMS DOUGLAS E | RGLS | Common Stock | D | 0 | ||||||||
| 2012-11-08 | 2012-11-07 | 4 | CARTER BRUCE L A | RGLS | Stock Option (Right to Buy) | D | 4,97 | -15.000 | 15.000 | |||||
| 2012-11-08 | 2012-10-31 | 4 | CARTER BRUCE L A | RGLS | Stock Option (Right to Buy) | D | 4,78 | -30.000 | 30.000 | |||||
| 2012-11-08 | 2012-11-05 | 4 | WILLIAMS DOUGLAS E | RGLS | Stock Option (Right to Buy) | D | 5,03 | 30.000 | 30.000 | |||||
| 2012-11-07 | 2012-11-05 | 4 | Greene Barry E | RGLS | Stock Option (Right to Buy) | D | 5,03 | 25.000 | 25.000 | |||||
| 2012-11-07 | 2012-11-05 | 4 | CROOKE STANLEY T | RGLS | Stock Option (Right to Buy) | D | 5,03 | 25.000 | 25.000 | |||||
| 2012-10-12 | 3 | ASTRAZENECA AB | RGLS | COMMON STOCK | I | 6.250.000 | ||||||||
| 2012-10-11 | 2012-10-10 | 4 | PARSHALL B LYNNE | RGLS | Series A Preferred Stock | I | -6.299.500 | 0 | ||||||
| 2012-10-11 | 2012-10-10 | 4 | PARSHALL B LYNNE | RGLS | Common Stock | I | 4,0000 | 750.000 | 3.000 | 7.049.500 | ||||
| 2012-10-11 | 2012-10-10 | 4 | PARSHALL B LYNNE | RGLS | Common Stock | I | 6.299.500 | 6.299.500 | ||||||
| 2012-10-11 | 2012-10-10 | 4 | MARAGANORE JOHN | RGLS | Series A Preferred Stock | I | -6.150.500 | 0 | ||||||
| 2012-10-11 | 2012-10-10 | 4 | MARAGANORE JOHN | RGLS | Common Stock | I | 6.150.500 | 6.150.500 | ||||||
| 2012-10-11 | 2012-10-10 | 4 | Greene Barry E | RGLS | Series A Preferred Stock | I | -6.150.500 | 0 | ||||||
| 2012-10-11 | 2012-10-10 | 4 | Greene Barry E | RGLS | Common Stock | I | 6.150.500 | 6.150.500 | ||||||
| 2012-10-11 | 2012-10-10 | 4 | ALNYLAM PHARMACEUTICALS, INC. | RGLS | Series A Preferred Stock | D | -6.150.500 | 0 | ||||||
| 2012-10-11 | 2012-10-10 | 4 | ALNYLAM PHARMACEUTICALS, INC. | RGLS | Common Stock | D | 6.150.500 | 6.150.500 | ||||||
| 2012-10-11 | 2012-10-10 | 4 | ISIS PHARMACEUTICALS INC | RGLS | Series A Preferred Stock | D | -6.299.500 | 0 | ||||||
| 2012-10-11 | 2012-10-10 | 4 | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 4,0000 | 750.000 | 3.000 | 7.049.500 | ||||
| 2012-10-11 | 2012-10-10 | 4 | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 6.299.500 | 6.299.500 | ||||||
| 2012-10-11 | 2012-10-10 | 4 | CROOKE STANLEY T | RGLS | Series A Preferred Stock | I | -6.299.500 | 0 | ||||||
| 2012-10-11 | 2012-10-10 | 4 | CROOKE STANLEY T | RGLS | Common Stock | I | 4,0000 | 750.000 | 3.000 | 7.049.500 | ||||
| 2012-10-11 | 2012-10-10 | 4 | CROOKE STANLEY T | RGLS | Common Stock | I | 6.299.500 | 6.299.500 | ||||||
| 2012-10-09 | 3 | Sanofi | RGLS | Common Stock | I | 3.749.999 | ||||||||
| 2012-10-04 | 3 | XANTHOPOULOS KLEANTHIS G By the Xanthopoulos Family Trust dated September 30, 2011 | RGLS | Common Stock | I | 82.216 | ||||||||
| 2012-10-04 | 3 | Menzel Garry E By the Garry E. Menzel and Mary E. Henshall Family Trust | RGLS | Common Stock | I | 111.842 |
P
Åbent marked eller privat køb af ikke-afledte eller afledte værdipapirer
S
Åbent marked eller privat salg af ikke-afledte eller afledte værdipapirer
A
Tildeling, tildeling eller anden erhvervelse af værdipapirer fra virksomheden (såsom en option)
C
Konvertering af derivat
D
Salg eller overførsel af værdipapirer tilbage til virksomheden
F
Betaling af udnyttelseskurs eller skatteforpligtelse ved brug af en del af værdipapirer modtaget fra selskabet
G
Gave af værdipapirer af eller til insideren
K
Aktieswaps og lignende sikringstransaktioner
M
Udnyttelse eller konvertering af afledt værdipapir modtaget fra virksomheden (såsom en option)
V
En transaktion rapporteret frivilligt på formular 4
J
Andet (ledsaget af en fodnote, der beskriver transaktionen)
