Ionis Pharmaceuticals, Inc.
US ˙ NasdaqGS ˙ US4622221004

Introduktion

Denne side giver en omfattende analyse af den kendte insiderhandelshistorie for Stanley T Crooke. Insidere er embedsmænd, direktører eller betydelige investorer i en virksomhed. Det er ulovligt for insidere at foretage handler i deres virksomheder baseret på specifik, ikke-offentlig information. Dette betyder ikke, at det er ulovligt for dem at handle i deres egne virksomheder. De skal dog rapportere alle handler til SEC via en formular 4. På trods af disse begrænsninger tyder akademisk forskning på, at insidere - generelt - har en tendens til at klare sig bedre end markedet i deres egne virksomheder.

Gennemsnitlig handelsrentabilitet

Den gennemsnitlige handelsrentabilitet er det gennemsnitlige afkast af alle køb på det åbne marked foretaget af insideren i de sidste tre år. For at beregne dette undersøger vi ethvert åbent marked, uplanlagte køb foretaget af insideren, eksklusive alle handler, der var markeret som en del af en 10b5-1-handelsplan. Vi beregner derefter den gennemsnitlige præstation for disse handler over 3, 6 og 12 måneder, idet vi tager et gennemsnit af hver af disse varigheder for at generere en endelig præstationsmåling for hver handel. Endelig tager vi et gennemsnit af alle præstationsmålingerne for at beregne en præstationsmåling for insideren. Denne liste inkluderer kun insidere, der har foretaget mindst tre handler i de sidste to år.

Hvis denne insiderhandelsrentabilitet er "N/A", så har insideren enten ikke foretaget nogen køb på det åbne marked i de sidste tre år, eller de handler, de har foretaget, er for nye til at beregne en pålidelig præstationsmåling.

Opdateringsfrekvens: Dagligt

Se listen over de mest profitable insiderhandlere.

Virksomheder med rapporterede insider-stillinger

SEC-registreringen viser, at Stanley T Crooke har rapporteret besiddelser eller handler i følgende virksomheder:

Sikkerhed Titel Senest indberettede beholdninger
US:IONS / Ionis Pharmaceuticals, Inc. Exec Chairman of the Board, Director 2.021
Director 0
US:RGLS / Regulus Therapeutics Inc. Director, 10% Owner 25.000
Sådan fortolkes diagrammerne

Følgende diagrammer viser aktieudviklingen for værdipapirer efter hver åben-marked, ikke-planlagt handel foretaget af Stanley T Crooke. Ikke-planlagt handel er handler, der ikke blev foretaget som en del af en 10b5-1-handelsplan. Aktieudviklingen er kortlagt som den kumulative procentvise ændring i aktiekursen. For eksempel, hvis en insiderhandel blev foretaget den 1. januar 2019, vil diagrammet vise den daglige procentvise ændring af værdipapiret til i dag. Hvis aktiekursen skulle gå fra $10 til $15 i løbet af denne tid, ville den kumulative procentvise ændring i aktiekursen være 50%. En prisændring fra 10 USD til 20 USD ville være 100 %, og en ændring i prisen på 10 USD til 5 USD ville være -50 %.

I sidste ende forsøger vi at bestemme, hvor tæt insiderens handler korrelerer med merafkast (positive eller negative) i aktiekursen for at se, om insideren timing deres handler til at drage fordel af insiderinformation. Overvej situationen, hvor en insider gjorde dette. I denne situation ville vi forvente enten (a) positive afkast efter køb eller (b) negative afkast efter salg. I tilfælde af (a) vil KØB-diagrammet vise en række opadskrånende kurver, der indikerer positive afkast efter hver købstransaktion. I tilfælde af (b) vil SALE-diagrammet vise en række nedadgående kurver, der indikerer negative afkast efter hver salgstransaktion.

Dette alene er dog ikke nok til at drage konklusioner. Hvis for eksempel aktiekursen i selskabet var i en ikke-cyklisk stigning over mange år, så ville vi forvente, at alle efterkøbsgrundene var opadgående. Ligeledes ville ikke-cykliske fald over mange år resultere i nedadgående post-trade plots. Ingen af disse diagrammer tyder på insiderhandel.

Den stærkeste indikator ville være en situation, hvor aktiekursen var ekstremt cyklisk, og der var både positive signaler i KØB-diagrammet og negative plots på SALG-diagrammet. Denne situation ville i høj grad tyde på en insider, der havde timing af handler til deres økonomiske fordel.

Insiderkøb IONS / Ionis Pharmaceuticals, Inc. – kortsigtet profitanalyse

I dette afsnit analyserer vi rentabiliteten af ethvert uplanlagt insiderkøb i åbent marked foretaget i IONS / Ionis Pharmaceuticals, Inc.. Denne analyse hjælper med at forstå, om insideren konsekvent genererer unormale afkast og er værd at følge. Denne analyse er for et år efter hver handel, og resultaterne er teoretiske .

Følgende tabel viser de seneste køb på det åbne marked, der ikke var en del af en automatisk handelsplan.

Handelsdato Ticker Insider Rapporteret
Aktier
Rapporteret
Pris
Justeret
Aktier
Justeret
Pris
Omkostningsgrundlag dage til
Maks
Pris kl
Maks
Maks
Fortjeneste ($)
Maks. afkast (%)
Der er ingen kendte uplanlagte åbne markedshandler for denne insider- og sikkerhedskombination

Justeret pris er den split-justerede pris. Adjusted Shares er de split-justerede aktier.

IONS / Ionis Pharmaceuticals, Inc. Insider Trades
Insidersalg IONS / Ionis Pharmaceuticals, Inc. – kortsigtet tabsanalyse

I dette afsnit analyserer vi den kortsigtede undgåelse af tab af ethvert uplanlagt insidersalg på åbent marked, der foretages i IONS / Ionis Pharmaceuticals, Inc.. Et konsekvent mønster af tabsforebyggelse kan tyde på, at fremtidige salgstransaktioner kan forudsige prisfald. Denne analyse er for et år efter hver handel, og resultaterne er teoretiske .

Følgende tabel viser de seneste salg på det åbne marked, der ikke var en del af en automatisk handelsplan.

Handelsdato Ticker Insider Rapporteret
Aktier
Rapporteret
Pris
Justeret
Aktier
Justeret
Pris
Omkostningsgrundlag dage til
Min
Pris kl
Min
Max tab
Undgået ($)
Max tab
Undgået (%)
2020-03-17 IONS CROOKE STANLEY T 4.579 44,5000 4.579 44,5000 203.766 6 41.6000 -13.279 -6,52
2020-03-17 IONS CROOKE STANLEY T 5.421 44,5000 5.421 44,5000 241.234
2020-03-17 IONS CROOKE STANLEY T 5.651 45,0000 5.651 45,0000 254.295
2020-03-17 IONS CROOKE STANLEY T 4.349 45,0000 4.349 45,0000 195.705
2018-01-15 IONS CROOKE STANLEY T 15.893 51,7600 15.893 51,7600 822.622
2018-01-15 IONS CROOKE STANLEY T 656 51,7600 656 51,7600 33.955
2017-01-17 IONS CROOKE STANLEY T 3.008 46,2890 3.008 46,2890 139.237
2017-01-17 IONS CROOKE STANLEY T 4.236 46,2890 4.236 46,2890 196.080
2017-01-17 IONS CROOKE STANLEY T 3.728 46,2900 3.728 46,2900 172.569
2017-01-17 IONS CROOKE STANLEY T 4.410 46,2900 4.410 46,2900 204.139
2017-01-17 IONS CROOKE STANLEY T 163 46,2910 163 46,2910 7.545
2017-01-17 IONS CROOKE STANLEY T 139 46,2900 139 46,2900 6.434
2017-01-17 IONS CROOKE STANLEY T 142 46,2910 142 46,2910 6.573
2017-01-17 IONS CROOKE STANLEY T 131 46,2900 131 46,2900 6.064
2016-01-19 IONS CROOKE STANLEY T 1.645 41,4582 1.645 41,4582 68.199
2016-01-19 IONS CROOKE STANLEY T 3.065 41,4582 3.065 41,4582 127.069
2016-01-19 IONS CROOKE STANLEY T 4.317 41,4551 4.317 41,4551 178.962
2016-01-19 IONS CROOKE STANLEY T 3.798 41,4655 3.798 41,4655 157.486
2016-01-19 IONS CROOKE STANLEY T 124 41,4610 124 41,4610 5.141
2016-01-19 IONS CROOKE STANLEY T 166 41,4626 166 41,4626 6.883
2016-01-19 IONS CROOKE STANLEY T 141 41,4633 141 41,4633 5.846
2016-01-19 IONS CROOKE STANLEY T 145 41,4600 145 41,4600 6.012
2015-01-16 ISIS CROOKE STANLEY T 1.574 67,9640 1.574 67,9640 106.975
2015-01-16 ISIS CROOKE STANLEY T 2.933 67,9640 2.933 67,9640 199.338
2015-01-16 ISIS CROOKE STANLEY T 4.130 67,9645 4.130 67,9645 280.693
2015-01-16 ISIS CROOKE STANLEY T 121 67,9640 121 67,9640 8.224
2015-01-16 ISIS CROOKE STANLEY T 160 67,9640 160 67,9640 10.874
2015-01-16 ISIS CROOKE STANLEY T 136 67,9640 136 67,9640 9.243
2014-01-16 ISIS CROOKE STANLEY T 2.112 47,0812 2.112 47,0812 99.435
2014-01-16 ISIS CROOKE STANLEY T 1.134 47,0811 1.134 47,0811 53.390
2014-01-16 ISIS CROOKE STANLEY T 160 47,0799 160 47,0799 7.533
2014-01-16 ISIS CROOKE STANLEY T 121 47,0807 121 47,0807 5.697
2013-04-23 ISIS CROOKE STANLEY T 30.000 22,0967 30.000 22,0967 662.901
2013-01-16 ISIS CROOKE STANLEY T 1.317 13,9999 1.317 13,9999 18.438
2013-01-16 ISIS CROOKE STANLEY T 143 13,9994 143 13,9994 2.002

Justeret pris er den split-justerede pris. Adjusted Shares er de split-justerede aktier.

IONS / Ionis Pharmaceuticals, Inc. Insider Trades
Insiderhandelshistorie

Denne tabel viser den komplette liste over insiderhandler foretaget af Stanley T Crooke som oplyst til Securities Exchange Commission (SEC).

Fil dato Transdato Form Ticker Sikkerhed Kode 10b5-1 Aktier Resterende aktier Procent
Lave om
Del
Pris
Tran
Værdi
Tilbage
Værdi
2021-01-28 2021-01-26 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -28.333 2.021 -93,34 63,74 -1.805.812 128.809
2021-01-25 2021-01-22 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -40.000 494.391 -7,49 61,68 -2.467.000 30.491.565
2021-01-25 2021-01-21 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -21.042 534.391 -3,79 61,65 -1.297.239 32.945.205
2021-01-25 2021-01-21 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -13.958 555.433 -2,45 60,53 -844.878 33.620.359
2021-01-20 2021-01-15 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -4.371 7.801 -35,91
2021-01-20 2021-01-15 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -47.257 87.885 -34,97
2021-01-20 2021-01-15 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
A - Award 5.333 5.333
2021-01-20 2021-01-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
F - Taxes -1.434 3.111 -31,55 61,28 -87.876 190.642
2021-01-20 2021-01-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 4.371 4.545 2.512,07
2021-01-20 2021-01-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
F - Taxes -18.924 30.354 -38,40 61,28 -1.159.663 1.860.093
2021-01-20 2021-01-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 47.257 49.278 2.338,30
2021-01-06 2021-01-04 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
A - Award 12.000 12.000
2021-01-06 2020-11-19 5 IONS IONIS PHARMACEUTICALS INC
Common Stock
G - Gift -31.000 569.391 -5,16
2020-12-17 2020-12-17 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1.407 174 -88,99 50,50 -71.054 8.787
2020-12-17 2020-12-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -39.000 600.391 -6,10 49,78 -1.941.225 29.884.462
2020-12-09 2020-12-07 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -6.000 639.391 -0,93 51,50 -309.000 32.928.636
2020-12-09 2020-12-07 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -5.000 645.391 -0,77 51,87 -259.350 33.476.496
2020-11-30 2020-11-25 4 IONS IONIS PHARMACEUTICALS INC
Non-Qualified Stock Option (right to buy)
M - Exercise -12.990 0 -100,00
2020-11-30 2020-11-25 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -12.990 2.021 -86,54 50,05 -650.150 101.151
2020-11-30 2020-11-25 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 12.990 15.011 642,75 39,87 517.911 598.489
2020-11-25 2020-11-24 4 IONS IONIS PHARMACEUTICALS INC
Non-Qualified Stock Option (right to buy)
M - Exercise -2.590 12.990 -16,62
2020-11-25 2020-11-24 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -2.590 2.021 -56,17 50,83 -131.650 102.727
2020-11-25 2020-11-24 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 2.590 4.611 128,15 39,87 103.263 183.841
2020-11-25 2020-11-23 4 IONS IONIS PHARMACEUTICALS INC
Non-Qualified Stock Option (right to buy)
M - Exercise -11.600 15.580 -42,68
2020-11-25 2020-11-23 4 IONS IONIS PHARMACEUTICALS INC
Non-Qualified Stock Option (right to buy)
M - Exercise -500 0 -100,00
2020-11-25 2020-11-23 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -11.600 2.021 -85,16 50,11 -581.276 101.272
2020-11-25 2020-11-23 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 11.600 13.621 573,97 39,87 462.492 543.069
2020-11-25 2020-11-23 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -500 1.581 -24,03 50,00 -25.000 79.050
2020-11-25 2020-11-23 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 500 2.081 31,63 39,87 19.935 82.969
2020-09-23 2020-09-22 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -50.000 650.391 -7,14 50,41 -2.520.460 32.785.690
2020-09-23 2020-09-21 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -2.000 1.581 -55,85 50,18 -100.360 79.335
2020-06-26 2020-06-25 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -9.914 2.021 -83,07 60,11 -595.907 121.477
2020-06-26 2020-06-24 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -5.000 11.935 -29,52 58,80 -294.000 701.778
2020-06-19 2020-06-19 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -10.000 16.935 -37,13 58,32 -583.250 987.734
2020-06-19 2020-06-17 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -2.000 3.581 -35,84 58,25 -116.500 208.593
2020-06-19 2020-06-17 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -15.000 26.935 -35,77 57,90 -868.521 1.559.574
2020-03-27 2020-03-25 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1.000 5.581 -15,20 47,00 -47.000 262.307
2020-03-27 2020-03-25 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -15.000 41.935 -26,35 47,00 -705.000 1.970.945
2020-03-27 2020-03-17 4/A IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale -4.349 71.935 -5,70 45,00 -195.705 3.237.075
2020-03-27 2020-03-17 4/A IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale -5.651 76.284 -6,90 45,00 -254.295 3.432.780
2020-03-27 2020-03-17 4/A IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale -5.421 81.935 -6,21 44,50 -241.234 3.646.108
2020-03-27 2020-03-17 4/A IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale -4.579 87.356 -4,98 44,50 -203.766 3.887.342
2020-03-23 2020-03-19 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1.000 6.581 -13,19 45,00 -45.000 296.145
2020-03-23 2020-03-19 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -5.000 56.545 -8,12 46,00 -230.000 2.601.070
2020-03-23 2020-03-19 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -10.000 61.545 -13,98 44,75 -447.546 2.754.422
2020-03-19 2020-03-17 4 IONS IONIS PHARMACEUTICALS INC
COMMON STOCK
S - Sale X -4.349 71.545 -5,73 45,00 -195.705 3.219.525
2020-03-19 2020-03-17 4 IONS IONIS PHARMACEUTICALS INC
COMMON STOCK
S - Sale X -5.651 75.894 -6,93 45,00 -254.295 3.415.230
2020-03-19 2020-03-17 4 IONS IONIS PHARMACEUTICALS INC
COMMON STOCK
S - Sale X -5.421 81.545 -6,23 44,50 -241.234 3.628.752
2020-03-19 2020-03-17 4 IONS IONIS PHARMACEUTICALS INC
COMMON STOCK
S - Sale X -4.969 86.966 -5,40 44,50 -221.120 3.869.987
2020-01-17 2020-01-15 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -3.317 6.627 -33,36
2020-01-17 2020-01-15 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -39.643 72.160 -35,46
2020-01-17 2020-01-15 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
A - Award 5.545 5.545
2020-01-17 2020-01-15 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
A - Award 62.982 62.982
2020-01-17 2020-01-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
F - Taxes -1.268 7.581 -14,33 62,06 -78.692 470.477
2020-01-17 2020-01-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 3.317 8.849 59,96
2020-01-17 2020-01-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
F - Taxes -17.342 91.935 -15,87 62,06 -1.076.245 5.705.486
2020-01-17 2020-01-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 39.643 109.277 56,93
2020-01-03 2020-01-02 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
A - Award 12.477 12.477
2020-01-03 2020-01-02 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
A - Award 141.709 141.709
2020-01-03 2019-12-06 5 IONS IONIS PHARMACEUTICALS INC
Common Stock
G - Gift -25.000 700.391 -3,45
2019-08-22 2019-08-21 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -10.000 27.180 -26,90
2019-08-22 2019-08-21 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -10.000 69.634 -12,56 72,15 -721.500 5.024.093
2019-08-22 2019-08-21 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 10.000 79.634 14,36 39,87 398.700 3.175.008
2019-08-22 2019-08-20 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -2.000 500 -80,00
2019-08-22 2019-08-20 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -10.000 37.180 -21,20
2019-08-22 2019-08-20 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -2.000 5.532 -26,55 71,00 -142.000 392.772
2019-08-22 2019-08-20 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 2.000 7.532 36,15 39,87 79.740 300.301
2019-08-22 2019-08-20 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -10.000 69.634 -12,56 71,00 -710.000 4.944.014
2019-08-22 2019-08-20 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 10.000 79.634 14,36 39,87 398.700 3.175.008
2019-07-22 2019-07-18 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -10.000 47.180 -17,49
2019-07-22 2019-07-18 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -10.000 69.634 -12,56 70,25 -702.506 4.891.830
2019-07-22 2019-07-18 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 10.000 79.634 14,36 39,87 398.700 3.175.008
2019-04-17 2019-04-16 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -700 2.500 -21,88
2019-04-17 2019-04-16 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -300 0 -100,00
2019-04-17 2019-04-16 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -13.320 57.180 -18,89
2019-04-17 2019-04-16 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -6.680 0 -100,00
2019-04-17 2019-04-16 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -700 5.532 -11,23 84,75 -59.325 468.837
2019-04-17 2019-04-16 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 700 6.232 12,65 39,87 27.909 248.470
2019-04-17 2019-04-16 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -300 5.532 -5,14 84,75 -25.425 468.837
2019-04-17 2019-04-16 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 300 5.832 5,42 10,82 3.246 63.102
2019-04-17 2019-04-16 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -13.320 69.634 -16,06 84,56 -1.126.370 5.888.411
2019-04-17 2019-04-16 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 13.320 82.954 19,13 39,87 531.068 3.307.376
2019-04-17 2019-04-16 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -6.680 69.634 -8,75 84,75 -566.130 5.901.482
2019-04-17 2019-04-16 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 6.680 76.314 9,59 14,69 98.129 1.121.053
2019-04-17 2019-04-15 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -1.000 300 -76,92
2019-04-17 2019-04-15 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -10.000 6.680 -59,95
2019-04-17 2019-04-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1.000 5.532 -15,31 85,25 -85.250 471.603
2019-04-17 2019-04-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 1.000 6.532 18,08 10,82 10.820 70.676
2019-04-17 2019-04-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -10.000 69.634 -12,56 85,25 -852.500 5.936.298
2019-04-17 2019-04-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 10.000 79.634 14,36 14,69 146.900 1.169.823
2019-02-27 2019-02-26 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -37.000 70.500 -34,42
2019-02-27 2019-02-26 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -37.000 69.634 -34,70 61,54 -2.276.799 4.284.935
2019-02-27 2019-02-26 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 37.000 106.634 53,13 39,87 1.475.190 4.251.498
2019-02-27 2019-02-25 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -40.000 107.500 -27,12
2019-02-27 2019-02-25 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -40.000 69.634 -36,49 60,07 -2.402.700 4.182.740
2019-02-27 2019-02-25 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 40.000 109.634 57,44 39,87 1.594.800 4.371.108
2019-02-14 2019-02-13 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -5.300 3.200 -62,35
2019-02-14 2019-02-13 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -1.604 1.300 -55,23
2019-02-14 2019-02-13 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -40.000 147.500 -21,33
2019-02-14 2019-02-13 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -5.300 5.532 -48,93 60,00 -318.000 331.920
2019-02-14 2019-02-13 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 5.300 10.832 95,81 39,87 211.311 431.872
2019-02-14 2019-02-13 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1.604 5.532 -22,48 60,00 -96.240 331.920
2019-02-14 2019-02-13 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 1.604 7.136 28,99 10,82 17.355 77.212
2019-02-14 2019-02-13 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -40.000 69.634 -36,49 60,10 -2.404.028 4.185.052
2019-02-14 2019-02-13 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 40.000 109.634 57,44 39,87 1.594.800 4.371.108
2019-01-17 2019-01-15 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -2.346 4.612 -33,72
2019-01-17 2019-01-15 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -30.587 48.077 -38,88
2019-01-17 2019-01-15 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
A - Award 5.332 5.332
2019-01-17 2019-01-15 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
A - Award 63.726 63.726
2019-01-17 2019-01-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
F - Taxes -942 5.532 -14,55 58,26 -54.881 322.294
2019-01-17 2019-01-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 2.346 6.474 56,83
2019-01-17 2019-01-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
F - Taxes -12.686 69.634 -15,41 58,26 -739.086 4.056.877
2019-01-17 2019-01-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 30.587 82.320 59,12
2019-01-03 2019-01-02 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
A - Award 12.000 12.000
2019-01-03 2019-01-02 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
A - Award 143.400 143.400
2018-04-19 2018-04-17 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -4.000 2.904 -57,94
2018-04-19 2018-04-17 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -9.962 16.680 -37,39
2018-04-19 2018-04-17 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -2.000 4.128 -32,64 44,50 -89.000 183.696
2018-04-19 2018-04-17 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 2.000 6.128 48,45 10,82 21.640 66.305
2018-04-19 2018-04-17 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 2.000 6.128 48,45 10,82 21.640 66.305
2018-04-19 2018-04-17 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -2.000 4.128 -32,64 44,30 -88.600 182.870
2018-04-19 2018-04-17 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -4.981 51.733 -8,78 44,50 -221.654 2.302.118
2018-04-19 2018-04-17 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 4.981 56.714 9,63 14,69 73.171 833.129
2018-04-19 2018-04-17 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 4.981 56.714 9,63 14,69 73.171 833.129
2018-04-19 2018-04-17 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -4.981 51.733 -8,78 44,30 -220.658 2.291.772
2018-01-31 2018-01-29 4/A IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -1.000 6.904 -12,65
2018-01-31 2018-01-29 4/A IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -10.000 26.642 -27,29
2018-01-31 2018-01-29 4/A IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1.000 4.128 -19,50 54,12 -54.120 223.407
2018-01-31 2018-01-29 4/A IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 1.000 5.128 24,22 10,82 10.820 55.485
2018-01-31 2018-01-29 4/A IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -10.000 51.733 -16,20 54,12 -541.200 2.799.790
2018-01-31 2018-01-29 4/A IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 10.000 61.733 19,33 14,69 146.900 906.858
2018-01-17 2018-01-15 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -1.722 3.047 -36,11
2018-01-17 2018-01-15 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -29.612 43.515 -40,49
2018-01-17 2018-01-15 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
A - Award 3.911 3.911
2018-01-17 2018-01-15 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
A - Award 35.149 35.149
2018-01-17 2018-01-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale -656 4.128 -13,71 51,76 -33.955 213.665
2018-01-17 2018-01-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 1.722 4.784 56,24
2018-01-17 2018-01-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale -15.893 51.733 -23,50 51,76 -822.622 2.677.700
2018-01-17 2018-01-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 29.612 67.626 77,90
2018-01-10 2018-01-08 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -1.000 7.904 -11,23
2018-01-10 2018-01-08 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -10.000 36.642 -21,44
2018-01-10 2018-01-08 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1.000 3.062 -24,62 52,01 -52.010 159.255
2018-01-10 2018-01-08 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 1.000 4.062 32,66 10,82 10.820 43.951
2018-01-10 2018-01-08 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -10.000 38.014 -20,83 52,01 -520.100 1.977.108
2018-01-10 2018-01-08 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 10.000 48.014 26,31 14,69 146.900 705.326
2018-01-05 2018-01-03 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -1.096 8.904 -10,96
2018-01-05 2018-01-03 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -904 0 -100,00
2018-01-05 2018-01-03 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -20.000 46.642 -30,01
2018-01-05 2018-01-03 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1.096 3.062 -26,36 50,02 -54.822 153.161
2018-01-05 2018-01-03 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 1.096 4.158 35,79 10,82 11.859 44.990
2018-01-05 2018-01-03 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -904 3.062 -22,79 49,71 -44.938 152.212
2018-01-05 2018-01-03 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 904 3.966 29,52 7,25 6.554 28.754
2018-01-05 2018-01-03 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -20.000 38.014 -34,47 50,02 -1.000.400 1.901.460
2018-01-05 2018-01-03 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 20.000 58.014 52,61 14,69 293.800 852.226
2018-01-02 2018-01-02 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
A - Award 17.603 17.603
2018-01-02 2018-01-02 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
A - Award 158.175 158.175
2017-10-17 2017-10-13 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -1.500 904 -62,40
2017-10-17 2017-10-13 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -15.000 66.642 -18,37
2017-10-17 2017-10-13 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1.500 3.062 -32,88 59,46 -89.190 182.067
2017-10-17 2017-10-13 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 1.500 4.562 48,99 7,25 10.875 33.074
2017-10-17 2017-10-13 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -15.000 38.014 -28,29 59,46 -891.900 2.260.312
2017-10-17 2017-10-13 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 15.000 53.014 39,46 14,69 220.350 778.776
2017-10-04 2017-10-04 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -1.000 2.404 -29,38
2017-10-04 2017-10-04 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -10.000 81.642 -10,91
2017-10-04 2017-10-04 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -500 3.062 -14,04 54,25 -27.125 166.114
2017-10-04 2017-10-04 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 500 3.562 16,33 7,25 3.625 25.824
2017-10-04 2017-10-04 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 500 3.562 16,33 7,25 3.625 25.824
2017-10-04 2017-10-04 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -500 3.062 -14,04 54,20 -27.100 165.960
2017-10-04 2017-10-04 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -5.000 38.014 -11,62 54,25 -271.250 2.062.260
2017-10-04 2017-10-04 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 5.000 43.014 13,15 14,69 73.450 631.876
2017-10-04 2017-10-04 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 5.000 43.014 13,15 14,69 73.450 631.876
2017-10-04 2017-10-04 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -5.000 38.014 -11,62 54,20 -271.000 2.060.359
2017-10-04 2017-10-02 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -1.500 3.404 -30,59
2017-10-04 2017-10-02 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -15.000 91.642 -14,07
2017-10-04 2017-10-02 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -500 3.062 -14,04 52,50 -26.250 160.755
2017-10-04 2017-10-02 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 500 3.562 16,33 7,25 3.625 25.824
2017-10-04 2017-10-02 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 500 3.562 16,33 7,25 3.625 25.824
2017-10-04 2017-10-02 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 500 3.562 16,33 7,25 3.625 25.824
2017-10-04 2017-10-02 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -500 3.062 -14,04 52,05 -26.025 159.377
2017-10-04 2017-10-02 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -500 3.062 -14,04 51,45 -25.725 157.540
2017-10-04 2017-10-02 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -5.000 38.014 -11,62 52,50 -262.500 1.995.735
2017-10-04 2017-10-02 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 5.000 43.014 13,15 14,69 73.450 631.876
2017-10-04 2017-10-02 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 5.000 43.014 13,15 14,69 73.450 631.876
2017-10-04 2017-10-02 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 5.000 43.014 13,15 14,69 73.450 631.876
2017-10-04 2017-10-02 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -5.000 38.014 -11,62 52,05 -260.250 1.978.629
2017-10-04 2017-10-02 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -5.000 38.014 -11,62 51,45 -257.250 1.955.820
2017-07-24 2017-07-20 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option
M - Exercise -1.000 4.904 -16,94
2017-07-24 2017-07-20 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -10.000 106.642 -8,57
2017-07-24 2017-07-20 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1.000 3.062 -24,62 55,35 -55.350 169.482
2017-07-24 2017-07-20 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 1.000 4.062 32,66 7,25 7.250 29.450
2017-07-24 2017-07-20 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -10.000 38.014 -20,83 55,35 -553.500 2.104.075
2017-07-24 2017-07-20 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 10.000 48.014 26,31 14,69 146.900 705.326
2017-07-18 2017-07-17 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -1.500 5.904 -20,26
2017-07-18 2017-07-17 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -15.000 116.642 -11,39
2017-07-18 2017-07-17 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1.500 3.062 -32,88 52,45 -78.675 160.602
2017-07-18 2017-07-17 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 1.500 4.562 48,99 7,25 10.875 33.074
2017-07-18 2017-07-17 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -15.000 38.014 -28,29 52,45 -786.750 1.993.834
2017-07-18 2017-07-17 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 15.000 53.014 39,46 14,69 220.350 778.776
2017-07-13 3 AKCA AKCEA THERAPEUTICS, INC.
No securities are beneficially owned.
0
2017-07-03 2017-07-03 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -1.500 7.404 -16,85
2017-07-03 2017-07-03 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -1.538 131.642 -1,15
2017-07-03 2017-07-03 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -13.462 0 -100,00
2017-07-03 2017-07-03 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1.500 3.062 -32,88 52,10 -78.150 159.530
2017-07-03 2017-07-03 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 1.500 4.562 48,99 7,25 10.875 33.074
2017-07-03 2017-07-03 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1.538 38.014 -3,89 52,30 -80.437 1.988.132
2017-07-03 2017-07-03 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 1.538 39.552 4,05 14,69 22.593 581.019
2017-07-03 2017-07-03 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -13.462 38.014 -26,15 52,08 -701.101 1.979.769
2017-07-03 2017-07-03 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 13.462 51.476 35,41 7,25 97.600 373.201
2017-04-27 2017-04-25 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -1.500 8.904 -14,42
2017-04-27 2017-04-25 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -15.000 13.462 -52,70
2017-04-27 2017-04-25 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1.500 3.062 -32,88 47,81 -71.715 146.394
2017-04-27 2017-04-25 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 1.500 4.562 48,99 7,25 10.875 33.074
2017-04-27 2017-04-25 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -15.000 38.014 -28,29 47,81 -717.150 1.817.449
2017-04-27 2017-04-25 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 15.000 53.014 39,46 7,25 108.750 384.352
2017-04-21 2017-04-19 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -500 10.404 -4,59
2017-04-21 2017-04-19 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -5.000 28.462 -14,94
2017-04-21 2017-04-19 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -500 3.062 -14,04 43,25 -21.625 132.432
2017-04-21 2017-04-19 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 500 3.562 16,33 7,25 3.625 25.824
2017-04-21 2017-04-19 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -5.000 38.014 -11,62 43,25 -216.250 1.644.106
2017-04-21 2017-04-19 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 5.000 43.014 13,15 7,25 36.250 311.852
2017-04-13 2017-04-13 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -500 10.904 -4,38
2017-04-13 2017-04-13 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -500 10.904 -4,38
2017-04-13 2017-04-13 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -10.000 33.462 -23,01
2017-04-13 2017-04-13 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -500 3.062 -14,04 41,30 -20.650 126.461
2017-04-13 2017-04-13 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -500 3.062 -14,04 41,30 -20.650 126.461
2017-04-13 2017-04-13 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 500 3.562 16,33 7,25 3.625 25.824
2017-04-13 2017-04-13 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 500 3.562 16,33 10,29 5.145 36.653
2017-04-13 2017-04-13 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -10.000 38.014 -20,83 41,30 -413.000 1.569.978
2017-04-13 2017-04-13 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 10.000 48.014 26,31 7,25 72.500 348.102
2017-04-13 2017-04-12 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -1.000 500 -66,67
2017-04-13 2017-04-12 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -10.000 43.462 -18,70
2017-04-13 2017-04-12 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1.000 3.062 -24,62 40,07 -40.070 122.694
2017-04-13 2017-04-12 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 1.000 4.062 32,66 10,29 10.290 41.798
2017-04-13 2017-04-12 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -10.000 38.014 -20,83 40,07 -400.700 1.523.221
2017-04-13 2017-04-12 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 10.000 48.014 26,31 7,25 72.500 348.102
2017-03-06 2017-03-02 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -1.100 1.500 -42,31
2017-03-06 2017-03-02 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -11.000 53.462 -17,06
2017-03-06 2017-03-02 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1.100 3.062 -26,43 51,05 -56.155 156.315
2017-03-06 2017-03-02 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 1.100 4.162 35,92 10,29 11.319 42.827
2017-03-06 2017-03-02 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -11.000 38.014 -22,44 51,05 -561.550 1.940.615
2017-03-06 2017-03-02 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 11.000 49.014 28,94 7,25 79.750 355.352
2017-01-18 2017-01-17 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale -131 3.062 -4,10 46,29 -6.064 141.740
2017-01-18 2017-01-17 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale -142 2.859 -4,73 46,29 -6.573 132.346
2017-01-18 2017-01-17 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale -139 2.638 -5,01 46,29 -6.434 122.113
2017-01-18 2017-01-17 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale -163 2.423 -6,30 46,29 -7.545 112.163
2017-01-18 2017-01-17 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale -4.410 38.014 -10,40 46,29 -204.139 1.759.668
2017-01-18 2017-01-17 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale -3.728 34.291 -9,81 46,29 -172.569 1.587.330
2017-01-18 2017-01-17 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale -4.236 31.144 -11,97 46,29 -196.080 1.441.625
2017-01-18 2017-01-17 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale -3.008 27.568 -9,84 46,29 -139.237 1.276.095
2017-01-18 2017-01-15 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -334 999 -25,06
2017-01-18 2017-01-15 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -363 724 -33,39
2017-01-18 2017-01-15 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -354 354 -50,00
2017-01-18 2017-01-15 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -416 0 -100,00
2017-01-18 2017-01-15 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -8.133 24.397 -25,00
2017-01-18 2017-01-15 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -6.875 13.750 -33,33
2017-01-18 2017-01-15 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -7.812 7.812 -50,00
2017-01-18 2017-01-15 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -5.547 0 -100,00
2017-01-18 2017-01-15 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
A - Award 2.692 2.692
2017-01-18 2017-01-15 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
A - Award 27.168 27.168
2017-01-18 2017-01-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 334 3.193 11,68
2017-01-18 2017-01-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 363 3.001 13,76
2017-01-18 2017-01-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 354 2.777 14,61
2017-01-18 2017-01-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 416 2.586 19,17
2017-01-18 2017-01-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 8.133 42.424 23,72
2017-01-18 2017-01-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 6.875 38.019 22,07
2017-01-18 2017-01-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 7.812 35.380 28,34
2017-01-18 2017-01-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 5.547 30.576 22,16
2017-01-12 2017-01-10 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -1.200 2.600 -31,58
2017-01-12 2017-01-10 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -12.000 64.462 -15,69
2017-01-12 2017-01-10 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1.200 2.170 -35,61 49,25 -59.100 106.872
2017-01-12 2017-01-10 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 1.200 3.370 55,30 10,29 12.348 34.677
2017-01-12 2017-01-10 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -12.000 25.029 -32,41 49,25 -591.000 1.232.678
2017-01-12 2017-01-10 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 12.000 37.029 47,94 7,25 87.000 268.460
2017-01-04 2017-01-04 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -700 3.800 -15,56
2017-01-04 2017-01-04 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -7.000 76.462 -8,39
2017-01-04 2017-01-04 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -700 2.170 -24,39 50,10 -35.070 108.717
2017-01-04 2017-01-04 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 700 2.870 32,26 10,29 7.203 29.532
2017-01-04 2017-01-04 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -7.000 25.029 -21,86 50,10 -350.700 1.253.953
2017-01-04 2017-01-04 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 7.000 32.029 27,97 7,25 50.750 232.210
2017-01-04 2017-01-03 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -1.000 4.500 -18,18
2017-01-04 2017-01-03 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -10.000 83.462 -10,70
2017-01-04 2017-01-03 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
A - Award 16.157 16.157
2017-01-04 2017-01-03 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
A - Award 163.013 163.013
2017-01-04 2017-01-03 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -500 2.170 -18,73 48,80 -24.400 105.896
2017-01-04 2017-01-03 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 500 2.670 23,04 10,29 5.145 27.474
2017-01-04 2017-01-03 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 500 2.670 23,04 10,29 5.145 27.474
2017-01-04 2017-01-03 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -500 2.170 -18,73 47,30 -23.650 102.641
2017-01-04 2017-01-03 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -5.000 25.029 -16,65 48,80 -244.000 1.221.415
2017-01-04 2017-01-03 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 5.000 30.029 19,98 7,25 36.250 217.710
2017-01-04 2017-01-03 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 5.000 30.029 19,98 7,25 36.250 217.710
2017-01-04 2017-01-03 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -5.000 25.029 -16,65 47,30 -236.500 1.183.872
2016-11-14 2016-11-10 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -1.000 5.500 -15,38
2016-11-14 2016-11-10 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -10.000 93.462 -9,67
2016-11-14 2016-11-10 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1.000 2.170 -31,55 42,22 -42.220 91.617
2016-11-14 2016-11-10 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 1.000 3.170 46,08 10,29 10.290 32.619
2016-11-14 2016-11-10 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -10.000 25.029 -28,55 40,23 -402.300 1.006.917
2016-11-14 2016-11-10 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 10.000 35.029 39,95 7,25 72.500 253.960
2016-11-14 2016-11-09 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -2.000 6.500 -23,53
2016-11-14 2016-11-09 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -3.741 103.462 -3,49
2016-11-14 2016-11-09 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -16.259 0 -100,00
2016-11-14 2016-11-09 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1.000 2.170 -31,55 37,25 -37.250 80.832
2016-11-14 2016-11-09 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 1.000 3.170 46,08 10,29 10.290 32.619
2016-11-14 2016-11-09 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 1.000 3.170 46,08 10,29 10.290 32.619
2016-11-14 2016-11-09 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1.000 2.170 -31,55 35,10 -35.100 76.167
2016-11-14 2016-11-09 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -3.741 25.029 -13,00 37,50 -140.288 938.588
2016-11-14 2016-11-09 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 3.741 28.770 14,95 7,25 27.122 208.582
2016-11-14 2016-11-09 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -6.259 25.029 -20,00 37,10 -232.209 928.576
2016-11-14 2016-11-09 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 6.259 31.288 25,01 10,29 64.405 321.954
2016-11-14 2016-11-09 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -10.000 25.029 -28,55 35,55 -355.500 889.781
2016-11-14 2016-11-09 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 10.000 35.029 39,95 10,29 102.900 360.448
2016-10-07 2016-10-05 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -1.000 8.500 -10,53
2016-10-07 2016-10-05 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -10.000 16.259 -38,08
2016-10-07 2016-10-05 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1.000 2.170 -31,55 36,61 -36.610 79.444
2016-10-07 2016-10-05 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 1.000 3.170 46,08 10,29 10.290 32.619
2016-10-07 2016-10-05 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -10.000 25.029 -28,55 36,61 -366.100 916.312
2016-10-07 2016-10-05 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 10.000 35.029 39,95 10,29 102.900 360.448
2016-09-29 2016-09-27 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -2.000 9.500 -17,39
2016-09-29 2016-09-27 4 IONS IONIS PHARMACEUTICALS INC
Empoyee Stock Option (right to buy)
M - Exercise -20.000 26.259 -43,23
2016-09-29 2016-09-27 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -2.000 2.170 -47,96 36,05 -72.100 78.228
2016-09-29 2016-09-27 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 2.000 4.170 92,17 10,29 20.580 42.909
2016-09-29 2016-09-27 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -20.000 25.029 -44,42 36,02 -720.400 901.545
2016-09-29 2016-09-27 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 20.000 45.029 79,91 10,29 205.800 463.348
2016-09-23 2016-09-21 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -2.000 11.500 -14,81
2016-09-23 2016-09-21 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -20.000 46.259 -30,18
2016-09-23 2016-09-21 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -2.000 2.170 -47,96 35,50 -71.000 77.035
2016-09-23 2016-09-21 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 2.000 4.170 92,17 10,29 20.580 42.909
2016-09-23 2016-09-21 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -20.000 25.029 -44,42 35,50 -710.000 888.530
2016-09-23 2016-09-21 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 20.000 45.029 79,91 10,29 205.800 463.348
2016-04-07 2016-04-06 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -1.000 13.500 -6,90
2016-04-07 2016-04-06 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -10.000 66.259 -13,11
2016-04-07 2016-04-06 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -500 2.170 -18,73 46,30 -23.150 100.471
2016-04-07 2016-04-06 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 500 2.670 23,04 10,29 5.145 27.474
2016-04-07 2016-04-06 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 500 2.670 23,04 10,29 5.145 27.474
2016-04-07 2016-04-06 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -500 2.170 -18,73 45,95 -22.975 99.712
2016-04-07 2016-04-06 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -5.000 25.029 -16,65 46,30 -231.500 1.158.843
2016-04-07 2016-04-06 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 5.000 30.029 19,98 10,29 51.450 308.998
2016-04-07 2016-04-06 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 5.000 30.029 19,98 10,29 51.450 308.998
2016-04-07 2016-04-06 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -5.000 25.029 -16,65 45,95 -229.750 1.150.083
2016-04-01 2016-03-31 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -500 14.500 -3,33
2016-04-01 2016-03-31 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -500 14.500 -3,33
2016-04-01 2016-03-31 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -10.000 76.259 -11,59
2016-04-01 2016-03-31 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -500 2.170 -18,73 40,75 -20.375 88.428
2016-04-01 2016-03-31 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 500 2.670 23,04 10,29 5.145 27.474
2016-04-01 2016-03-31 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -500 2.170 -18,73 40,72 -20.360 88.362
2016-04-01 2016-03-31 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 500 2.670 23,04 9,22 4.610 24.617
2016-04-01 2016-03-31 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -5.000 25.029 -16,65 40,72 -203.600 1.019.181
2016-04-01 2016-03-31 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 5.000 30.029 19,98 10,29 51.450 308.998
2016-04-01 2016-03-31 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 5.000 30.029 19,98 10,29 51.450 308.998
2016-04-01 2016-03-31 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -5.000 25.029 -16,65 40,75 -203.750 1.019.932
2016-01-19 2016-01-19 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale -145 2.170 -6,26 41,46 -6.012 89.968
2016-01-19 2016-01-19 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale -141 1.952 -6,74 41,46 -5.846 80.936
2016-01-19 2016-01-19 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale -166 1.739 -8,71 41,46 -6.883 72.103
2016-01-19 2016-01-19 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale -124 1.489 -7,69 41,46 -5.141 61.735
2016-01-19 2016-01-19 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale -3.798 25.029 -13,18 41,47 -157.486 1.037.840
2016-01-19 2016-01-19 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale -4.317 21.952 -16,43 41,46 -178.962 910.022
2016-01-19 2016-01-19 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale -3.065 18.456 -14,24 41,46 -127.069 765.153
2016-01-19 2016-01-19 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale -1.645 15.974 -9,34 41,46 -68.199 662.253
2016-01-19 2016-01-15 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -363 1.087 -25,03
2016-01-19 2016-01-15 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -354 708 -33,33
2016-01-19 2016-01-15 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -416 416 -50,00
2016-01-19 2016-01-15 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -316 0 -100,00
2016-01-19 2016-01-15 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -6.875 20.625 -25,00
2016-01-19 2016-01-15 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -7.813 15.624 -33,34
2016-01-19 2016-01-15 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -5.547 5.547 -50,00
2016-01-19 2016-01-15 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -2.977 0 -100,00
2016-01-19 2016-01-15 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
A - Award 1.333 1.333
2016-01-19 2016-01-15 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
A - Award 32.530 32.530
2016-01-19 2016-01-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 363 2.315 18,60
2016-01-19 2016-01-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 354 2.093 20,36
2016-01-19 2016-01-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 416 1.905 27,94
2016-01-19 2016-01-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 316 1.613 24,36
2016-01-19 2016-01-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 6.875 28.827 31,32
2016-01-19 2016-01-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 7.813 26.269 42,33
2016-01-19 2016-01-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 5.547 21.521 34,73
2016-01-19 2016-01-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 2.977 17.619 20,33
2016-01-07 2016-01-05 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -500 500 -50,00
2016-01-07 2016-01-05 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -5.000 86.259 -5,48
2016-01-07 2016-01-05 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -500 1.297 -27,82 62,10 -31.050 80.544
2016-01-07 2016-01-05 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 500 1.797 38,55 9,22 4.610 16.568
2016-01-07 2016-01-05 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -5.000 14.642 -25,46 62,10 -310.500 909.268
2016-01-07 2016-01-05 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 5.000 19.642 34,15 10,29 51.450 202.116
2016-01-04 2016-01-04 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -1.000 1.000 -50,00
2016-01-04 2016-01-04 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -10.000 91.259 -9,88
2016-01-04 2016-01-04 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
A - Award 8.000 8.000
2016-01-04 2016-01-04 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
A - Award 195.182 195.182
2016-01-04 2016-01-04 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1.000 1.297 -43,54 61,05 -61.050 79.182
2016-01-04 2016-01-04 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 1.000 2.297 77,10 9,22 9.220 21.178
2016-01-04 2016-01-04 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -10.000 14.642 -40,58 61,05 -610.500 893.894
2016-01-04 2016-01-04 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 10.000 24.642 68,30 10,29 102.900 253.566
2015-10-23 2015-10-23 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -2.500 2.000 -55,56
2015-10-23 2015-10-23 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -20.837 101.259 -17,07
2015-10-23 2015-10-23 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -4.163 0 -100,00
2015-10-23 2015-10-23 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -500 1.297 -27,82 45,30 -22.650 58.754
2015-10-23 2015-10-23 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 500 1.797 38,55 9,22 4.610 16.568
2015-10-23 2015-10-23 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -2.000 1.297 -60,66 44,18 -88.350 57.295
2015-10-23 2015-10-23 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 2.000 3.297 154,20 9,22 18.440 30.398
2015-10-23 2015-10-23 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -5.000 14.642 -25,46 45,30 -226.500 663.283
2015-10-23 2015-10-23 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 5.000 19.642 34,15 10,29 51.450 202.116
2015-10-23 2015-10-23 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -15.837 14.642 -51,96 44,18 -699.599 646.810
2015-10-23 2015-10-23 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 15.837 30.479 108,16 10,29 162.963 313.629
2015-10-23 2015-10-23 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -4.163 14.642 -22,14 43,90 -182.756 642.784
2015-10-23 2015-10-23 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 4.163 18.805 28,43 11,27 46.917 211.932
2015-10-23 2015-10-21 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -500 4.500 -10,00
2015-10-23 2015-10-21 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -1.000 0 -100,00
2015-10-23 2015-10-21 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -15.000 4.163 -78,28
2015-10-23 2015-10-21 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -500 1.297 -27,82 43,00 -21.500 55.771
2015-10-23 2015-10-21 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 500 1.797 38,55 9,22 4.610 16.568
2015-10-23 2015-10-21 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1.000 1.297 -43,54 43,00 -43.000 55.771
2015-10-23 2015-10-21 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 1.000 2.297 77,10 11,27 11.270 25.887
2015-10-23 2015-10-21 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -15.000 14.642 -50,60 43,00 -645.000 629.606
2015-10-23 2015-10-21 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 15.000 29.642 102,45 11,27 169.050 334.065
2015-07-08 2015-07-06 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -1.175 5.000 -19,03
2015-07-08 2015-07-06 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -5.000 19.163 -20,69
2015-07-08 2015-07-06 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1.175 1.297 -47,53 57,01 -66.983 73.938
2015-07-08 2015-07-06 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 1.175 2.472 90,59 9,22 10.834 22.792
2015-07-08 2015-07-06 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -5.000 14.642 -25,46 57,01 -285.035 834.696
2015-07-08 2015-07-06 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 5.000 19.642 34,15 11,27 56.350 221.365
2015-07-02 2015-07-01 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -1.175 6.175 -15,99
2015-07-02 2015-07-01 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -5.000 24.163 -17,15
2015-07-02 2015-07-01 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1.175 1.297 -47,53 57,56 -67.634 74.657
2015-07-02 2015-07-01 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 1.175 2.472 90,59 9,22 10.834 22.792
2015-07-02 2015-07-01 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -5.000 14.642 -25,46 57,56 -287.805 842.808
2015-07-02 2015-07-01 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 5.000 19.642 34,15 11,27 56.350 221.365
2015-04-08 2015-04-07 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -2.034 7.350 -21,68
2015-04-08 2015-04-07 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -20.343 29.163 -41,09
2015-04-08 2015-04-07 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -2.034 1.297 -61,06 63,07 -128.286 81.803
2015-04-08 2015-04-07 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 2.034 3.331 156,82 9,22 18.753 30.712
2015-04-08 2015-04-07 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -20.343 14.642 -58,15 63,07 -1.283.053 923.486
2015-04-08 2015-04-07 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 20.343 34.985 138,94 11,27 229.266 394.281
2015-04-06 2015-04-01 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -1.966 9.384 -17,32
2015-04-06 2015-04-01 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -19.657 49.506 -28,42
2015-04-06 2015-04-01 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1.966 1.297 -60,25 61,93 -121.759 80.326
2015-04-06 2015-04-01 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 1.966 3.263 151,58 9,22 18.127 30.085
2015-04-06 2015-04-01 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -19.657 14.642 -57,31 61,93 -1.217.399 906.810
2015-04-06 2015-04-01 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 19.657 34.299 134,25 11,27 221.534 386.550
2015-01-29 2015-01-27 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -1.000 11.350 -8,10
2015-01-29 2015-01-27 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -10.000 69.163 -12,63
2015-01-29 2015-01-27 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1.000 1.297 -43,54 72,93 -72.926 94.585
2015-01-29 2015-01-27 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 1.000 2.297 77,10 9,22 9.220 21.178
2015-01-29 2015-01-27 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -10.000 14.642 -40,58 72,93 -729.260 1.067.782
2015-01-29 2015-01-27 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 10.000 24.642 68,30 11,27 112.700 277.715
2015-01-20 2015-01-16 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale -136 1.297 -9,49 67,96 -9.243 88.149
2015-01-20 2015-01-16 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale -160 1.079 -12,91 67,96 -10.874 73.333
2015-01-20 2015-01-16 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale -121 822 -12,83 67,96 -8.224 55.866
2015-01-20 2015-01-16 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale -4.130 14.642 -22,00 67,96 -280.693 995.136
2015-01-20 2015-01-16 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale -2.933 10.959 -21,11 67,96 -199.338 744.817
2015-01-20 2015-01-16 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale -1.574 8.344 -15,87 67,96 -106.975 567.092
2015-01-20 2015-01-15 4 ISIS ISIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -354 1.062 -25,00
2015-01-20 2015-01-15 4 ISIS ISIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -417 832 -33,39
2015-01-20 2015-01-15 4 ISIS ISIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -316 316 -50,00
2015-01-20 2015-01-15 4 ISIS ISIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -7.813 23.437 -25,00
2015-01-20 2015-01-15 4 ISIS ISIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -5.548 11.094 -33,34
2015-01-20 2015-01-15 4 ISIS ISIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -2.977 2.977 -50,00
2015-01-20 2015-01-15 4 ISIS ISIS PHARMACEUTICALS INC
Restricted Stock Units
A - Award 1.450 1.450
2015-01-20 2015-01-15 4 ISIS ISIS PHARMACEUTICALS INC
Restricted Stock Units
A - Award 27.500 27.500
2015-01-20 2015-01-15 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise 354 1.433 32,81
2015-01-20 2015-01-15 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise 417 1.239 50,73
2015-01-20 2015-01-15 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise 316 943 50,40
2015-01-20 2015-01-15 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise 7.813 18.772 71,29
2015-01-20 2015-01-15 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise 5.548 13.892 66,49
2015-01-20 2015-01-15 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise 2.977 9.918 42,89
2015-01-13 2015-01-09 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -1.000 12.350 -7,49
2015-01-13 2015-01-09 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -10.000 79.163 -11,22
2015-01-13 2015-01-09 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1.000 627 -61,46 73,57 -73.570 46.128
2015-01-13 2015-01-09 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 1.000 1.627 159,49 9,22 9.220 15.001
2015-01-13 2015-01-09 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -10.000 6.941 -59,03 73,57 -735.700 510.649
2015-01-13 2015-01-09 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 10.000 16.941 144,07 11,27 112.700 190.925
2015-01-08 2015-01-07 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -1.000 13.350 -6,97
2015-01-08 2015-01-07 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -10.000 89.163 -10,08
2015-01-08 2015-01-07 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1.000 627 -61,46 68,05 -68.048 42.666
2015-01-08 2015-01-07 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 1.000 1.627 159,49 9,22 9.220 15.001
2015-01-08 2015-01-07 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -10.000 6.941 -59,03 68,05 -680.480 472.321
2015-01-08 2015-01-07 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 10.000 16.941 144,07 11,27 112.700 190.925
2015-01-08 2015-01-06 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -1.000 14.350 -6,51
2015-01-08 2015-01-06 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -10.000 99.163 -9,16
2015-01-08 2015-01-06 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1.000 627 -61,46 66,04 -66.038 41.406
2015-01-08 2015-01-06 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 1.000 1.627 159,49 9,22 9.220 15.001
2015-01-08 2015-01-06 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -10.000 6.941 -59,03 66,04 -660.380 458.370
2015-01-08 2015-01-06 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 10.000 16.941 144,07 11,27 112.700 190.925
2015-01-05 2015-01-02 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise 8.700 8.700
2015-01-05 2015-01-02 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
A - Award 165.000 165.000
2014-10-24 2014-10-23 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -1.600 15.350 -9,44
2014-10-24 2014-10-23 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -10.000 109.163 -8,39
2014-10-24 2014-10-23 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -3.000 0 -100,00
2014-10-24 2014-10-23 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1.600 627 -71,85 42,22 -67.552 26.472
2014-10-24 2014-10-23 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 1.600 2.227 255,18 9,22 14.752 20.533
2014-10-24 2014-10-23 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -10.000 6.941 -59,03 42,22 -422.200 293.049
2014-10-24 2014-10-23 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 10.000 16.941 144,07 11,27 112.700 190.925
2014-10-24 2014-10-23 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -3.000 6.941 -30,18 42,22 -126.660 293.049
2014-10-24 2014-10-23 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 3.000 9.941 43,22 14,47 43.410 143.846
2014-10-03 2014-10-03 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -1.000 16.950 -5,57
2014-10-03 2014-10-03 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -13.000 3.000 -81,25
2014-10-03 2014-10-03 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1.000 627 -61,46 39,49 -39.487 24.758
2014-10-03 2014-10-03 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 1.000 1.627 159,49 9,22 9.220 15.001
2014-10-03 2014-10-03 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -13.000 6.941 -65,19 39,49 -513.331 274.079
2014-10-03 2014-10-03 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 13.000 19.941 187,29 14,47 188.110 288.546
2014-10-03 2014-10-01 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -800 17.950 -4,27
2014-10-03 2014-10-01 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -1.200 1.000 -54,55
2014-10-03 2014-10-01 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -20.000 16.000 -55,56
2014-10-03 2014-10-01 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -800 627 -56,06 37,91 -30.329 23.770
2014-10-03 2014-10-01 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 800 1.427 127,59 9,22 7.376 13.157
2014-10-03 2014-10-01 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1.200 627 -65,68 37,91 -45.493 23.770
2014-10-03 2014-10-01 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 1.200 1.827 191,39 11,27 13.524 20.590
2014-10-03 2014-10-01 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -20.000 6.941 -74,24 37,91 -758.220 263.140
2014-10-03 2014-10-01 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 20.000 26.941 288,14 14,47 289.400 389.836
2014-08-15 2014-08-13 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -1.600 2.200 -42,11
2014-08-15 2014-08-13 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -15.500 36.000 -30,10
2014-08-15 2014-08-13 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1.600 627 -71,85 35,45 -56.726 22.230
2014-08-15 2014-08-13 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 1.600 2.227 255,18 11,27 18.032 25.098
2014-08-15 2014-08-13 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -15.500 6.941 -69,07 35,45 -549.537 246.086
2014-08-15 2014-08-13 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 15.500 22.441 223,31 14,47 224.285 324.721
2014-08-01 2014-08-01 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -1.000 3.800 -20,83
2014-08-01 2014-08-01 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -15.000 51.500 -22,56
2014-08-01 2014-08-01 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1.000 627 -61,46 30,52 -30.525 19.139
2014-08-01 2014-08-01 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 1.000 1.627 159,49 11,27 11.270 18.336
2014-08-01 2014-08-01 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -15.000 6.941 -68,37 30,52 -457.875 211.874
2014-08-01 2014-08-01 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 15.000 21.941 216,11 14,47 217.050 317.486
2014-07-02 2014-07-01 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -1.800 4.800 -27,27
2014-07-02 2014-07-01 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -200 0 -100,00
2014-07-02 2014-07-01 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise 15.500 66.500 30,39
2014-07-02 2014-07-01 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1.800 627 -74,17 35,55 -63.990 22.290
2014-07-02 2014-07-01 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 1.800 2.427 287,08 11,27 20.286 27.352
2014-07-02 2014-07-01 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -200 627 -24,18 35,55 -7.110 22.290
2014-07-02 2014-07-01 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 200 827 31,90 14,47 2.894 11.967
2014-07-02 2014-07-01 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -15.500 6.941 -69,07 35,58 -551.459 246.947
2014-07-02 2014-07-01 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 15.500 22.441 223,31 14,47 224.285 324.721
2014-06-20 2014-06-19 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -11.000 82.000 -11,83
2014-06-20 2014-06-19 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -11.000 6.941 -61,31 35,10 -386.111 243.636
2014-06-20 2014-06-19 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 11.000 17.941 158,48 14,47 159.170 259.606
2014-06-12 2014-06-10 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -1.000 200 -83,33
2014-06-12 2014-06-10 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -10.000 93.000 -9,71
2014-06-12 2014-06-10 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1.000 627 -61,46 33,46 -33.455 20.976
2014-06-12 2014-06-10 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 1.000 1.627 159,49 14,47 14.470 23.543
2014-06-12 2014-06-10 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -10.000 6.941 -59,03 33,46 -334.550 232.211
2014-06-12 2014-06-10 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 10.000 16.941 144,07 14,47 144.700 245.136
2014-04-04 2014-04-02 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -1.800 1.200 -60,00
2014-04-04 2014-04-02 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -7.000 103.000 -6,36
2014-04-04 2014-04-02 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1.800 627 -74,17 43,65 -78.566 27.367
2014-04-04 2014-04-02 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 1.800 2.427 287,08 14,47 26.046 35.119
2014-04-04 2014-04-02 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -7.000 6.941 -50,21 43,65 -305.536 302.961
2014-04-04 2014-04-02 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 7.000 13.941 100,85 14,47 101.290 201.726
2014-01-17 2014-01-16 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale -121 627 -16,18 47,08 -5.697 29.520
2014-01-17 2014-01-16 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale -160 431 -27,07 47,08 -7.533 20.291
2014-01-17 2014-01-16 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale -1.134 6.941 -14,04 47,08 -53.390 326.790
2014-01-17 2014-01-16 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale -2.112 5.097 -29,30 47,08 -99.435 239.973
2014-01-17 2014-01-15 4 ISIS ISIS PHARMACEUTICALS INC
Restricted StockUnits
M - Exercise -317 632 -33,40
2014-01-17 2014-01-15 4 ISIS ISIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -417 1.249 -25,03
2014-01-17 2014-01-15 4 ISIS ISIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -2.978 5.954 -33,34
2014-01-17 2014-01-15 4 ISIS ISIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -5.548 16.642 -25,00
2014-01-17 2014-01-15 4 ISIS ISIS PHARMACEUTICALS INC
Restricted Stock Units
A - Award 1.416 1.416
2014-01-17 2014-01-15 4 ISIS ISIS PHARMACEUTICALS INC
Restricted Stock Units
A - Award 31.250 31.250
2014-01-17 2014-01-15 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise 317 748 73,55
2014-01-17 2014-01-15 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise 417 591 239,66
2014-01-17 2014-01-15 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise 2.978 8.075 58,43
2014-01-17 2014-01-15 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise 5.548 7.209 334,02
2014-01-10 2014-01-08 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -1.500 3.000 -33,33
2014-01-10 2014-01-08 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -11.000 110.000 -9,09
2014-01-10 2014-01-08 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1.500 174 -89,61 40,05 -60.078 6.969
2014-01-10 2014-01-08 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 1.500 1.674 862,07 14,47 21.705 24.223
2014-01-10 2014-01-08 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -11.000 1.661 -86,88 40,05 -440.572 66.526
2014-01-10 2014-01-08 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 11.000 12.661 662,25 14,47 159.170 183.205
2014-01-03 2014-01-02 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
A - Award 8.500 8.500
2014-01-03 2014-01-02 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
A - Award 187.500 187.500
2014-01-03 2014-01-02 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -2.500 174 -93,49 39,25 -98.132 6.830
2014-01-03 2014-01-02 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 2.500 2.674 1.436,78 14,47 36.175 38.693
2014-01-03 2014-01-02 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -4.000 1.661 -70,66 40,00 -160.000 66.440
2014-01-03 2014-01-02 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 4.000 5.661 240,82 14,47 57.880 81.915
2014-01-03 2014-01-02 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -25.000 1.661 -93,77 39,25 -981.325 65.199
2014-01-03 2014-01-02 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 25.000 26.661 1.505,12 14,47 361.750 385.785
2013-09-23 2013-09-20 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -8.740 0 -100,00
2013-09-23 2013-09-20 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -8.740 1.661 -84,03 35,90 -313.749 59.627
2013-09-23 2013-09-20 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 8.740 10.401 526,19 11,12 97.189 115.659
2013-09-23 2013-09-19 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -50.000 8.740 -85,12
2013-09-23 2013-09-19 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -30.000 1.661 -94,75 35,02 -1.050.600 58.168
2013-09-23 2013-09-19 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 30.000 31.661 1.806,14 11,12 333.600 352.070
2013-09-23 2013-09-19 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -20.000 1.661 -92,33 35,12 -702.480 58.341
2013-09-23 2013-09-19 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 20.000 21.661 1.204,09 11,12 222.400 240.870
2013-09-11 2013-09-11 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -20.000 725.391 -2,68 31,18 -623.620 22.618.417
2013-09-11 2013-09-10 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -30.000 745.391 -3,87 31,65 -949.440 23.590.134
2013-09-11 2013-09-09 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -26.615 58.740 -31,18
2013-09-11 2013-09-09 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -26.615 1.661 -94,13 30,42 -809.495 50.519
2013-09-11 2013-09-09 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 26.615 28.276 1.602,35 11,12 295.959 314.429
2013-07-25 2013-07-23 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -11.500 85.355 -11,87
2013-07-25 2013-07-23 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -11.500 1.661 -87,38 30,00 -345.000 49.830
2013-07-25 2013-07-23 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 11.500 13.161 692,35 11,12 127.880 146.350
2013-07-22 2013-07-22 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -1.885 96.855 -1,91
2013-07-22 2013-07-22 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -18.115 0 -100,00
2013-07-22 2013-07-22 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1.885 1.661 -53,16 31,02 -58.473 51.524
2013-07-22 2013-07-22 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 1.885 3.546 113,49 11,12 20.961 39.432
2013-07-22 2013-07-22 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -8.115 1.661 -83,01 31,02 -251.727 51.524
2013-07-22 2013-07-22 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 8.115 9.776 488,56 15,38 124.809 150.355
2013-07-22 2013-07-22 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -10.000 1.661 -85,76 30,52 -305.250 50.702
2013-07-22 2013-07-22 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 10.000 11.661 602,05 15,38 153.800 179.346
2013-07-22 2013-07-19 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -22.200 18.115 -55,07
2013-07-22 2013-07-19 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -10.000 1.661 -85,76 30,18 -301.850 50.137
2013-07-22 2013-07-19 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 10.000 11.661 602,05 15,38 153.800 179.346
2013-07-22 2013-07-19 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 10.000 11.661 602,05 15,38 153.800 179.346
2013-07-22 2013-07-19 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -10.000 1.661 -85,76 30,87 -308.720 51.278
2013-07-22 2013-07-19 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -2.200 1.661 -56,98 31,40 -69.080 52.155
2013-07-22 2013-07-19 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 2.200 3.861 132,45 15,38 33.836 59.382
2013-07-22 2013-07-18 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -20.000 98.740 -16,84
2013-07-22 2013-07-18 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -10.000 1.661 -85,76 30,02 -300.220 49.867
2013-07-22 2013-07-18 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 10.000 11.661 602,05 11,12 111.200 129.670
2013-07-22 2013-07-18 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 10.000 11.661 602,05 11,12 111.200 129.670
2013-07-22 2013-07-18 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -10.000 1.661 -85,76 30,20 -302.000 50.162
2013-07-17 2013-07-17 4 ISIS ISIS PHARMACEUTICALS INC
Emloyee Stock Option (right to buy)
M - Exercise -5.000 0 -100,00
2013-07-17 2013-07-17 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -8.300 0 -100,00
2013-07-17 2013-07-17 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -5.000 174 -96,64 31,96 -159.800 5.561
2013-07-17 2013-07-17 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 5.000 5.174 2.873,56 9,92 49.600 51.326
2013-07-17 2013-07-17 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -44 174 -20,18 31,96 -1.406 5.561
2013-07-17 2013-07-17 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 44 218 25,29 15,38 677 3.353
2013-07-17 2013-07-17 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -8.256 174 -97,94 31,22 -257.752 5.432
2013-07-17 2013-07-17 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 8.256 8.430 4.744,83 15,38 126.977 129.653
2013-07-17 2013-07-16 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -6.000 118.740 -4,81
2013-07-17 2013-07-16 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -6.000 1.661 -78,32 33,31 -199.842 55.323
2013-07-17 2013-07-16 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 6.000 7.661 361,23 11,12 66.720 85.190
2013-07-17 2013-07-15 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -30.000 124.740 -19,39
2013-07-17 2013-07-15 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -10.000 1.661 -85,76 33,56 -335.650 55.751
2013-07-17 2013-07-15 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 10.000 11.661 602,05 11,12 111.200 129.670
2013-07-17 2013-07-15 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 10.000 11.661 602,05 11,12 111.200 129.670
2013-07-17 2013-07-15 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -10.000 1.661 -85,76 33,80 -338.050 56.150
2013-07-17 2013-07-15 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -10.000 1.661 -85,76 34,05 -340.480 56.554
2013-07-17 2013-07-15 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 10.000 11.661 602,05 11,12 111.200 129.670
2013-07-12 2013-07-12 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -24.000 36.000 -40,00
2013-07-12 2013-07-12 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -6.000 40.315 -12,95
2013-07-12 2013-07-12 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -12.000 1.661 -87,84 33,50 -402.010 55.645
2013-07-12 2013-07-12 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 12.000 13.661 722,46 11,12 133.440 151.910
2013-07-12 2013-07-12 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 12.000 13.661 722,46 11,12 133.440 151.910
2013-07-12 2013-07-12 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -12.000 1.661 -87,84 33,08 -397.008 54.953
2013-07-12 2013-07-12 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -6.000 1.661 -78,32 32,83 -196.980 54.531
2013-07-12 2013-07-12 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 6.000 7.661 361,23 15,38 92.280 117.826
2013-07-12 2013-07-11 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -30.000 46.315 -39,31
2013-07-12 2013-07-11 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -30.000 1.661 -94,75 32,00 -960.090 53.157
2013-07-12 2013-07-11 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 30.000 311.661 10,65 15,38 461.400 4.793.346
2013-07-12 2013-07-10 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -30.000 76.315 -28,22
2013-07-12 2013-07-10 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -30.000 1.661 -94,75 30,05 -901.440 49.910
2013-07-12 2013-07-10 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 30.000 31.661 1.806,14 15,38 461.400 486.946
2013-07-09 2013-07-09 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -30.000 106.315 -22,01
2013-07-09 2013-07-09 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -30.000 1.661 -94,75 30,04 -901.290 49.901
2013-07-09 2013-07-09 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 30.000 31.661 1.806,14 15,38 461.400 486.946
2013-07-09 2013-07-08 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -30.000 136.315 -18,04
2013-07-09 2013-07-08 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -24.992 1.661 -93,77 30,09 -752.009 49.979
2013-07-09 2013-07-08 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X 24.992 26.653 1.504,64 15,38 384.377 409.923
2013-07-09 2013-07-08 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -5.008 1.661 -75,09 30,03 -150.370 49.873
2013-07-09 2013-07-08 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 5.008 6.669 301,51 15,38 77.023 102.569
2013-07-09 2013-07-05 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -24.180 166.315 -12,69
2013-07-09 2013-07-05 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -24.180 1.661 -93,57 30,02 -725.763 49.855
2013-07-09 2013-07-05 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 24.180 25.841 1.455,75 15,38 371.888 397.435
2013-07-01 2013-07-01 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -10.000 775.391 -1,27 28,17 -281.700 21.842.764
2013-07-01 2013-06-28 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -5.958 0 -100,00
2013-07-01 2013-06-28 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -4.725 0 -100,00
2013-07-01 2013-06-28 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -10.000 0 -100,00
2013-07-01 2013-06-28 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -5.958 174 -97,16 27,31 -162.713 4.752
2013-07-01 2013-06-28 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 5.958 6.132 3.424,14 11,12 66.253 68.188
2013-07-01 2013-06-28 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -4.725 174 -96,45 27,31 -129.040 4.752
2013-07-01 2013-06-28 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 4.725 4.899 2.715,52 6,81 32.177 33.362
2013-07-01 2013-06-28 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -10.000 1.661 -85,76 27,07 -270.700 44.963
2013-07-01 2013-06-28 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 10.000 11.661 602,05 6,81 68.100 79.411
2013-07-01 2013-06-27 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -20.000 10.000 -66,67
2013-07-01 2013-06-27 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -10.000 1.661 -85,76 27,40 -274.000 45.511
2013-07-01 2013-06-27 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 10.000 11.661 602,05 6,81 68.100 79.411
2013-07-01 2013-06-27 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 10.000 11.661 602,05 6,81 68.100 79.411
2013-07-01 2013-06-27 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -10.000 1.661 -85,76 28,30 -283.000 47.006
2013-06-26 2013-06-26 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -20.000 30.000 -40,00
2013-06-26 2013-06-26 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -10.000 785.391 -1,26 26,70 -267.000 20.969.940
2013-06-26 2013-06-26 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -20.000 1.661 -92,33 27,10 -542.020 45.015
2013-06-26 2013-06-26 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 20.000 21.661 1.204,09 6,81 136.200 147.511
2013-06-26 2013-06-25 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -30.000 50.000 -37,50
2013-06-26 2013-06-25 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -19.565 1.661 -92,17 27,86 -545.179 46.284
2013-06-26 2013-06-25 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 19.565 21.226 1.177,90 6,81 133.238 144.549
2013-06-26 2013-06-25 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -10.435 1.661 -86,27 28,32 -295.519 47.040
2013-06-26 2013-06-25 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 10.435 12.096 628,24 6,81 71.062 82.374
2013-06-26 2013-06-24 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -13.730 795.391 -1,70 25,22 -346.271 20.059.761
2013-06-26 2013-06-24 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -16.270 809.121 -1,97 25,16 -409.353 20.357.484
2013-04-26 2013-04-24 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -10.000 825.391 -1,20 22,12 -221.200 18.257.649
2013-04-23 2013-04-23 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale -30.000 835.391 -3,47 22,10 -662.901 18.459.384
2013-04-23 2013-04-22 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -20.000 0 -100,00
2013-04-23 2013-04-22 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -10.000 865.391 -1,14 20,99 -209.900 18.164.557
2013-04-23 2013-04-22 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -20.000 1.661 -92,33 20,99 -419.800 34.864
2013-04-23 2013-04-22 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 20.000 21.661 1.204,09 7,26 145.200 157.259
2013-04-23 2013-04-19 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -30.000 20.000 -60,00
2013-04-23 2013-04-19 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -30.000 1.661 -94,75 20,01 -600.180 33.230
2013-04-23 2013-04-19 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 30.000 31.661 1.806,14 7,26 217.800 229.859
2013-02-01 2013-01-30 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
A - Award 133.180 133.180
2013-02-01 2013-01-30 4 ISIS ISIS PHARMACEUTICALS INC
Restricted Stock Units
A - Award 22.190 22.190
2013-01-17 2013-01-16 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale -143 174 -45,11 14,00 -2.002 2.436
2013-01-17 2013-01-16 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale -1.317 1.661 -44,22 14,00 -18.438 23.254
2013-01-17 2013-01-15 4 ISIS ISIS PHARMACEUTICALS INC
Restricted Stock Units
A - Award 1.666 1.666
2013-01-17 2013-01-15 4 ISIS ISIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -317 949 -25,04
2013-01-17 2013-01-15 4 ISIS ISIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -2.978 8.932 -25,00
2013-01-17 2013-01-15 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise 317 317
2013-01-17 2013-01-15 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise 2.978 2.978
2013-01-03 2013-01-02 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
A - Award 10.000 10.000
2012-11-07 2012-11-05 4 RGLS Regulus Therapeutics Inc.
Stock Option (Right to Buy)
A - Award 25.000 25.000
2012-10-11 2012-10-10 4 RGLS Regulus Therapeutics Inc.
Series A Preferred Stock
C - Conversion -6.299.500 0 -100,00
2012-10-11 2012-10-10 4 RGLS Regulus Therapeutics Inc.
Common Stock
P - Purchase 750.000 7.049.500 11,91 4,00 3.000.000 28.198.000
2012-10-11 2012-10-10 4 RGLS Regulus Therapeutics Inc.
Common Stock
C - Conversion 6.299.500 6.299.500
2012-09-21 2012-09-21 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -29.462 0 -100,00
2012-09-21 2012-09-21 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -29.462 0 -100,00 14,06 -414.236
2012-09-21 2012-09-21 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 29.462 29.462 6,84 201.520 201.520
2012-09-21 2012-09-20 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -20.538 29.462 -41,08
2012-09-21 2012-09-20 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -9.462 0 -100,00
2012-09-21 2012-09-20 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X 20.538 0 -100,00 15,01 308.234
2012-09-21 2012-09-20 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 20.538 20.538 6,84 140.480 140.480
2012-09-21 2012-09-20 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -9.462 0 -100,00 15,01 -142.006
2012-09-21 2012-09-20 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 9.462 9.462 5,25 49.676 49.676
2012-09-21 2012-09-19 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -30.000 9.462 -76,02
2012-09-21 2012-09-19 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -30.000 0 -100,00 14,82 -444.450
2012-09-21 2012-09-19 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 30.000 30.000 5,25 157.500 157.500
2012-09-17 2012-09-13 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -27.074 39.462 -40,69
2012-09-17 2012-09-13 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -27.074 0 -100,00 14,55 -393.927
2012-09-17 2012-09-13 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 27.074 27.074 5,25 142.138 142.138
2012-09-06 2012-09-06 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -6.000 0 -100,00
2012-09-06 2012-09-06 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -4.687 0 -100,00
2012-09-06 2012-09-06 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -1.925 0 -100,00
2012-09-06 2012-09-06 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -17.388 66.536 -20,72
2012-09-06 2012-09-06 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -6.000 0 -100,00 15,00 -90.012
2012-09-06 2012-09-06 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 6.000 6.000 5,25 31.500 31.500
2012-09-06 2012-09-06 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -306 0 -100,00 15,00 -4.591
2012-09-06 2012-09-06 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 306 306 5,25 1.606 1.606
2012-09-06 2012-09-06 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -4.381 0 -100,00 15,04 -65.868
2012-09-06 2012-09-06 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 4.381 4.381 5,25 23.000 23.000
2012-09-06 2012-09-06 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1.925 0 -100,00 15,04 -28.942
2012-09-06 2012-09-06 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 1.925 1.925 6,84 13.167 13.167
2012-09-06 2012-09-06 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -8.694 0 -100,00 15,04 -130.714
2012-09-06 2012-09-06 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 8.694 8.694 5,25 45.644 45.644
2012-09-06 2012-09-06 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -8.694 0 -100,00 15,00 -130.427
2012-09-06 2012-09-06 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 8.694 8.694 5,25 45.644 45.644
2012-09-06 2012-09-05 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -15.000 83.924 -15,16
2012-09-06 2012-09-05 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -15.000 0 -100,00 14,82 -222.345
2012-09-06 2012-09-05 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 15.000 15.000 5,25 78.750 78.750
2012-09-06 2012-09-04 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -30.000 98.924 -23,27
2012-09-06 2012-09-04 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -30.000 0 -100,00 14,11 -423.255
2012-09-06 2012-09-04 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 30.000 30.000 5,25 157.500 157.500
2012-01-17 2012-01-15 4 ISIS ISIS PHARMACEUTICALS INC
Restricted Stock Units
A - Award 1.266 1.266
2012-01-17 2012-01-15 4 ISIS ISIS PHARMACEUTICALS INC
Restricted Stock Units
A - Award 11.910 11.910
2012-01-03 2012-01-03 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
A - Award 11.404 11.404
2012-01-03 2012-01-03 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
A - Award 107.203 107.203
2010-01-05 2010-01-04 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
A - Award 6.600 6.600
2010-01-05 2010-01-04 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
A - Award 119.163 119.163
2004-12-01 2004-12-01 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -5.000 7.051 -41,49
2004-12-01 2004-12-01 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -5.000 922.241 -0,54 4,90 -24.479 4.515.107
2004-12-01 2004-12-01 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise 5.000 927.241 0,54 4,00 20.000 3.708.964
2004-12-01 2004-11-30 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -4.000 12.051 -24,92
2004-12-01 2004-11-30 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -4.000 922.241 -0,43 4,70 -18.820 4.339.144
2004-12-01 2004-11-30 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise 4.000 926.241 0,43 4,00 16.000 3.704.964
2004-12-01 2004-11-29 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -1.549 16.051 -8,80
2004-12-01 2004-11-29 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1.549 922.241 -0,17 4,62 -7.153 4.258.817
2004-12-01 2004-11-29 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise 1.549 923.790 0,17 4,00 6.196 3.695.160
P
Åbent marked eller privat køb af ikke-afledte eller afledte værdipapirer
S
Åbent marked eller privat salg af ikke-afledte eller afledte værdipapirer
A
Tildeling, tildeling eller anden erhvervelse af værdipapirer fra virksomheden (såsom en option)
C
Konvertering af derivat
D
Salg eller overførsel af værdipapirer tilbage til virksomheden
F
Betaling af udnyttelseskurs eller skatteforpligtelse ved brug af en del af værdipapirer modtaget fra selskabet
G
Gave af værdipapirer af eller til insideren
K
Aktieswaps og lignende sikringstransaktioner
M
Udnyttelse eller konvertering af afledt værdipapir modtaget fra virksomheden (såsom en option)
V
En transaktion rapporteret frivilligt på formular 4
J
Andet (ledsaget af en fodnote, der beskriver transaktionen)