Xeris Biopharma Holdings, Inc.
US ˙ NasdaqGS ˙ US98422E1038

SecurityXERS / Xeris Biopharma Holdings, Inc.
InstitutionDriehaus Capital Management Llc
Latest Disclosed Ownership902,740 shares
Latest Disclosed Value $ 5,235,892
Driehaus Capital Management Llc reports 69.71% decrease in ownership of XERS / Xeris Biopharma Holdings, Inc.

On May 15, 2026 - Driehaus Capital Management Llc filed a 13F-HR form disclosing ownership of 902,740 shares of Xeris Biopharma Holdings, Inc. (US:XERS) valued at $5,235,892 USD as of March 31, 2026. The entity filed a previous 13F-HR on February 17, 2026 disclosing 2,980,567 shares of Xeris Biopharma Holdings, Inc.. This represents a change in shares of -69.71% during the quarter. The current value of the position is $5,317,139 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date
Effective
Date
Form Security Class ID Avg Price
Paid (Est)
Reported
Shares
ΔShares ΔShares
(%)
Reported
Value
(x1000)
ΔValue
(%)
Alloc
(%)
ΔAlloc ΔAlloc (%) Cost Basis
(x1000)
Unrealized
Gain/Loss
(x1000)
2026-05-15 2026-03-31 13F Xeris Biopharma Holdings COM 98422E103 902,740 -2,077,827 -69.71 5,236 -77.63 0.0385
2026-02-17 2025-12-31 13F Xeris Biopharma Holdings COM 98422E103 2,980,567 361,438 13.80 23,397 9.75 0.1589
2025-11-14 2025-09-30 13F XERIS BIOPHARMA HOLDINGS COM 98422E103 2,619,129 548,054 26.46 21,320 120.44 0.1527
2025-08-14 2025-06-30 13F XERIS BIOPHARMA HOLDINGS COM 98422E103 2,071,075 659,535 46.72 9,672 24.80 0.0774
2025-05-15 2025-03-31 13F XERIS BIOPHARMA HOLDINGS COM 98422E103 1,411,540 817,525 137.63 7,749 284.95 0.0747
2025-02-14 2024-12-31 13F XERIS BIOPHARMA HOLDINGS COM 98422E103 594,015 594,015 2,014 0.0166
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.