Supernus Pharmaceuticals, Inc.
US ˙ NasdaqGM ˙ US8684591089

SecuritySUPN / Supernus Pharmaceuticals, Inc.
InstitutionD. E. Shaw & Co., Inc.
ManagerDE Shaw
Latest Disclosed Ownership622,450 shares
Latest Disclosed Value $ 32,174,441
D. E. Shaw & Co., Inc. reports 12.08% decrease in ownership of SUPN / Supernus Pharmaceuticals, Inc.

On May 15, 2026 - D. E. Shaw & Co., Inc. filed a 13F-HR form disclosing ownership of 622,450 shares of Supernus Pharmaceuticals, Inc. (US:SUPN) valued at $32,174,440 USD as of March 31, 2026. The entity filed a previous 13F-HR on February 17, 2026 disclosing 707,982 shares of Supernus Pharmaceuticals, Inc.. This represents a change in shares of -12.08% during the quarter. The current value of the position is $27,409,586 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-05-15 2026-03-31 13F SUPERNUS PHARMACEUTICALS COM 868459108 622,450 -85,532 -12.08 32,174 -8.56 0.0193
2026-02-17 2025-12-31 13F SUPERNUS PHARMACEUTICALS COM 868459108 707,982 -271,622 -27.73 35,187 -24.84 0.0193
2025-11-14 2025-09-30 13F SUPERNUS PHARMACEUTICALS COM 868459108 979,604 380,983 63.64 46,815 148.12 0.0264
2025-08-14 2025-06-30 13F SUPERNUS PHARMACEUTICALS COM 868459108 598,621 130,740 27.94 18,869 23.14 0.0134
2025-05-15 2025-03-31 13F SUPERNUS PHARMACEUTICALS COM 868459108 467,881 -77,777 -14.25 15,323 -22.34 0.0136
2025-02-14 2024-12-31 13F SUPERNUS PHARMACEUTICALS COM 868459108 545,658 136,870 33.48 19,731 54.79 0.0145
2024-11-14 2024-09-30 13F SUPERNUS PHARMACEUTICALS COM 868459108 408,788 117,991 40.58 12,746 63.87 0.0109
2024-08-14 2024-06-30 13F SUPERNUS PHARMACEUTICALS COM 868459108 290,797 160,431 123.06 7,779 74.94 0.0073
2024-05-15 2024-03-31 13F SUPERNUS PHARMACEUTICALS COM 868459108 130,366 1,213 0.94 4,447 18.97 0.0038
2024-02-14 2023-12-31 13F SUPERNUS PHARMACEUTICALS COM 868459108 129,153 104,130 416.14 3,738 442.38 0.0033
2023-11-14 2023-09-30 13F SUPERNUS PHARMACEUTICALS COM 868459108 25,023 523 2.13 690 -6.39 0.0007
2023-08-14 2023-06-30 13F SUPERNUS PHARMACEUTICALS COM 868459108 24,500 -4,776 -16.31 736 -30.57 0.0008
2023-05-15 2023-03-31 13F SUPERNUS PHARMACEUTICALS COM 868459108 29,276 -77 -0.26 1,061 1.24 0.0011
2023-02-14 2022-12-31 13F SUPERNUS PHARMACEUTICALS COM 868459108 29,353 2,153 7.92 1,047 13.68 0.0012
2022-11-14 2022-09-30 13F SUPERNUS PHARMACEUTICALS COM 868459108 27,200 11,100 68.94 921 97.64 0.0011
2022-08-15 2022-06-30 13F SUPERNUS PHARMACEUTICALS COM 868459108 16,100 8,360 108.01 466 86.40 0.0005
2022-05-16 2022-03-31 13F SUPERNUS PHARMACEUTICALS COM 868459108 7,740 7,740 250 0.0002
2021-11-15 2021-09-30 13F SUPERNUS PHARMACEUTICALS COM 868459108 0 -9,923 -100.00 0 -100.00
2021-08-16 2021-06-30 13F SUPERNUS PHARMACEUTICALS COM 868459108 9,923 -4,841 -32.79 306 -20.93 0.0003
2021-05-17 2021-03-31 13F SUPERNUS PHARMACEUTICALS COM 868459108 14,764 -6,643 -31.03 387 -28.20 0.0004
2021-02-16 2020-12-31 13F SUPERNUS PHARMACEUTICALS COM 868459108 21,407 -117,117 -84.55 539 -81.33 0.0005
2020-11-16 2020-09-30 13F SUPERNUS PHARMACEUTICALS COM 868459108 138,524 -93,251 -40.23 2,887 -47.56 0.0030
2020-08-14 2020-06-30 13F SUPERNUS PHARMACEUTICALS COM 868459108 231,775 3,297 1.44 5,505 33.91 0.0066
2020-05-15 2020-03-31 13F SUPERNUS PHARMACEUTICALS COM 868459108 228,478 69,630 43.83 4,111 9.10 0.0064
2020-02-14 2019-12-31 13F SUPERNUS PHARMACEUTICALS COM 868459108 158,848 145,748 1,112.58 3,768 946.67 0.0043
2019-11-14 2019-09-30 13F SUPERNUS PHARMACEUTICALS COM 868459108 13,100 13,100 360 0.0004
2019-08-14 2019-06-30 13F SUPERNUS PHARMACEUTICALS COM 868459108 0 -27,535 -100.00 0 -100.00
2019-05-15 2019-03-31 13F SUPERNUS PHARMACEUTICALS COM 868459108 27,535 -25,367 -47.95 965 -45.08 0.0012
2019-02-14 2018-12-31 13F SUPERNUS PHARMACEUTICALS COM 868459108 52,902 52,902 1,757 0.0024
2018-08-14 2018-06-30 13F SUPERNUS PHARMACEUTICALS COM 868459108 0 -7,400 -100.00 0 -100.00
2018-05-15 2018-03-31 13F SUPERNUS PHARMACEUTICALS COM 868459108 7,400 -5,057 -40.60 339 -31.65 0.0005
2018-02-14 2017-12-31 13F SUPERNUS PHARMACEUTICALS COM 868459108 12,457 -395 -3.07 496 -3.50 0.0007
2017-11-14 2017-09-30 13F SUPERNUS PHARMACEUTICALS COM 868459108 12,852 -4,396 -25.49 514 -30.82 0.0008
2017-08-14 2017-06-30 13F SUPERNUS PHARMACEUTICALS COM 868459108 17,248 -760 -4.22 743 31.74 0.0012
2017-05-15 2017-03-31 13F SUPERNUS PHARMACEUTICALS COM 868459108 18,008 -4,586 -20.30 564 -1.05 0.0010
2017-02-14 2016-12-31 13F SUPERNUS PHARMACEUTICALS COM 868459108 22,594 8,840 64.27 570 67.65 0.0010
2016-11-14 2016-09-30 13F SUPERNUS PHARMACEUTICALS COM 868459108 13,754 -1,719 -11.11 340 7.94 0.0006
2016-08-15 2016-06-30 13F SUPERNUS PHARMACEUTICALS COM 868459108 15,473 -6,537 -29.70 315 -6.25 0.0006
2016-05-16 2016-03-31 13F SUPERNUS PHARMACEUTICALS COM 868459108 22,010 -3,915 -15.10 336 -3.45 0.0006
2016-02-16 2015-12-31 13F SUPERNUS PHARMACEUTICALS COM 868459108 25,925 -54,163 -67.63 348 -69.04 0.0005
2015-11-16 2015-09-30 13F SUPERNUS PHARMACEUTICALS COM 868459108 80,088 -38,340 -32.37 1,124 -44.11 0.0017
2015-08-14 2015-06-30 13F SUPERNUS PHARMACEUTICALS COM 868459108 118,428 108,119 1,048.78 2,011 1,508.80 0.0030
2015-05-15 2015-03-31 13F SUPERNUS PHARMACEUTICALS COM 868459108 10,309 -27,489 -72.73 125 -60.19 0.0002
2015-02-17 2014-12-31 13F SUPERNUS PHARMACEUTICALS COM 868459108 37,798 -30,745 -44.86 314 -47.32 0.0004
2014-11-14 2014-09-30 13F SUPERNUS PHARMACEUTICALS COM 868459108 68,543 -57,742 -45.72 596 -56.91 0.0008
2014-08-14 2014-06-30 13F SUPERNUS PHARMACEUTICALS COM 868459108 126,285 -26,157 -17.16 1,383 1.47 0.0019
2014-05-15 2014-03-31 13F SUPERNUS PHARMACEUTICALS COM 868459108 152,442 152,442 354.16 1,363 454.07 0.0019
2014-02-14 2013-12-31 13F SUPERNUS PHARMACEUTICALS COM 868459108 0 -33,566 -100.00 0 -100.00
2013-11-20 2013-09-30 13F/A-1 SUPERNUS PHARMACEUTICALS COM 868459108 33,566 33,566 246 0.0004
2013-11-14 2013-09-30 13F SUPERNUS PHARMACEUTICALS COM 868459108 33,566 246 0.0004
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.