Rhythm Pharmaceuticals, Inc.
US ˙ NasdaqGM ˙ US76243J1051

SecurityRYTM / Rhythm Pharmaceuticals, Inc.
InstitutionFranklin Resources Inc
Latest Disclosed Ownership626,845 shares
Latest Disclosed Value $ 54,516,709
Franklin Resources Inc reports 9.90% decrease in ownership of RYTM / Rhythm Pharmaceuticals, Inc.

On May 13, 2026 - Franklin Resources Inc filed a 13F-HR form disclosing ownership of 626,845 shares of Rhythm Pharmaceuticals, Inc. (US:RYTM) valued at $54,516,710 USD as of March 31, 2026. The entity filed a previous 13F-HR on February 11, 2026 disclosing 695,735 shares of Rhythm Pharmaceuticals, Inc.. This represents a change in shares of -9.90% during the quarter. The current value of the position is $53,100,040 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date
Effective
Date
Form Security Class ID Avg Price
Paid (Est)
Reported
Shares
ΔShares ΔShares
(%)
Reported
Value
(x1000)
ΔValue
(%)
Alloc
(%)
ΔAlloc ΔAlloc (%) Cost Basis
(x1000)
Unrealized
Gain/Loss
(x1000)
2026-05-13 2026-03-31 13F RHYTHM PHARMACEUTICALS COM 76243J105 626,845 -68,890 -9.90 54,517 -26.80 0.0022
2026-02-11 2025-12-31 13F RHYTHM PHARMACEUTICALS COM 76243J105 695,735 127,953 22.54 74,471 29.88 0.0183
2025-11-13 2025-09-30 13F RHYTHM PHARMACEUTICALS COM 76243J105 567,782 23,980 4.41 57,340 66.87 0.0143
2025-08-12 2025-06-30 13F RHYTHM PHARMACEUTICALS COM 76243J105 543,802 217,642 66.73 34,363 98.90 0.0091
2025-05-13 2025-03-31 13F RHYTHM PHARMACEUTICALS COM 76243J105 326,160 57,955 21.61 17,277 15.07 0.0050
2025-02-12 2024-12-31 13F RHYTHM PHARMACEUTICALS COM 76243J105 268,205 8,789 3.39 15,014 15.20 0.0042
2024-11-27 2024-09-30 13F/A-1 RHYTHM PHARMACEUTICALS COM 76243J105 259,416 26,739 11.49 13,033 36.43 0.0037
2024-11-12 2024-09-30 13F RHYTHM PHARMACEUTICALS COM 76243J105 259,416 26,739 13,033 0.0006
2024-08-14 2024-06-30 13F RHYTHM PHARMACEUTICALS COM 76243J105 232,677 11,772 5.33 9,554 -0.19 0.0029
2024-05-13 2024-03-31 13F RHYTHM PHARMACEUTICALS COM 76243J105 220,905 215,029 3,659.45 9,572 3,444.81 0.0030
2024-02-09 2023-12-31 13F RHYTHM PHARMACEUTICALS COM 76243J105 5,876 5,876 270 0.0001
2022-11-14 2022-09-30 13F RHYTHM PHARMACEUTICALS COM 76243J105 0 -1,779,465 -100.00 0 -100.00
2022-08-11 2022-06-30 13F RHYTHM PHARMACEUTICALS COM 76243J105 1,779,465 11 0.00 7,385 -63.97 0.0037
2022-05-13 2022-03-31 13F RHYTHM PHARMACEUTICALS COM 76243J105 1,779,454 242,582 15.78 20,499 33.65 0.0082
2022-02-11 2021-12-31 13F RHYTHM PHARMACEUTICALS COM 76243J105 1,536,872 1,368,789 814.35 15,338 598.77 0.0055
2021-11-12 2021-09-30 13F RHYTHM PHARMACEUTICALS COM 76243J105 168,083 168,083 2,195 0.0008
2018-08-14 2018-06-30 13F RHYTHM PHARMACEUTICALS COM 76243J105 0 -107,900 -100.00 0 -100.00
2018-05-10 2018-03-31 13F RHYTHM PHARMACEUTICALS COM 76243J105 107,900 -139,000 -56.30 2,147 -70.08 0.0011
2018-02-14 2017-12-31 13F RHYTHM PHARMACEUTICALS COM 76243J105 246,900 246,900 7,175 0.0034
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.