Rhythm Pharmaceuticals, Inc.
US ˙ NasdaqGM ˙ US76243J1051

SecurityRYTM / Rhythm Pharmaceuticals, Inc.
InstitutionDimensional Fund Advisors Lp
Latest Disclosed Ownership19,151 shares
Latest Disclosed Value $ 1,665,562
Dimensional Fund Advisors Lp reports 40.19% decrease in ownership of RYTM / Rhythm Pharmaceuticals, Inc.

On May 7, 2026 - Dimensional Fund Advisors Lp filed a 13F-HR form disclosing ownership of 19,151 shares of Rhythm Pharmaceuticals, Inc. (US:RYTM) valued at $1,665,562 USD as of March 31, 2026. The entity filed a previous 13F-HR on February 12, 2026 disclosing 32,018 shares of Rhythm Pharmaceuticals, Inc.. This represents a change in shares of -40.19% during the quarter. The current value of the position is $1,622,281 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-05-07 2026-03-31 13F RHYTHM PHARMACEUTICALS COM 76243J105 19,151 -12,867 -40.19 1,666 -51.42 0.0001
2026-02-12 2025-12-31 13F RHYTHM PHARMACEUTICALS COM 76243J105 32,018 3,640 12.83 3,427 19.62 0.0007
2025-11-12 2025-09-30 13F RHYTHM PHARMACEUTICALS COM 76243J105 28,378 28,378 2,866 0.0006
2024-05-10 2024-03-31 13F RHYTHM PHARMACEUTICALS COM 76243J105 0 -96,948 -100.00 0 -100.00
2024-02-07 2023-12-31 13F RHYTHM PHARMACEUTICALS COM 76243J105 96,948 0 0.00 4,459 100.54 0.0013
2023-11-09 2023-09-30 13F RHYTHM PHARMACEUTICALS COM 76243J105 96,948 -7,010 -6.74 2,223 29.70 0.0007
2023-08-09 2023-06-30 13F RHYTHM PHARMACEUTICALS COM 76243J105 103,958 -20,551 -16.51 1,715 -22.83 0.0005
2023-05-12 2023-03-31 13F RHYTHM PHARMACEUTICALS COM 76243J105 124,509 -12,482 -9.11 2,221 73,933.33 0.0007
2023-02-09 2022-12-31 13F RHYTHM PHARMACEUTICALS COM 76243J105 136,991 -86,140 -38.61 4 -99.95 0.0012
2022-11-10 2022-09-30 13F RHYTHM PHARMACEUTICALS COM 76243J105 223,131 -30,110 -11.89 5,466 420.57 0.0021
2022-08-12 2022-06-30 13F RHYTHM PHARMACEUTICALS COM 76243J105 253,241 59,532 30.73 1,050 -52.94 0.0004
2022-05-13 2022-03-31 13F RHYTHM PHARMACEUTICALS COM 76243J105 193,709 34,840 21.93 2,231 40.67 0.0007
2022-02-09 2021-12-31 13F RHYTHM PHARMACEUTICALS COM 76243J105 158,869 -21,576 -11.96 1,586 -32.71 0.0005
2021-11-12 2021-09-30 13F RHYTHM PHARMACEUTICALS COM 76243J105 180,445 -109,825 -37.84 2,357 -58.53 0.0008
2021-08-12 2021-06-30 13F RHYTHM PHARMACEUTICALS COM 76243J105 290,270 -18,303 -5.93 5,684 -13.54 0.0018
2021-05-14 2021-03-31 13F RHYTHM PHARMACEUTICALS COM 76243J105 308,573 -31,084 -9.15 6,574 -34.90 0.0022
2021-03-08 2020-12-31 13F/A-2 RHYTHM PHARMACEUTICALS COM 76243J105 339,657 4,843 1.45 10,098 39.17 0.0036
2021-02-11 2020-12-31 13F RHYTHM PHARMACEUTICALS COM 76243J105 339,657 4,843 10,098 3,646.8609
2020-11-12 2020-09-30 13F RHYTHM PHARMACEUTICALS COM 76243J105 334,814 12,179 3.77 7,256 0.86 0.0031
2020-08-13 2020-06-30 13F RHYTHM PHARMACEUTICALS COM 76243J105 322,635 54,104 20.15 7,194 76.06 0.0032
2020-05-14 2020-03-31 13F RHYTHM PHARMACEUTICALS COM 76243J105 268,531 -4,015 -1.47 4,086 -34.71 0.0021
2020-02-14 2019-12-31 13F RHYTHM PHARMACEUTICALS COM 76243J105 272,546 13,032 5.02 6,258 11.69 0.0023
2019-11-12 2019-09-30 13F RHYTHM PHARMACEUTICALS COM 76243J105 259,514 45,497 21.26 5,603 19.01 0.0022
2019-08-13 2019-06-30 13F RHYTHM PHARMACEUTICALS COM 76243J105 214,017 116,406 119.26 4,708 75.80 0.0018
2019-08-12 2019-03-31 13F/A-2 RHYTHM PHARMACEUTICALS COM 76243J105 97,611 43,787 81.35 2,678 85.07 0.0011
2019-05-10 2019-03-31 13F RHYTHM PHARMACEUTICALS COM 76243J105 97,611 43,787 2,678
2019-02-26 2018-12-31 13F/A-1 RHYTHM PHARMACEUTICALS COM 76243J105 53,824 53,824 1,447 0.0007
2019-02-13 2018-12-31 13F RHYTHM PHARMACEUTICALS COM 76243J105 53,824 1,447 0.0007
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.