Relay Therapeutics, Inc.
US ˙ NasdaqGM ˙ US75943R1023

SecurityRLAY / Relay Therapeutics, Inc.
InstitutionBarclays Plc
Latest Disclosed Ownership414,143 shares
Latest Disclosed Value $ 3,503,650
Barclays Plc reports 10.34% decrease in ownership of RLAY / Relay Therapeutics, Inc.

On February 13, 2026 - Barclays Plc filed a 13F-HR form disclosing ownership of 414,143 shares of Relay Therapeutics, Inc. (US:RLAY) valued at $3,503,650 USD as of December 31, 2025. The entity filed a previous 13F-HR/A on March 31, 2026 disclosing 461,879 shares of Relay Therapeutics, Inc.. This represents a change in shares of -10.34% during the quarter. The current value of the position is $6,336,388 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-02-13 2025-12-31 13F RELAY THERAPEUTICS COM 75943R102 414,143 -47,736 -10.34 3,504 45.29 0.0008
2026-03-31 2025-09-30 13F/A-3 RELAY THERAPEUTICS COM 75943R102 461,879 -94,643 -17.01 2,411 25.25 0.0005
2026-03-19 2025-09-30 13F/A-2 RELAY THERAPEUTICS COM 75943R102 251,819 -304,703 1,783 0.0005
2025-11-12 2025-09-30 13F RELAY THERAPEUTICS COM 75943R102 461,879 -94,643 2,411 0.0005
2026-02-27 2025-06-30 13F/A-2 RELAY THERAPEUTICS COM 75943R102 556,522 87,351 18.62 1,926 56.63 0.0004
2025-08-14 2025-06-30 13F/A-1 RELAY THERAPEUTICS COM 75943R102 556,522 87,351 2 0.0004
2025-08-13 2025-06-30 13F RELAY THERAPEUTICS COM 75943R102 556,522 87,351 2 0.0001
2026-03-17 2025-03-31 13F/A-1 RELAY THERAPEUTICS COM 75943R102 469,171 155,969 49.80 1,229 -4.73 0.0003
2025-05-15 2025-03-31 13F RELAY THERAPEUTICS COM 75943R102 469,171 155,969 1 0.0003
2026-03-19 2024-12-31 13F/A-1 RELAY THERAPEUTICS COM 75943R102 313,202 61,383 24.38 1,290 -27.61 0.0004
2025-02-13 2024-12-31 13F RELAY THERAPEUTICS COM 75943R102 313,202 61,383 1 0.0004
2026-03-31 2024-09-30 13F/A-2 RELAY THERAPEUTICS COM 75943R102 251,819 136,541 118.44 1,783 137.28 0.0005
2024-11-19 2024-09-30 13F/A-1 RELAY THERAPEUTICS COM 75943R102 251,819 136,541 2 0.0005
2024-11-15 2024-09-30 13F RELAY THERAPEUTICS COM 75943R102 251,819 136,541 2 0.0001
2026-03-23 2024-06-30 13F/A-1 RELAY THERAPEUTICS COM 75943R102 115,278 -24,718 -17.66 752 -35.31 0.0002
2024-08-14 2024-06-30 13F RELAY THERAPEUTICS COM 75943R102 115,278 -24,718 1 0.0002
2026-03-24 2024-03-31 13F/A-1 RELAY THERAPEUTICS COM 75943R102 139,996 -154,789 -52.51 1,162 -64.22 0.0004
2024-05-15 2024-03-31 13F RELAY THERAPEUTICS COM 75943R102 139,996 -154,789 1 0.0004
2026-03-25 2023-12-31 13F/A-1 RELAY THERAPEUTICS COM 75943R102 294,785 79,316 36.81 3,246 79.08 0.0012
2024-02-15 2023-12-31 13F RELAY THERAPEUTICS COM 75943R102 294,785 79,316 3 0.0012
2026-03-26 2023-09-30 13F/A-1 RELAY THERAPEUTICS COM 75943R102 215,469 -93,710 -30.31 1,812 -53.34 0.0011
2023-11-07 2023-09-30 13F RELAY THERAPEUTICS COM 75943R102 215,469 -93,710 2 0.0011
2026-03-30 2023-06-30 13F/A-2 RELAY THERAPEUTICS COM 75943R102 309,179 114,709 58.99 3,883 21.27 0.0025
2023-09-20 2023-06-30 13F/A-1 RELAY THERAPEUTICS COM 75943R102 309,179 114,709 4 0.0025
2023-08-03 2023-06-30 13F RELAY THERAPEUTICS COM 75943R102 309,179 114,709 4 0.0024
2026-03-30 2023-03-31 13F/A-1 RELAY THERAPEUTICS COM 75943R102 194,470 -77,369 -28.46 3,203 -21.15 0.0015
2023-05-04 2023-03-31 13F RELAY THERAPEUTICS COM 75943R102 194,470 -77,369 3 0.0015
2026-03-30 2022-12-31 13F/A-1 RELAY THERAPEUTICS COM 75943R102 271,839 121,628 80.97 4,061 20.83 0.0018
2023-02-13 2022-12-31 13F RELAY THERAPEUTICS COM 75943R102 271,839 121,628 4 0.0018
2022-11-03 2022-09-30 13F RELAY THERAPEUTICS COM 75943R102 150,211 80,404 115.18 3,361 187.51 0.0037
2022-08-12 2022-06-30 13F RELAY THERAPEUTICS COM 75943R102 69,807 -6,261 -8.23 1,169 -48.66 0.0007
2022-05-16 2022-03-31 13F RELAY THERAPEUTICS COM 75943R102 76,068 76,068 2,277 0.0018
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.