Opus Genetics, Inc.
US ˙ NasdaqCM ˙ US67577R1023
DETTE SYMBOL ER IKKE LÆNGERE AKTIVT

SecurityOCUP / Opus Genetics, Inc.
InstitutionVanguard Group Inc
Latest Disclosed Ownership2,322,897 shares
Latest Disclosed Value $ 4,669,022
Vanguard Group Inc reports 73.09% increase in ownership of OCUP / Opus Genetics, Inc.

On January 29, 2026 - Vanguard Group Inc filed a 13F-HR form disclosing ownership of 2,322,897 shares of Opus Genetics, Inc. (US:OCUP) valued at $4,669,022 USD as of December 31, 2025. The entity filed a previous 13F-HR on November 7, 2025 disclosing 1,342,025 shares of Opus Genetics, Inc.. This represents a change in shares of 73.09% during the quarter. The current value of the position is $2,717,789 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-01-29 2025-12-31 13F OPUS GENETICS COM 67577R102 2,322,897 980,872 73.09 4,669 110.89 0.0001
2025-11-07 2025-09-30 13F OPUS GENETICS COM 67577R102 1,342,025 349,825 35.26 2,214 137.04 0.0000
2025-08-11 2025-06-30 13F OPUS GENETICS COM 67577R102 992,200 0 0.00 935 -4.11 0.0000
2025-05-09 2025-03-31 13F OPUS GENETICS COM 67577R102 992,200 0 0.00 974 -17.46 0.0000
2025-02-11 2024-12-31 13F OPUS GENETICS COM 67577R102 992,200 0 0.00 1,181 -9.16 0.0000
2024-11-13 2024-09-30 13F OCUPHIRE PHARMA COM 67577R102 992,200 0 0.00 1,300 -14.43 0.0000
2024-08-13 2024-06-30 13F OCUPHIRE PHARMA COM 67577R102 992,200 0 0.00 1,518 -23.87 0.0000
2024-05-10 2024-03-31 13F OCUPHIRE PHARMA COM 67577R102 992,200 64,400 6.94 1,994 -28.58 0.0000
2024-03-11 2023-12-31 13F/A-1 OCUPHIRE PHARMA COM 67577R102 927,800 68,995 8.03 2,793 -2.92 0.0001
2024-02-14 2023-12-31 13F OCUPHIRE PHARMA COM 67577R102 927,800 68,995 2,793 0.0001
2023-12-18 2023-09-30 13F/A-1 OCUPHIRE PHARMA COM 67577R102 858,805 -27,073 -3.06 2,877 -25.18 0.0001
2023-11-14 2023-09-30 13F OCUPHIRE PHARMA COM 67577R102 858,805 -27,073 2,877 0.0001
2023-08-14 2023-06-30 13F OCUPHIRE PHARMA COM 67577R102 885,878 39,176 4.63 3,845 21.07 0.0001
2023-07-14 2023-03-31 13F/A-1 OCUPHIRE PHARMA COM 67577R102 846,702 143,348 20.38 3,175 27.92 0.0001
2023-05-15 2023-03-31 13F OCUPHIRE PHARMA COM 67577R102 846,702 143,348 3,175 0.0000
2023-02-10 2022-12-31 13F OCUPHIRE PHARMA COM 67577R102 703,354 266 0.04 2,483 75.53 0.0001
2022-11-14 2022-09-30 13F OCUPHIRE PHARMA COM 67577R102 703,088 0 0.00 1,414 4.74 0.0000
2022-08-12 2022-06-30 13F OCUPHIRE PHARMA COM 67577R102 703,088 0 0.00 1,350 -40.74 0.0000
2022-05-13 2022-03-31 13F OCUPHIRE PHARMA COM 67577R102 703,088 0 0.00 2,278 -13.15 0.0001
2022-02-14 2021-12-31 13F OCUPHIRE PHARMA COM 67577R102 703,088 -277,649 -28.31 2,623 -48.07 0.0001
2021-11-12 2021-09-30 13F OCUPHIRE PHARMA COM 67577R102 980,737 943,591 2,540.22 5,051 2,477.04 0.0001
2021-08-13 2021-06-30 13F OCUPHIRE PHARMA COM 67577R102 37,146 23,426 170.74 196 148.10 0.0000
2021-05-14 2021-03-31 13F OCUPHIRE PHARMA COM 67577R102 13,720 -595 -4.16 79 -15.05 0.0000
2021-02-12 2020-12-31 13F OCUPHIRE PHARMA COM 67577R102 14,315 -61,507 -81.12 93 -41.14 0.0000
2020-11-16 2020-09-30 13F REXAHN PHARMACEUTICALS COM 761640309 75,822 20,942 38.16 158 1.28 0.0000
2020-08-14 2020-06-30 13F REXAHN PHARMACEUTICALS COM 761640309 54,880 -704 -1.27 156 57.58 0.0000
2020-05-15 2020-03-31 13F REXAHN PHARMACEUTICALS COM 761640309 55,584 0 0.00 99 -6.60 0.0000
2020-02-14 2019-12-31 13F REXAHN PHARMACEUTICALS COM 761640309 55,584 0 0.00 106 -6.19 0.0000
2019-11-14 2019-09-30 13F REXAHN PHARMACEUTICALS COM 761640309 55,584 -1,114 -1.96 113 -61.43 0.0000
2019-08-14 2019-06-30 13F REXAHN PHARMACEUTICALS COM 761640309 56,698 -5,165,375 -98.91 293 -89.00 0.0000
2017-05-12 2017-03-31 13F REXAHN PHARMACEUTICALS COM 761640101 5,222,073 2,935,450 128.37 2,663 721.91 0.0001
2017-02-14 2016-12-31 13F REXAHN PHARMACEUTICALS COM 761640101 2,286,623 -2,640,774 -53.59 324 -68.70 0.0000
2016-11-14 2016-09-30 13F REXAHN PHARMACEUTICALS COM 761640101 4,927,397 23,300 0.48 1,035 -15.99 0.0001
2016-08-10 2016-06-30 13F REXAHN PHARMACEUTICALS COM 761640101 4,904,097 49,761 1.03 1,232 -23.10 0.0001
2016-05-13 2016-03-31 13F REXAHN PHARMACEUTICALS COM 761640101 4,854,336 -43,786 -0.89 1,602 -9.90 0.0001
2016-02-08 2015-12-31 13F REXAHN PHARMACEUTICALS COM 761640101 4,898,122 38,035 0.78 1,778 -29.64 0.0001
2015-11-12 2015-09-30 13F/A-1 REXAHN PHARMACEUTICALS COM 761640101 4,860,087 40,646 0.84 2,527 -13.72 0.0001
2015-11-12 2015-09-30 13F/A-1 REXAHN PHARMACEUTICALS COM 761640101 4,860,087 40,646 2,527 0.0001
2015-08-13 2015-06-30 13F REXAHN PHARMACEUTICALS COM 761640101 4,819,441 170,018 3.66 2,929 -13.70 0.0002
2015-05-15 2015-03-31 13F/A-1 REXAHN PHARMACEUTICALS COM 761640101 4,649,423 310,801 7.16 3,394 11.76 0.0002
2015-05-14 2015-03-31 13F REXAHN PHARMACEUTICALS COM 761640101 4,649,423 3,394
2015-02-12 2014-12-31 13F REXAHN PHARMACEUTICALS COM 761640101 4,338,622 232,838 5.67 3,037 -8.66 0.0002
2014-11-12 2014-09-30 13F REXAHN PHARMACEUTICALS COM 761640101 4,105,784 531,484 14.87 3,325 6.95 0.0003
2014-08-11 2014-06-30 13F REXAHN PHARMACEUTICALS COM 761640101 3,574,300 19,900 0.56 3,109 -19.02 0.0002
2014-05-13 2014-03-31 13F REXAHN PHARMACEUTICALS COM 761640101 3,554,400 1,575,823 79.64 3,839 280.48 0.0003
2014-02-12 2013-12-31 13F REXAHN PHARMACEUTICALS COM 761640101 1,978,577 0 0.00 1,009 13.37 0.0001
2013-11-07 2013-09-30 13F REXAHN PHARMACEUTICALS COM 761640101 1,978,577 1,197,220 153.22 890 156.48 0.0001
2013-08-13 2013-06-30 13F REXAHN PHARMACEUTICALS COM 761640101 781,357 781,357 347 0.0000
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.