Ocular Therapeutix, Inc.
US ˙ NasdaqGM ˙ US67576A1007

SecurityOCUL / Ocular Therapeutix, Inc.
InstitutionD. E. Shaw & Co., Inc.
ManagerDE Shaw
Latest Disclosed Ownership218,478 shares
Latest Disclosed Value $ 1,850,509
D. E. Shaw & Co., Inc. reports 81.07% decrease in ownership of OCUL / Ocular Therapeutix, Inc.

On May 15, 2026 - D. E. Shaw & Co., Inc. filed a 13F-HR form disclosing ownership of 218,478 shares of Ocular Therapeutix, Inc. (US:OCUL) valued at $1,850,509 USD as of March 31, 2026. The entity filed a previous 13F-HR on February 17, 2026 disclosing 1,153,910 shares of Ocular Therapeutix, Inc.. This represents a change in shares of -81.07% during the quarter. The current value of the position is $1,824,291 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-05-15 2026-03-31 13F OCULAR THERAPEUTIX COM 67576A100 218,478 -935,432 -81.07 1,851 -86.79 0.0008
2026-02-17 2025-12-31 13F OCULAR THERAPEUTIX COM 67576A100 1,153,910 1,040,631 918.64 14,008 958.01 0.0077
2025-11-14 2025-09-30 13F OCULAR THERAPEUTIX COM 67576A100 113,279 10,446 10.16 1,324 38.78 0.0007
2025-08-14 2025-06-30 13F OCULAR THERAPEUTIX COM 67576A100 102,833 42,710 71.04 954 116.82 0.0007
2025-05-15 2025-03-31 13F OCULAR THERAPEUTIX COM 67576A100 60,123 28,704 91.36 441 64.18 0.0004
2025-02-14 2024-12-31 13F OCULAR THERAPEUTIX COM 67576A100 31,419 31,419 268 0.0002
2024-08-14 2024-06-30 13F OCULAR THERAPEUTIX COM 67576A100 0 -160,142 -100.00 0 -100.00
2024-05-15 2024-03-31 13F OCULAR THERAPEUTIX COM 67576A100 160,142 -230,693 -59.03 1,457 -16.41 0.0012
2024-02-14 2023-12-31 13F OCULAR THERAPEUTIX COM 67576A100 390,835 -194,045 -33.18 1,743 -5.07 0.0015
2023-11-14 2023-09-30 13F OCULAR THERAPEUTIX COM 67576A100 584,880 -71,225 -10.86 1,837 -45.76 0.0019
2023-08-14 2023-06-30 13F OCULAR THERAPEUTIX COM 67576A100 656,105 -443,665 -40.34 3,386 -41.59 0.0035
2023-05-15 2023-03-31 13F OCULAR THERAPEUTIX COM 67576A100 1,099,770 131,436 13.57 5,796 112.97 0.0062
2023-02-14 2022-12-31 13F OCULAR THERAPEUTIX COM 67576A100 968,334 176,045 22.22 2,721 -17.24 0.0030
2022-11-14 2022-09-30 13F OCULAR THERAPEUTIX COM 67576A100 792,289 43,824 5.86 3,288 9.27 0.0039
2022-08-15 2022-06-30 13F OCULAR THERAPEUTIX COM 67576A100 748,465 134,927 21.99 3,009 -0.92 0.0035
2022-05-16 2022-03-31 13F OCULAR THERAPEUTIX COM 67576A100 613,538 133,870 27.91 3,037 -9.15 0.0028
2022-02-14 2021-12-31 13F OCULAR THERAPEUTIX COM 67576A100 479,668 -87,434 -15.42 3,343 -41.05 0.0028
2021-11-15 2021-09-30 13F OCULAR THERAPEUTIX COM 67576A100 567,102 -120,078 -17.47 5,671 -41.80 0.0051
2021-08-16 2021-06-30 13F OCULAR THERAPEUTIX COM 67576A100 687,180 35,052 5.38 9,744 -8.94 0.0084
2021-05-17 2021-03-31 13F OCULAR THERAPEUTIX COM 67576A100 652,128 -397,618 -37.88 10,701 -50.75 0.0103
2021-02-16 2020-12-31 13F OCULAR THERAPEUTIX COM 67576A100 1,049,746 776,758 284.54 21,730 946.22 0.0194
2020-11-16 2020-09-30 13F OCULAR THERAPEUTIX COM 67576A100 272,988 -148,546 -35.24 2,077 -40.84 0.0021
2020-08-14 2020-06-30 13F OCULAR THERAPEUTIX COM 67576A100 421,534 381,362 949.32 3,511 1,664.32 0.0042
2020-05-15 2020-03-31 13F OCULAR THERAPEUTIX COM 67576A100 40,172 40,172 199 0.0003
2019-02-14 2018-12-31 13F OCULAR THERAPEUTIX COM 67576A100 0 -211,609 -100.00 0 -100.00
2018-11-14 2018-09-30 13F OCULAR THERAPEUTIX COM 67576A100 211,609 37,586 21.60 1,456 23.91 0.0017
2018-08-14 2018-06-30 13F OCULAR THERAPEUTIX COM 67576A100 174,023 174,023 1,175 0.0015
2018-05-15 2018-03-31 13F OCULAR THERAPEUTIX COM 67576A100 0 -60,057 -100.00 0 -100.00
2018-02-14 2017-12-31 13F OCULAR THERAPEUTIX COM 67576A100 60,057 2,911 5.09 267 -24.36 0.0004
2017-11-14 2017-09-30 13F OCULAR THERAPEUTIX COM 67576A100 57,146 14,768 34.85 353 -10.18 0.0005
2017-08-14 2017-06-30 13F OCULAR THERAPEUTIX COM 67576A100 42,378 -94,375 -69.01 393 -69.03 0.0007
2017-05-15 2017-03-31 13F OCULAR THERAPEUTIX COM 67576A100 136,753 118,800 661.73 1,269 746.00 0.0022
2017-02-14 2016-12-31 13F OCULAR THERAPEUTIX COM 67576A100 17,953 2,806 18.53 150 44.23 0.0003
2016-11-14 2016-09-30 13F OCULAR THERAPEUTIX COM 67576A100 15,147 -41,740 -73.37 104 -63.12 0.0002
2016-08-15 2016-06-30 13F OCULAR THERAPEUTIX COM 67576A100 56,887 -32,843 -36.60 282 -67.47 0.0005
2016-05-16 2016-03-31 13F OCULAR THERAPEUTIX COM 67576A100 89,730 89,730 0.00 867 0.0016
2016-02-16 2015-12-31 13F OCULAR THERAPEUTIX COM 67576A100 0 -11,567 -100.00 0 -100.00
2015-11-16 2015-09-30 13F OCULAR THERAPEUTIX COM 67576A100 11,567 -70,061 -85.83 163 -90.51 0.0002
2015-08-14 2015-06-30 13F OCULAR THERAPEUTIX COM 67576A100 81,628 81,628 0.00 1,717 0.0026
2015-02-17 2014-12-31 13F OCULAR THERAPEUTIX COM 67576A100 0 -13,684 -100.00 0 -100.00
2014-11-14 2014-09-30 13F OCULAR THERAPEUTIX COM 67576A100 13,684 13,684 205 0.0003
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.