Lexicon Pharmaceuticals, Inc.
US ˙ NasdaqCM ˙ US5288723027

SecurityLXRX / Lexicon Pharmaceuticals, Inc.
InstitutionD. E. Shaw & Co., Inc.
ManagerDE Shaw
Latest Disclosed Ownership0 shares
Latest Disclosed Value $ 0
D. E. Shaw & Co., Inc. closes position in LXRX / Lexicon Pharmaceuticals, Inc.

On November 14, 2025 - D. E. Shaw & Co., Inc. filed a 13F-HR form disclosing ownership of 0 shares of Lexicon Pharmaceuticals, Inc. (US:LXRX) valued at $0 USD as of September 30, 2025. The entity filed a previous 13F-HR on August 14, 2025 disclosing 23,723 shares of Lexicon Pharmaceuticals, Inc.. This represents a change in shares of -100.00% during the quarter. The current value of the position is $0 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2025-11-14 2025-09-30 13F LEXICON PHARMACEUTICALS COM NEW 528872302 0 -23,723 -100.00 0 -100.00
2025-08-14 2025-06-30 13F LEXICON PHARMACEUTICALS COM NEW 528872302 23,723 23,723 22 0.0000
2024-05-15 2024-03-31 13F LEXICON PHARMACEUTICALS COM NEW 528872302 0 -359,210 -100.00 0 -100.00
2024-02-14 2023-12-31 13F LEXICON PHARMACEUTICALS COM NEW 528872302 359,210 -424,912 -54.19 550 -35.71 0.0005
2023-11-14 2023-09-30 13F LEXICON PHARMACEUTICALS COM NEW 528872302 784,122 -429,604 -35.40 855 -69.27 0.0009
2023-08-14 2023-06-30 13F LEXICON PHARMACEUTICALS COM NEW 528872302 1,213,726 -1,727,271 -58.73 2,779 -61.11 0.0028
2023-05-15 2023-03-31 13F LEXICON PHARMACEUTICALS COM NEW 528872302 2,940,997 -136,976 -4.45 7,147 21.57 0.0077
2023-02-14 2022-12-31 13F LEXICON PHARMACEUTICALS COM NEW 528872302 3,077,973 33,996 1.12 5,879 -19.55 0.0065
2022-11-14 2022-09-30 13F LEXICON PHARMACEUTICALS COM NEW 528872302 3,043,977 -184,095 -5.70 7,306 21.69 0.0087
2022-08-15 2022-06-30 13F LEXICON PHARMACEUTICALS COM NEW 528872302 3,228,072 -632 -0.02 6,004 -11.03 0.0070
2022-05-16 2022-03-31 13F LEXICON PHARMACEUTICALS COM NEW 528872302 3,228,704 420,276 14.96 6,748 -39.02 0.0063
2022-02-14 2021-12-31 13F LEXICON PHARMACEUTICALS COM NEW 528872302 2,808,428 -407,620 -12.67 11,066 -28.47 0.0092
2021-11-15 2021-09-30 13F LEXICON PHARMACEUTICALS COM NEW 528872302 3,216,048 -186,377 -5.48 15,470 -0.94 0.0140
2021-08-16 2021-06-30 13F LEXICON PHARMACEUTICALS COM NEW 528872302 3,402,425 395,813 13.16 15,617 -11.51 0.0135
2021-05-17 2021-03-31 13F LEXICON PHARMACEUTICALS COM NEW 528872302 3,006,612 1,212,603 67.59 17,649 187.63 0.0170
2021-02-16 2020-12-31 13F LEXICON PHARMACEUTICALS COM NEW 528872302 1,794,009 827,402 85.60 6,136 340.80 0.0055
2020-11-16 2020-09-30 13F LEXICON PHARMACEUTICALS COM NEW 528872302 966,607 -352,544 -26.73 1,392 -47.11 0.0014
2020-08-14 2020-06-30 13F LEXICON PHARMACEUTICALS COM NEW 528872302 1,319,151 806,739 157.44 2,632 163.46 0.0031
2020-05-15 2020-03-31 13F LEXICON PHARMACEUTICALS COM NEW 528872302 512,412 349,441 214.42 999 47.78 0.0016
2020-02-14 2019-12-31 13F LEXICON PHARMACEUTICALS COM NEW 528872302 162,971 147,109 927.43 676 1,308.33 0.0008
2019-11-14 2019-09-30 13F LEXICON PHARMACEUTICALS COM NEW 528872302 15,862 -49,575 -75.76 48 -88.32 0.0001
2019-08-14 2019-06-30 13F LEXICON PHARMACEUTICALS COM NEW 528872302 65,437 -170,684 -72.29 411 -68.70 0.0005
2019-05-15 2019-03-31 13F LEXICON PHARMACEUTICALS COM NEW 528872302 236,121 -32,355 -12.05 1,313 -26.36 0.0017
2019-02-14 2018-12-31 13F LEXICON PHARMACEUTICALS COM NEW 528872302 268,476 173,096 181.48 1,783 75.15 0.0025
2018-11-14 2018-09-30 13F LEXICON PHARMACEUTICALS COM NEW 528872302 95,380 17,744 22.86 1,018 9.23 0.0012
2018-08-14 2018-06-30 13F LEXICON PHARMACEUTICALS COM NEW 528872302 77,636 31,741 69.16 932 137.15 0.0012
2018-05-15 2018-03-31 13F LEXICON PHARMACEUTICALS COM NEW 528872302 45,895 11,017 31.59 393 13.91 0.0005
2018-02-14 2017-12-31 13F LEXICON PHARMACEUTICALS COM NEW 528872302 34,878 3,257 10.30 345 -11.31 0.0005
2017-11-14 2017-09-30 13F LEXICON PHARMACEUTICALS COM NEW 528872302 31,621 -83,635 -72.56 389 -79.48 0.0006
2017-08-14 2017-06-30 13F LEXICON PHARMACEUTICALS COM NEW 528872302 115,256 -53,238 -31.60 1,896 -21.52 0.0031
2017-05-15 2017-03-31 13F LEXICON PHARMACEUTICALS COM NEW 528872302 168,494 80,542 91.57 2,416 98.68 0.0042
2017-02-14 2016-12-31 13F LEXICON PHARMACEUTICALS COM NEW 528872302 87,952 -579,178 -86.82 1,216 -89.91 0.0021
2016-11-14 2016-09-30 13F LEXICON PHARMACEUTICALS COM NEW 528872302 667,130 469,827 238.12 12,055 325.82 0.0213
2016-08-15 2016-06-30 13F LEXICON PHARMACEUTICALS COM NEW 528872302 197,303 113,003 134.05 2,831 181.13 0.0052
2016-05-16 2016-03-31 13F LEXICON PHARMACEUTICALS COM NEW 528872302 84,300 64,991 336.58 1,007 291.83 0.0018
2016-02-16 2015-12-31 13F LEXICON PHARMACEUTICALS COM NEW 528872302 19,309 -2,891 -13.02 257 7.98 0.0004
2015-11-16 2015-09-30 13F LEXICON PHARMACEUTICALS COM NEW 528872302 22,200 22,200 238 0.0004
2015-08-14 2015-06-30 13F LEXICON PHARMACEUTICALS COM 528872104 0 -11,792 -100.00 0 -100.00
2015-05-15 2015-03-31 13F LEXICON PHARMACEUTICALS COM 528872104 11,792 -26,511 -69.21 11 -83.33 0.0000
2014-05-15 2014-03-31 13F LEXICON PHARMACEUTICALS COM 528872104 38,303 -279,486 -87.95 66 -88.46 0.0001
2014-02-14 2013-12-31 13F LEXICON PHARMACEUTICALS COM 528872104 317,789 49,973 18.66 572 -9.92 0.0008
2013-11-20 2013-09-30 13F/A-1 LEXICON PHARMACEUTICALS COM 528872104 267,816 146,169 120.16 635 140.53 0.0010
2013-11-14 2013-09-30 13F LEXICON PHARMACEUTICALS COM 528872104 267,816 635
2013-08-14 2013-06-30 13F LEXICON PHARMACEUTICALS COM 528872104 121,647 121,647 264 0.0005
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.