Janux Therapeutics, Inc.
US ˙ NasdaqGM ˙ US47103J1051

SecurityJANX / Janux Therapeutics, Inc.
InstitutionJanus Henderson Group Plc
Latest Disclosed Ownership4,196,409 shares
Ownership 6.90%
Janus Henderson Group Plc ownership in JANX / Janux Therapeutics, Inc.

2026-05-15 - Janus Henderson Group Plc has filed an SCHEDULE 13G/A form with the Securities and Exchange Commission (SEC) disclosing ownership of 4,196,409 shares of Janux Therapeutics, Inc. (US:JANX). This represents 6.9 percent ownership of the company. In their previous filing dated 2026-02-17 , Janus Henderson Group Plc had reported owning 5,350,453 shares, indicating a decrease of -21.57 percent.

Institutional Ownership: 13D/G Filings

This table shows a history of the 13D/G filings made by the investor and/or investor group. Note that the share values in this table are not directly comparable to any numbers shown in the 13F table (if any).

File
Date
Effective
Date
Form Prev
Shares
Latest
Shares
ΔShares
(Percent)
Ownership
(Percent)
ΔOwnership
(Percent)
2026-05-15 2026-05-15 13G/A 5,350,453 4,196,409 -21.57 6.90 -22.47
2026-02-17 2026-02-17 13G/A 6,033,949 5,350,453 -11.33 8.90 -11.00
2025-11-07 2025-11-07 13G/A 4,460,332 6,033,949 35.28 10.00 33.33
2025-08-14 2025-08-14 13G/A 4,598,537 4,460,332 -3.01 7.50 -3.85
2025-05-14 2025-05-14 13G/A 3,562,402 4,598,537 29.09 7.80 27.87
2025-02-14 2025-02-14 13G 1,837,791 3,562,402 93.84 6.10 38.64
2023-02-09 2023-02-09 13G/A 2,400,893 1,837,791 -23.45 4.40 -24.14
2022-02-14 2022-02-14 13G 2,400,893 5.80

Important Note: One of the primary uses of the 13D/G filings is to evaluate the ability of a firm to control a company (ie, the "beneficial ownership"). To that end, firms are required to report not just direct holdings in companies, but indirect holdings that they control. For investment firms, these indirect holdings can include shares in funds they manage, advisory accounts, and in the case of activist campaigns, pledged votes. Therefore, share counts listed in 13D/G filings can differ significantly than share counts listed in 13F filings.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date
Effective
Date
Form Security Class ID Avg Price
Paid (Est)
Reported
Shares
ΔShares ΔShares
(%)
Reported
Value
(x1000)
ΔValue
(%)
Alloc
(%)
ΔAlloc ΔAlloc (%) Cost Basis
(x1000)
Unrealized
Gain/Loss
(x1000)
2026-05-18 2026-03-31 13F/A-1 JANUX THERAPEUTICS COM 47103J105 4,196,409 -1,154,044 -21.57 58,280 -21.08 0.0098
2026-05-15 2026-03-31 13F JANUX THERAPEUTICS COM 47103J105 4,196,409 -1,154,044 58,280 0.0108
2026-02-17 2025-12-31 13F JANUX THERAPEUTICS COM 47103J105 5,350,453 649,341 13.81 73,850 -35.78 0.0331
2025-11-14 2025-09-30 13F JANUX THERAPEUTICS COM 47103J105 4,701,112 240,780 5.40 114,988 11.59 0.0525
2025-08-14 2025-06-30 13F JANUX THERAPEUTICS COM 47103J105 4,460,332 -137,760 -3.00 103,045 -22.92 0.0505
2025-05-15 2025-03-31 13F JANUX THERAPEUTICS COM 47103J105 4,598,092 1,035,690 29.07 133,682 -29.87 0.0733
2025-02-14 2024-12-31 13F JANUX THERAPEUTICS COM 47103J105 3,562,402 1,038,996 41.17 190,617 66.35 0.0969
2024-11-14 2024-09-30 13F JANUX THERAPEUTICS COM 47103J105 2,523,406 721,563 40.05 114,587 51.99 0.0586
2024-08-14 2024-06-30 13F JANUX THERAPEUTICS COM 47103J105 1,801,843 -163,703 -8.33 75,390 1.93 0.0404
2024-05-15 2024-03-31 13F JANUX THERAPEUTICS COM 47103J105 1,965,546 34,069 1.76 73,961 256.54 0.0403
2024-02-14 2023-12-31 13F JANUX THERAPEUTICS COM 47103J105 1,931,477 -135,991 -6.58 20,744 -0.38 0.0124
2023-11-14 2023-09-30 13F JANUX THERAPEUTICS COM 47103J105 2,067,468 -41,870 -1.98 20,824 -16.81 0.0136
2023-08-14 2023-06-30 13F JANUX THERAPEUTICS COM 47103J105 2,109,338 240,262 12.85 25,031 10.70 0.0156
2023-05-15 2023-03-31 13F JANUX THERAPEUTICS COM 47103J105 1,869,076 31,285 1.70 22,612 -6.46 0.0149
2023-02-14 2022-12-31 13F JANUX THERAPEUTICS COM 47103J105 1,837,791 -122,253 -6.24 24,173 -8.94 0.0173
2023-01-13 2022-09-30 13F/A-1 JANUX THERAPEUTICS COM 47103J105 1,960,044 -167,753 -7.88 26,546 2.23 0.0199
2022-11-14 2022-09-30 13F JANUX THERAPEUTICS COM 47103J105 1,960,044 -167,753 26,546 0.0067
2022-08-15 2022-06-30 13F JANUX THERAPEUTICS COM 47103J105 2,127,797 -211,349 -9.04 25,966 -22.59 0.0179
2022-05-16 2022-03-31 13F JANUX THERAPEUTICS COM 47103J105 2,339,146 -61,747 -2.57 33,542 -27.96 0.0162
2022-02-14 2021-12-31 13F JANUX THERAPEUTICS COM 47103J105 2,400,893 -15,511 -0.64 46,558 -9.38 0.0194
2021-11-16 2021-09-30 13F JANUX THERAPEUTICS COM 47103J105 2,416,404 -251,803 -9.44 51,375 -20.38 0.0225
2021-08-16 2021-06-30 13F JANUX THERAPEUTICS COM 47103J105 2,668,207 2,668,207 64,522 0.0276
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.