Heron Therapeutics, Inc.
US ˙ NasdaqCM ˙ US4277461020

SecurityHRTX / Heron Therapeutics, Inc.
InstitutionD. E. Shaw & Co., Inc.
ManagerDE Shaw
Latest Disclosed Ownership2,600,990 shares
Latest Disclosed Value $ 2,081,052
D. E. Shaw & Co., Inc. reports 13.43% decrease in ownership of HRTX / Heron Therapeutics, Inc.

On May 15, 2026 - D. E. Shaw & Co., Inc. filed a 13F-HR form disclosing ownership of 2,600,990 shares of Heron Therapeutics, Inc. (US:HRTX) valued at $2,081,052 USD as of March 31, 2026. The entity filed a previous 13F-HR on February 17, 2026 disclosing 3,004,640 shares of Heron Therapeutics, Inc.. This represents a change in shares of -13.43% during the quarter. The current value of the position is $1,162,122 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-05-15 2026-03-31 13F HERON THERAPEUTICS COM 427746102 2,600,990 -403,650 -13.43 2,081 -46.72 0.0013
2026-02-17 2025-12-31 13F HERON THERAPEUTICS COM 427746102 3,004,640 -83,852 -2.71 3,906 0.39 0.0021
2025-11-14 2025-09-30 13F HERON THERAPEUTICS COM 427746102 3,088,492 -111,807 -3.49 3,892 -41.26 0.0022
2025-08-14 2025-06-30 13F HERON THERAPEUTICS COM 427746102 3,200,299 214,102 7.17 6,625 0.84 0.0047
2025-05-15 2025-03-31 13F HERON THERAPEUTICS COM 427746102 2,986,197 -737,509 -19.81 6,570 15.31 0.0058
2025-02-14 2024-12-31 13F HERON THERAPEUTICS COM 427746102 3,723,706 -660,971 -15.07 5,697 -34.70 0.0042
2024-11-14 2024-09-30 13F HERON THERAPEUTICS COM 427746102 4,384,677 521,302 13.49 8,726 -35.47 0.0075
2024-08-14 2024-06-30 13F HERON THERAPEUTICS COM 427746102 3,863,375 1,168,329 43.35 13,522 81.13 0.0126
2024-05-15 2024-03-31 13F HERON THERAPEUTICS COM 427746102 2,695,046 1,404,049 108.76 7,465 240.25 0.0064
2024-02-14 2023-12-31 13F HERON THERAPEUTICS COM 427746102 1,290,997 1,045,724 426.35 2,195 770.63 0.0019
2023-11-14 2023-09-30 13F HERON THERAPEUTICS COM 427746102 245,273 -103,687 -29.71 253 -37.62 0.0003
2023-08-14 2023-06-30 13F HERON THERAPEUTICS COM 427746102 348,960 -372,122 -51.61 405 -62.87 0.0004
2023-05-15 2023-03-31 13F HERON THERAPEUTICS COM 427746102 721,082 -65,998 -8.39 1,089 -44.69 0.0012
2023-02-14 2022-12-31 13F HERON THERAPEUTICS COM 427746102 787,080 -112,491 -12.50 1,968 -48.20 0.0022
2022-11-14 2022-09-30 13F HERON THERAPEUTICS COM 427746102 899,571 -715,411 -44.30 3,797 -15.73 0.0045
2022-08-15 2022-06-30 13F HERON THERAPEUTICS COM 427746102 1,614,982 -419,247 -20.61 4,506 -61.28 0.0053
2022-05-16 2022-03-31 13F HERON THERAPEUTICS COM 427746102 2,034,229 683,738 50.63 11,636 -5.63 0.0109
2022-02-14 2021-12-31 13F HERON THERAPEUTICS COM 427746102 1,350,491 -81,438 -5.69 12,330 -19.45 0.0102
2021-11-15 2021-09-30 13F HERON THERAPEUTICS COM 427746102 1,431,929 -532,221 -27.10 15,307 -49.79 0.0138
2021-08-16 2021-06-30 13F HERON THERAPEUTICS COM 427746102 1,964,150 -243,240 -11.02 30,483 -14.81 0.0263
2021-05-17 2021-03-31 13F HERON THERAPEUTICS COM 427746102 2,207,390 -53,888 -2.38 35,781 -25.24 0.0345
2021-02-16 2020-12-31 13F HERON THERAPEUTICS COM 427746102 2,261,278 168,612 8.06 47,860 54.32 0.0428
2020-11-16 2020-09-30 13F HERON THERAPEUTICS COM 427746102 2,092,666 -25,776 -1.22 31,013 -0.48 0.0317
2020-08-14 2020-06-30 13F HERON THERAPEUTICS COM 427746102 2,118,442 -206,661 -8.89 31,162 14.16 0.0371
2020-05-15 2020-03-31 13F HERON THERAPEUTICS COM 427746102 2,325,103 -519,946 -18.28 27,297 -59.17 0.0426
2020-02-14 2019-12-31 13F HERON THERAPEUTICS COM 427746102 2,845,049 1,207,750 73.76 66,859 120.73 0.0765
2019-11-14 2019-09-30 13F HERON THERAPEUTICS COM 427746102 1,637,299 265,008 19.31 30,290 18.73 0.0373
2019-08-14 2019-06-30 13F HERON THERAPEUTICS COM 427746102 1,372,291 -99,305 -6.75 25,511 -29.07 0.0318
2019-05-15 2019-03-31 13F HERON THERAPEUTICS COM 427746102 1,471,596 417,588 39.62 35,966 31.55 0.0465
2019-02-14 2018-12-31 13F HERON THERAPEUTICS COM 427746102 1,054,008 473,127 81.45 27,341 48.71 0.0377
2018-11-14 2018-09-30 13F HERON THERAPEUTICS COM 427746102 580,881 142,648 32.55 18,385 7.99 0.0221
2018-08-14 2018-06-30 13F HERON THERAPEUTICS COM 427746102 438,233 -537,780 -55.10 17,025 -36.80 0.0222
2018-05-15 2018-03-31 13F HERON THERAPEUTICS COM 427746102 976,013 480,381 96.92 26,938 200.28 0.0367
2018-02-14 2017-12-31 13F HERON THERAPEUTICS COM 427746102 495,632 255,457 106.36 8,971 131.27 0.0124
2017-11-14 2017-09-30 13F HERON THERAPEUTICS COM 427746102 240,175 182,875 319.15 3,879 388.54 0.0060
2017-08-14 2017-06-30 13F HERON THERAPEUTICS COM 427746102 57,300 28,048 95.88 794 80.87 0.0013
2017-05-15 2017-03-31 13F HERON THERAPEUTICS COM 427746102 29,252 15,132 107.17 439 137.30 0.0008
2017-02-14 2016-12-31 13F HERON THERAPEUTICS COM 427746102 14,120 14,120 0.00 185 0.0003
2016-11-14 2016-09-30 13F HERON THERAPEUTICS COM 427746102 0 -57,850 -100.00 0 -100.00
2016-08-15 2016-06-30 13F HERON THERAPEUTICS COM 427746102 57,850 8,180 16.47 1,044 10.71 0.0019
2016-05-16 2016-03-31 13F HERON THERAPEUTICS COM 427746102 49,670 49,670 0.00 943 0.0017
2016-02-16 2015-12-31 13F HERON THERAPEUTICS COM 427746102 0 -60,281 -100.00 0 -100.00
2015-11-16 2015-09-30 13F HERON THERAPEUTICS COM 427746102 60,281 -168,657 -73.67 1,471 -79.38 0.0022
2015-08-14 2015-06-30 13F HERON THERAPEUTICS COM 427746102 228,938 216,205 1,697.99 7,134 3,756.22 0.0106
2015-05-15 2015-03-31 13F HERON THERAPEUTICS COM 427746102 12,733 -6,877 -35.07 185 -6.09 0.0003
2015-02-17 2014-12-31 13F HERON THERAPEUTICS COM 427746102 19,610 19,610 197 0.0003
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.