Fulcrum Therapeutics, Inc.
US ˙ NasdaqGM ˙ US3596161097

SecurityFULC / Fulcrum Therapeutics, Inc.
InstitutionState Street Corp
Latest Disclosed Ownership1,549,851 shares
Latest Disclosed Value $ 11,887,357
State Street Corp reports 54.16% increase in ownership of FULC / Fulcrum Therapeutics, Inc.

On May 15, 2026 - State Street Corp filed a 13F-HR form disclosing ownership of 1,549,851 shares of Fulcrum Therapeutics, Inc. (US:FULC) valued at $11,887,357 USD as of March 31, 2026. The entity filed a previous 13F-HR on February 13, 2026 disclosing 1,005,345 shares of Fulcrum Therapeutics, Inc.. This represents a change in shares of 54.16% during the quarter. The current value of the position is $5,222,998 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-05-15 2026-03-31 13F FULCRUM THERAPEUTICS COM 359616109 1,549,851 544,506 54.16 11,887 4.55 0.0004
2026-02-13 2025-12-31 13F FULCRUM THERAPEUTICS COM 359616109 1,005,345 -57,862 -5.44 11,370 16.25 0.0004
2025-11-14 2025-09-30 13F FULCRUM THERAPEUTICS COM 359616109 1,063,207 -155,159 -12.74 9,782 16.69 0.0003
2025-08-14 2025-06-30 13F FULCRUM THERAPEUTICS COM 359616109 1,218,366 -34,074 -2.72 8,382 132.38 0.0003
2025-05-15 2025-03-31 13F FULCRUM THERAPEUTICS COM 359616109 1,252,440 7,121 0.57 3,607 -38.36 0.0001
2025-02-14 2024-12-31 13F FULCRUM THERAPEUTICS COM 359616109 1,245,319 -434,910 -25.88 5,853 -2.43 0.0002
2024-11-14 2024-09-30 13F FULCRUM THERAPEUTICS COM 359616109 1,680,229 638,955 61.36 5,998 -7.08 0.0002
2024-08-14 2024-06-30 13F FULCRUM THERAPEUTICS COM 359616109 1,041,274 784,413 305.38 6,456 166.30 0.0003
2024-05-15 2024-03-31 13F FULCRUM THERAPEUTICS COM 359616109 256,861 73,714 40.25 2,425 96.12 0.0001
2024-02-14 2023-12-31 13F FULCRUM THERAPEUTICS COM 359616109 183,147 0 0.00 1,236 52.03 0.0001
2023-11-14 2023-09-30 13F FULCRUM THERAPEUTICS COM 359616109 183,147 -22,800 -11.07 813 19.73 0.0000
2023-08-14 2023-06-30 13F FULCRUM THERAPEUTICS COM 359616109 205,947 -759,641 -78.67 680 -75.32 0.0000
2023-05-15 2023-03-31 13F FULCRUM THERAPEUTICS COM 359616109 965,588 185,174 23.73 2,752 -51.58 0.0002
2023-05-15 2022-12-31 13F/A-99 FULCRUM THERAPEUTICS COM 359616109 780,414 54,897 7.57 5,681 -3.20 0.0003
2023-05-15 2022-12-31 13F FULCRUM THERAPEUTICS COM 359616109 780,414 54,897 5,681 0.0003
2022-11-15 2022-09-30 13F FULCRUM THERAPEUTICS COM 359616109 725,517 76,851 11.85 5,869 84.68 0.0004
2022-08-15 2022-06-30 13F FULCRUM THERAPEUTICS COM 359616109 648,666 -27,288 -4.04 3,178 -80.12 0.0002
2022-05-16 2022-03-31 13F FULCRUM THERAPEUTICS COM 359616109 675,954 -21,957 -3.15 15,986 29.48 0.0008
2022-02-14 2021-12-31 13F FULCRUM THERAPEUTICS COM 359616109 697,911 245,599 54.30 12,346 -3.24 0.0006
2021-11-15 2021-09-30 13F FULCRUM THERAPEUTICS COM 359616109 452,312 140,087 44.87 12,760 289.98 0.0007
2021-08-16 2021-06-30 13F FULCRUM THERAPEUTICS COM 359616109 312,225 57,728 22.68 3,272 9.14 0.0002
2021-07-09 2021-03-31 13F/A-1 FULCRUM THERAPEUTICS COM 359616109 254,497 15,048 6.28 2,998 6.92 0.0002
2021-05-17 2021-03-31 13F FULCRUM THERAPEUTICS COM 359616109 254,497 15,048 2,998 0.0002
2021-02-16 2020-12-31 13F FULCRUM THERAPEUTICS COM 359616109 239,449 27,394 12.92 2,804 66.71 0.0002
2020-11-10 2020-09-30 13F FULCRUM THERAPEUTICS COM 359616109 212,055 4,957 2.39 1,682 -55.60 0.0001
2020-08-14 2020-06-30 13F FULCRUM THERAPEUTICS COM 359616109 207,098 12,836 6.61 3,788 63.35 0.0003
2020-06-19 2020-03-31 13F/A-1 FULCRUM THERAPEUTICS COM 359616109 194,262 155,213 397.48 2,319 256.77 0.0002
2020-05-11 2020-03-31 13F FULCRUM THERAPEUTICS COM 359616109 194,262 155,213 2,319 203.6549
2020-02-06 2019-12-31 13F FULCRUM THERAPEUTICS COM 359616109 39,049 39,049 650 0.0000
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.