Fulcrum Therapeutics, Inc.
US ˙ NasdaqGM ˙ US3596161097

SecurityFULC / Fulcrum Therapeutics, Inc.
InstitutionMorgan Stanley
Latest Disclosed Ownership173,337 shares
Latest Disclosed Value $ 1,329,495
Morgan Stanley reports 4.66% increase in ownership of FULC / Fulcrum Therapeutics, Inc.

On May 15, 2026 - Morgan Stanley filed a 13F-HR form disclosing ownership of 173,337 shares of Fulcrum Therapeutics, Inc. (US:FULC) valued at $1,329,495 USD as of March 31, 2026. The entity filed a previous 13F-HR/A on May 27, 2026 disclosing 165,623 shares of Fulcrum Therapeutics, Inc.. This represents a change in shares of 4.66% during the quarter. The current value of the position is $584,146 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-05-15 2026-03-31 13F FULCRUM THERAPEUTICS COM 359616109 173,337 7,714 4.66 1,329 -29.04 0.0001
2026-05-27 2025-12-31 13F/A-1 FULCRUM THERAPEUTICS COM 359616109 165,623 -78,212 -32.08 1,873 -16.50 0.0001
2026-02-13 2025-12-31 13F FULCRUM THERAPEUTICS COM 359616109 165,623 -78,212 1,873
2026-05-27 2025-09-30 13F/A-1 FULCRUM THERAPEUTICS COM 359616109 243,835 -70,575 -22.45 2,243 3.70 0.0001
2025-11-14 2025-09-30 13F FULCRUM THERAPEUTICS COM 359616109 243,835 -70,575 2,243 0.0001
2025-08-15 2025-06-30 13F FULCRUM THERAPEUTICS COM 359616109 314,410 28,811 10.09 2,163 163.14 0.0001
2025-05-15 2025-03-31 13F FULCRUM THERAPEUTICS COM 359616109 285,599 -1,246,133 -81.35 823 -88.58 0.0001
2025-05-15 2024-12-31 13F/A-1 FULCRUM THERAPEUTICS COM 359616109 1,531,732 1,181,047 336.78 7,199 475.46 0.0005
2025-02-14 2024-12-31 13F FULCRUM THERAPEUTICS COM 359616109 1,531,732 1,181,047 7,199 0.0005
2025-05-14 2024-09-30 13F/A-2 FULCRUM THERAPEUTICS COM 359616109 350,685 -884,128 -71.60 1,252 -83.66 0.0001
2025-02-14 2024-09-30 13F/A-1 FULCRUM THERAPEUTICS COM 359616109 350,685 -884,128 1,252 0.0001
2024-11-14 2024-09-30 13F FULCRUM THERAPEUTICS COM 359616109 350,685 -884,128 1,252 0.0000
2025-05-14 2024-06-30 13F/A-2 FULCRUM THERAPEUTICS COM 359616109 1,234,813 77,676 6.71 7,656 -29.92 0.0006
2024-10-17 2024-06-30 13F/A-1 FULCRUM THERAPEUTICS COM 359616109 1,234,813 77,676 7,656 0.0006
2024-08-14 2024-06-30 13F FULCRUM THERAPEUTICS COM 359616109 1,234,813 77,676 7,656 0.0006
2024-10-17 2024-03-31 13F/A-2 FULCRUM THERAPEUTICS COM 359616109 1,157,137 -61,922 -5.08 10,923 32.75 0.0009
2024-08-16 2024-03-31 13F/A-1 FULCRUM THERAPEUTICS COM 359616109 1,157,137 -61,922 10,923 0.0001
2024-05-15 2024-03-31 13F FULCRUM THERAPEUTICS COM 359616109 1,157,137 -61,922 10,923 0.0009
2024-08-16 2023-12-31 13F/A-1 FULCRUM THERAPEUTICS COM 359616109 1,219,059 307,188 33.69 8,229 103.26 0.0007
2024-02-13 2023-12-31 13F FULCRUM THERAPEUTICS COM 359616109 1,219,059 307,188 8,229 0.0007
2023-11-15 2023-09-30 13F FULCRUM THERAPEUTICS COM 359616109 911,871 -192,003 -17.39 4,049 11.15 0.0004
2023-08-14 2023-06-30 13F FULCRUM THERAPEUTICS COM 359616109 1,103,874 -58,494 -5.03 3,643 9.96 0.0004
2023-05-15 2023-03-31 13F FULCRUM THERAPEUTICS COM 359616109 1,162,368 -11,243 -0.96 3,313 -61.23 0.0004
2023-02-14 2022-12-31 13F FULCRUM THERAPEUTICS COM 359616109 1,173,611 -26,691 -2.22 8,544 -12.03 0.0010
2022-11-14 2022-09-30 13F FULCRUM THERAPEUTICS COM 359616109 1,200,302 21,346 1.81 9,711 68.13 0.0013
2022-10-27 2022-06-30 13F/A-1 FULCRUM THERAPEUTICS COM 359616109 1,178,956 70,532 6.36 5,776 -77.97 0.0007
2022-08-15 2022-06-30 13F FULCRUM THERAPEUTICS COM 359616109 1,178,956 70,532 5,776 0.0002
2022-10-27 2022-03-31 13F/A-1 FULCRUM THERAPEUTICS COM 359616109 1,108,424 1,018,874 1,137.77 26,215 1,554.99 0.0035
2022-05-13 2022-03-31 13F FULCRUM THERAPEUTICS COM 359616109 1,108,424 1,018,874 26,215 0.0035
2022-02-14 2021-12-31 13F FULCRUM THERAPEUTICS COM 359616109 89,550 4,539 5.34 1,584 -33.94 0.0002
2021-11-15 2021-09-30 13F FULCRUM THERAPEUTICS COM 359616109 85,011 12,715 17.59 2,398 216.78 0.0003
2021-08-23 2021-06-30 13F/A-1 FULCRUM THERAPEUTICS COM 359616109 72,296 4,491 6.62 757 -5.26 0.0001
2021-08-16 2021-06-30 13F FULCRUM THERAPEUTICS COM 359616109 72,296 4,491 757 0.0000
2021-05-17 2021-03-31 13F FULCRUM THERAPEUTICS COM 359616109 67,805 -31,093 -31.44 799 -31.00 0.0001
2021-02-16 2020-12-31 13F FULCRUM THERAPEUTICS COM 359616109 98,898 67,249 212.48 1,158 361.35 0.0002
2020-11-13 2020-09-30 13F FULCRUM THERAPEUTICS COM 359616109 31,649 -9,401 -22.90 251 -66.58 0.0000
2020-08-14 2020-06-30 13F FULCRUM THERAPEUTICS COM 359616109 41,050 11,902 40.83 751 115.80 0.0002
2020-05-26 2020-03-31 13F/A-1 FULCRUM THERAPEUTICS COM 359616109 29,148 15,532 114.07 348 53.98 0.0001
2020-05-15 2020-03-31 13F FULCRUM THERAPEUTICS COM 359616109 29,148 15,532 348 26.7337
2020-02-14 2019-12-31 13F FULCRUM THERAPEUTICS COM 359616109 13,616 10,163 294.32 226 882.61 0.0001
2019-11-14 2019-09-30 13F FULCRUM THERAPEUTICS COM 359616109 3,453 3,453 23 0.0000
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.