Amicus Therapeutics, Inc.
US ˙ NasdaqGM ˙ US03152W1099
DETTE SYMBOL ER IKKE LÆNGERE AKTIVT

SecurityFOLD / Amicus Therapeutics, Inc.
InstitutionTwo Sigma Advisers, Lp
Latest Disclosed Ownership590,676 shares
Latest Disclosed Value $ 8,411,226
Two Sigma Advisers, Lp reports 71.02% increase in ownership of FOLD / Amicus Therapeutics, Inc.

On February 17, 2026 - Two Sigma Advisers, Lp filed a 13F-HR form disclosing ownership of 590,676 shares of Amicus Therapeutics, Inc. (US:FOLD) valued at $8,411,226 USD as of December 31, 2025. The entity filed a previous 13F-HR on November 14, 2025 disclosing 345,376 shares of Amicus Therapeutics, Inc.. This represents a change in shares of 71.02% during the quarter. The current value of the position is $8,558,895 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-02-17 2025-12-31 13F AMICUS THERAPEUTICS COM 03152W109 590,676 245,300 71.02 8,411 209.11 0.0164
2025-11-14 2025-09-30 13F AMICUS THERAPEUTICS COM 03152W109 345,376 -551,200 -61.48 2,722 -47.03 0.0054
2025-08-14 2025-06-30 13F AMICUS THERAPEUTICS COM 03152W109 896,576 -136,700 -13.23 5,137 -39.07 0.0105
2025-05-15 2025-03-31 13F AMICUS THERAPEUTICS COM 03152W109 1,033,276 921,300 822.77 8,432 699.91 0.0190
2025-02-14 2024-12-31 13F AMICUS THERAPEUTICS COM 03152W109 111,976 52,000 86.70 1,055 64.69 0.0024
2024-11-14 2024-09-30 13F AMICUS THERAPEUTICS COM 03152W109 59,976 -23,700 -28.32 641 -22.89 0.0015
2024-08-14 2024-06-30 13F AMICUS THERAPEUTICS COM 03152W109 83,676 59,100 240.48 830 187.20 0.0019
2024-05-15 2024-03-31 13F AMICUS THERAPEUTICS COM 03152W109 24,576 24,576 290 0.0007
2023-11-14 2023-09-30 13F AMICUS THERAPEUTICS COM 03152W109 0 -235,676 -100.00 0 -100.00
2023-08-14 2023-06-30 13F AMICUS THERAPEUTICS COM 03152W109 235,676 -201,000 -46.03 2,960 -38.87 0.0075
2023-05-15 2023-03-31 13F AMICUS THERAPEUTICS COM 03152W109 436,676 -82,200 -15.84 4,843 -23.57 0.0125
2023-02-14 2022-12-31 13F AMICUS THERAPEUTICS COM 03152W109 518,876 -209,500 -28.76 6,335 -16.69 0.0177
2022-11-14 2022-09-30 13F AMICUS THERAPEUTICS COM 03152W109 728,376 112,000 18.17 7,604 14.86 0.0220
2022-08-15 2022-06-30 13F AMICUS THERAPEUTICS COM 03152W109 616,376 -15,200 -2.41 6,620 10.68 0.0188
2022-05-16 2022-03-31 13F AMICUS THERAPEUTICS COM 03152W109 631,576 -224,000 -26.18 5,981 -39.48 0.0159
2022-02-14 2021-12-31 13F AMICUS THERAPEUTICS COM 03152W109 855,576 503,500 143.01 9,882 193.93 0.0247
2021-11-15 2021-09-30 13F AMICUS THERAPEUTICS COM 03152W109 352,076 -659,400 -65.19 3,362 -65.52 0.0087
2021-08-16 2021-06-30 13F AMICUS THERAPEUTICS COM 03152W109 1,011,476 -542,300 -34.90 9,751 -36.48 0.0257
2021-05-17 2021-03-31 13F AMICUS THERAPEUTICS COM 03152W109 1,553,776 507,600 48.52 15,351 -36.45 0.0422
2021-02-16 2020-12-31 13F AMICUS THERAPEUTICS COM 03152W109 1,046,176 688,200 192.25 24,156 377.86 0.0645
2020-11-16 2020-09-30 13F AMICUS THERAPEUTICS COM 03152W109 357,976 214,100 148.81 5,055 132.95 0.0144
2020-09-15 2020-06-30 13F/A-1 AMICUS THERAPEUTICS COM 03152W109 143,876 122,976 588.40 2,170 1,024.35 0.0064
2020-08-14 2020-06-30 13F AMICUS THERAPEUTICS COM 03152W109 143,876 122,976 2,170 6,270.5793
2020-05-15 2020-03-31 13F AMICUS THERAPEUTICS COM 03152W109 20,900 -30,476 -59.32 193 -61.40 0.0007
2020-02-14 2019-12-31 13F AMICUS THERAPEUTICS COM 03152W109 51,376 51,376 500 0.0012
2018-08-14 2018-06-30 13F AMICUS THERAPEUTICS COM 03152W109 0 -16,000 -100.00 0 -100.00
2018-05-15 2018-03-31 13F AMICUS THERAPEUTICS COM 03152W109 16,000 -1,200 -6.98 241 -2.82 0.0007
2018-02-14 2017-12-31 13F AMICUS THERAPEUTICS COM 03152W109 17,200 1,800 11.69 248 6.90 0.0007
2017-11-14 2017-09-30 13F AMICUS THERAPEUTICS COM 03152W109 15,400 15,400 232 0.0007
2016-05-16 2016-03-31 13F AMICUS THERAPEUTICS Common Stock 03152W109 0 -10,500 -100.00 0 -100.00
2016-02-16 2015-12-31 13F AMICUS THERAPEUTICS COM 03152W109 10,500 10,500 0.00 102 0.0006
2015-05-15 2015-03-31 13F AMICUS THERAPEUTICS COMMON STOCK 03152W109 0 -207,673 -100.00 0 -100.00
2016-02-09 2014-12-31 13F/A-1 AMICUS THERAPEUTICS COMMON STOCK 03152W109 207,673 -1,400 -0.67 1,728 38.91 0.0138
2015-02-17 2014-12-31 13F AMICUS THERAPEUTICS COMMON STOCK 03152W109 207,673 1,726
2016-02-09 2014-09-30 13F/A-1 AMICUS THERAPEUTICS COM 03152W109 209,073 194,100 1,296.33 1,244 2,388.00 0.0098
2014-11-14 2014-09-30 13F AMICUS THERAPEUTICS COM 03152W109 208,573 1,240
2016-02-09 2014-06-30 13F/A-1 AMICUS THERAPEUTICS Common Stock 03152W109 14,973 14,973 50 0.0004
2014-08-14 2014-06-30 13F AMICUS THERAPEUTICS Common Stock 03152W109 14,973 50 0.0004
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.