Amicus Therapeutics, Inc.
US ˙ NasdaqGM ˙ US03152W1099
DETTE SYMBOL ER IKKE LÆNGERE AKTIVT

SecurityFOLD / Amicus Therapeutics, Inc.
InstitutionD. E. Shaw & Co., Inc.
ManagerDE Shaw
Latest Disclosed Ownership488,098 shares
Latest Disclosed Value $ 7,057,897
D. E. Shaw & Co., Inc. reports 68.49% decrease in ownership of FOLD / Amicus Therapeutics, Inc.

On May 15, 2026 - D. E. Shaw & Co., Inc. filed a 13F-HR form disclosing ownership of 488,098 shares of Amicus Therapeutics, Inc. (US:FOLD) valued at $7,057,897 USD as of March 31, 2026. The entity filed a previous 13F-HR on February 17, 2026 disclosing 1,549,003 shares of Amicus Therapeutics, Inc.. This represents a change in shares of -68.49% during the quarter. The current value of the position is $7,072,540 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-05-15 2026-03-31 13F AMICUS THERAPEUTIC COM 03152W109 488,098 -1,060,905 -68.49 7,058 -68.01 0.0042
2026-02-17 2025-12-31 13F AMICUS THERAPEUTICS COM 03152W109 1,549,003 -2,319,207 -59.96 22,058 -27.64 0.0121
2025-11-14 2025-09-30 13F AMICUS THERAPEUTICS COM 03152W109 3,868,210 -2,494,040 -39.20 30,481 -16.39 0.0172
2025-08-14 2025-06-30 13F AMICUS THERAPEUTICS COM 03152W109 6,362,250 4,071,968 177.79 36,456 95.07 0.0258
2025-05-15 2025-03-31 13F AMICUS THERAPEUTICS COM 03152W109 2,290,282 729,872 46.77 18,689 27.14 0.0166
2025-02-14 2024-12-31 13F AMICUS THERAPEUTICS COM 03152W109 1,560,410 889,968 132.74 14,699 105.29 0.0108
2024-11-14 2024-09-30 13F AMICUS THERAPEUTICS COM 03152W109 670,442 581,167 650.99 7,160 709.04 0.0061
2024-08-14 2024-06-30 13F AMICUS THERAPEUTICS COM 03152W109 89,275 -35,751 -28.59 886 -39.88 0.0008
2024-05-15 2024-03-31 13F AMICUS THERAPEUTICS COM 03152W109 125,026 -161,198 -56.32 1,473 -63.75 0.0013
2024-02-14 2023-12-31 13F AMICUS THERAPEUTICS COM 03152W109 286,224 -73,967 -20.54 4,062 -7.26 0.0035
2023-11-14 2023-09-30 13F AMICUS THERAPEUTICS COM 03152W109 360,191 -771,735 -68.18 4,380 -69.20 0.0046
2023-08-14 2023-06-30 13F AMICUS THERAPEUTICS COM 03152W109 1,131,926 -519,671 -31.46 14,217 -22.38 0.0145
2023-05-15 2023-03-31 13F AMICUS THERAPEUTICS COM 03152W109 1,651,597 -581,728 -26.05 18,316 -32.83 0.0196
2023-02-14 2022-12-31 13F AMICUS THERAPEUTICS COM 03152W109 2,233,325 -670,171 -23.08 27,269 -10.04 0.0301
2022-11-14 2022-09-30 13F AMICUS THERAPEUTICS COM 03152W109 2,903,496 -65,240 -2.20 30,312 -4.93 0.0362
2022-08-15 2022-06-30 13F AMICUS THERAPEUTICS COM 03152W109 2,968,736 -75,702 -2.49 31,884 10.59 0.0374
2022-05-16 2022-03-31 13F AMICUS THERAPEUTICS COM 03152W109 3,044,438 279,142 10.09 28,831 -9.73 0.0270
2022-02-14 2021-12-31 13F AMICUS THERAPEUTICS COM 03152W109 2,765,296 573,279 26.15 31,939 52.57 0.0265
2021-11-15 2021-09-30 13F AMICUS THERAPEUTICS COM 03152W109 2,192,017 -766,130 -25.90 20,934 -26.59 0.0189
2021-08-16 2021-06-30 13F AMICUS THERAPEUTICS COM 03152W109 2,958,147 -1,456,829 -33.00 28,516 -34.63 0.0246
2021-05-17 2021-03-31 13F AMICUS THERAPEUTICS COM 03152W109 4,414,976 -2,664,620 -37.64 43,620 -73.32 0.0421
2021-02-16 2020-12-31 13F AMICUS THERAPEUTICS COM 03152W109 7,079,596 -264,668 -3.60 163,468 57.63 0.1462
2020-11-16 2020-09-30 13F AMICUS THERAPEUTICS COM 03152W109 7,344,264 296,215 4.20 103,701 -2.43 0.1061
2020-08-14 2020-06-30 13F AMICUS THERAPEUTICS COM 03152W109 7,048,049 1,482,310 26.63 106,285 106.67 0.1266
2020-05-15 2020-03-31 13F AMICUS THERAPEUTICS COM 03152W109 5,565,739 1,739,698 45.47 51,428 38.00 0.0802
2020-02-14 2019-12-31 13F AMICUS THERAPEUTICS COM 03152W109 3,826,041 1,034,197 37.04 37,266 66.43 0.0426
2019-11-14 2019-09-30 13F AMICUS THERAPEUTICS COM 03152W109 2,791,844 644,441 30.01 22,391 -16.45 0.0276
2019-08-14 2019-06-30 13F AMICUS THERAPEUTICS COM 03152W109 2,147,403 1,146,777 114.61 26,800 96.93 0.0334
2019-05-15 2019-03-31 13F AMICUS THERAPEUTICS COM 03152W109 1,000,626 109,646 12.31 13,609 59.43 0.0176
2019-02-14 2018-12-31 13F AMICUS THERAPEUTICS COM 03152W109 890,980 -1,509,694 -62.89 8,536 -70.59 0.0118
2018-11-14 2018-09-30 13F AMICUS THERAPEUTICS COM 03152W109 2,400,674 -1,324,370 -35.55 29,024 -50.12 0.0349
2018-08-14 2018-06-30 13F AMICUS THERAPEUTICS COM 03152W109 3,725,044 -694,735 -15.72 58,185 -12.47 0.0759
2018-05-15 2018-03-31 13F AMICUS THERAPEUTICS COM 03152W109 4,419,779 1,963,566 79.94 66,473 88.07 0.0905
2018-02-14 2017-12-31 13F AMICUS THERAPEUTICS COM 03152W109 2,456,213 -2,049,287 -45.48 35,345 -47.98 0.0487
2017-11-14 2017-09-30 13F AMICUS THERAPEUTICS COM 03152W109 4,505,500 435,205 10.69 67,943 65.76 0.1044
2017-08-14 2017-06-30 13F AMICUS THERAPEUTICS COM 03152W109 4,070,295 488,357 13.63 40,988 60.49 0.0678
2017-05-15 2017-03-31 13F AMICUS THERAPEUTICS COM 03152W109 3,581,938 1,251,339 53.69 25,539 120.49 0.0449
2017-02-14 2016-12-31 13F AMICUS THERAPEUTICS COM 03152W109 2,330,599 31,528 1.37 11,583 -31.92 0.0197
2016-11-14 2016-09-30 13F AMICUS THERAPEUTICS COM 03152W109 2,299,071 -476,522 -17.17 17,013 12.26 0.0300
2016-08-15 2016-06-30 13F AMICUS THERAPEUTICS COM 03152W109 2,775,593 -127,879 -4.40 15,155 -38.23 0.0279
2016-05-16 2016-03-31 13F AMICUS THERAPEUTICS COM 03152W109 2,903,472 -522,024 -15.24 24,535 -26.16 0.0440
2016-02-16 2015-12-31 13F AMICUS THERAPEUTICS COM 03152W109 3,425,496 2,030,981 145.64 33,227 70.32 0.0495
2015-11-16 2015-09-30 13F AMICUS THERAPEUTICS COM 03152W109 1,394,515 -236,209 -14.48 19,509 -15.45 0.0287
2015-08-14 2015-06-30 13F AMICUS THERAPEUTICS COM 03152W109 1,630,724 -938,602 -36.53 23,075 -17.45 0.0344
2015-05-15 2015-03-31 13F AMICUS THERAPEUTICS COM 03152W109 2,569,326 -486,838 -15.93 27,954 9.94 0.0428
2015-02-17 2014-12-31 13F AMICUS THERAPEUTICS COM 03152W109 3,056,164 1,550,432 102.97 25,427 183.82 0.0327
2014-11-14 2014-09-30 13F AMICUS THERAPEUTICS COM 03152W109 1,505,732 921,150 157.57 8,959 358.97 0.0116
2014-08-14 2014-06-30 13F AMICUS THERAPEUTICS COM 03152W109 584,582 -76,208 -11.53 1,952 42.69 0.0027
2014-05-15 2014-03-31 13F AMICUS THERAPEUTICS COM 03152W109 660,790 53,742 8.85 1,368 -4.07 0.0020
2014-02-14 2013-12-31 13F AMICUS THERAPEUTICS COM 03152W109 607,048 187,355 44.64 1,426 46.41 0.0019
2013-11-20 2013-09-30 13F/A-1 AMICUS THERAPEUTICS COM 03152W109 419,693 48,832 13.17 974 12.73 0.0016
2013-11-14 2013-09-30 13F AMICUS THERAPEUTICS COM 03152W109 419,693 974
2013-08-14 2013-06-30 13F AMICUS THERAPEUTICS COM 03152W109 370,861 370,861 864 0.0016
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.