Castle Biosciences, Inc.
US ˙ NasdaqGM ˙ US14843C1053

SecurityCSTL / Castle Biosciences, Inc.
InstitutionQube Research & Technologies Ltd
Latest Disclosed Ownership559,583 shares
Latest Disclosed Value $ 13,737,763
Qube Research & Technologies Ltd reports 137.60% increase in ownership of CSTL / Castle Biosciences, Inc.

On May 15, 2026 - Qube Research & Technologies Ltd filed a 13F-HR form disclosing ownership of 559,583 shares of Castle Biosciences, Inc. (US:CSTL) valued at $13,737,763 USD as of March 31, 2026. The entity filed a previous 13F-HR on February 17, 2026 disclosing 235,518 shares of Castle Biosciences, Inc.. This represents a change in shares of 137.60% during the quarter. The current value of the position is $11,756,839 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date
Effective
Date
Form Security Class ID Avg Price
Paid (Est)
Reported
Shares
ΔShares ΔShares
(%)
Reported
Value
(x1000)
ΔValue
(%)
Alloc
(%)
ΔAlloc ΔAlloc (%) Cost Basis
(x1000)
Unrealized
Gain/Loss
(x1000)
2026-05-15 2026-03-31 13F CASTLE BIOSCIENCES COM 14843C105 559,583 324,065 137.60 13,738 49.95 0.0153
2026-02-17 2025-12-31 13F CASTLE BIOSCIENCES COM 14843C105 235,518 14,557 6.59 9,162 82.09 0.0093
2025-11-14 2025-09-30 13F CASTLE BIOSCIENCES COM 14843C105 220,961 28,408 14.75 5,031 27.98 0.0052
2025-08-14 2025-06-30 13F CASTLE BIOSCIENCES COM 14843C105 192,553 -86,811 -31.07 3,932 -29.70 0.0040
2025-05-15 2025-03-31 13F CASTLE BIOSCIENCES COM 14843C105 279,364 61,820 28.42 5,593 -3.54 0.0065
2025-02-14 2024-12-31 13F CASTLE BIOSCIENCES COM 14843C105 217,544 159,699 276.08 5,798 251.55 0.0076
2024-11-14 2024-09-30 13F CASTLE BIOSCIENCES COM 14843C105 57,845 57,845 1,650 0.0024
2023-11-13 2023-09-30 13F CASTLE BIOSCIENCES COM 14843C105 0 -12,699 -100.00 0 -100.00
2023-08-14 2023-06-30 13F CASTLE BIOSCIENCES COM 14843C105 12,699 12,699 174 0.0006
2022-11-14 2022-09-30 13F CASTLE BIOSCIENCES COM 14843C105 0 -18,792 -100.00 0 -100.00
2022-08-15 2022-06-30 13F CASTLE BIOSCIENCES COM 14843C105 18,792 18,792 412 0.0030
2022-05-09 2022-03-31 13F CASTLE BIOSCIENCES COM 14843C105 0 -12,814 -100.00 0 -100.00
2022-02-10 2021-12-31 13F/A-1 CASTLE BIOSCIENCES COM 14843C105 12,814 6,299 96.68 549 26.79 0.0042
2022-02-01 2021-12-31 13F CASTLE BIOSCIENCES COM 14843C105 12,814 6,299 549 0.0042
2021-11-12 2021-09-30 13F CASTLE BIOSCIENCES COM 14843C105 6,515 -2,552 -28.15 433 -34.89 0.0054
2021-08-13 2021-06-30 13F CASTLE BIOSCIENCES COM 14843C105 9,067 718 8.60 665 16.26 0.0076
2021-05-14 2021-03-31 13F CASTLE BIOSCIENCES COM 14843C105 8,349 371 4.65 572 6.72 0.0091
2021-02-16 2020-12-31 13F CASTLE BIOSCIENCES COM 14843C105 7,978 7,978 536 0.0076
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.