Bicycle Therapeutics plc - Depositary Receipt (Common Stock)
DE ˙ DB ˙ US0887861088
3,56 € ↓ -0,04 (-1,11%)
2026-06-04
DEL PRIS
SecurityDE:50BA / Bicycle Therapeutics plc - Depositary Receipt (Common Stock)
InstitutionRenaissance Technologies Llc
ManagerJames Simons
Latest Disclosed Ownership979,300 shares
Latest Disclosed Value $ 4,543,952
Renaissance Technologies Llc reports 72.84% increase in ownership of 50BA / Bicycle Therapeutics plc - Depositary Receipt (Common Stock)

On May 14, 2026 - Renaissance Technologies Llc filed a 13F-HR form disclosing ownership of 979,300 shares of Bicycle Therapeutics plc - Depositary Receipt (Common Stock) (DE:50BA) valued at $3,623,410 USD as of March 31, 2026. The entity filed a previous 13F-HR on February 12, 2026 disclosing 566,600 shares of Bicycle Therapeutics plc - Depositary Receipt (Common Stock). This represents a change in shares of 72.84% during the quarter. The current value of the position is $3,486,308 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-05-14 2026-03-31 13F BICYCLE THERAPEUTICS SPONSORED ADS 088786108 979,300 412,700 72.84 4,544 13.26 0.0071
2026-02-12 2025-12-31 13F BICYCLE THERAPEUTICS SPONSORED ADS 088786108 566,600 47,900 9.23 4,012 -0.07 0.0062
2025-11-13 2025-09-30 13F BICYCLE THERAPEUTICS SPONSORED ADS 088786108 518,700 200,300 62.91 4,015 81.46 0.0053
2025-08-13 2025-06-30 13F BICYCLE THERAPEUTICS SPONSORED ADS 088786108 318,400 16,900 5.61 2,213 -13.56 0.0029
2025-05-14 2025-03-31 13F BICYCLE THERAPEUTICS SPONSORED ADS 088786108 301,500 32,000 11.87 2,560 -32.18 0.0039
2025-02-13 2024-12-31 13F BICYCLE THERAPEUTICS SPONSORED ADS 088786108 269,500 -3,100 -1.14 3,773 -38.83 0.0056
2024-11-13 2024-09-30 13F BICYCLE THERAPEUTICS SPONSORED ADS 088786108 272,600 -54,200 -16.59 6,169 -6.74 0.0093
2024-08-09 2024-06-30 13F BICYCLE THERAPEUTICS SPONSORED ADS 088786108 326,800 161,100 97.22 6,614 165,250.00 0.0112
2024-05-13 2024-03-31 13F BICYCLE THERAPEUTICS SPONSORED ADS 088786108 165,700 60,200 57.06 4 300.00 0.0065
2024-02-13 2023-12-31 13F BICYCLE THERAPEUTICS SPONSORED ADS 088786108 105,500 23,500 28.66 2 0.00 0.0030
2023-11-14 2023-09-30 13F BICYCLE THERAPEUTICS SPONSORED ADS 088786108 82,000 11,100 15.66 2 0.00 0.0028
2023-08-11 2023-06-30 13F BICYCLE THERAPEUTICS SPONSORED ADS 088786108 70,900 9,000 14.54 2 0.00 0.0026
2023-05-12 2023-03-31 13F BICYCLE THERAPEUTICS SPONSORED ADS 088786108 61,900 61,900 1 0.0017
2022-11-14 2022-09-30 13F BICYCLE THERAPEUTICS SPONSORED ADS 088786108 0 -153,200 -100.00 0 -100.00
2022-08-12 2022-06-30 13F BICYCLE THERAPEUTICS SPONSORED ADS 088786108 153,200 88,801 137.89 2,571 -9.02 0.0030
2022-05-13 2022-03-31 13F BICYCLE THERAPEUTICS SPONSORED ADS 088786108 64,399 -8,780 -12.00 2,826 -36.55 0.0033
2022-02-11 2021-12-31 13F BICYCLE THERAPEUTICS SPONSORED ADS 088786108 73,179 73,179 4,454 0.0055
2021-11-12 2021-09-30 13F BICYCLE THERAPEUTICS SPONSORED ADS 088786108 0 -14,600 -100.00 0 -100.00
2021-08-13 2021-06-30 13F BICYCLE THERAPEUTICS SPONSORED ADS 088786108 14,600 -12,200 -45.52 443 -44.69 0.0006
2021-05-13 2021-03-31 13F BICYCLE THERAPEUTICS SPONSORED ADS 088786108 26,800 -54,400 -67.00 801 -45.06 0.0010
2021-02-10 2020-12-31 13F BICYCLE THERAPEUTICS SPONSORED ADS 088786108 81,200 21,700 36.47 1,458 28.68 0.0016
2020-11-13 2020-09-30 13F BICYCLE THERAPEUTICS SPONSORED ADS 088786108 59,500 -15,200 -20.35 1,133 -3.66 0.0011
2020-08-13 2020-06-30 13F BICYCLE THERAPEUTICS SPONSORED ADS 088786108 74,700 55,900 297.34 1,176 357.59 0.0010
2020-05-14 2020-03-31 13F BICYCLE THERAPEUTICS SPONSORED ADS 088786108 18,800 18,800 257 0.0002
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.