| Insideraktier | 812.677 shares |
Insider-stemningsscore
Insider Sentiment Score viser, at virksomhederne bliver købt af virksomheders insidere.
Det er resultatet af en sofistikeret, multi-faktor kvantitativ model, der identificerer virksomheder med de højeste niveauer af insider-akkumulering. Scoringsmodellen bruger en kombination af nettoantallet af insidere, der har købt de foregående 90 dage, det samlede antal aktier købt som en procentdel af float og det samlede antal aktier ejet af insidere. Tallet går fra 0 til 100, hvor højere tal indikerer et højere niveau af akkumulering for sine jævnaldrende, og 50 er gennemsnittet.
Opdateringsfrekvens: Dagligt
Se Insiders Top Picks, som giver en liste over virksomheder med den højeste insider-akkumulering.
Officers sentiment score
Officer Sentiment Score finder virksomheder, der bliver købt af Corporate Officers.
Per definition er Corporate Officers Corporate Insiders, men i modsætning til nogle af de andre Insiders (10 % aktionærer og bestyrelsesmedlemmer), arbejder officerer for virksomheden på daglig basis, og de bruger deres egne penge, når de handler . (10 % aktionærer og bestyrelsesmedlemmer er ofte fondsforvaltere, der administrerer andres penge.) Som sådan er insiderhandler foretaget af embedsmænd meget mere betydningsfulde og bør behandles passende.
Ligesom Insider Sentiment Score er Officer Sentiment Score resultatet af en sofistikeret, multi-faktor kvantitativ model, der identificerer virksomheder med de højeste niveauer af officerakkumulering.
Opdateringsfrekvens: Dagligt
Se Insiders Top Picks, som giver en liste over virksomheder med højeste insider-stemning.
Nøgle Insider Metrics
Dette kort viser, hvordan virksomheden rangerer langs forskellige insider-metrics. Percentilrangen viser, hvordan denne virksomhed sammenligner sig med andre virksomheder på de amerikanske markeder. Højere placeringer er tegn på bedre situationer.
For eksempel er det generelt accepteret, at insider-køb er en positiv indikator, så virksomheder med flere insider-køb vil rangere højere end virksomheder med mindre insider-køb (eller endda insider-salg).
Netto antal insidere, der køber (rang)
Netto antal insidere, der køber, er det samlede antal insiders, der køber minus det samlede antal insiders, der har solgt inden for de sidste 90 dage. Percentilrangen vises her (spænder fra 0 til 100%).
Procent af float købt af insidere (rangering)
Procent af float købt af insidere er det samlede antal aktier købt af insidere minus det samlede antal aktier solgt af insidere inden for de sidste 90 dage, divideret med den samlede float og ganget med 100.
Insiderhandelsdiagram
Pieris Pharmaceuticals, Inc. insiderhandler er vist i følgende diagram. Insidere er embedsmænd, direktører eller betydelige investorer i en virksomhed. Generelt er det generelt ulovligt for insidere at foretage handler i deres virksomheder baseret på væsentlige, ikke-offentlige oplysninger. Dette betyder ikke, at det er ulovligt for dem at handle i deres egne virksomheder. De skal dog rapportere alle handler til SEC via en formular 4.
Insiderliste og lønsomhedsmålinger
Denne tabel viser listen over kendte insidere og genereres automatisk fra arkiveringer, der er videregivet til SEC. Ud over navnene, den seneste titel og direktør, officer eller 10 % ejerbetegnelse giver vi de seneste offentliggjorte besiddelser. Derudover giver vi, når det er muligt, den historiske handelspræstation for insideren. Den historiske handelspræstation er et vægtet gennemsnit af præstationen af faktiske købstransaktioner på det åbne marked foretaget af insideren. For mere information om, hvordan dette beregnes, se dette YouTube-webinar.
See our leaderboard of most profitable insider traders.
| Insider | Gennemsnitlig fortjeneste (%) | Aktier Ejet |
Dele Justeret |
|---|
Report errors via our new Insider Auditing Tool
Track Records af insiderkøb - Kortsigtet profitanalyse
I dette afsnit analyserer vi rentabiliteten af ethvert uplanlagt insiderkøb i åbent marked foretaget i PIRS / Pieris Pharmaceuticals, Inc.. Denne analyse hjælper med at forstå, om insideren konsekvent genererer unormale afkast og er værd at følge. Denne analyse er for et år efter hver handel, og resultaterne er teoretiske .
Følgende tabel viser de seneste køb på det åbne marked, der ikke var en del af en automatisk handelsplan.
Justeret pris er den split-justerede pris. Adjusted Shares er de split-justerede aktier.
Track Records af insidersalg - Kortsigtet tabsanalyse
I dette afsnit analyserer vi den kortsigtede undgåelse af tab af ethvert uplanlagt insidersalg på åbent marked, der foretages i PIRS / Pieris Pharmaceuticals, Inc.. Et konsekvent mønster af tabsforebyggelse kan tyde på, at fremtidige salgstransaktioner kan forudsige prisfald. Denne analyse er for et år efter hver handel, og resultaterne er teoretiske .
Følgende tabel viser de seneste salg på det åbne marked, der ikke var en del af en automatisk handelsplan.
Justeret pris er den split-justerede pris. Adjusted Shares er de split-justerede aktier.
Transaktionshistorik
Klik på linkikonet for at se den fulde transaktionshistorik. Transaktioner, der rapporteres som en del af en automatisk handelsplan 10b5-1, vil have et X i kolonnen markeret 10b-5.
| Fil Dato |
Handle Dato |
Form | Insider | Ticker | Sikkerhedstitel | Kode | Direkte | Dyrke motion Pris |
Enhed Pris |
Enheder Ændret |
Værdi Ændret (1K) |
Tilbage Muligheder |
Tilbage Aktier |
|
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2026-05-22 | 2026-05-20 | 4 | Goin Kathleen | PVLA | Common Stock | D | 111,8950 | -48 | -5 | 0 | ||||
| 2026-05-22 | 2026-05-20 | 4 | Goin Kathleen | PVLA | Common Stock | D | 111,2963 | -891 | -99 | 48 | ||||
| 2026-05-22 | 2026-05-20 | 4 | Goin Kathleen | PVLA | Common Stock | D | 110,3464 | -3.363 | -371 | 939 | ||||
| 2026-05-22 | 2026-05-20 | 4 | Goin Kathleen | PVLA | Common Stock | D | 9,0800 | 2.148 | 20 | 4.302 | ||||
| 2026-05-22 | 2026-05-20 | 4 | Goin Kathleen | PVLA | Common Stock | D | 7,1400 | 2.154 | 15 | 2.154 | ||||
| 2026-04-17 | 2026-04-15 | 4 | Goin Kathleen | PVLA | Common Stock | D | 130,3300 | -100 | -13 | 0 | ||||
| 2026-04-17 | 2026-04-15 | 4 | Goin Kathleen | PVLA | Common Stock | D | 129,1692 | -639 | -83 | 100 | ||||
| 2026-04-17 | 2026-04-15 | 4 | Goin Kathleen | PVLA | Common Stock | D | 128,2349 | -561 | -72 | 739 | ||||
| 2026-04-17 | 2026-04-15 | 4 | Goin Kathleen | PVLA | Common Stock | D | 127,1254 | -1.500 | -191 | 1.300 | ||||
| 2026-04-17 | 2026-04-15 | 4 | Goin Kathleen | PVLA | Common Stock | D | 125,9647 | -1.502 | -189 | 2.800 | ||||
| 2026-04-17 | 2026-04-15 | 4 | Goin Kathleen | PVLA | Common Stock | D | 9,0800 | 2.148 | 20 | 4.302 | ||||
| 2026-04-17 | 2026-04-15 | 4 | Goin Kathleen | PVLA | Common Stock | D | 7,1400 | 2.154 | 15 | 2.154 | ||||
| 2026-04-01 | 2026-03-30 | 4 | JENKINS GEORGE M | PVLA | Common Stock | D | 112,3000 | 445 | 50 | 187.616 | ||||
| 2026-03-20 | 2026-03-18 | 4 | Goin Kathleen | PVLA | Common Stock | D | 119,0817 | -304 | -36 | 0 | ||||
| 2026-03-20 | 2026-03-18 | 4 | Goin Kathleen | PVLA | Common Stock | D | 118,3681 | -1.730 | -205 | 304 | ||||
| 2026-03-20 | 2026-03-18 | 4 | Goin Kathleen | PVLA | Common Stock | D | 117,5632 | -2.268 | -267 | 2.034 | ||||
| 2026-03-20 | 2026-03-18 | 4 | Goin Kathleen | PVLA | Common Stock | D | 9,0800 | 2.148 | 20 | 4.302 | ||||
| 2026-03-20 | 2026-03-18 | 4 | Goin Kathleen | PVLA | Common Stock | D | 7,1400 | 2.154 | 15 | 2.154 | ||||
| 2026-03-02 | 2026-02-27 | 4 | JENKINS GEORGE M | PVLA | Common Stock | D | 125,0000 | 4.000 | 500 | 187.171 | ||||
| 2026-03-02 | 2026-02-27 | 4 | HERON ELAINE J | PVLA | Common Stock | D | 125,0000 | 2.400 | 300 | 47.812 | ||||
| 2026-02-20 | 2026-02-18 | 4 | Goin Kathleen | PVLA | Common Stock | D | 79,9651 | -1.276 | -102 | 0 | ||||
| 2026-02-20 | 2026-02-18 | 4 | Goin Kathleen | PVLA | Common Stock | D | 79,1569 | -3.026 | -240 | 1.276 | ||||
| 2026-02-20 | 2026-02-18 | 4 | Goin Kathleen | PVLA | Common Stock | D | 9,0800 | 2.148 | 20 | 4.302 | ||||
| 2026-02-20 | 2026-02-18 | 4 | Goin Kathleen | PVLA | Common Stock | D | 7,1400 | 2.154 | 15 | 2.154 | ||||
| 2026-01-23 | 2026-01-21 | 4 | Goin Kathleen | PVLA | Common Stock | D | 97,9400 | -3.749 | -367 | 0 | ||||
| 2026-01-23 | 2026-01-21 | 4 | Goin Kathleen | PVLA | Common Stock | D | 95,4900 | -553 | -53 | 3.749 | ||||
| 2026-01-23 | 2026-01-21 | 4 | Goin Kathleen | PVLA | Common Stock | D | 9,0800 | 2.148 | 20 | 4.302 | ||||
| 2026-01-23 | 2026-01-21 | 4 | Goin Kathleen | PVLA | Common Stock | D | 7,1400 | 2.154 | 15 | 2.154 | ||||
| 2025-12-19 | 2025-12-17 | 4 | Goin Kathleen | PVLA | Common Stock | D | 96,4720 | -4.302 | -415 | 0 | ||||
| 2025-12-19 | 2025-12-17 | 4 | Goin Kathleen | PVLA | Common Stock | D | 9,0800 | 2.148 | 20 | 4.302 | ||||
| 2025-12-19 | 2025-12-17 | 4 | Goin Kathleen | PVLA | Common Stock | D | 7,1400 | 2.154 | 15 | 2.154 | ||||
| 2025-11-21 | 2025-11-19 | 4 | Goin Kathleen | PVLA | Common Stock | D | 86,5053 | -2.802 | -242 | 0 | ||||
| 2025-11-21 | 2025-11-19 | 4 | Goin Kathleen | PVLA | Common Stock | D | 85,7183 | -1.500 | -129 | 2.802 | ||||
| 2025-11-21 | 2025-11-19 | 4 | Goin Kathleen | PVLA | Common Stock | D | 9,0800 | 2.148 | 20 | 4.302 | ||||
| 2025-11-21 | 2025-11-19 | 4 | Goin Kathleen | PVLA | Common Stock | D | 7,1400 | 2.154 | 15 | 2.154 | ||||
| 2025-04-10 | 2025-04-09 | 4 | JENKINS GEORGE M by foundation | PVLA | Common Stock | I | 20,2700 | 2.490 | 50 | 13.516 | ||||
| 2025-04-10 | 2025-04-09 | 4 | JENKINS GEORGE M | PVLA | Common Stock | D | 20,1300 | 2.500 | 50 | 183.171 | ||||
| 2025-01-06 | 3/A | Kaupinen Wes | PVLA | Common Stock | D | 44.410 | ||||||||
| 2024-12-19 | 2024-12-18 | 4 | JENKINS GEORGE M | PVLA | Common Stock | D | 12,9300 | 4.000 | 52 | 180.671 | ||||
| 2024-12-17 | 2024-12-13 | 4 | BVF PARTNERS L P/IL | PVLA | Common Stock, $0.001 par value | D | 29.648 | 38.961 | ||||||
| 2024-12-17 | 2024-12-13 | 4 | BVF PARTNERS L P/IL | PVLA | Common Stock, $0.001 par value | D | 174.958 | 282.223 | ||||||
| 2024-12-17 | 2024-12-13 | 4 | BVF PARTNERS L P/IL | PVLA | Common Stock, $0.001 par value | D | 234.323 | 371.916 | ||||||
| 2024-12-16 | 3 | Kaupinen Wes | PVLA | Common Stock | D | 42.940 | ||||||||
| 2024-12-16 | 3 | Kaupinen Wes by Christine L. Kaupinen 2019 Irrevocable Trust dated February 28, 2019 | PVLA | Common Stock | I | 781.409 | ||||||||
| 2024-12-16 | 3 | Kaupinen Wes by Wesley H. Kaupinen 2019 Irrevocable Trust dated February 28, 2019 | PVLA | Common Stock | I | 781.409 | ||||||||
| 2024-12-16 | 3 | Davis Todd C | PVLA | Common Stock | D | 112.547 | ||||||||
| 2024-12-16 | 3 | JENKINS GEORGE M by Eagles Mere Air Museum Foundation | PVLA | Common Stock | I | 11.026 | ||||||||
| 2024-12-16 | 3 | JENKINS GEORGE M | PVLA | Common Stock | D | 176.671 | ||||||||
| 2024-12-16 | 3 | HERON ELAINE J | PVLA | Common Stock | D | 45.412 | ||||||||
| 2024-12-16 | 3 | HERON ELAINE J by Trust | PVLA | Common Stock | I | 5.879 | ||||||||
| 2024-12-12 | 2024-12-12 | 4 | GERAGHTY JAMES A | PIRS | Series F Preferred Stock, par value $0.001 per share | D | 0,0100 | -1 | -0 | 0 | ||||
| 2024-11-18 | 3 | Dellora Investments LP | PIRS | Common Stock | I | 141.079 | ||||||||
| 2024-10-28 | 2024-08-07 | 4 | GERAGHTY JAMES A | PIRS | Series F Preferred Stock, par value $0.001 per share | D | 1,0000 | 1 | 0 | 1 | ||||
| 2024-08-12 | 2024-08-12 | 4 | ADAR1 Capital Management, LLC By: Spearhead Insurance Solutions IDF, LLC - Series ADAR1 | PIRS | Common Stock | I | 15,8824 | 757 | 12 | 15.067 | ||||
| 2024-08-12 | 2024-08-12 | 4 | ADAR1 Capital Management, LLC By: ADAR1 Partners | PIRS | Common Stock | I | 15,8824 | 2.243 | 36 | 129.574 | ||||
| 2024-08-12 | 2024-08-09 | 4 | ADAR1 Capital Management, LLC By: ADAR1 Partners | PIRS | Common Stock | I | 14,8929 | 3.000 | 45 | 127.331 | ||||
| 2024-07-31 | 3 | ADAR1 Capital Management, LLC By: Spearhead Insurance Solutions IDF, LLC - Series ADAR1 | PIRS | Common Stock | I | 14.310 | ||||||||
| 2024-07-31 | 3 | ADAR1 Capital Management, LLC By: ADAR1 Partners | PIRS | Common Stock | I | 124.331 | ||||||||
| 2023-05-30 | 2023-05-25 | 4 | KIRITSY CHRISTOPHER P | PIRS | Common Stock | D | 0,8500 | 10.000 | 8 | 20.000 | ||||
| 2023-05-22 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 8.581.171 | ||||||||
| 2023-05-22 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 744.966 | ||||||||
| 2023-05-22 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 11.007.420 | ||||||||
| 2022-05-16 | 2022-05-13 | 4 | Demuth Tim | PIRS | Common Stock | D | 1,7100 | 6.000 | 10 | 6.000 | ||||
| 2022-02-24 | 2022-02-22 | 4 | Yoder Stephen S. | PIRS | Stock Option (Right to buy) | D | 3,03 | 625.874 | 625.874 | |||||
| 2022-02-24 | 2022-02-22 | 4 | Mousa Ahmed | PIRS | Stock Option (Right to buy) | D | 3,03 | 215.819 | 215.819 | |||||
| 2022-02-24 | 2022-02-22 | 4 | Olwill Shane | PIRS | Stock Option (Right to buy) | D | 3,03 | 215.819 | 215.819 | |||||
| 2022-02-24 | 2022-02-22 | 4 | Demuth Tim | PIRS | Stock Option (Right to buy) | D | 3,03 | 100.000 | 100.000 | |||||
| 2022-02-24 | 2022-02-22 | 4 | Kaufmann Hitto | PIRS | Stock Option (Right to buy) | D | 3,03 | 215.819 | 215.819 | |||||
| 2022-02-24 | 2022-02-22 | 4 | Bures Thomas | PIRS | Stock Options (Right to buy) | D | 3,03 | 215.819 | 215.819 | |||||
| 2021-09-01 | 2021-08-30 | 4 | Olwill Shane | PIRS | Stock Option (right to buy) | D | 1,52 | -38.400 | 61.600 | |||||
| 2021-09-01 | 2021-08-30 | 4 | Olwill Shane | PIRS | Common Stock | D | 5,1500 | -29.200 | -150 | 4.638 | ||||
| 2021-09-01 | 2021-08-30 | 4 | Olwill Shane | PIRS | Common Stock | D | 5,0000 | -9.200 | -46 | 33.838 | ||||
| 2021-09-01 | 2021-08-30 | 4 | Olwill Shane | PIRS | Common Stock | D | 1,5200 | 38.400 | 58 | 43.038 | ||||
| 2021-08-03 | 2021-08-01 | 4 | Demuth Tim | PIRS | Stock Option (right to buy) | D | 3,48 | 360.000 | 360.000 | |||||
| 2021-08-03 | 3 | Olwill Shane | PIRS | Common Stock | D | 4.638 | ||||||||
| 2021-06-29 | 2021-06-25 | 4 | Sherman Matthew L | PIRS | Stock Option (right to buy) | D | 4,00 | 40.000 | 40.000 | |||||
| 2021-06-29 | 2021-06-25 | 4 | Said Maya R. | PIRS | Stock Option (right to buy) | D | 4,00 | 40.000 | 40.000 | |||||
| 2021-06-29 | 2021-06-25 | 4 | Richman Michael | PIRS | Stock Option (right to buy) | D | 4,00 | 40.000 | 40.000 | |||||
| 2021-06-29 | 2021-06-25 | 4 | KIRITSY CHRISTOPHER P | PIRS | Stock Option (right to buy) | D | 4,00 | 40.000 | 40.000 | |||||
| 2021-06-29 | 2021-06-25 | 4 | Kiener Peter A | PIRS | Stock Option (right to buy) | D | 4,00 | 40.000 | 40.000 | |||||
| 2021-06-29 | 2021-06-25 | 4 | GERAGHTY JAMES A | PIRS | Stock Option (right to buy) | D | 4,00 | 45.000 | 45.000 | |||||
| 2021-06-29 | 2021-06-25 | 4 | Barbier Ann | PIRS | Stock Option (right to buy) | D | 4,00 | 40.000 | 40.000 | |||||
| 2021-03-08 | 2021-03-04 | 4 | Bures Thomas | PIRS | Stock Options (Right to buy) | D | 2,50 | 150.000 | 150.000 | |||||
| 2021-03-08 | 2021-03-04 | 4 | Yoder Stephen S. | PIRS | Stock Options (Right to buy) | D | 2,50 | 530.000 | 530.000 | |||||
| 2021-03-08 | 2021-03-04 | 4 | Kaufmann Hitto | PIRS | Stock Options (Right to buy) | D | 2,50 | 220.000 | 220.000 | |||||
| 2020-07-22 | 2020-07-21 | 4 | Aquilo Capital Management, LLC See footnotes | PIRS | Common Stock, $0.001 par value | I | 2,9500 | -1.900.000 | -5.605 | 3.675.530 | ||||
| 2020-06-25 | 2020-06-23 | 4/A | Said Maya R. | PIRS | Stock Option (right to buy) | D | 3,27 | 40.000 | 40.000 | |||||
| 2020-06-25 | 2020-06-23 | 4/A | KIRITSY CHRISTOPHER P | PIRS | Stock Option (right to buy) | D | 3,27 | 40.000 | 40.000 | |||||
| 2020-06-25 | 2020-06-23 | 4 | Kiener Peter A | PIRS | Stock Options (Right to buy) | D | 3,27 | 40.000 | 40.000 | |||||
| 2020-06-25 | 2020-06-23 | 4 | KIRITSY CHRISTOPHER P | PIRS | Stock Option (right to buy) | D | 3,27 | 40.000 | 40.000 | |||||
| 2020-06-25 | 2020-06-23 | 4 | Richman Michael | PIRS | Stock Option (right to buy) | D | 3,27 | 40.000 | 40.000 | |||||
| 2020-06-25 | 2020-06-23 | 4 | Sherman Matthew L | PIRS | Stock Option (right to buy) | D | 3,27 | 40.000 | 40.000 | |||||
| 2020-06-25 | 2020-06-25 | 4 | Said Maya R. | PIRS | Stock Option (right to buy) | D | 3,27 | 40.000 | 40.000 | |||||
| 2020-06-25 | 2020-06-23 | 4 | Barbier Ann | PIRS | Stock Options (Right to buy) | D | 3,27 | 40.000 | 40.000 | |||||
| 2020-06-25 | 2020-06-23 | 4 | GERAGHTY JAMES A | PIRS | Stock Option (right to buy) | D | 3,27 | 45.000 | 45.000 | |||||
| 2020-03-23 | 3 | Aquilo Capital Management, LLC See footnotes | PIRS | Common Stock, $0.001 par value | I | 11.151.060 | ||||||||
| 2020-03-23 | 3 | Aquilo Capital Management, LLC See footnotes | PIRS | Common Stock, $0.001 par value | I | 11.151.060 | ||||||||
| 2020-03-23 | 3 | Aquilo Capital Management, LLC See footnotes | PIRS | Common Stock, $0.001 par value | I | 11.151.060 | ||||||||
| 2020-03-02 | 2020-02-27 | 4 | Yoder Stephen S. | PIRS | Stock Option (Right to Buy) | D | 3,15 | 420.000 | 420.000 | |||||
| 2020-03-02 | 2020-02-27 | 4 | Kaufmann Hitto | PIRS | Stock Option (Right to Buy) | D | 3,15 | 45.000 | 45.000 | |||||
| 2020-03-02 | 2020-02-27 | 4 | Bures Thomas | PIRS | Stock Option (Right to Buy) | D | 3,15 | 80.000 | 80.000 | |||||
| 2020-01-28 | 2020-01-25 | 4 | GERAGHTY JAMES A | PIRS | Stock Option (right to buy) | D | 3,23 | 22.500 | 22.500 | |||||
| 2020-01-28 | 2020-01-25 | 4 | Richman Michael | PIRS | Stock Option (right to buy) | D | 3,23 | 20.000 | 20.000 | |||||
| 2020-01-28 | 2020-01-25 | 4 | Richman Michael | PIRS | Stock Option (right to buy) | D | 3,23 | 2,1070 | 5.431 | 11 | 5.431 | |||
| 2020-01-28 | 2020-01-25 | 4 | BIZZARI JEAN-PIERRE | PIRS | Stock Option (right to buy) | D | 3,23 | 20.000 | 20.000 | |||||
| 2020-01-28 | 2020-01-25 | 4 | KIRITSY CHRISTOPHER P | PIRS | Stock Option (right to buy) | D | 3,23 | 20.000 | 20.000 | |||||
| 2020-01-28 | 2020-01-25 | 4 | Barbier Ann | PIRS | Stock Option (right to buy) | D | 3,23 | 20.000 | 20.000 | |||||
| 2020-01-28 | 2020-01-25 | 4 | Kiener Peter A | PIRS | Stock Option (right to buy) | D | 3,23 | 20.000 | 20.000 | |||||
| 2020-01-28 | 2020-01-25 | 4 | Said Maya R. | PIRS | Stock Option (right to buy) | D | 3,23 | 20.000 | 20.000 | |||||
| 2020-01-28 | 2020-01-25 | 4 | Sherman Matthew L | PIRS | Stock Option (right to buy) | D | 3,23 | 20.000 | 20.000 | |||||
| 2019-10-28 | 2019-10-25 | 4 | Richman Michael | PIRS | Stock Options (right to buy) | D | 3,24 | 2,1180 | 5.165 | 11 | 5.165 | |||
| 2019-09-10 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 7.241.062 | ||||||||
| 2019-09-10 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 5.297.535 | ||||||||
| 2019-09-10 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 5.297.535 | ||||||||
| 2019-09-10 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 7.241.062 | ||||||||
| 2019-09-10 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 7.390.475 | ||||||||
| 2019-09-10 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 5.297.535 | ||||||||
| 2019-09-10 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 5.297.535 | ||||||||
| 2019-09-10 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 7.241.062 | ||||||||
| 2019-09-10 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 7.390.475 | ||||||||
| 2019-09-10 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 5.297.535 | ||||||||
| 2019-09-10 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 7.241.062 | ||||||||
| 2019-09-10 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 7.390.475 | ||||||||
| 2019-09-10 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 5.297.535 | ||||||||
| 2019-09-10 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 7.241.062 | ||||||||
| 2019-09-10 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 7.390.475 | ||||||||
| 2019-09-10 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 7.390.475 | ||||||||
| 2019-09-10 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 7.241.062 | ||||||||
| 2019-09-10 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 5.297.535 | ||||||||
| 2019-09-10 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 7.390.475 | ||||||||
| 2019-09-10 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 7.241.062 | ||||||||
| 2019-09-10 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 5.297.535 | ||||||||
| 2019-09-10 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 7.390.475 | ||||||||
| 2019-09-10 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 7.241.062 | ||||||||
| 2019-09-10 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 7.390.475 | ||||||||
| 2019-09-10 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 7.241.062 | ||||||||
| 2019-09-10 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 5.297.535 | ||||||||
| 2019-09-10 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 7.390.475 | ||||||||
| 2019-09-10 | 2019-09-06 | 4 | BVF PARTNERS L P/IL | PIRS | Common Stock, $0.001 par value | D | 4,4994 | -1.128 | -5 | 314.139 | ||||
| 2019-09-10 | 2019-09-06 | 4 | BVF PARTNERS L P/IL | PIRS | Common Stock, $0.001 par value | D | 4,4994 | -25.720 | -116 | 2.233.074 | ||||
| 2019-09-10 | 2019-09-06 | 4 | BVF PARTNERS L P/IL | PIRS | Common Stock, $0.001 par value | D | 4,4994 | -23.152 | -104 | 2.385.055 | ||||
| 2019-09-03 | 3 | Bures Thomas | PIRS | Common Stock | D | 10.218 | ||||||||
| 2019-09-03 | 3 | Bures Thomas | PIRS | Common Stock | D | 10.218 | ||||||||
| 2019-09-03 | 3 | Bures Thomas | PIRS | Common Stock | D | 10.218 | ||||||||
| 2019-09-03 | 2019-08-30 | 4 | Kaufmann Hitto | PIRS | Stock Option (right to buy) | D | 4,65 | 300.000 | 300.000 | |||||
| 2019-08-01 | 2019-07-31 | 4 | Said Maya R. | PIRS | Stock Option (right to buy) | D | 5,50 | 30.000 | 30.000 | |||||
| 2019-07-26 | 2019-07-25 | 4 | Richman Michael | PIRS | Stock Option (right to buy) | D | 4,40 | 2,8900 | 3.789 | 11 | 3.789 | |||
| 2019-04-30 | 2019-04-25 | 4 | Richman Michael | PIRS | Stock Option (right to buy) | D | 2,94 | 1,9400 | 5.640 | 11 | 5.640 | |||
| 2019-02-28 | 2019-02-26 | 4 | Yoder Stephen S. | PIRS | Stock Options (Right to Buy) | D | 3,09 | 380.000 | 380.000 | |||||
| 2019-02-28 | 2019-02-26 | 4 | Reine Allan | PIRS | Stock Options (Right to Buy) | D | 3,09 | 162.500 | 162.500 | |||||
| 2019-02-28 | 2019-02-26 | 4 | Matis Louis | PIRS | Stock Option (Right to Buy) | D | 3,09 | 96.500 | 96.500 | |||||
| 2019-02-01 | 2019-01-30 | 4 | BVF PARTNERS L P/IL | PIRS | Series B Convertible Preferred Stock, $0.001 par value | D | 284 | 284 | ||||||
| 2019-02-01 | 2019-01-30 | 4 | BVF PARTNERS L P/IL | PIRS | Series B Convertible Preferred Stock, $0.001 par value | D | 2.143 | 2.143 | ||||||
| 2019-02-01 | 2019-01-30 | 4 | BVF PARTNERS L P/IL | PIRS | Series B Convertible Preferred Stock, $0.001 par value | D | 2.573 | 2.573 | ||||||
| 2019-02-01 | 2019-01-30 | 4 | BVF PARTNERS L P/IL | PIRS | Common Stock, $0.001 par value | D | -284.000 | 141.346 | ||||||
| 2019-02-01 | 2019-01-30 | 4 | BVF PARTNERS L P/IL | PIRS | Common Stock, $0.001 par value | D | -2.143.000 | 772.324 | ||||||
| 2019-02-01 | 2019-01-30 | 4 | BVF PARTNERS L P/IL | PIRS | Common Stock, $0.001 par value | D | -2.573.000 | 978.200 | ||||||
| 2019-01-29 | 2019-01-25 | 4 | GERAGHTY JAMES A | PIRS | Stock Option (right to buy) | D | 2,74 | 25.000 | 25.000 | |||||
| 2019-01-29 | 2019-01-25 | 4 | Barbier Ann | PIRS | Stock Option (right to buy) | D | 2,74 | 20.000 | 20.000 | |||||
| 2019-01-29 | 2019-01-25 | 4 | BIZZARI JEAN-PIERRE | PIRS | Stock Option (right to buy) | D | 2,74 | 20.000 | 20.000 | |||||
| 2019-01-29 | 2019-01-25 | 4 | Kiener Peter A | PIRS | Stock Option (right to buy) | D | 2,74 | 20.000 | 20.000 | |||||
| 2019-01-29 | 2019-01-25 | 4 | KIRITSY CHRISTOPHER P | PIRS | Stock Option (right to buy) | D | 2,74 | 20.000 | 20.000 | |||||
| 2019-01-29 | 2019-01-25 | 4 | Prelack Steven | PIRS | Stock Option (right to buy) | D | 2,74 | 20.000 | 20.000 | |||||
| 2019-01-29 | 2019-01-25 | 4 | Richman Michael | PIRS | Stock Option (right to buy) | D | 2,74 | 20.000 | 20.000 | |||||
| 2019-01-29 | 2019-01-25 | 4 | Richman Michael | PIRS | Stock Option (right to buy) | D | 2,74 | 1,7900 | 6.096 | 11 | 6.096 | |||
| 2019-01-29 | 2019-01-25 | 4 | Sherman Matthew L | PIRS | Stock Option (right to buy) | D | 2,74 | 20.000 | 20.000 | |||||
| 2018-11-26 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 10.443.070 | ||||||||
| 2018-11-26 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 9.807.194 | ||||||||
| 2018-11-26 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 7.317.216 | ||||||||
| 2018-11-26 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 9.807.194 | ||||||||
| 2018-11-26 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 7.317.216 | ||||||||
| 2018-11-26 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 10.443.070 | ||||||||
| 2018-11-26 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 10.443.070 | ||||||||
| 2018-11-26 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 9.807.194 | ||||||||
| 2018-11-26 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 7.317.216 | ||||||||
| 2018-11-26 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 10.443.070 | ||||||||
| 2018-11-26 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 9.807.194 | ||||||||
| 2018-11-26 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 7.317.216 | ||||||||
| 2018-11-26 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 10.443.070 | ||||||||
| 2018-11-26 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 9.807.194 | ||||||||
| 2018-11-26 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 7.317.216 | ||||||||
| 2018-11-26 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 10.443.070 | ||||||||
| 2018-11-26 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 9.807.194 | ||||||||
| 2018-11-26 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 7.317.216 | ||||||||
| 2018-11-26 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 10.443.070 | ||||||||
| 2018-11-26 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 9.807.194 | ||||||||
| 2018-11-26 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 7.317.216 | ||||||||
| 2018-11-26 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 10.443.070 | ||||||||
| 2018-11-26 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 9.807.194 | ||||||||
| 2018-11-26 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 7.317.216 | ||||||||
| 2018-11-26 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 10.443.070 | ||||||||
| 2018-11-26 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 9.807.194 | ||||||||
| 2018-11-26 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 7.317.216 | ||||||||
| 2018-10-29 | 2018-10-25 | 4 | Richman Michael | PIRS | Stock Option (right to buy) | D | 4,36 | 2,8600 | 3.829 | 11 | 3.829 | |||
| 2018-10-25 | 2018-10-24 | 4 | Kiener Peter A | PIRS | Stock Option (right to buy) | D | 4,46 | 30.000 | 30.000 | |||||
| 2018-10-25 | 2018-10-24 | 4 | Sherman Matthew L | PIRS | Stock Option (right to buy) | D | 4,46 | 30.000 | 30.000 | |||||
| 2018-09-17 | 2018-09-14 | 4 | KIRITSY CHRISTOPHER P | PIRS | Common Stock | D | 5,1050 | 5.000 | 26 | 10.000 | ||||
| 2018-07-26 | 2018-07-25 | 4 | Richman Michael | PIRS | Stock Option (right to buy) | D | 5,92 | 3,8600 | 2.837 | 11 | 2.837 | |||
| 2018-05-16 | 2018-05-15 | 4 | GERAGHTY JAMES A | PIRS | Common Stock | D | 5,7500 | 10.000 | 58 | 20.000 | ||||
| 2018-05-02 | 2018-04-30 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Common Stock | I | 6,3500 | -10.400 | -66 | 38.870 | ||||
| 2018-05-02 | 2018-04-30 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Common Stock | I | 6,3500 | -989.600 | -6.284 | 4.511.130 | ||||
| 2018-04-26 | 2018-04-25 | 4 | Barbier Ann | PIRS | Stock Option (right to buy) | D | 6,43 | 30.000 | 30.000 | |||||
| 2018-04-26 | 2018-04-25 | 4 | Richman Michael | PIRS | Stock Option (right to buy) | D | 6,43 | 4,1000 | 2.665 | 11 | 2.665 | |||
| 2018-02-26 | 2018-02-20 | 4 | Yoder Stephen S. | PIRS | Stock Options (Right to buy) | D | 8,56 | 325.000 | 325.000 | |||||
| 2018-02-26 | 2018-02-20 | 4 | Reine Allan | PIRS | Stock Options (Right to buy) | D | 5,00 | 50.000 | 50.000 | |||||
| 2018-02-26 | 2018-02-20 | 4 | Reine Allan | PIRS | Stock Options (Right to buy) | D | 8,56 | 53.833 | 53.833 | |||||
| 2018-02-26 | 2018-02-20 | 4 | Matis Louis | PIRS | Stock Options (Right to buy) | D | 8,56 | 100.000 | 100.000 | |||||
| 2018-02-15 | 2018-02-13 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Stock Option (right to buy) | I | 5,08 | -17 | 0 | |||||
| 2018-02-15 | 2018-02-13 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Stock Option (right to buy) | I | 5,08 | -1.765 | 0 | |||||
| 2018-02-15 | 2018-02-13 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Stock Option (right to buy) | I | 4,68 | -58 | 0 | |||||
| 2018-02-15 | 2018-02-13 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Stock Option (right to buy) | I | 4,68 | -6.057 | 0 | |||||
| 2018-02-15 | 2018-02-13 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Common Stock | I | 8,9800 | -75 | -1 | 49.270 | ||||
| 2018-02-15 | 2018-02-13 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Common Stock | I | 8,9800 | -7.822 | -70 | 5.500.730 | ||||
| 2018-02-15 | 2018-02-13 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Common Stock | I | 5,0800 | 17 | 0 | 49.345 | ||||
| 2018-02-15 | 2018-02-13 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Common Stock | I | 5,0800 | 1.765 | 9 | 5.508.552 | ||||
| 2018-02-15 | 2018-02-13 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Common Stock | I | 4,6800 | 58 | 0 | 49.328 | ||||
| 2018-02-15 | 2018-02-13 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Common Stock | I | 4,6800 | 6.057 | 28 | 5.506.787 | ||||
| 2018-01-29 | 2018-01-25 | 4 | GERAGHTY JAMES A | PIRS | Stock Option (right to buy) | D | 7,72 | 25.000 | 25.000 | |||||
| 2018-01-29 | 2018-01-25 | 4 | Prelack Steven | PIRS | Stock Option (right to buy) | D | 7,72 | 20.000 | 20.000 | |||||
| 2018-01-29 | 2018-01-25 | 4 | Richman Michael | PIRS | Stock Option (right to buy) | D | 7,72 | 20.000 | 20.000 | |||||
| 2018-01-29 | 2018-01-25 | 4 | Richman Michael | PIRS | Stock Option (right to buy) | D | 7,72 | 5,0900 | 2.243 | 11 | 2.243 | |||
| 2018-01-29 | 2018-01-25 | 4 | BIZZARI JEAN-PIERRE | PIRS | Stock Option (right to buy) | D | 7,72 | 20.000 | 20.000 | |||||
| 2018-01-29 | 2018-01-25 | 4 | ADAMS JULIAN | PIRS | Stock Option (right to buy) | D | 7,72 | 20.000 | 20.000 | |||||
| 2018-01-29 | 2018-01-25 | 4 | KIRITSY CHRISTOPHER P | PIRS | Stock Option (right to buy) | D | 7,72 | 20.000 | 20.000 | |||||
| 2018-01-04 | 2018-01-03 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Common Stock | I | 7,3500 | -16.128 | -119 | 49.270 | ||||
| 2018-01-04 | 2018-01-03 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Common Stock | I | 7,3500 | -1.693.492 | -12.447 | 5.500.730 | ||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Stock Option (right to buy) | I | 5,64 | -47 | 0 | |||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Stock Option (right to buy) | I | 5,64 | -4.971 | 0 | |||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Stock Option (right to buy) | I | 2,32 | -99 | 0 | |||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Stock Option (right to buy) | I | 2,32 | -10.447 | 0 | |||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Stock Option (right to buy) | I | 1,62 | -97 | 0 | |||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Stock Option (right to buy) | I | 2,01 | -97 | 0 | |||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Stock Option (right to buy) | I | 2,01 | -10.216 | 0 | |||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Stock Option (right to buy) | I | 2,01 | -142 | 0 | |||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Stock Option (right to buy) | I | 2,01 | -14.858 | 0 | |||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Stock Option (right to buy) | I | 1,64 | -97 | 0 | |||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Stock Option (right to buy) | I | 1,64 | -10.182 | 0 | |||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Stock Option (right to buy) | I | 1,73 | -92 | 0 | |||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Stock Option (right to buy) | I | 1,73 | -9.642 | 0 | |||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Stock Option (right to buy) | I | 2,05 | -77 | 0 | |||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Stock Option (right to buy) | I | 2,05 | -8.097 | 0 | |||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Stock Option (right to buy) | I | 1,59 | -189 | 0 | |||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Stock Option (right to buy) | I | 1,59 | -19.811 | 0 | |||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Stock Option (right to buy) | I | 1,62 | -10.180 | 0 | |||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Stock Option (right to buy) | I | 1,94 | -83 | 0 | |||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Stock Option (right to buy) | I | 1,94 | -8.717 | 0 | |||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Stock Option (right to buy) | I | 2,62 | -63 | 0 | |||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Stock Option (right to buy) | I | 2,62 | -6.654 | 0 | |||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Stock Option (right to buy) | I | 3,00 | -50 | 0 | |||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Stock Option (right to buy) | I | 3,00 | -5.227 | 0 | |||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Stock Option (right to buy) | I | 2,00 | -259 | 0 | |||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Stock Option (right to buy) | I | 2,00 | -27.241 | 0 | |||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Common Stock | I | 5,7000 | -1.392 | -8 | 65.398 | ||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Common Stock | I | 5,7000 | -146.243 | -834 | 7.194.222 | ||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Common Stock | I | 5,6400 | 47 | 0 | 66.790 | ||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Common Stock | I | 5,6400 | 4.971 | 28 | 7.340.465 | ||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Common Stock | I | 2,3200 | 99 | 0 | 66.743 | ||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Common Stock | I | 2,3200 | 10.447 | 24 | 7.335.494 | ||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Common Stock | I | 2,0100 | 97 | 0 | 66.644 | ||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Common Stock | I | 2,0100 | 10.216 | 21 | 7.325.047 | ||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Common Stock | I | 2,0100 | 142 | 0 | 66.547 | ||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Common Stock | I | 2,0100 | 14.858 | 30 | 7.314.831 | ||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Common Stock | I | 1,6400 | 97 | 0 | 66.405 | ||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Common Stock | I | 1,6400 | 10.182 | 17 | 7.299.973 | ||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Common Stock | I | 1,7300 | 92 | 0 | 66.308 | ||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Common Stock | I | 1,7300 | 9.642 | 17 | 7.289.791 | ||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Common Stock | I | 2,0500 | 77 | 0 | 66.216 | ||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Common Stock | I | 2,0500 | 8.097 | 17 | 7.280.149 | ||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Common Stock | I | 1,5900 | 189 | 0 | 66.139 | ||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Common Stock | I | 1,5900 | 19.811 | 31 | 7.272.052 | ||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Common Stock | I | 1,6200 | 97 | 0 | 65.950 | ||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Common Stock | I | 1,6200 | 10.180 | 16 | 7.252.241 | ||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Common Stock | I | 1,9400 | 83 | 0 | 65.853 | ||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Common Stock | I | 1,9400 | 8.717 | 17 | 7.242.061 | ||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Common Stock | I | 2,6200 | 63 | 0 | 65.770 | ||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Common Stock | I | 2,6200 | 6.654 | 17 | 7.233.344 | ||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Common Stock | I | 3,0000 | 50 | 0 | 65.707 | ||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Common Stock | I | 3,0000 | 5.227 | 16 | 7.226.690 | ||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Common Stock | I | 2,0000 | 259 | 1 | 65.657 | ||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Common Stock | I | 2,0000 | 27.241 | 54 | 7.221.463 | ||||
| 2017-12-14 | 2017-12-12 | 4 | GERAGHTY JAMES A | PIRS | Stock Option (right to buy) | D | 5,79 | 40.000 | 40.000 | |||||
| 2017-10-27 | 2017-10-25 | 4 | Khuong Chau Quang | PIRS | Stock Options (Right to buy) | D | 4,68 | 6.115 | 6.115 | |||||
| 2017-10-27 | 2017-10-25 | 4 | Richman Michael | PIRS | Stock Option (Rights to buy) | D | 4,68 | 4.006 | 4.006 | |||||
| 2017-08-17 | 2017-08-17 | 4 | Reine Allan | PIRS | Common Stock | D | 4,8900 | 20.000 | 98 | 65.000 | ||||
| 2017-08-17 | 2017-08-16 | 4 | Reine Allan | PIRS | Common Stock | D | 4,7900 | 45.000 | 216 | 45.000 | ||||
| 2017-08-17 | 2017-08-17 | 4 | GERAGHTY JAMES A | PIRS | Common Stock | D | 4,8200 | 10.000 | 48 | 10.000 | ||||
| 2017-08-11 | 2017-08-09 | 4 | Reine Allan | PIRS | Common Stock | D | 5,00 | 450.000 | 450.000 | |||||
| 2017-07-27 | 2017-07-25 | 4 | Richman Michael | PIRS | Stock Option (right to buy) | D | 5,64 | 3.288 | 3.288 | |||||
| 2017-07-27 | 2017-07-25 | 4 | Khuong Chau Quang | PIRS | Stock Option (right to buy) | D | 5,64 | 5.018 | 5.018 | |||||
| 2017-05-24 | 2017-05-22 | 4 | GERAGHTY JAMES A | PIRS | Stock Option (right to buy) | D | 3,94 | 30.000 | 30.000 | |||||
| 2017-05-09 | 2017-04-21 | 4 | KIRITSY CHRISTOPHER P | PIRS | Stock Option (right to buy) | D | 1,59 | -5.000 | 25.000 | |||||
| 2017-05-09 | 2017-04-21 | 4 | KIRITSY CHRISTOPHER P | PIRS | Common Stock | D | 1,5900 | 5.000 | 8 | 5.000 | ||||
| 2017-04-27 | 2017-04-25 | 4 | Richman Michael | PIRS | Stock Option (right to buy) | D | 2,32 | 7.821 | 7.821 | |||||
| 2017-04-27 | 2017-04-25 | 4 | Khuong Chau Quang | PIRS | Stock Option (right to buy) | D | 2,32 | 10.546 | 10.546 | |||||
| 2017-03-06 | 2017-02-23 | 4 | Matis Louis | PIRS | Stock option (Right to buy) | D | 1,99 | 145.000 | 145.000 | |||||
| 2017-03-06 | 2017-02-23 | 4 | Yoder Stephen S. | PIRS | Stock Option (Right to buy) | D | 1,99 | 434.350 | 434.350 | |||||
| 2017-01-30 | 2017-01-25 | 4 | Prelack Steven | PIRS | Stock Option (right to buy) | D | 2,01 | 20.000 | 20.000 | |||||
| 2017-01-30 | 2017-01-25 | 4 | Richman Michael | PIRS | Stock Option (right to buy) | D | 2,01 | 20.000 | 20.000 | |||||
| 2017-01-30 | 2017-01-25 | 4 | Richman Michael | PIRS | Stock Option (right to buy) | D | 2,01 | 9.687 | 9.687 | |||||
| 2017-01-30 | 2017-01-25 | 4 | ADAMS JULIAN | PIRS | Stock Option (right to buy) | D | 2,01 | 20.000 | 20.000 | |||||
| 2017-01-30 | 2017-01-25 | 4 | KIRITSY CHRISTOPHER P | PIRS | Stock Option (right to buy) | D | 2,01 | 20.000 | 20.000 | |||||
| 2017-01-30 | 2017-01-25 | 4 | Khuong Chau Quang | PIRS | Stock Option (right to buy) | D | 2,01 | 20.000 | 20.000 | |||||
| 2017-01-30 | 2017-01-25 | 4 | Khuong Chau Quang | PIRS | Stock Option (right to buy) | D | 2,01 | 10.313 | 10.313 | |||||
| 2017-01-30 | 2017-01-25 | 4 | BIZZARI JEAN-PIERRE | PIRS | Stock Option (right to buy) | D | 2,01 | 20.000 | 20.000 | |||||
| 2016-11-30 | 2016-11-28 | 4 | Knopf Claude | PIRS | Common Stock | D | 1,45 | 500.000 | 500.000 | |||||
| 2016-10-27 | 2016-10-25 | 4 | Richman Michael | PIRS | Stock Option (right to buy) | D | 1,64 | 9.656 | 9.656 | |||||
| 2016-10-27 | 2016-10-25 | 4 | Khuong Chau Quang | PIRS | Stock Option (right to buy) | D | 1,64 | 10.279 | 10.279 | |||||
| 2016-09-22 | 2016-09-20 | 4 | KIRITSY CHRISTOPHER P | PIRS | Stock Option (right to buy) | D | 1,59 | 30.000 | 30.000 | |||||
| 2016-08-01 | 2016-07-25 | 4 | Richman Michael | PIRS | Stock Option (right to buy) | D | 1,73 | 9.144 | 9.144 | |||||
| 2016-08-01 | 2016-07-25 | 4 | Khuong Chau Quang | PIRS | Stock Option (right to buy) | D | 1,73 | 9.734 | 9.734 | |||||
| 2016-07-26 | 2016-07-25 | 4 | ADAMS JULIAN | PIRS | Stock Option (right to buy) | D | 1,73 | 30.000 | 30.000 | |||||
| 2016-06-15 | 2016-06-13 | 4 | DEPTULA-HICKS DARLENE M | PIRS | Common Stock | D | 1,6600 | 5.000 | 8 | 5.000 | ||||
| 2016-06-15 | 2016-06-13 | 4 | Yoder Stephen S. | PIRS | Common Stock | D | 1,6800 | 6.000 | 10 | 6.000 | ||||
| 2016-06-15 | 2016-06-14 | 4 | Matis Louis | PIRS | Common Stock | D | 1,7100 | 7.915 | 14 | 10.000 | ||||
| 2016-06-15 | 2016-06-13 | 4 | Matis Louis | PIRS | Common Stock | D | 1,6800 | 2.085 | 4 | 2.085 | ||||
| 2016-04-29 | 2016-04-27 | 4 | Richman Michael | PIRS | Stock Option (right to buy) | D | 2,05 | 7.679 | 7.679 | |||||
| 2016-04-29 | 2016-04-27 | 4 | Khuong Chau Quang | PIRS | Stock Option (right to buy) | D | 2,05 | 8.174 | 8.174 | |||||
| 2016-02-18 | 2016-02-16 | 4 | Richman Michael | PIRS | Stock Option (right to buy) | D | 1,59 | 20.000 | 20.000 | |||||
| 2016-02-18 | 2016-02-16 | 4 | Prelack Steven | PIRS | Stock Option (right to buy) | D | 1,59 | 20.000 | 20.000 | |||||
| 2016-02-18 | 2016-02-16 | 4 | Khuong Chau Quang | PIRS | Stock Option (right to buy) | D | 1,59 | 20.000 | 20.000 | |||||
| 2016-02-18 | 2016-02-16 | 4 | BIZZARI JEAN-PIERRE | PIRS | Stock Option (right to buy) | D | 1,59 | 20.000 | 20.000 | |||||
| 2016-02-17 | 2016-02-12 | 4 | Yoder Stephen S. | PIRS | Stock Option (right to buy) | D | 1,52 | 492.000 | 492.000 | |||||
| 2016-01-20 | 2016-01-15 | 4 | Khuong Chau Quang | PIRS | Stock Option (right to buy) | D | 1,62 | 10.277 | 10.277 | |||||
| 2016-01-20 | 2016-01-15 | 4 | Richman Michael | PIRS | Stock Option (right to buy) | D | 1,62 | 9.654 | 9.654 | |||||
| 2015-10-30 | 2015-10-15 | 4 | Khuong Chau Quang | PIRS | Stock Option (right to buy) | D | 1,94 | 8.800 | 8.800 | |||||
| 2015-10-30 | 2015-10-15 | 4 | Richman Michael | PIRS | Stock Option (right to buy) | D | 1,94 | 8.267 | 8.267 | |||||
| 2015-09-03 | 2015-09-01 | 4 | DEPTULA-HICKS DARLENE M | PIRS | Common Stock | D | 2,80 | 450.000 | 450.000 | |||||
| 2015-08-18 | 2015-08-17 | 4 | Matis Louis | PIRS | Common Stock | D | 3,36 | 500.000 | 500.000 | |||||
| 2015-07-17 | 2015-07-15 | 4 | Khuong Chau Quang | PIRS | Stock Option (right to buy) | D | 2,55 | 6.717 | 6.717 | |||||
| 2015-07-17 | 2015-07-15 | 4 | Richman Michael | PIRS | Stock Option (right to buy) | D | 2,55 | 6.310 | 6.310 | |||||
| 2015-07-08 | 2015-07-06 | 4 | Khuong Chau Quang See Footnotes | PIRS | Common Stock | I | 2,7500 | 4.717 | 13 | 65.398 | ||||
| 2015-07-08 | 2015-07-06 | 4 | Khuong Chau Quang See Footnotes | PIRS | Common Stock | I | 2,7500 | 495.283 | 1.362 | 7.194.222 | ||||
| 2015-07-08 | 2015-07-06 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Common Stock | I | 2,7500 | 4.717 | 13 | 65.398 | ||||
| 2015-07-08 | 2015-07-06 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Common Stock | I | 2,7500 | 495.283 | 1.362 | 7.194.222 | ||||
| 2015-06-29 | 3 | Khuong Chau Quang See Footnotes | PIRS | Common Stock | I | 13.458.559 | ||||||||
| 2015-06-29 | 3 | Khuong Chau Quang See Footnotes | PIRS | Common Stock | I | 6.820.301 | ||||||||
| 2015-06-29 | 3 | Khuong Chau Quang See Footnotes | PIRS | Common Stock | I | 13.458.559 | ||||||||
| 2015-06-29 | 3 | Khuong Chau Quang See Footnotes | PIRS | Common Stock | I | 6.820.301 | ||||||||
| 2015-06-29 | 3 | ISALY SAMUEL D See Footnotes | PIRS | Common Stock | I | 13.458.559 | ||||||||
| 2015-06-29 | 3 | ISALY SAMUEL D See Footnotes | PIRS | Common Stock | I | 13.458.559 | ||||||||
| 2015-06-29 | 3 | ISALY SAMUEL D See Footnotes | PIRS | Common Stock | I | 13.458.559 | ||||||||
| 2015-06-29 | 3 | ISALY SAMUEL D See Footnotes | PIRS | Common Stock | I | 6.820.301 | ||||||||
| 2015-06-29 | 3 | ISALY SAMUEL D See Footnotes | PIRS | Common Stock | I | 6.820.301 | ||||||||
| 2015-06-29 | 3 | ISALY SAMUEL D See Footnotes | PIRS | Common Stock | I | 13.458.559 | ||||||||
| 2015-06-29 | 3 | ISALY SAMUEL D See Footnotes | PIRS | Common Stock | I | 6.820.301 | ||||||||
| 2015-06-29 | 3 | ISALY SAMUEL D See Footnotes | PIRS | Common Stock | I | 6.820.301 |
