| Insideraktier | 14.972.175 shares |
Insider-stemningsscore
Insider Sentiment Score viser, at virksomhederne bliver købt af virksomheders insidere.
Det er resultatet af en sofistikeret, multi-faktor kvantitativ model, der identificerer virksomheder med de højeste niveauer af insider-akkumulering. Scoringsmodellen bruger en kombination af nettoantallet af insidere, der har købt de foregående 90 dage, det samlede antal aktier købt som en procentdel af float og det samlede antal aktier ejet af insidere. Tallet går fra 0 til 100, hvor højere tal indikerer et højere niveau af akkumulering for sine jævnaldrende, og 50 er gennemsnittet.
Opdateringsfrekvens: Dagligt
Se Insiders Top Picks, som giver en liste over virksomheder med den højeste insider-akkumulering.
Officers sentiment score
Officer Sentiment Score finder virksomheder, der bliver købt af Corporate Officers.
Per definition er Corporate Officers Corporate Insiders, men i modsætning til nogle af de andre Insiders (10 % aktionærer og bestyrelsesmedlemmer), arbejder officerer for virksomheden på daglig basis, og de bruger deres egne penge, når de handler . (10 % aktionærer og bestyrelsesmedlemmer er ofte fondsforvaltere, der administrerer andres penge.) Som sådan er insiderhandler foretaget af embedsmænd meget mere betydningsfulde og bør behandles passende.
Ligesom Insider Sentiment Score er Officer Sentiment Score resultatet af en sofistikeret, multi-faktor kvantitativ model, der identificerer virksomheder med de højeste niveauer af officerakkumulering.
Opdateringsfrekvens: Dagligt
Se Insiders Top Picks, som giver en liste over virksomheder med højeste insider-stemning.
Nøgle Insider Metrics
Dette kort viser, hvordan virksomheden rangerer langs forskellige insider-metrics. Percentilrangen viser, hvordan denne virksomhed sammenligner sig med andre virksomheder på de amerikanske markeder. Højere placeringer er tegn på bedre situationer.
For eksempel er det generelt accepteret, at insider-køb er en positiv indikator, så virksomheder med flere insider-køb vil rangere højere end virksomheder med mindre insider-køb (eller endda insider-salg).
Netto antal insidere, der køber (rang)
Netto antal insidere, der køber, er det samlede antal insiders, der køber minus det samlede antal insiders, der har solgt inden for de sidste 90 dage. Percentilrangen vises her (spænder fra 0 til 100%).
Procent af float købt af insidere (rangering)
Procent af float købt af insidere er det samlede antal aktier købt af insidere minus det samlede antal aktier solgt af insidere inden for de sidste 90 dage, divideret med den samlede float og ganget med 100.
Insiderhandelsdiagram
Dicerna Pharmaceuticals Inc insiderhandler er vist i følgende diagram. Insidere er embedsmænd, direktører eller betydelige investorer i en virksomhed. Generelt er det generelt ulovligt for insidere at foretage handler i deres virksomheder baseret på væsentlige, ikke-offentlige oplysninger. Dette betyder ikke, at det er ulovligt for dem at handle i deres egne virksomheder. De skal dog rapportere alle handler til SEC via en formular 4.
Insiderliste og lønsomhedsmålinger
Denne tabel viser listen over kendte insidere og genereres automatisk fra arkiveringer, der er videregivet til SEC. Ud over navnene, den seneste titel og direktør, officer eller 10 % ejerbetegnelse giver vi de seneste offentliggjorte besiddelser. Derudover giver vi, når det er muligt, den historiske handelspræstation for insideren. Den historiske handelspræstation er et vægtet gennemsnit af præstationen af faktiske købstransaktioner på det åbne marked foretaget af insideren. For mere information om, hvordan dette beregnes, se dette YouTube-webinar.
See our leaderboard of most profitable insider traders.
| Insider | Gennemsnitlig fortjeneste (%) | Aktier Ejet |
Dele Justeret |
|---|
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Track Records af insiderkøb - Kortsigtet profitanalyse
I dette afsnit analyserer vi rentabiliteten af ethvert uplanlagt insiderkøb i åbent marked foretaget i DRNA / Dicerna Pharmaceuticals Inc. Denne analyse hjælper med at forstå, om insideren konsekvent genererer unormale afkast og er værd at følge. Denne analyse er for et år efter hver handel, og resultaterne er teoretiske .
Følgende tabel viser de seneste køb på det åbne marked, der ikke var en del af en automatisk handelsplan.
Justeret pris er den split-justerede pris. Adjusted Shares er de split-justerede aktier.
Track Records af insidersalg - Kortsigtet tabsanalyse
I dette afsnit analyserer vi den kortsigtede undgåelse af tab af ethvert uplanlagt insidersalg på åbent marked, der foretages i DRNA / Dicerna Pharmaceuticals Inc. Et konsekvent mønster af tabsforebyggelse kan tyde på, at fremtidige salgstransaktioner kan forudsige prisfald. Denne analyse er for et år efter hver handel, og resultaterne er teoretiske .
Følgende tabel viser de seneste salg på det åbne marked, der ikke var en del af en automatisk handelsplan.
Justeret pris er den split-justerede pris. Adjusted Shares er de split-justerede aktier.
Transaktionshistorik
Klik på linkikonet for at se den fulde transaktionshistorik. Transaktioner, der rapporteres som en del af en automatisk handelsplan 10b5-1, vil have et X i kolonnen markeret 10b-5.
| Fil Dato |
Handle Dato |
Form | Insider | Ticker | Sikkerhedstitel | Kode | Direkte | Dyrke motion Pris |
Enhed Pris |
Enheder Ændret |
Værdi Ændret (1K) |
Tilbage Muligheder |
Tilbage Aktier |
|
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2021-12-29 | 2021-12-28 | 4 | Koppel Adam | DRNA | Director Stock Option (Right to Buy) | D | 30,47 | -15.000 | 0 | |||||
| 2021-12-29 | 2021-12-28 | 4 | Koppel Adam | DRNA | Director Stock Option (Right to Buy) | D | 21,61 | -15.000 | 0 | |||||
| 2021-12-29 | 2021-12-28 | 4 | Koppel Adam | DRNA | Director Stock Option (Right to Buy) | D | 15,44 | -25.000 | 0 | |||||
| 2021-12-29 | 2021-12-28 | 4 | Koppel Adam | DRNA | Director Stock Option (Right to Buy) | D | 3,42 | -25.000 | 0 | |||||
| 2021-12-29 | 2021-12-28 | 4 | Koppel Adam | DRNA | Director Stock Option (Right to Buy) | D | 13,08 | -25.000 | 0 | |||||
| 2021-12-29 | 2021-12-28 | 4 | Koppel Adam | DRNA | Director Stock Option (Right to Buy) | D | 3,47 | -25.000 | 0 | |||||
| 2021-12-29 | 2021-12-28 | 4 | Koppel Adam | DRNA | Restricted Stock Units | D | -3.333 | 0 | ||||||
| 2021-12-29 | 2021-12-28 | 4 | Koppel Adam See footnotes | DRNA | Common Stock | I | 38,2500 | -3.080.237 | -117.819 | 0 | ||||
| 2021-12-29 | 2021-12-28 | 4 | Koppel Adam | DRNA | Common Stock | D | 38,2500 | -3.333 | -127 | 0 | ||||
| 2021-12-29 | 2021-12-28 | 4 | Weissman James B | DRNA | Employee Stock Option (Right to Buy) | D | 24,05 | -68.100 | 0 | |||||
| 2021-12-29 | 2021-12-28 | 4 | Weissman James B | DRNA | Employee Stock Option (Right to Buy) | D | 22,58 | -121.300 | 0 | |||||
| 2021-12-29 | 2021-12-28 | 4 | Weissman James B | DRNA | Employee Stock Option (Right to Buy) | D | 18,50 | -75.000 | 0 | |||||
| 2021-12-29 | 2021-12-28 | 4 | Weissman James B | DRNA | Employee Stock Option (Right to Buy) | D | 16,30 | -111.800 | 0 | |||||
| 2021-12-29 | 2021-12-28 | 4 | Weissman James B | DRNA | Employee Stock Option (Right to Buy) | D | 11,77 | -180.000 | 0 | |||||
| 2021-12-29 | 2021-12-28 | 4 | Weissman James B | DRNA | Employee Stock Option (Right to Buy) | D | 9,30 | -105.000 | 0 | |||||
| 2021-12-29 | 2021-12-28 | 4 | Weissman James B | DRNA | Employee Stock Option (Right to Buy) | D | 9,09 | -33.999 | 0 | |||||
| 2021-12-29 | 2021-12-28 | 4 | Weissman James B | DRNA | Employee Stock Option (Right to Buy) | D | 2,97 | -11.879 | 0 | |||||
| 2021-12-29 | 2021-12-28 | 4 | Weissman James B | DRNA | Restricted Stock Units | D | -11.325 | 0 | ||||||
| 2021-12-29 | 2021-12-28 | 4 | Weissman James B | DRNA | Restricted Stock Units | D | -25.950 | 0 | ||||||
| 2021-12-29 | 2021-12-28 | 4 | Weissman James B | DRNA | Common Stock | D | 38,2500 | -18.100 | -692 | 0 | ||||
| 2021-12-29 | 2021-12-28 | 4 | Zeng Ling | DRNA | Employee Stock Option (Right to Buy) | D | 24,05 | -46.120 | 0 | |||||
| 2021-12-29 | 2021-12-28 | 4 | Zeng Ling | DRNA | Employee Stock Option (Right to Buy) | D | 18,69 | -81.825 | 0 | |||||
| 2021-12-29 | 2021-12-28 | 4 | Zeng Ling | DRNA | Restricted Stock Units | D | -13.669 | 0 | ||||||
| 2021-12-29 | 2021-12-28 | 4 | Zeng Ling | DRNA | Restricted Stock Units | D | -7.688 | 0 | ||||||
| 2021-12-29 | 2021-12-28 | 4 | Zeng Ling | DRNA | Common Stock | D | 38,2500 | -5.032 | -192 | 0 | ||||
| 2021-12-29 | 2021-12-28 | 4 | HOFFMAN STEPHEN J | DRNA | Director Stock Option (Right to Buy) | D | 30,47 | -15.000 | 0 | |||||
| 2021-12-29 | 2021-12-28 | 4 | HOFFMAN STEPHEN J | DRNA | Director Stock Option (Right to Buy) | D | 3,26 | -15.000 | 0 | |||||
| 2021-12-29 | 2021-12-28 | 4 | HOFFMAN STEPHEN J | DRNA | Director Stock Option (Right to Buy) | D | 21,61 | -15.000 | 0 | |||||
| 2021-12-29 | 2021-12-28 | 4 | HOFFMAN STEPHEN J | DRNA | Director Stock Option (Right to Buy) | D | 18,73 | -15.000 | 0 | |||||
| 2021-12-29 | 2021-12-28 | 4 | HOFFMAN STEPHEN J | DRNA | Director Stock Option (Right to Buy) | D | 3,42 | -25.000 | 0 | |||||
| 2021-12-29 | 2021-12-28 | 4 | HOFFMAN STEPHEN J | DRNA | Director Stock Option (Right to Buy) | D | 16,30 | -25.000 | 0 | |||||
| 2021-12-29 | 2021-12-28 | 4 | HOFFMAN STEPHEN J | DRNA | Director Stock Option (Right to Buy) | D | 15,44 | -25.000 | 0 | |||||
| 2021-12-29 | 2021-12-28 | 4 | HOFFMAN STEPHEN J | DRNA | Director Stock Option (Right to Buy) | D | 13,87 | -15.000 | 0 | |||||
| 2021-12-29 | 2021-12-28 | 4 | HOFFMAN STEPHEN J | DRNA | Director Stock Option (Right to Buy) | D | 13,08 | -25.000 | 0 | |||||
| 2021-12-29 | 2021-12-28 | 4 | HOFFMAN STEPHEN J | DRNA | Restricted Stock Units | D | -3.333 | 0 | ||||||
| 2021-12-29 | 2021-12-28 | 4 | HOFFMAN STEPHEN J | DRNA | Common Stock | D | 38,2500 | -16.157 | -618 | 0 | ||||
| 2021-12-29 | 2021-12-28 | 4 | KOZIN MARC D | DRNA | Director Stock Option (Right to Buy) | D | 30,47 | -15.000 | 0 | |||||
| 2021-12-29 | 2021-12-28 | 4 | KOZIN MARC D | DRNA | Director Stock Option (Right to Buy) | D | 21,61 | -15.000 | 0 | |||||
| 2021-12-29 | 2021-12-28 | 4 | KOZIN MARC D | DRNA | Director Stock Option (Right to Buy) | D | 10,31 | -25.000 | 0 | |||||
| 2021-12-29 | 2021-12-28 | 4 | KOZIN MARC D | DRNA | Director Stock Option (Right to Buy) | D | 15,44 | -25.000 | 0 | |||||
| 2021-12-29 | 2021-12-28 | 4 | KOZIN MARC D | DRNA | Restricted Stock Units | D | -3.333 | 0 | ||||||
| 2021-12-29 | 2021-12-28 | 4 | KOZIN MARC D By Marc D. Kozin Revocable Trust | DRNA | Common Stock | I | 38,2500 | -5.000 | -191 | 0 | ||||
| 2021-12-29 | 2021-12-28 | 4 | KOZIN MARC D | DRNA | Common Stock | D | 38,2500 | -6.333 | -242 | 0 | ||||
| 2021-12-29 | 2021-12-28 | 4 | Pagan Douglas W. | DRNA | Employee Stock Option (Right to Buy) | D | 24,05 | -36.900 | 0 | |||||
| 2021-12-29 | 2021-12-28 | 4 | Pagan Douglas W. | DRNA | Employee Stock Option (Right to Buy) | D | 20,79 | -95.650 | 0 | |||||
| 2021-12-29 | 2021-12-28 | 4 | Pagan Douglas W. | DRNA | Restricted Stock Units | D | -6.150 | 0 | ||||||
| 2021-12-29 | 2021-12-28 | 4 | Pagan Douglas W. | DRNA | Restricted Stock Units | D | -20.475 | 0 | ||||||
| 2021-12-29 | 2021-12-28 | 4 | Pagan Douglas W. | DRNA | Common Stock | D | 38,2500 | -7.775 | -297 | 0 | ||||
| 2021-12-29 | 2021-12-28 | 4 | GRAY PATRICK M. | DRNA | Director Stock Option (Right to Buy) | D | 21,61 | -15.000 | 0 | |||||
| 2021-12-29 | 2021-12-28 | 4 | GRAY PATRICK M. | DRNA | Director Stock Option (Right to Buy) | D | 30,47 | -15.000 | 0 | |||||
| 2021-12-29 | 2021-12-28 | 4 | GRAY PATRICK M. | DRNA | Director Stock Option (Right to Buy) | D | 14,32 | -25.000 | 0 | |||||
| 2021-12-29 | 2021-12-28 | 4 | GRAY PATRICK M. | DRNA | Restricted Stock Units | D | -3.333 | 0 | ||||||
| 2021-12-29 | 2021-12-28 | 4 | GRAY PATRICK M. | DRNA | Common Stock | D | 38,2500 | -3.333 | -127 | 0 | ||||
| 2021-12-29 | 2021-12-28 | 4 | Smith Cynthia | DRNA | Director Stock Option (Right to Buy) | D | 30,47 | -15.000 | 0 | |||||
| 2021-12-29 | 2021-12-28 | 4 | Smith Cynthia | DRNA | Director Stock Option (Right to Buy) | D | 21,61 | -15.000 | 0 | |||||
| 2021-12-29 | 2021-12-28 | 4 | Smith Cynthia | DRNA | Director Stock Option (Right to Buy) | D | 15,44 | -25.000 | 0 | |||||
| 2021-12-29 | 2021-12-28 | 4 | Smith Cynthia | DRNA | Director Stock Option (Right to Buy) | D | 14,76 | -25.000 | 0 | |||||
| 2021-12-29 | 2021-12-28 | 4 | Smith Cynthia | DRNA | Restricted Stock Units | D | -3.333 | 0 | ||||||
| 2021-12-29 | 2021-12-28 | 4 | Smith Cynthia | DRNA | Common Stock | D | 38,2500 | -3.333 | -127 | 0 | ||||
| 2021-12-29 | 2021-12-28 | 4 | Freed Martin I | DRNA | Director Stock Option (Right to Buy) | D | 21,61 | -15.000 | 0 | |||||
| 2021-12-29 | 2021-12-28 | 4 | Freed Martin I | DRNA | Director Stock Option (Right to Buy) | D | 30,47 | -15.000 | 0 | |||||
| 2021-12-29 | 2021-12-28 | 4 | Freed Martin I | DRNA | Director Stock Option (Right to Buy) | D | 3,26 | -25.000 | 0 | |||||
| 2021-12-29 | 2021-12-28 | 4 | Freed Martin I | DRNA | Director Stock Option (Right to Buy) | D | 15,44 | -25.000 | 0 | |||||
| 2021-12-29 | 2021-12-28 | 4 | Freed Martin I | DRNA | Director Stock Option (Right to Buy) | D | 13,08 | -25.000 | 0 | |||||
| 2021-12-29 | 2021-12-28 | 4 | Freed Martin I | DRNA | Director Stock Option (Right to Buy) | D | 3,42 | -25.000 | 0 | |||||
| 2021-12-29 | 2021-12-28 | 4 | Freed Martin I | DRNA | Restricted Stock Units | D | -3.333 | 0 | ||||||
| 2021-12-29 | 2021-12-28 | 4 | Freed Martin I | DRNA | Common Stock | D | 38,2500 | -3.333 | -127 | 0 | ||||
| 2021-12-29 | 2021-12-28 | 4 | Doberstein Stephen K | DRNA | Director Stock Option (Right to Buy) | D | 21,61 | -15.000 | 0 | |||||
| 2021-12-29 | 2021-12-28 | 4 | Doberstein Stephen K | DRNA | Director Stock Option (Right to Buy) | D | 30,47 | -15.000 | 0 | |||||
| 2021-12-29 | 2021-12-28 | 4 | Doberstein Stephen K | DRNA | Director Stock Option (Right to Buy) | D | 15,61 | -25.000 | 0 | |||||
| 2021-12-29 | 2021-12-28 | 4 | Doberstein Stephen K | DRNA | Restricted Stock Units | D | -3.333 | 0 | ||||||
| 2021-12-29 | 2021-12-28 | 4 | Doberstein Stephen K | DRNA | Common Stock | D | 38,2500 | -3.333 | -127 | 0 | ||||
| 2021-12-29 | 2021-12-28 | 4 | FAMBROUGH DOUGLAS | DRNA | Employee Stock Option (Right to Buy) | D | 24,05 | -247.700 | 0 | |||||
| 2021-12-29 | 2021-12-28 | 4 | FAMBROUGH DOUGLAS | DRNA | Employee Stock Option (Right to Buy) | D | 22,58 | -250.000 | 0 | |||||
| 2021-12-29 | 2021-12-28 | 4 | FAMBROUGH DOUGLAS | DRNA | Employee Stock Option (Right to Buy) | D | 18,50 | -225.000 | 0 | |||||
| 2021-12-29 | 2021-12-28 | 4 | FAMBROUGH DOUGLAS | DRNA | Employee Stock Option (Right to Buy) | D | 9,09 | -225.000 | 0 | |||||
| 2021-12-29 | 2021-12-28 | 4 | FAMBROUGH DOUGLAS By Trust | DRNA | Employee Stock Option (Right to Buy) | I | 16,30 | -200.000 | 0 | |||||
| 2021-12-29 | 2021-12-28 | 4 | FAMBROUGH DOUGLAS By Trust | DRNA | Employee Stock Option (Right to Buy) | I | 16,30 | -200.000 | 0 | |||||
| 2021-12-29 | 2021-12-28 | 4 | FAMBROUGH DOUGLAS | DRNA | Employee Stock Option (Right to Buy) | D | 16,30 | -71.900 | 0 | |||||
| 2021-12-29 | 2021-12-28 | 4 | FAMBROUGH DOUGLAS | DRNA | Employee Stock Option (Right to Buy) | D | 11,77 | -505.000 | 0 | |||||
| 2021-12-29 | 2021-12-28 | 4 | FAMBROUGH DOUGLAS | DRNA | Employee Stock Option (Right to Buy) | D | 9,30 | -255.000 | 0 | |||||
| 2021-12-29 | 2021-12-28 | 4 | FAMBROUGH DOUGLAS | DRNA | Employee Stock Option (Right to Buy) | D | 3,42 | -55.055 | 0 | |||||
| 2021-12-29 | 2021-12-28 | 4 | FAMBROUGH DOUGLAS | DRNA | Employee Stock Option (Right to Buy) | D | 3,42 | -281.250 | 0 | |||||
| 2021-12-29 | 2021-12-28 | 4 | FAMBROUGH DOUGLAS | DRNA | Employee Stock Option (Right to Buy) | D | 2,97 | -191.330 | 0 | |||||
| 2021-12-29 | 2021-12-28 | 4 | FAMBROUGH DOUGLAS | DRNA | Restricted Stock Units | D | -41.250 | 0 | ||||||
| 2021-12-29 | 2021-12-28 | 4 | FAMBROUGH DOUGLAS | DRNA | Restricted Stock Units | D | -59.850 | 0 | ||||||
| 2021-12-29 | 2021-12-28 | 4 | FAMBROUGH DOUGLAS | DRNA | Common Stock | D | 38,2500 | -231.431 | -8.852 | 0 | ||||
| 2021-12-29 | 2021-12-28 | 4 | Aradhye Shreeram | DRNA | Employee Stock Option (Right to Buy) | D | 24,05 | -51.070 | 0 | |||||
| 2021-12-29 | 2021-12-28 | 4 | Aradhye Shreeram | DRNA | Employee Stock Option (Right to Buy) | D | 18,69 | -124.700 | 0 | |||||
| 2021-12-29 | 2021-12-28 | 4 | Aradhye Shreeram | DRNA | Restricted Stock Units | D | -8.513 | 0 | ||||||
| 2021-12-29 | 2021-12-28 | 4 | Aradhye Shreeram | DRNA | Restricted Stock Units | D | -21.075 | 0 | ||||||
| 2021-12-29 | 2021-12-28 | 4 | Aradhye Shreeram | DRNA | Common Stock | D | 38,2500 | -6.973 | -267 | 0 | ||||
| 2021-12-29 | 2021-12-28 | 4 | Brown Bob D | DRNA | Employee Stock Option (Right to Buy) | D | 24,05 | -68.100 | 0 | |||||
| 2021-12-29 | 2021-12-28 | 4 | Brown Bob D | DRNA | Employee Stock Option (Right to Buy) | D | 22,58 | -121.300 | 0 | |||||
| 2021-12-29 | 2021-12-28 | 4 | Brown Bob D | DRNA | Employee Stock Option (Right to Buy) | D | 18,50 | -75.000 | 0 | |||||
| 2021-12-29 | 2021-12-28 | 4 | Brown Bob D | DRNA | Employee Stock Option (Right to Buy) | D | 16,30 | -165.050 | 0 | |||||
| 2021-12-29 | 2021-12-28 | 4 | Brown Bob D | DRNA | Employee Stock Option (Right to Buy) | D | 11,77 | -180.000 | 0 | |||||
| 2021-12-29 | 2021-12-28 | 4 | Brown Bob D | DRNA | Employee Stock Option (Right to Buy) | D | 9,30 | -105.000 | 0 | |||||
| 2021-12-29 | 2021-12-28 | 4 | Brown Bob D | DRNA | Employee Stock Option (Right to Buy) | D | 9,09 | -85.000 | 0 | |||||
| 2021-12-29 | 2021-12-28 | 4 | Brown Bob D | DRNA | Restricted Stock Units | D | -11.325 | 0 | ||||||
| 2021-12-29 | 2021-12-28 | 4 | Brown Bob D | DRNA | Restricted Stock Units | D | -25.950 | 0 | ||||||
| 2021-12-29 | 2021-12-28 | 4 | Brown Bob D | DRNA | Common Stock | D | 38,2500 | -2.367 | -91 | 0 | ||||
| 2021-12-29 | 2021-12-28 | 4 | Ciappenelli Robert D. | DRNA | Employee Stock Option (Right to Buy) | D | 24,05 | -61.500 | 0 | |||||
| 2021-12-29 | 2021-12-28 | 4 | Ciappenelli Robert D. | DRNA | Employee Stock Option (Right to Buy) | D | 22,58 | -76.144 | 0 | |||||
| 2021-12-29 | 2021-12-28 | 4 | Ciappenelli Robert D. | DRNA | Employee Stock Option (Right to Buy) | D | 15,61 | -270.000 | 0 | |||||
| 2021-12-29 | 2021-12-28 | 4 | Ciappenelli Robert D. | DRNA | Restricted Stock Units | D | -17.325 | 0 | ||||||
| 2021-12-29 | 2021-12-28 | 4 | Ciappenelli Robert D. | DRNA | Restricted Stock Units | D | -10.275 | 0 | ||||||
| 2021-12-29 | 2021-12-28 | 4 | Ciappenelli Robert D. | DRNA | Common Stock | D | 38,2500 | -14.813 | -567 | 0 | ||||
| 2021-12-29 | 2021-12-28 | 4 | BUCHI J KEVIN | DRNA | Director Stock Option (Right to Buy) | D | 30,47 | -15.000 | 0 | |||||
| 2021-12-29 | 2021-12-28 | 4 | BUCHI J KEVIN | DRNA | Director Stock Option (Right to Buy) | D | 21,61 | -21.000 | 0 | |||||
| 2021-12-29 | 2021-12-28 | 4 | BUCHI J KEVIN | DRNA | Director Stock Option (Right to Buy) | D | 15,44 | -33.000 | 0 | |||||
| 2021-12-29 | 2021-12-28 | 4 | BUCHI J KEVIN | DRNA | Director Stock Option (Right to Buy) | D | 14,76 | -25.000 | 0 | |||||
| 2021-12-29 | 2021-12-28 | 4 | BUCHI J KEVIN | DRNA | Director Stock Option (Right to Buy) | D | 14,13 | -8.000 | 0 | |||||
| 2021-12-29 | 2021-12-28 | 4 | BUCHI J KEVIN | DRNA | Restricted Stock Units | D | -3.333 | 0 | ||||||
| 2021-12-29 | 2021-12-28 | 4 | BUCHI J KEVIN | DRNA | Common Stock | D | 38,2500 | -4.666 | -178 | 0 | ||||
| 2021-12-17 | 2021-12-15 | 4 | Aradhye Shreeram | DRNA | Restricted Stock Units | D | -2.837 | 8.513 | ||||||
| 2021-12-17 | 2021-12-15 | 4 | Aradhye Shreeram | DRNA | Common Stock | D | 38,0500 | -833 | -32 | 6.973 | ||||
| 2021-12-17 | 2021-12-15 | 4 | Aradhye Shreeram | DRNA | Common Stock | D | 2.837 | 7.806 | ||||||
| 2021-12-17 | 2021-12-15 | 4 | Ciappenelli Robert D. | DRNA | Restricted Stock Units | D | -3.425 | 10.275 | ||||||
| 2021-12-17 | 2021-12-15 | 4 | Ciappenelli Robert D. | DRNA | Common Stock | D | 38,0500 | -1.241 | -47 | 14.813 | ||||
| 2021-12-17 | 2021-12-15 | 4 | Ciappenelli Robert D. | DRNA | Common Stock | D | 3.425 | 16.054 | ||||||
| 2021-12-17 | 2021-12-15 | 4 | Pagan Douglas W. | DRNA | Restricted Stock Units | D | -2.050 | 6.150 | ||||||
| 2021-12-17 | 2021-12-15 | 4 | Pagan Douglas W. | DRNA | Common Stock | D | 38,0500 | -602 | -23 | 7.775 | ||||
| 2021-12-17 | 2021-12-15 | 4 | Pagan Douglas W. | DRNA | Common Stock | D | 2.050 | 8.377 | ||||||
| 2021-12-17 | 2021-12-15 | 4 | Zeng Ling | DRNA | Restricted Stock Units | D | -2.562 | 7.688 | ||||||
| 2021-12-17 | 2021-12-15 | 4 | Zeng Ling | DRNA | Common Stock | D | 38,0500 | -752 | -29 | 5.032 | ||||
| 2021-12-17 | 2021-12-15 | 4 | Zeng Ling | DRNA | Common Stock | D | 2.562 | 5.784 | ||||||
| 2021-12-17 | 2021-12-15 | 4 | Brown Bob D | DRNA | Restricted Stock Units | D | -3.775 | 11.325 | ||||||
| 2021-12-17 | 2021-12-15 | 4 | Brown Bob D | DRNA | Common Stock | D | 38,0500 | -1.675 | -64 | 2.367 | ||||
| 2021-12-17 | 2021-12-15 | 4 | Brown Bob D | DRNA | Common Stock | D | 3.775 | 4.042 | ||||||
| 2021-12-17 | 2021-12-15 | 4 | FAMBROUGH DOUGLAS | DRNA | Restricted Stock Units | D | -13.750 | 41.250 | ||||||
| 2021-12-17 | 2021-12-15 | 4 | FAMBROUGH DOUGLAS | DRNA | Common Stock | D | 38,0500 | -5.348 | -203 | 231.431 | ||||
| 2021-12-17 | 2021-12-15 | 4 | FAMBROUGH DOUGLAS | DRNA | Common Stock | D | 13.750 | 236.779 | ||||||
| 2021-12-17 | 2021-12-15 | 4 | Weissman James B | DRNA | Restricted Stock Units | D | -3.775 | 11.325 | ||||||
| 2021-12-17 | 2021-12-15 | 4 | Weissman James B | DRNA | Common Stock | D | 38,0500 | -1.675 | -64 | 18.100 | ||||
| 2021-12-17 | 2021-12-15 | 4 | Weissman James B | DRNA | Common Stock | D | 3.775 | 19.775 | ||||||
| 2021-12-14 | 2021-12-13 | 4 | Ciappenelli Robert D. | DRNA | Employee Stock Option (Right to Buy) | D | 22,58 | -8.856 | 76.144 | |||||
| 2021-12-14 | 2021-12-13 | 4 | Ciappenelli Robert D. | DRNA | Common Stock | D | 22,5800 | 8.856 | 200 | 12.629 | ||||
| 2021-12-13 | 2021-12-10 | 4 | FAMBROUGH DOUGLAS | DRNA | Employee Stock Option (Right to Buy) | D | 3,42 | -146.195 | 55.055 | |||||
| 2021-12-13 | 2021-12-10 | 4 | FAMBROUGH DOUGLAS | DRNA | Employee Stock Option (Right to Buy) | D | 2,97 | -33.670 | 191.330 | |||||
| 2021-12-13 | 2021-12-10 | 4 | FAMBROUGH DOUGLAS | DRNA | Common Stock | D | 3,4200 | 146.195 | 500 | 223.029 | ||||
| 2021-12-13 | 2021-12-10 | 4 | FAMBROUGH DOUGLAS | DRNA | Common Stock | D | 2,9700 | 33.670 | 100 | 76.834 | ||||
| 2021-11-22 | 2021-11-18 | 4 | Brown Bob D | DRNA | Employee Stock Option (Right to Buy) | D | 3,42 | -24.936 | 0 | |||||
| 2021-11-22 | 2021-11-18 | 4 | Brown Bob D | DRNA | Common Stock | D | 37,9400 | -24.936 | -946 | 267 | ||||
| 2021-11-22 | 2021-11-18 | 4 | Brown Bob D | DRNA | Common Stock | D | 3,4200 | 24.936 | 85 | 25.203 | ||||
| 2021-09-21 | 2021-09-17 | 4 | Brown Bob D | DRNA | Common Stock | D | 21,0596 | -21.250 | -448 | 267 | ||||
| 2021-09-17 | 2021-09-17 | 4 | Zeng Ling | DRNA | Common Stock | D | 21,4700 | -1.334 | -29 | 3.222 | ||||
| 2021-09-17 | 2021-09-15 | 4 | Zeng Ling | DRNA | Restricted Stock Units | D | -4.556 | 13.669 | ||||||
| 2021-09-17 | 2021-09-15 | 4 | Zeng Ling | DRNA | Common Stock | D | 4.556 | 4.556 | ||||||
| 2021-09-17 | 2021-09-17 | 4 | Aradhye Shreeram | DRNA | Common Stock | D | 21,4700 | -2.056 | -44 | 4.969 | ||||
| 2021-09-17 | 2021-09-15 | 4 | Aradhye Shreeram | DRNA | Restricted Stock Units | D | -7.025 | 21.075 | ||||||
| 2021-09-17 | 2021-09-15 | 4 | Aradhye Shreeram | DRNA | Common Stock | D | 7.025 | 7.025 | ||||||
| 2021-08-10 | 2021-08-10 | 4 | FAMBROUGH DOUGLAS | DRNA | Common Stock | D | 22,0960 | 5.000 | 110 | 43.164 | ||||
| 2021-08-10 | 2021-08-10 | 4 | KOZIN MARC D | DRNA | Common Stock | D | 23,6620 | 3.000 | 71 | 6.333 | ||||
| 2021-08-03 | 2021-08-02 | 4 | Brown Bob D | DRNA | Employee Stock Option (Right to Buy) | D | 3,42 | -8.312 | 24.936 | |||||
| 2021-08-03 | 2021-08-02 | 4 | Brown Bob D | DRNA | Common Stock | D | 37,3770 | -8.312 | -311 | 21.517 | ||||
| 2021-08-03 | 2021-08-02 | 4 | Brown Bob D | DRNA | Common Stock | D | 3,4200 | 8.312 | 28 | 29.829 | ||||
| 2021-07-08 | 2021-07-06 | 4 | Paglia Regina M. | DRNA | Restricted Stock Units | D | -1.712 | 11.988 | ||||||
| 2021-07-08 | 2021-07-06 | 4 | Paglia Regina M. | DRNA | Restricted Stock Units | D | -1.450 | 7.250 | ||||||
| 2021-07-08 | 2021-07-06 | 4 | Paglia Regina M. | DRNA | Common Stock | D | 37,0500 | -1.404 | -52 | 2.027 | ||||
| 2021-07-08 | 2021-07-06 | 4 | Paglia Regina M. | DRNA | Common Stock | D | 1.712 | 3.431 | ||||||
| 2021-07-08 | 2021-07-06 | 4 | Paglia Regina M. | DRNA | Common Stock | D | 1.450 | 1.719 | ||||||
| 2021-07-08 | 2021-07-06 | 4 | Weissman James B | DRNA | Employee Stock Option (Right to Buy) | D | 9,09 | -30.000 | 33.999 | |||||
| 2021-07-08 | 2021-07-06 | 4 | Weissman James B | DRNA | Common Stock | D | 39,0900 | -30.000 | -1.173 | 16.000 | ||||
| 2021-07-08 | 2021-07-06 | 4 | Weissman James B | DRNA | Common Stock | D | 9,0900 | 30.000 | 273 | 46.000 | ||||
| 2021-07-06 | 2021-07-01 | 4 | Brown Bob D | DRNA | Employee Stock Option (Right to Buy) | D | 3,42 | -8.312 | 33.248 | |||||
| 2021-07-06 | 2021-07-01 | 4 | Brown Bob D | DRNA | Common Stock | D | 37,8466 | -1.066 | -40 | 21.517 | ||||
| 2021-07-06 | 2021-07-01 | 4 | Brown Bob D | DRNA | Common Stock | D | 37,3029 | -7.246 | -270 | 22.583 | ||||
| 2021-07-06 | 2021-07-01 | 4 | Brown Bob D | DRNA | Common Stock | D | 3,4200 | 8.312 | 28 | 29.829 | ||||
| 2021-06-29 | 2021-06-25 | 4 | Paglia Regina M. | DRNA | Employee Stock Option (Right to Buy) | D | 22,58 | -1.000 | 49.221 | |||||
| 2021-06-29 | 2021-06-25 | 4 | Paglia Regina M. | DRNA | Common Stock | D | 38,0037 | -1.000 | -38 | 269 | ||||
| 2021-06-29 | 2021-06-25 | 4 | Paglia Regina M. | DRNA | Common Stock | D | 22,5800 | 1.000 | 23 | 1.269 | ||||
| 2021-06-24 | 2021-06-22 | 4 | Paglia Regina M. | DRNA | Employee Stock Option (Right to Buy) | D | 24,05 | -2.406 | 55.094 | |||||
| 2021-06-24 | 2021-06-22 | 4 | Paglia Regina M. | DRNA | Employee Stock Option (Right to Buy) | D | 22,58 | -2.279 | 50.221 | |||||
| 2021-06-24 | 2021-06-22 | 4 | Paglia Regina M. | DRNA | Employee Stock Option (Right to Buy) | D | 12,93 | -13.750 | 85.000 | |||||
| 2021-06-24 | 2021-06-22 | 4 | Paglia Regina M. | DRNA | Common Stock | D | 36,7108 | -4.880 | -179 | 269 | ||||
| 2021-06-24 | 2021-06-22 | 4 | Paglia Regina M. | DRNA | Common Stock | D | 37,0957 | -13.555 | -503 | 5.149 | ||||
| 2021-06-24 | 2021-06-22 | 4 | Paglia Regina M. | DRNA | Common Stock | D | 24,0500 | 2.406 | 58 | 18.704 | ||||
| 2021-06-24 | 2021-06-22 | 4 | Paglia Regina M. | DRNA | Common Stock | D | 22,5800 | 2.279 | 51 | 16.298 | ||||
| 2021-06-24 | 2021-06-22 | 4 | Paglia Regina M. | DRNA | Common Stock | D | 12,9300 | 13.750 | 178 | 14.019 | ||||
| 2021-06-22 | 2021-06-17 | 4 | Paglia Regina M. | DRNA | Employee Stock Option (Right to Buy) | D | 24,05 | -4.000 | 57.500 | |||||
| 2021-06-22 | 2021-06-17 | 4 | Paglia Regina M. | DRNA | Employee Stock Option (Right to Buy) | D | 12,93 | -4.664 | 98.750 | |||||
| 2021-06-22 | 2021-06-17 | 4 | Paglia Regina M. | DRNA | Common Stock | D | 35,7881 | -8.664 | -310 | 269 | ||||
| 2021-06-22 | 2021-06-17 | 4 | Paglia Regina M. | DRNA | Common Stock | D | 24,0500 | 4.000 | 96 | 8.933 | ||||
| 2021-06-22 | 2021-06-17 | 4 | Paglia Regina M. | DRNA | Common Stock | D | 12,9300 | 4.664 | 60 | 4.933 | ||||
| 2021-06-17 | 2021-06-15 | 4 | Pagan Douglas W. | DRNA | Restricted Stock Units | D | -6.825 | 20.475 | ||||||
| 2021-06-17 | 2021-06-15 | 4 | Pagan Douglas W. | DRNA | Common Stock | D | 35,7400 | -2.004 | -72 | 5.760 | ||||
| 2021-06-17 | 2021-06-15 | 4 | Pagan Douglas W. | DRNA | Common Stock | D | 6.825 | 7.764 | ||||||
| 2021-06-17 | 2021-06-16 | 4 | Paglia Regina M. | DRNA | Employee Stock Option (Right to Buy) | D | 26,62 | -1.564 | 5.261 | |||||
| 2021-06-17 | 2021-06-16 | 4 | Paglia Regina M. | DRNA | Employee Stock Option (Right to Buy) | D | 22,58 | -10.000 | 52.500 | |||||
| 2021-06-17 | 2021-06-16 | 4 | Paglia Regina M. | DRNA | Employee Stock Option (Right to Buy) | D | 12,93 | -20.000 | 103.414 | |||||
| 2021-06-17 | 2021-06-16 | 4 | Paglia Regina M. | DRNA | Common Stock | D | 36,1500 | -100 | -4 | 269 | ||||
| 2021-06-17 | 2021-06-16 | 4 | Paglia Regina M. | DRNA | Common Stock | D | 35,6284 | -31.464 | -1.121 | 369 | ||||
| 2021-06-17 | 2021-06-16 | 4 | Paglia Regina M. | DRNA | Common Stock | D | 26,6200 | 1.564 | 42 | 31.833 | ||||
| 2021-06-17 | 2021-06-16 | 4 | Paglia Regina M. | DRNA | Common Stock | D | 22,5800 | 10.000 | 226 | 30.269 | ||||
| 2021-06-17 | 2021-06-16 | 4 | Paglia Regina M. | DRNA | Common Stock | D | 12,9300 | 20.000 | 259 | 20.269 | ||||
| 2021-06-17 | 2021-06-15 | 4 | Paglia Regina M. | DRNA | Restricted Stock Units | D | -381 | 1.144 | ||||||
| 2021-06-17 | 2021-06-15 | 4 | Paglia Regina M. | DRNA | Common Stock | D | 35,7400 | -112 | -4 | 269 | ||||
| 2021-06-17 | 2021-06-15 | 4 | Paglia Regina M. | DRNA | Common Stock | D | 381 | 381 | ||||||
| 2021-06-15 | 2021-06-14 | 4 | Ciappenelli Robert D. | DRNA | Employee Stock Option (Right to Buy) | D | 15,61 | -20.000 | 270.000 | |||||
| 2021-06-15 | 2021-06-14 | 4 | Ciappenelli Robert D. | DRNA | Common Stock | D | 38,0000 | -20.000 | -760 | 3.773 | ||||
| 2021-06-15 | 2021-06-14 | 4 | Ciappenelli Robert D. | DRNA | Common Stock | D | 15,6100 | 20.000 | 312 | 23.773 | ||||
| 2021-06-15 | 2021-06-11 | 4 | Ciappenelli Robert D. | DRNA | Employee Stock Option (Right to Buy) | D | 15,61 | -10.000 | 290.000 | |||||
| 2021-06-15 | 2021-06-11 | 4 | Ciappenelli Robert D. | DRNA | Common Stock | D | 35,0000 | -10.000 | -350 | 3.773 | ||||
| 2021-06-15 | 2021-06-11 | 4 | Ciappenelli Robert D. | DRNA | Common Stock | D | 15,6100 | 10.000 | 156 | 13.773 | ||||
| 2021-06-15 | 2021-06-11 | 4 | Brown Bob D | DRNA | Employee Stock Option (Right to Buy) | D | 9,09 | -10.000 | 85.000 | |||||
| 2021-06-15 | 2021-06-11 | 4 | Brown Bob D | DRNA | Common Stock | D | 34,0000 | -10.000 | -340 | 21.517 | ||||
| 2021-06-15 | 2021-06-11 | 4 | Brown Bob D | DRNA | Common Stock | D | 9,0900 | 10.000 | 91 | 31.517 | ||||
| 2021-06-08 | 2021-06-07 | 4 | Brown Bob D | DRNA | Employee Stock Option (Right to Buy) | D | 9,09 | -10.000 | 95.000 | |||||
| 2021-06-08 | 2021-06-07 | 4 | Brown Bob D | DRNA | Common Stock | D | 33,0000 | -10.000 | -330 | 21.517 | ||||
| 2021-06-08 | 2021-06-07 | 4 | Brown Bob D | DRNA | Common Stock | D | 9,0900 | 10.000 | 91 | 31.517 | ||||
| 2021-06-07 | 2021-06-03 | 4 | HOFFMAN STEPHEN J | DRNA | Director Stock Option (Right to Buy) | D | 30,47 | 15.000 | 15.000 | |||||
| 2021-06-07 | 2021-06-03 | 4 | HOFFMAN STEPHEN J | DRNA | Restricted Stock Units | D | 3.333 | 3.333 | ||||||
| 2021-06-07 | 2021-06-03 | 4 | HOFFMAN STEPHEN J | DRNA | Restricted Stock Units | D | -3.333 | 0 | ||||||
| 2021-06-07 | 2021-06-03 | 4 | HOFFMAN STEPHEN J | DRNA | Common Stock | D | 3.333 | 29.071 | ||||||
| 2021-06-07 | 2021-06-03 | 4 | Freed Martin I | DRNA | Director Stock Option (Right to Buy) | D | 30,47 | 15.000 | 15.000 | |||||
| 2021-06-07 | 2021-06-03 | 4 | Freed Martin I | DRNA | Restricted Stock Units | D | 3.333 | 3.333 | ||||||
| 2021-06-07 | 2021-06-03 | 4 | Freed Martin I | DRNA | Restricted Stock Units | D | -3.333 | 0 | ||||||
| 2021-06-07 | 2021-06-03 | 4 | Freed Martin I | DRNA | Common Stock | D | 3.333 | 3.333 | ||||||
| 2021-06-07 | 2021-06-03 | 4 | Smith Cynthia | DRNA | Director Stock Option (Right to Buy) | D | 30,47 | 15.000 | 15.000 | |||||
| 2021-06-07 | 2021-06-03 | 4 | Smith Cynthia | DRNA | Restricted Stock Units | D | 3.333 | 3.333 | ||||||
| 2021-06-07 | 2021-06-03 | 4 | Smith Cynthia | DRNA | Restricted Stock Units | D | -3.333 | 0 | ||||||
| 2021-06-07 | 2021-06-03 | 4 | Smith Cynthia | DRNA | Common Stock | D | 3.333 | 3.333 | ||||||
| 2021-06-07 | 2021-06-03 | 4 | KOZIN MARC D | DRNA | Director Stock Option (Right to Buy) | D | 30,47 | 15.000 | 15.000 | |||||
| 2021-06-07 | 2021-06-03 | 4 | KOZIN MARC D | DRNA | Restricted Stock Units | D | 3.333 | 3.333 | ||||||
| 2021-06-07 | 2021-06-03 | 4 | KOZIN MARC D | DRNA | Restricted Stock Units | D | -3.333 | 0 | ||||||
| 2021-06-07 | 2021-06-03 | 4 | KOZIN MARC D | DRNA | Common Stock | D | 3.333 | 3.333 | ||||||
| 2021-06-07 | 2021-06-03 | 4 | GRAY PATRICK M. | DRNA | Director Stock Option (Right to Buy) | D | 30,47 | 15.000 | 15.000 | |||||
| 2021-06-07 | 2021-06-03 | 4 | GRAY PATRICK M. | DRNA | Restricted Stock Units | D | 3.333 | 3.333 | ||||||
| 2021-06-07 | 2021-06-03 | 4 | GRAY PATRICK M. | DRNA | Restricted Stock Units | D | -3.333 | 0 | ||||||
| 2021-06-07 | 2021-06-03 | 4 | GRAY PATRICK M. | DRNA | Common Stock | D | 3.333 | 3.333 | ||||||
| 2021-06-07 | 2021-06-03 | 4 | Protopapas Anna | DRNA | Restricted Stock Units | D | -3.333 | 0 | ||||||
| 2021-06-07 | 2021-06-03 | 4 | Protopapas Anna | DRNA | Common Stock | D | 3.333 | 3.333 | ||||||
| 2021-06-07 | 2021-06-03 | 4 | BUCHI J KEVIN | DRNA | Director Stock Option (Right to Buy) | D | 30,47 | 15.000 | 15.000 | |||||
| 2021-06-07 | 2021-06-03 | 4 | BUCHI J KEVIN | DRNA | Restricted Stock Units | D | 3.333 | 3.333 | ||||||
| 2021-06-07 | 2021-06-03 | 4 | BUCHI J KEVIN | DRNA | Restricted Stock Units | D | -4.666 | 0 | ||||||
| 2021-06-07 | 2021-06-03 | 4 | BUCHI J KEVIN | DRNA | Common Stock | D | 4.666 | 4.666 | ||||||
| 2021-06-07 | 2021-06-03 | 4 | Doberstein Stephen K | DRNA | Director Stock Option (Right to Buy) | D | 30,47 | 15.000 | 15.000 | |||||
| 2021-06-07 | 2021-06-03 | 4 | Doberstein Stephen K | DRNA | Restricted Stock Units | D | 3.333 | 3.333 | ||||||
| 2021-06-07 | 2021-06-03 | 4 | Doberstein Stephen K | DRNA | Restricted Stock Units | D | -3.333 | 0 | ||||||
| 2021-06-07 | 2021-06-03 | 4 | Doberstein Stephen K | DRNA | Common Stock | D | 3.333 | 3.333 | ||||||
| 2021-06-07 | 2021-06-03 | 4 | Koppel Adam | DRNA | Director Stock Option (Right to Buy) | D | 30,47 | 15.000 | 15.000 | |||||
| 2021-06-07 | 2021-06-03 | 4 | Koppel Adam | DRNA | Restricted Stock Units | D | 3.333 | 3.333 | ||||||
| 2021-06-07 | 2021-06-03 | 4 | Koppel Adam | DRNA | Restricted Stock Units | D | -3.333 | 0 | ||||||
| 2021-06-07 | 2021-06-03 | 4 | Koppel Adam | DRNA | Common Stock | D | 3.333 | 3.333 | ||||||
| 2021-06-03 | 2021-06-01 | 4 | Paglia Regina M. | DRNA | Employee Stock Option (Right to Buy) | D | 12,93 | -4.431 | 123.414 | |||||
| 2021-06-03 | 2021-06-01 | 4 | Paglia Regina M. | DRNA | Common Stock | D | 31,9687 | -305 | -10 | 0 | ||||
| 2021-06-03 | 2021-06-01 | 4 | Paglia Regina M. | DRNA | Common Stock | D | 30,8599 | -4.126 | -127 | 305 | ||||
| 2021-06-03 | 2021-06-01 | 4 | Paglia Regina M. | DRNA | Common Stock | D | 12,9300 | 4.431 | 57 | 4.431 | ||||
| 2021-06-03 | 2021-06-01 | 4 | Brown Bob D | DRNA | Employee Stock Option (Right to Buy) | D | 3,42 | -8.312 | 41.560 | |||||
| 2021-06-03 | 2021-06-01 | 4 | Brown Bob D | DRNA | Common Stock | D | 32,0165 | -342 | -11 | 21.517 | ||||
| 2021-06-03 | 2021-06-01 | 4 | Brown Bob D | DRNA | Common Stock | D | 30,8818 | -7.970 | -246 | 21.859 | ||||
| 2021-06-03 | 2021-06-01 | 4 | Brown Bob D | DRNA | Common Stock | D | 3,4200 | 8.312 | 28 | 29.829 | ||||
| 2021-05-05 | 2021-05-03 | 4 | Paglia Regina M. | DRNA | Employee Stock Option (Right to Buy) | D | 12,93 | -4.431 | 127.845 | |||||
| 2021-05-05 | 2021-05-03 | 4 | Paglia Regina M. | DRNA | Common Stock | D | 31,2485 | -475 | -15 | 0 | ||||
| 2021-05-05 | 2021-05-03 | 4 | Paglia Regina M. | DRNA | Common Stock | D | 30,1692 | -3.956 | -119 | 475 | ||||
| 2021-05-05 | 2021-05-03 | 4 | Paglia Regina M. | DRNA | Common Stock | D | 12,9300 | 4.431 | 57 | 4.431 | ||||
| 2021-05-05 | 2021-05-03 | 4 | Brown Bob D | DRNA | Employee Stock Option (Right to Buy) | D | 3,42 | -8.312 | 49.872 | |||||
| 2021-05-05 | 2021-05-03 | 4 | Brown Bob D | DRNA | Common Stock | D | 31,6600 | -24 | -1 | 21.517 | ||||
| 2021-05-05 | 2021-05-03 | 4 | Brown Bob D | DRNA | Common Stock | D | 31,0103 | -1.135 | -35 | 21.541 | ||||
| 2021-05-05 | 2021-05-03 | 4 | Brown Bob D | DRNA | Common Stock | D | 30,1574 | -7.153 | -216 | 22.676 | ||||
| 2021-05-05 | 2021-05-03 | 4 | Brown Bob D | DRNA | Common Stock | D | 3,4200 | 8.312 | 28 | 29.829 | ||||
| 2021-05-03 | 2021-04-30 | 4 | Brown Bob D | DRNA | Employee Stock Option (Right to Buy) | D | 9,09 | -10.000 | 105.000 | |||||
| 2021-05-03 | 2021-04-30 | 4 | Brown Bob D | DRNA | Common Stock | D | 32,0000 | -10.000 | -320 | 21.517 | ||||
| 2021-05-03 | 2021-04-30 | 4 | Brown Bob D | DRNA | Common Stock | D | 9,0900 | 10.000 | 91 | 31.517 | ||||
| 2021-05-03 | 2021-04-29 | 4 | Brown Bob D | DRNA | Employee Stock Option (Right to Buy) | D | 9,09 | -10.000 | 115.000 | |||||
| 2021-05-03 | 2021-04-29 | 4 | Brown Bob D | DRNA | Common Stock | D | 31,0000 | -10.000 | -310 | 21.517 | ||||
| 2021-05-03 | 2021-04-29 | 4 | Brown Bob D | DRNA | Common Stock | D | 9,0900 | 10.000 | 91 | 31.517 | ||||
| 2021-04-20 | 2021-04-16 | 4 | Weissman James B | DRNA | Common Stock | D | 29,9900 | -4.904 | -147 | 16.000 | ||||
| 2021-04-05 | 2021-04-01 | 4 | Brown Bob D | DRNA | Employee Stock Option (Right to Buy) | D | 3,42 | -8.312 | 58.184 | |||||
| 2021-04-05 | 2021-04-01 | 4 | Brown Bob D | DRNA | Common Stock | D | 26,4950 | -188 | -5 | 21.517 | ||||
| 2021-04-05 | 2021-04-01 | 4 | Brown Bob D | DRNA | Common Stock | D | 25,8548 | -8.124 | -210 | 21.705 | ||||
| 2021-04-05 | 2021-04-01 | 4 | Brown Bob D | DRNA | Common Stock | D | 3,4200 | 8.312 | 28 | 29.829 | ||||
| 2021-04-05 | 2021-03-01 | 4/A | Brown Bob D | DRNA | Employee Stock Option (Right to Buy) | D | 3,42 | -8.312 | 66.496 | |||||
| 2021-04-05 | 2021-03-01 | 4/A | Brown Bob D | DRNA | Common Stock | D | 3,4200 | 8.312 | 28 | 29.829 | ||||
| 2021-04-05 | 2021-02-03 | 4/A | Brown Bob D | DRNA | Employee Stock Option (Right to Buy) | D | 2,97 | -5.246 | 0 | |||||
| 2021-04-05 | 2021-02-03 | 4/A | Brown Bob D | DRNA | Employee Stock Option (Right to Buy) | D | 3,42 | -3.066 | 74.808 | |||||
| 2021-04-05 | 2021-02-03 | 4/A | Brown Bob D | DRNA | Common Stock | D | 2,9700 | 5.246 | 16 | 29.829 | ||||
| 2021-04-05 | 2021-02-03 | 4/A | Brown Bob D | DRNA | Common Stock | D | 3,4200 | 3.066 | 10 | 24.583 | ||||
| 2021-04-05 | 2021-01-25 | 4/A | Brown Bob D | DRNA | Employee Stock Option (Right to Buy) | D | 2,97 | -16.630 | 5.246 | |||||
| 2021-04-05 | 2021-01-25 | 4/A | Brown Bob D | DRNA | Common Stock | D | 2,9700 | 16.630 | 49 | 43.147 | ||||
| 2021-04-05 | 2021-04-01 | 4 | Paglia Regina M. | DRNA | Employee Stock Option (Right to Buy) | D | 12,93 | -4.431 | 132.276 | |||||
| 2021-04-05 | 2021-04-01 | 4 | Paglia Regina M. | DRNA | Common Stock | D | 25,8551 | -4.431 | -115 | 0 | ||||
| 2021-04-05 | 2021-04-01 | 4 | Paglia Regina M. | DRNA | Common Stock | D | 12,9300 | 4.431 | 57 | 4.431 | ||||
| 2021-03-02 | 2021-03-01 | 4 | Brown Bob D | DRNA | Employee Stock Option (Right to Buy) | D | 9,09 | -8.312 | 91.746 | |||||
| 2021-03-02 | 2021-03-01 | 4 | Brown Bob D | DRNA | Common Stock | D | 29,4889 | -783 | -23 | 21.517 | ||||
| 2021-03-02 | 2021-03-01 | 4 | Brown Bob D | DRNA | Common Stock | D | 28,9031 | -7.529 | -218 | 22.300 | ||||
| 2021-03-02 | 2021-03-01 | 4 | Brown Bob D | DRNA | Common Stock | D | 9,0900 | 8.312 | 76 | 29.829 | ||||
| 2021-03-02 | 2021-03-01 | 4 | Paglia Regina M. | DRNA | Employee Stock Option (Right to Buy) | D | 12,93 | -4.431 | 136.707 | |||||
| 2021-03-02 | 2021-03-01 | 4 | Paglia Regina M. | DRNA | Common Stock | D | 29,4699 | -356 | -10 | 0 | ||||
| 2021-03-02 | 2021-03-01 | 4 | Paglia Regina M. | DRNA | Common Stock | D | 28,9197 | -4.075 | -118 | 356 | ||||
| 2021-03-02 | 2021-03-01 | 4 | Paglia Regina M. | DRNA | Common Stock | D | 12,9300 | 4.431 | 57 | 4.431 | ||||
| 2021-02-08 | 2021-02-05 | 4 | Weissman James B | DRNA | Common Stock | D | 26,9900 | -7.156 | -193 | 20.904 | ||||
| 2021-02-04 | 2021-02-03 | 4 | Brown Bob D | DRNA | Employee Stock Option (Right to Buy) | D | 9,09 | -8.312 | 100.058 | |||||
| 2021-02-04 | 2021-02-03 | 4 | Brown Bob D | DRNA | Common Stock | D | 25,0000 | -8.312 | -208 | 21.517 | ||||
| 2021-02-04 | 2021-02-03 | 4 | Brown Bob D | DRNA | Common Stock | D | 9,0900 | 8.312 | 76 | 29.829 | ||||
| 2021-02-04 | 2021-02-02 | 4 | Paglia Regina M. | DRNA | Employee Stock Option (Right to Buy) | D | 12,93 | -4.431 | 141.138 | |||||
| 2021-02-04 | 2021-02-02 | 4 | Paglia Regina M. | DRNA | Common Stock | D | 24,0000 | -4.431 | -106 | 0 | ||||
| 2021-02-04 | 2021-02-02 | 4 | Paglia Regina M. | DRNA | Common Stock | D | 12,9300 | 4.431 | 57 | 4.431 | ||||
| 2021-01-27 | 2021-01-25 | 4 | Brown Bob D | DRNA | Employee Stock Option (Right to Buy) | D | 9,09 | -16.630 | 108.370 | |||||
| 2021-01-27 | 2021-01-25 | 4 | Brown Bob D | DRNA | Common Stock | D | 25,0000 | -21.630 | -541 | 21.517 | ||||
| 2021-01-27 | 2021-01-25 | 4 | Brown Bob D | DRNA | Common Stock | D | 9,0900 | 16.630 | 151 | 43.147 | ||||
| 2021-01-27 | 2021-01-25 | 4 | Paglia Regina M. | DRNA | Employee Stock Option (Right to Buy) | D | 12,93 | -4.431 | 145.569 | |||||
| 2021-01-27 | 2021-01-25 | 4 | Paglia Regina M. | DRNA | Common Stock | D | 25,0000 | -6.326 | -158 | 0 | ||||
| 2021-01-27 | 2021-01-25 | 4 | Paglia Regina M. | DRNA | Common Stock | D | 12,9300 | 4.431 | 57 | 6.326 | ||||
| 2021-01-13 | 2021-01-12 | 4 | Weissman James B | DRNA | Common Stock | D | 24,0820 | -5.808 | -140 | 28.060 | ||||
| 2021-01-13 | 2021-01-12 | 4 | Brown Bob D | DRNA | Common Stock | D | 24,0732 | -5.808 | -140 | 26.517 | ||||
| 2021-01-12 | 2021-01-12 | 4 | Aradhye Shreeram | DRNA | Employee Stock Option (Right to Buy) | D | 24,05 | 51.070 | 51.070 | |||||
| 2021-01-12 | 2021-01-12 | 4 | Aradhye Shreeram | DRNA | Restricted Stock Units | D | 11.350 | 11.350 | ||||||
| 2021-01-12 | 2021-01-12 | 4 | Weissman James B | DRNA | Employee Stock Option (Right to Buy) | D | 24,05 | 68.100 | 68.100 | |||||
| 2021-01-12 | 2021-01-12 | 4 | Weissman James B | DRNA | Restricted Stock Units | D | 15.100 | 15.100 | ||||||
| 2021-01-12 | 2021-01-11 | 4 | Weissman James B | DRNA | Common Stock | D | 23,9900 | -3.800 | -91 | 33.868 | ||||
| 2021-01-12 | 2021-01-08 | 4 | Weissman James B | DRNA | Restricted Stock Units | D | -8.650 | 25.950 | ||||||
| 2021-01-12 | 2021-01-08 | 4 | Weissman James B | DRNA | Common Stock | D | 23,2900 | -2.842 | -66 | 37.668 | ||||
| 2021-01-12 | 2021-01-08 | 4 | Weissman James B | DRNA | Common Stock | D | 8.650 | 40.510 | ||||||
| 2021-01-12 | 2021-01-12 | 4 | FAMBROUGH DOUGLAS | DRNA | Employee Stock Option (Right to Buy) | D | 24,05 | 247.700 | 247.700 | |||||
| 2021-01-12 | 2021-01-12 | 4 | FAMBROUGH DOUGLAS | DRNA | Restricted Stock Units | D | 55.000 | 55.000 | ||||||
| 2021-01-12 | 2021-01-08 | 4 | FAMBROUGH DOUGLAS | DRNA | Restricted Stock Units | D | -19.950 | 59.850 | ||||||
| 2021-01-12 | 2021-01-08 | 4 | FAMBROUGH DOUGLAS | DRNA | Common Stock | D | 23,2900 | -6.159 | -143 | 37.030 | ||||
| 2021-01-12 | 2021-01-08 | 4 | FAMBROUGH DOUGLAS | DRNA | Common Stock | D | 19.950 | 43.189 | ||||||
| 2021-01-12 | 2021-01-12 | 4 | Brown Bob D | DRNA | Employee Stock Option (Right to Buy) | D | 24,05 | 68.100 | 68.100 | |||||
| 2021-01-12 | 2021-01-12 | 4 | Brown Bob D | DRNA | Restricted Stock Units | D | 15.100 | 15.100 | ||||||
| 2021-01-12 | 2021-01-08 | 4 | Brown Bob D | DRNA | Restricted Stock Units | D | -8.650 | 25.950 | ||||||
| 2021-01-12 | 2021-01-08 | 4 | Brown Bob D | DRNA | Common Stock | D | 23,2900 | -2.842 | -66 | 32.325 | ||||
| 2021-01-12 | 2021-01-08 | 4 | Brown Bob D | DRNA | Common Stock | D | 8.650 | 35.167 | ||||||
| 2021-01-12 | 2021-01-12 | 4 | Zeng Ling | DRNA | Employee Stock Option (Right to Buy) | D | 24,05 | 46.120 | 46.120 | |||||
| 2021-01-12 | 2021-01-12 | 4 | Zeng Ling | DRNA | Restricted Stock Units | D | 10.250 | 10.250 | ||||||
| 2021-01-12 | 2021-01-12 | 4 | Pagan Douglas W. | DRNA | Employee Stock Option (Right to Buy) | D | 24,05 | 36.900 | 36.900 | |||||
| 2021-01-12 | 2021-01-12 | 4 | Pagan Douglas W. | DRNA | Restricted Stock Units | D | 8.200 | 8.200 | ||||||
| 2021-01-12 | 2021-01-12 | 4 | Paglia Regina M. | DRNA | Employee Stock Option (Right to Buy) | D | 24,05 | 61.500 | 61.500 | |||||
| 2021-01-12 | 2021-01-12 | 4 | Paglia Regina M. | DRNA | Restricted Stock Units | D | 13.700 | 13.700 | ||||||
| 2021-01-12 | 2021-01-08 | 4 | Paglia Regina M. | DRNA | Restricted Stock Units | D | -2.900 | 8.700 | ||||||
| 2021-01-12 | 2021-01-08 | 4 | Paglia Regina M. | DRNA | Common Stock | D | 23,2900 | -1.005 | -23 | 1.895 | ||||
| 2021-01-12 | 2021-01-08 | 4 | Paglia Regina M. | DRNA | Common Stock | D | 2.900 | 2.900 | ||||||
| 2021-01-12 | 2021-01-12 | 4 | Ciappenelli Robert D. | DRNA | Employee Stock Option (Right to Buy) | D | 24,05 | 61.500 | 61.500 | |||||
| 2021-01-12 | 2021-01-12 | 4 | Ciappenelli Robert D. | DRNA | Restricted Stock Units | D | 13.700 | 13.700 | ||||||
| 2021-01-12 | 2021-01-08 | 4 | Ciappenelli Robert D. | DRNA | Restricted Stock Units | D | -5.775 | 17.325 | ||||||
| 2021-01-12 | 2021-01-08 | 4 | Ciappenelli Robert D. | DRNA | Common Stock | D | 23,2900 | -2.002 | -47 | 3.773 | ||||
| 2021-01-12 | 2021-01-08 | 4 | Ciappenelli Robert D. | DRNA | Common Stock | D | 5.775 | 5.775 | ||||||
| 2020-12-14 | 2020-12-10 | 4 | Koppel Adam See footnotes | DRNA | Common Stock | I | 23,4000 | -1.000.000 | -23.400 | 3.080.237 | ||||
| 2020-12-03 | 2020-12-01 | 4 | Brown Bob D | DRNA | Employee Stock Option (Right to Buy) | D | 3,42 | -8.185 | 0 | |||||
| 2020-12-03 | 2020-12-01 | 4 | Brown Bob D | DRNA | Common Stock | D | 25,1931 | -8.185 | -206 | 26.517 | ||||
| 2020-12-03 | 2020-12-01 | 4 | Brown Bob D | DRNA | Common Stock | D | 3,4200 | 8.185 | 28 | 34.702 | ||||
| 2020-12-03 | 2020-12-01 | 4 | Weissman James B | DRNA | Employee Stock Option (Right to Buy) | D | 3,42 | -4.360 | 0 | |||||
| 2020-12-03 | 2020-12-01 | 4 | Weissman James B | DRNA | Common Stock | D | 25,2071 | -4.360 | -110 | 31.860 | ||||
| 2020-12-03 | 2020-12-01 | 4 | Weissman James B | DRNA | Common Stock | D | 3,4200 | 4.360 | 15 | 36.220 | ||||
| 2020-11-06 | 2020-11-04 | 4 | Paglia Regina M. | DRNA | Employee Stock Option (Right to Buy) | D | 12,93 | -30.000 | 150.000 | |||||
| 2020-11-06 | 2020-11-04 | 4 | Paglia Regina M. | DRNA | Common Stock | D | 23,2500 | -15.000 | -349 | 0 | ||||
| 2020-11-06 | 2020-11-04 | 4 | Paglia Regina M. | DRNA | Common Stock | D | 22,2500 | -15.000 | -334 | 15.000 | ||||
| 2020-11-06 | 2020-11-04 | 4 | Paglia Regina M. | DRNA | Common Stock | D | 12,9300 | 30.000 | 388 | 30.000 | ||||
| 2020-11-03 | 2020-11-02 | 4 | Brown Bob D | DRNA | Employee Stock Option (Right to Buy) | D | 3,42 | -8.185 | 8.185 | |||||
| 2020-11-03 | 2020-11-02 | 4 | Brown Bob D | DRNA | Common Stock | D | 21,0300 | -8.185 | -172 | 26.517 | ||||
| 2020-11-03 | 2020-11-02 | 4 | Brown Bob D | DRNA | Common Stock | D | 3,4200 | 8.185 | 28 | 34.702 | ||||
| 2020-11-03 | 2020-11-02 | 4 | Weissman James B | DRNA | Employee Stock Option (Right to Buy) | D | 3,42 | -4.360 | 4.360 | |||||
| 2020-11-03 | 2020-11-02 | 4 | Weissman James B | DRNA | Common Stock | D | 20,9480 | -4.360 | -91 | 31.860 | ||||
| 2020-11-03 | 2020-11-02 | 4 | Weissman James B | DRNA | Common Stock | D | 3,4200 | 4.360 | 15 | 36.220 | ||||
| 2020-10-22 | 2020-10-20 | 4 | Weissman James B | DRNA | Employee Stock Option (Right to Buy) | D | 2,97 | -10.000 | 11.879 | |||||
| 2020-10-22 | 2020-10-20 | 4 | Weissman James B | DRNA | Common Stock | D | 2,9700 | 10.000 | 30 | 31.860 | ||||
| 2020-10-20 | 2020-10-16 | 4 | Brown Bob D | DRNA | Employee Stock Option (Right to Buy) | D | 3,42 | -16.370 | 16.370 | |||||
| 2020-10-20 | 2020-10-16 | 4 | Brown Bob D | DRNA | Common Stock | D | 21,0000 | -16.370 | -344 | 26.517 | ||||
| 2020-10-20 | 2020-10-16 | 4 | Brown Bob D | DRNA | Common Stock | D | 3,4200 | 16.370 | 56 | 42.887 | ||||
| 2020-10-19 | 2020-10-15 | 4 | Weissman James B | DRNA | Employee Stock Option (Right to Buy) | D | 3,42 | -8.720 | 8.720 | |||||
| 2020-10-19 | 2020-10-15 | 4 | Weissman James B | DRNA | Common Stock | D | 20,2000 | -8.720 | -176 | 21.860 | ||||
| 2020-10-19 | 2020-10-15 | 4 | Weissman James B | DRNA | Common Stock | D | 3,4200 | 8.720 | 30 | 30.580 | ||||
| 2020-10-02 | 2020-10-01 | 4 | Aradhye Shreeram | DRNA | Employee Stock Option (Right to Buy) | D | 18,69 | 124.700 | 124.700 | |||||
| 2020-10-02 | 2020-10-01 | 4 | Aradhye Shreeram | DRNA | Restricted Stock Units | D | 28.100 | 28.100 | ||||||
| 2020-10-02 | 2020-10-01 | 4 | Zeng Ling | DRNA | Employee Stock Option (Right to Buy) | D | 18,69 | 81.825 | 81.825 | |||||
| 2020-10-02 | 2020-10-01 | 4 | Zeng Ling | DRNA | Restricted Stock Units | D | 18.225 | 18.225 | ||||||
| 2020-09-18 | 2020-09-16 | 4 | Brown Bob D | DRNA | Employee Stock Option (Right to Buy) | D | 3,42 | -21.250 | 77.874 | |||||
| 2020-09-18 | 2020-09-16 | 4 | Brown Bob D | DRNA | Common Stock | D | 3,4200 | 21.250 | 73 | 26.517 | ||||
| 2020-09-16 | 2020-09-14 | 4 | Brown Bob D | DRNA | Employee Stock Option (Right to Buy) | D | 3,42 | -267 | 0 | |||||
| 2020-09-16 | 2020-09-14 | 4 | Brown Bob D | DRNA | Common Stock | D | 3,4200 | 267 | 1 | 5.267 | ||||
| 2020-09-04 | 2020-07-01 | 4/A | Weissman James B | DRNA | Employee Stock Option (Right to Buy) | D | 2,97 | -4.360 | 25.980 | |||||
| 2020-09-04 | 2020-07-01 | 4/A | Weissman James B | DRNA | Common Stock | D | 26,8678 | -1.307 | -35 | 21.860 | ||||
| 2020-09-04 | 2020-07-01 | 4/A | Weissman James B | DRNA | Common Stock | D | 26,3881 | -3.053 | -81 | 23.167 | ||||
| 2020-09-04 | 2020-07-01 | 4/A | Weissman James B | DRNA | Common Stock | D | 2,9700 | 4.360 | 13 | 26.220 | ||||
| 2020-09-01 | 2020-09-01 | 4 | FAMBROUGH DOUGLAS | DRNA | Common Stock | D | 18,0597 | 10.000 | 181 | 22.300 | ||||
| 2020-08-05 | 2020-08-03 | 4 | Brown Bob D | DRNA | Employee Stock Option (Right to Buy) | D | 3,42 | -8.185 | 32.740 | |||||
| 2020-08-05 | 2020-08-03 | 4 | Brown Bob D | DRNA | Common Stock | D | 22,7999 | -2.521 | -57 | 5.000 | ||||
| 2020-08-05 | 2020-08-03 | 4 | Brown Bob D | DRNA | Common Stock | D | 22,3355 | -5.664 | -127 | 7.521 | ||||
| 2020-08-05 | 2020-08-03 | 4 | Brown Bob D | DRNA | Common Stock | D | 3,4200 | 8.185 | 28 | 13.185 | ||||
| 2020-08-05 | 2020-08-03 | 4 | Weissman James B | DRNA | Employee Stock Option (Right to Buy) | D | 3,42 | -259 | 17.440 | |||||
| 2020-08-05 | 2020-08-03 | 4 | Weissman James B | DRNA | Employee Stock Option (Right to Buy) | D | 2,97 | -4.101 | 21.879 | |||||
| 2020-08-05 | 2020-08-03 | 4 | Weissman James B | DRNA | Common Stock | D | 22,7993 | -1.432 | -33 | 21.860 | ||||
| 2020-08-05 | 2020-08-03 | 4 | Weissman James B | DRNA | Common Stock | D | 22,3120 | -2.928 | -65 | 23.292 | ||||
| 2020-08-05 | 2020-08-03 | 4 | Weissman James B | DRNA | Common Stock | D | 3,4200 | 259 | 1 | 26.220 | ||||
| 2020-08-05 | 2020-08-03 | 4 | Weissman James B | DRNA | Common Stock | D | 2,9700 | 4.101 | 12 | 25.961 | ||||
| 2020-07-06 | 2020-07-01 | 4 | Weissman James B | DRNA | Employee Stock Option (Right to Buy) | D | 2,97 | -4.360 | 25.980 | |||||
| 2020-07-06 | 2020-07-01 | 4 | Weissman James B | DRNA | Common Stock | D | 26,8678 | -1.307 | -35 | 21.860 | ||||
| 2020-07-06 | 2020-07-01 | 4 | Weissman James B | DRNA | Common Stock | D | 26,3881 | -3.053 | -81 | 23.167 | ||||
| 2020-07-06 | 2020-07-01 | 4 | Weissman James B | DRNA | Common Stock | D | 2,9700 | 4.360 | 13 | 26.220 | ||||
| 2020-07-06 | 2020-07-01 | 4 | Brown Bob D | DRNA | Employee Stock Option (Right to Buy) | D | 3,42 | -8.185 | 40.925 | |||||
| 2020-07-06 | 2020-07-01 | 4 | Brown Bob D | DRNA | Common Stock | D | 26,8533 | -2.371 | -64 | 5.000 | ||||
| 2020-07-06 | 2020-07-01 | 4 | Brown Bob D | DRNA | Common Stock | D | 26,3604 | -5.814 | -153 | 7.371 | ||||
| 2020-07-06 | 2020-07-01 | 4 | Brown Bob D | DRNA | Common Stock | D | 3,4200 | 8.185 | 28 | 13.185 | ||||
| 2020-07-02 | 2020-07-01 | 4 | Paglia Regina M. | DRNA | Employee Stock Option (Right to Buy) | D | 26,62 | 6.825 | 6.825 | |||||
| 2020-07-02 | 2020-07-01 | 4 | Paglia Regina M. | DRNA | Restricted Stock Units | D | 1.525 | 1.525 | ||||||
| 2020-06-23 | 2020-06-19 | 4 | Brown Bob D | DRNA | Employee Stock Option (Right to Buy) | D | 2,97 | -9.670 | 21.876 | |||||
| 2020-06-23 | 2020-06-19 | 4 | Brown Bob D | DRNA | Common Stock | D | 25,0000 | -9.670 | -242 | 5.000 | ||||
| 2020-06-23 | 2020-06-19 | 4 | Brown Bob D | DRNA | Common Stock | D | 2,9700 | 9.670 | 29 | 14.670 | ||||
| 2020-06-16 | 2020-06-15 | 4 | HOFFMAN STEPHEN J | DRNA | Director Stock Option (Right to Buy) | D | 21,61 | 15.000 | 15.000 | |||||
| 2020-06-16 | 2020-06-15 | 4 | HOFFMAN STEPHEN J | DRNA | Restricted Stock Units | D | 3.333 | 3.333 | ||||||
| 2020-06-16 | 2020-06-15 | 4 | Koppel Adam | DRNA | Director Stock Option (Right to Buy) | D | 21,61 | 15.000 | 15.000 | |||||
| 2020-06-16 | 2020-06-15 | 4 | Koppel Adam | DRNA | Restricted Stock Units | D | 3.333 | 3.333 | ||||||
| 2020-06-16 | 2020-06-15 | 4 | GRAY PATRICK M. | DRNA | Director Stock Option (Right to Buy) | D | 21,61 | 15.000 | 15.000 | |||||
| 2020-06-16 | 2020-06-15 | 4 | GRAY PATRICK M. | DRNA | Restricted Stock Units | D | 3.333 | 3.333 | ||||||
| 2020-06-16 | 2020-06-15 | 4 | Doberstein Stephen K | DRNA | Director Stock Option (Right to Buy) | D | 21,61 | 15.000 | 15.000 | |||||
| 2020-06-16 | 2020-06-15 | 4 | Doberstein Stephen K | DRNA | Restricted Stock Units | D | 3.333 | 3.333 | ||||||
| 2020-06-16 | 2020-06-15 | 4 | BUCHI J KEVIN | DRNA | Director Stock Option (Right to Buy) | D | 21,61 | 21.000 | 21.000 | |||||
| 2020-06-16 | 2020-06-15 | 4 | BUCHI J KEVIN | DRNA | Restricted Stock Units | D | 4.666 | 4.666 | ||||||
| 2020-06-16 | 2020-06-15 | 4 | Smith Cynthia | DRNA | Director Stock Option (Right to Buy) | D | 21,61 | 15.000 | 15.000 | |||||
| 2020-06-16 | 2020-06-15 | 4 | Smith Cynthia | DRNA | Restricted Stock Units | D | 3.333 | 3.333 | ||||||
| 2020-06-16 | 2020-06-15 | 4 | Protopapas Anna | DRNA | Director Stock Option (Right to Buy) | D | 21,61 | 15.000 | 15.000 | |||||
| 2020-06-16 | 2020-06-15 | 4 | Protopapas Anna | DRNA | Restricted Stock Units | D | 3.333 | 3.333 | ||||||
| 2020-06-16 | 2020-06-15 | 4 | KOZIN MARC D | DRNA | Director Stock Option (Right to Buy) | D | 21,61 | 15.000 | 15.000 | |||||
| 2020-06-16 | 2020-06-15 | 4 | KOZIN MARC D | DRNA | Restricted Stock Units | D | 3.333 | 3.333 | ||||||
| 2020-06-16 | 2020-06-15 | 4 | Freed Martin I | DRNA | Director Stock Option (Right to Buy) | D | 21,61 | 15.000 | 15.000 | |||||
| 2020-06-16 | 2020-06-15 | 4 | Freed Martin I | DRNA | Restricted Stock Units | D | 3.333 | 3.333 | ||||||
| 2020-06-02 | 2020-06-01 | 4 | Pagan Douglas W. | DRNA | Employee Stock Option (Right to Buy) | D | 20,79 | 95.650 | 95.650 | |||||
| 2020-06-02 | 2020-06-01 | 4 | Pagan Douglas W. | DRNA | Restricted Stock Units | D | 27.300 | 27.300 | ||||||
| 2020-06-02 | 2020-06-01 | 4 | Brown Bob D | DRNA | Employee Stock Option (Right to Buy) | D | 3,42 | -8.185 | 49.110 | |||||
| 2020-06-02 | 2020-06-01 | 4 | Brown Bob D | DRNA | Common Stock | D | 21,0091 | -8.185 | -172 | 5.000 | ||||
| 2020-06-02 | 2020-06-01 | 4 | Brown Bob D | DRNA | Common Stock | D | 3,4200 | 8.185 | 28 | 13.185 | ||||
| 2020-06-02 | 2020-06-01 | 4 | Weissman James B | DRNA | Employee Stock Option (Right to Buy) | D | 2,97 | -4.360 | 30.340 | |||||
| 2020-06-02 | 2020-06-01 | 4 | Weissman James B | DRNA | Common Stock | D | 21,0567 | -4.360 | -92 | 21.860 | ||||
| 2020-06-02 | 2020-06-01 | 4 | Weissman James B | DRNA | Common Stock | D | 2,9700 | 4.360 | 13 | 26.220 | ||||
| 2020-05-12 | 2020-05-11 | 4 | Brown Bob D | DRNA | Employee Stock Option (Right to Buy) | D | 2,97 | -13.281 | 31.546 | |||||
| 2020-05-12 | 2020-05-11 | 4 | Brown Bob D | DRNA | Common Stock | D | 24,0000 | -13.281 | -319 | 5.000 | ||||
| 2020-05-12 | 2020-05-11 | 4 | Brown Bob D | DRNA | Common Stock | D | 2,9700 | 13.281 | 39 | 18.281 | ||||
| 2020-05-07 | 2020-05-05 | 4 | Brown Bob D | DRNA | Employee Stock Option (Right to Buy) | D | 3,42 | -8.185 | 57.295 | |||||
| 2020-05-07 | 2020-05-05 | 4 | Brown Bob D | DRNA | Common Stock | D | 21,0000 | -8.185 | -172 | 5.000 | ||||
| 2020-05-07 | 2020-05-05 | 4 | Brown Bob D | DRNA | Common Stock | D | 3,4200 | 8.185 | 28 | 13.185 | ||||
| 2020-05-06 | 2020-05-04 | 4 | Weissman James B | DRNA | Employee Stock Option (Right to Buy) | D | 2,97 | 4.360 | 34.700 | |||||
| 2020-05-06 | 2020-05-04 | 4 | Weissman James B | DRNA | Common Stock | D | 20,2000 | -4.360 | -88 | 21.860 | ||||
| 2020-05-06 | 2020-05-04 | 4 | Weissman James B | DRNA | Common Stock | D | 2,9700 | 4.360 | 13 | 26.220 | ||||
| 2020-04-22 | 2020-04-20 | 4 | GREEN JOHN B | DRNA | Employee Stock Option (Right to Buy) | D | 5,45 | -25.624 | 186.375 | |||||
| 2020-04-22 | 2020-04-20 | 4 | GREEN JOHN B | DRNA | Common Stock | D | 22,9500 | -25.624 | -588 | 19.421 | ||||
| 2020-04-22 | 2020-04-20 | 4 | GREEN JOHN B | DRNA | Common Stock | D | 5,4500 | 25.624 | 140 | 45.045 | ||||
| 2020-04-21 | 2020-04-20 | 4 | Brown Bob D | DRNA | Employee Stock Option (Right to Buy) | D | 2,97 | -13.281 | 44.827 | |||||
| 2020-04-21 | 2020-04-20 | 4 | Brown Bob D | DRNA | Common Stock | D | 23,0000 | -13.281 | -305 | 5.000 | ||||
| 2020-04-21 | 2020-04-20 | 4 | Brown Bob D | DRNA | Common Stock | D | 2,9700 | 13.281 | 39 | 18.281 | ||||
| 2020-04-21 | 2020-04-17 | 4 | Brown Bob D | DRNA | Employee Stock Option (Right to Buy) | D | 3,42 | -8.185 | 65.480 | |||||
| 2020-04-21 | 2020-04-17 | 4 | Brown Bob D | DRNA | Common Stock | D | 21,1800 | -8.185 | -173 | 5.000 | ||||
| 2020-04-21 | 2020-04-17 | 4 | Brown Bob D | DRNA | Common Stock | D | 3,4200 | 8.185 | 28 | 13.185 | ||||
| 2020-04-14 | 2020-04-13 | 4 | Weissman James B | DRNA | Employee Stock Option (Right to Buy) | D | 2,97 | -4.360 | 39.060 | |||||
| 2020-04-14 | 2020-04-13 | 4 | Weissman James B | DRNA | Common Stock | D | 20,2000 | -4.360 | -88 | 21.860 | ||||
| 2020-04-14 | 2020-04-13 | 4 | Weissman James B | DRNA | Common Stock | D | 2,9700 | 4.360 | 13 | 26.220 | ||||
| 2020-04-09 | 2020-04-07 | 4 | GREEN JOHN B | DRNA | Employee Stock Option (Right to Buy) | D | 2,97 | -12.968 | 14.063 | |||||
| 2020-04-09 | 2020-04-07 | 4 | GREEN JOHN B | DRNA | Employee Stock Option (Right to Buy) | D | 5,45 | -7.501 | 211.999 | |||||
| 2020-04-09 | 2020-04-07 | 4 | GREEN JOHN B | DRNA | Common Stock | D | 19,9500 | -20.469 | -408 | 19.421 | ||||
| 2020-04-09 | 2020-04-07 | 4 | GREEN JOHN B | DRNA | Common Stock | D | 2,9700 | 12.968 | 39 | 39.890 | ||||
| 2020-04-09 | 2020-04-07 | 4 | GREEN JOHN B | DRNA | Common Stock | D | 5,4500 | 7.501 | 41 | 26.922 | ||||
| 2020-03-16 | 2020-03-12 | 4 | Doberstein Stephen K | DRNA | Director Stock Option (Right to Buy) | D | 15,61 | 25.000 | 25.000 | |||||
| 2020-03-03 | 2020-03-02 | 4 | Weissman James B | DRNA | Employee Stock Option (Right to Buy) | D | 2,97 | -4.360 | 43.420 | |||||
| 2020-03-03 | 2020-03-02 | 4 | Weissman James B | DRNA | Common Stock | D | 20,6087 | -4.360 | -90 | 21.860 | ||||
| 2020-03-03 | 2020-03-02 | 4 | Weissman James B | DRNA | Common Stock | D | 2,9700 | 4.360 | 13 | 26.220 | ||||
| 2020-03-03 | 2020-03-02 | 4 | Brown Bob D | DRNA | Employee Stock Option (Right to Buy) | D | 3,42 | -8.185 | 73.665 | |||||
| 2020-03-03 | 2020-03-02 | 4 | Brown Bob D | DRNA | Common Stock | D | 21,0000 | -8.185 | -172 | 5.000 | ||||
| 2020-03-03 | 2020-03-02 | 4 | Brown Bob D | DRNA | Common Stock | D | 3,4200 | 8.185 | 28 | 13.185 | ||||
| 2020-02-11 | 2020-02-10 | 4 | Brown Bob D | DRNA | Employee Stock Option (Right to Buy) | D | 3,42 | -2.535 | 99.124 | |||||
| 2020-02-11 | 2020-02-10 | 4 | Brown Bob D | DRNA | Employee Stock Option (Right to Buy) | D | 3,42 | -5.650 | 81.850 | |||||
| 2020-02-11 | 2020-02-10 | 4 | Brown Bob D | DRNA | Common Stock | D | 21,0000 | -8.185 | -172 | 5.000 | ||||
| 2020-02-11 | 2020-02-10 | 4 | Brown Bob D | DRNA | Common Stock | D | 3,4200 | 2.535 | 9 | 13.185 | ||||
| 2020-02-11 | 2020-02-10 | 4 | Brown Bob D | DRNA | Common Stock | D | 3,4200 | 5.650 | 19 | 10.650 | ||||
| 2020-02-04 | 2020-02-03 | 4 | Weissman James B | DRNA | Employee Stock Option (Right to Buy) | D | 2,97 | -4.360 | 47.780 | |||||
| 2020-02-04 | 2020-02-03 | 4 | Weissman James B | DRNA | Common Stock | D | 20,2000 | -4.360 | -88 | 21.860 | ||||
| 2020-02-04 | 2020-02-03 | 4 | Weissman James B | DRNA | Common Stock | D | 2,9700 | 4.360 | 13 | 26.220 | ||||
| 2020-01-21 | 2020-01-17 | 4 | GREEN JOHN B | DRNA | Employee Stock Option (Right to Buy) | D | 2,97 | -20.469 | 27.031 | |||||
| 2020-01-21 | 2020-01-17 | 4 | GREEN JOHN B | DRNA | Employee Stock Option (Right to Buy) | D | 2,97 | -27.500 | 47.500 | |||||
| 2020-01-21 | 2020-01-17 | 4 | GREEN JOHN B | DRNA | Common Stock | D | 21,2628 | -20.469 | -435 | 19.421 | ||||
| 2020-01-21 | 2020-01-17 | 4 | GREEN JOHN B | DRNA | Common Stock | D | 21,2704 | -27.500 | -585 | 39.890 | ||||
| 2020-01-21 | 2020-01-17 | 4 | GREEN JOHN B | DRNA | Common Stock | D | 2,9700 | 20.469 | 61 | 67.390 | ||||
| 2020-01-21 | 2020-01-17 | 4 | GREEN JOHN B | DRNA | Common Stock | D | 2,9700 | 27.500 | 82 | 46.921 | ||||
| 2020-01-10 | 2020-01-08 | 4 | GREEN JOHN B | DRNA | Employee Stock Option (Right to Buy) | D | 22,58 | 85.000 | 85.000 | |||||
| 2020-01-10 | 2020-01-08 | 4 | GREEN JOHN B | DRNA | Restricted Stock Units | D | 23.100 | 23.100 | ||||||
| 2020-01-10 | 2020-01-08 | 4 | Ciappenelli Robert D. | DRNA | Employee Stock Option (Right to Buy) | D | 22,58 | 85.000 | 85.000 | |||||
| 2020-01-10 | 2020-01-08 | 4 | Ciappenelli Robert D. | DRNA | Restricted Stock Units | D | 23.100 | 23.100 | ||||||
| 2020-01-10 | 2020-01-08 | 4 | Weissman James B | DRNA | Employee Stock Option (Right to Buy) | D | 22,58 | 121.300 | 121.300 | |||||
| 2020-01-10 | 2020-01-08 | 4 | Weissman James B | DRNA | Restricted Stock Units | D | 34.600 | 34.600 | ||||||
| 2020-01-10 | 2020-01-08 | 4 | ROSSKAMP RALF | DRNA | Employee Stock Option (Right to Buy) | D | 22,58 | 85.000 | 85.000 | |||||
| 2020-01-10 | 2020-01-08 | 4 | ROSSKAMP RALF | DRNA | Restricted Stock Units | D | 23.100 | 23.100 | ||||||
| 2020-01-10 | 2020-01-08 | 4 | Brown Bob D | DRNA | Employee Stock Option (Right to Buy) | D | 22,58 | 121.300 | 121.300 | |||||
| 2020-01-10 | 2020-01-08 | 4 | Brown Bob D | DRNA | Restricted Stock Units | D | 34.600 | 34.600 | ||||||
| 2020-01-10 | 2020-01-08 | 4 | FAMBROUGH DOUGLAS | DRNA | Employee Stock Option (Right to Buy) | D | 22,58 | 250.000 | 250.000 | |||||
| 2020-01-10 | 2020-01-08 | 4 | FAMBROUGH DOUGLAS | DRNA | Restricted Stock Units | D | 79.800 | 79.800 | ||||||
| 2020-01-03 | 2020-01-02 | 4 | Weissman James B | DRNA | Employee Stock Option (Right to Buy) | D | 2,97 | -2.860 | 52.140 | |||||
| 2020-01-03 | 2020-01-02 | 4 | Weissman James B | DRNA | Employee Stock Option (Right to Buy) | D | 3,42 | -1.500 | 0 | |||||
| 2020-01-03 | 2020-01-02 | 4 | Weissman James B | DRNA | Common Stock | D | 21,8753 | -4.360 | -95 | 21.860 | ||||
| 2020-01-03 | 2020-01-02 | 4 | Weissman James B | DRNA | Common Stock | D | 2,9700 | 2.860 | 8 | 26.220 | ||||
| 2020-01-03 | 2020-01-02 | 4 | Weissman James B | DRNA | Common Stock | D | 3,4200 | 1.500 | 5 | 23.360 | ||||
| 2019-12-31 | 2019-12-31 | 4 | Brown Bob D | DRNA | Employee Stock Option (Right to Buy) | D | 2,97 | -11.941 | 58.108 | |||||
| 2019-12-31 | 2019-12-31 | 4 | Brown Bob D | DRNA | Employee Stock Option (Right to Buy) | D | 3,42 | -5.000 | 101.659 | |||||
| 2019-12-31 | 2019-12-31 | 4 | Brown Bob D | DRNA | Common Stock | D | 22,0000 | -11.941 | -263 | 5.000 | ||||
| 2019-12-31 | 2019-12-31 | 4 | Brown Bob D | DRNA | Common Stock | D | 2,9700 | 11.941 | 35 | 16.941 | ||||
| 2019-12-31 | 2019-12-31 | 4 | Brown Bob D | DRNA | Common Stock | D | 3,4200 | 5.000 | 17 | 5.000 | ||||
| 2019-12-31 | 2019-12-30 | 4 | Brown Bob D | DRNA | Employee Stock Option (Right to Buy) | D | 2,97 | -4.951 | 70.049 | |||||
| 2019-12-31 | 2019-12-30 | 4 | Brown Bob D | DRNA | Employee Stock Option (Right to Buy) | D | 3,42 | -8.185 | 106.659 | |||||
| 2019-12-31 | 2019-12-30 | 4 | Brown Bob D | DRNA | Common Stock | D | 22,0051 | -1.340 | -29 | 0 | ||||
| 2019-12-31 | 2019-12-30 | 4 | Brown Bob D | DRNA | Common Stock | D | 21,8445 | -21.466 | -469 | 1.340 | ||||
| 2019-12-31 | 2019-12-30 | 4 | Brown Bob D | DRNA | Common Stock | D | 2,9700 | 4.951 | 15 | 22.806 | ||||
| 2019-12-31 | 2019-12-30 | 4 | Brown Bob D | DRNA | Common Stock | D | 3,4200 | 8.185 | 28 | 17.855 | ||||
| 2019-12-27 | 2019-12-26 | 4 | ROSSKAMP RALF | DRNA | Employee Stock Option (Right to Buy) | D | 2,91 | -20.000 | 230.000 | |||||
| 2019-12-27 | 2019-12-26 | 4 | ROSSKAMP RALF | DRNA | Common Stock | D | 22,6882 | -20.000 | -454 | 3.564 | ||||
| 2019-12-27 | 2019-12-26 | 4 | ROSSKAMP RALF | DRNA | Common Stock | D | 2,9100 | 20.000 | 58 | 23.564 | ||||
| 2019-12-19 | 2019-12-18 | 4 | FAMBROUGH DOUGLAS | DRNA | Employee Stock Option (Right to Buy) | D | 3,42 | -80.000 | 201.250 | |||||
| 2019-12-19 | 2019-12-18 | 4 | FAMBROUGH DOUGLAS | DRNA | Common Stock | D | 27,0735 | -1.431 | -39 | 12.300 | ||||
| 2019-12-19 | 2019-12-18 | 4 | FAMBROUGH DOUGLAS | DRNA | Common Stock | D | 25,8479 | -78.569 | -2.031 | 13.731 | ||||
| 2019-12-19 | 2019-12-18 | 4 | FAMBROUGH DOUGLAS | DRNA | Common Stock | D | 3,4200 | 80.000 | 274 | 92.300 | ||||
| 2019-12-19 | 2019-12-17 | 4 | FAMBROUGH DOUGLAS | DRNA | Common Stock | D | 26,9443 | -2.305 | -62 | 12.300 | ||||
| 2019-12-19 | 2019-12-17 | 4 | FAMBROUGH DOUGLAS | DRNA | Common Stock | D | 26,1344 | -56.716 | -1.482 | 14.605 | ||||
| 2019-12-19 | 2019-12-18 | 4 | Weissman James B | DRNA | Employee Stock Option (Right to Buy) | D | 9,09 | -11.001 | 63.999 | |||||
| 2019-12-19 | 2019-12-18 | 4 | Weissman James B | DRNA | Common Stock | D | 26,0100 | -3.845 | -100 | 21.860 | ||||
| 2019-12-19 | 2019-12-18 | 4 | Weissman James B | DRNA | Common Stock | D | 9,0900 | 11.001 | 100 | 25.705 | ||||
| 2019-12-11 | 2019-12-11 | 4 | GREEN JOHN B | DRNA | Employee Stock Option (Right to Buy) | D | 5,45 | -8.000 | 219.500 | |||||
| 2019-12-11 | 2019-12-11 | 4 | GREEN JOHN B | DRNA | Common Stock | D | 5,4500 | 8.000 | 44 | 18.698 | ||||
| 2019-12-06 | 2019-12-04 | 4 | Koppel Adam See footnotes | DRNA | Common Stock | I | 24,6800 | -1.500.000 | -37.020 | 4.080.237 | ||||
| 2019-12-03 | 2019-12-02 | 4 | Weissman James B | DRNA | Employee Stock Option (Right to Buy) | D | 2,97 | -20.000 | 55.000 | |||||
| 2019-12-03 | 2019-12-02 | 4 | Weissman James B | DRNA | Common Stock | D | 26,0000 | -20.000 | -520 | 14.704 | ||||
| 2019-12-03 | 2019-12-02 | 4 | Weissman James B | DRNA | Common Stock | D | 2,9700 | 20.000 | 59 | 34.704 | ||||
| 2019-12-02 | 2019-12-02 | 4 | Kolchinsky Peter See Note | DRNA | Common Stock | I | 24,9835 | -137.176 | -3.427 | 0 | ||||
| 2019-12-02 | 2019-11-29 | 4 | Kolchinsky Peter See Note | DRNA | Common Stock | I | 24,2154 | -138.000 | -3.342 | 137.176 | ||||
| 2019-12-02 | 2019-11-27 | 4 | Kolchinsky Peter See Note | DRNA | Common Stock | I | 24,0433 | -368.700 | -8.865 | 275.176 | ||||
| 2019-11-27 | 2019-11-25 | 4 | GREEN JOHN B | DRNA | Employee Stock Option (Right to Buy) | D | 5,45 | -12.500 | 227.500 | |||||
| 2019-11-27 | 2019-11-25 | 4 | GREEN JOHN B | DRNA | Common Stock | D | 24,9500 | -12.500 | -312 | 10.698 | ||||
| 2019-11-27 | 2019-11-25 | 4 | GREEN JOHN B | DRNA | Common Stock | D | 5,4500 | 12.500 | 68 | 23.198 | ||||
| 2019-11-26 | 2019-11-26 | 4 | Kolchinsky Peter See Note | DRNA | Common Stock | I | 23,5855 | -239.700 | -5.653 | 643.876 | ||||
| 2019-11-26 | 2019-11-25 | 4 | Kolchinsky Peter See Note | DRNA | Common Stock | I | 24,0578 | -361.200 | -8.690 | 883.576 | ||||
| 2019-11-26 | 2019-11-22 | 4 | Kolchinsky Peter See Note | DRNA | Common Stock | I | 22,5164 | -197.700 | -4.451 | 1.244.776 | ||||
| 2019-11-21 | 2019-11-19 | 4 | Bain Capital Life Sciences Investors, LLC See Footnotes | DRNA | Common Stock | I | 22,0300 | -1.750.000 | -38.552 | 5.580.237 | ||||
| 2019-11-21 | 2019-11-21 | 4 | Kolchinsky Peter See Note | DRNA | Common Stock | I | 22,9782 | -351.505 | -8.077 | 1.442.476 | ||||
| 2019-11-21 | 2019-11-20 | 4 | Kolchinsky Peter See Note | DRNA | Common Stock | I | 22,9332 | -265.505 | -6.089 | 1.793.981 | ||||
| 2019-11-21 | 2019-11-19 | 4 | Kolchinsky Peter See Note | DRNA | Common Stock | I | 23,9217 | -397.183 | -9.501 | 2.059.486 | ||||
| 2019-11-20 | 2019-11-18 | 4 | GREEN JOHN B | DRNA | Employee Stock Option (Right to Buy) | D | 5,45 | -12.500 | 240.000 | |||||
| 2019-11-20 | 2019-11-18 | 4 | GREEN JOHN B | DRNA | Common Stock | D | 21,0500 | -12.500 | -263 | 10.698 | ||||
| 2019-11-20 | 2019-11-18 | 4 | GREEN JOHN B | DRNA | Common Stock | D | 5,4500 | 12.500 | 68 | 23.198 | ||||
| 2019-11-20 | 2019-11-19 | 4 | Weissman James B | DRNA | Employee Stock Option (Right to Buy) | D | 3,42 | -20.000 | 0 | |||||
| 2019-11-20 | 2019-11-19 | 4 | Weissman James B | DRNA | Common Stock | D | 24,0000 | -20.000 | -480 | 14.704 | ||||
| 2019-11-20 | 2019-11-19 | 4 | Weissman James B | DRNA | Common Stock | D | 3,4200 | 20.000 | 68 | 34.704 | ||||
| 2019-11-20 | 2019-11-18 | 4 | Weissman James B | DRNA | Employee Stock Option (Right to Buy) | D | 3,42 | -20.000 | 20.000 | |||||
| 2019-11-20 | 2019-11-18 | 4 | Weissman James B | DRNA | Common Stock | D | 22,0000 | -20.000 | -440 | 14.704 | ||||
| 2019-11-20 | 2019-11-18 | 4 | Weissman James B | DRNA | Common Stock | D | 3,4200 | 20.000 | 68 | 34.704 | ||||
| 2019-11-15 | 2019-11-14 | 4 | GREEN JOHN B | DRNA | Common Stock | D | 20,0000 | -3.562 | -71 | 10.698 | ||||
| 2019-11-15 | 2019-11-14 | 4 | Weissman James B | DRNA | Employee Stock Option (Right to Buy) | D | 3,42 | -20.000 | 40.000 | |||||
| 2019-11-15 | 2019-11-14 | 4 | Weissman James B | DRNA | Common Stock | D | 20,0000 | -20.000 | -400 | 14.704 | ||||
| 2019-11-15 | 2019-11-14 | 4 | Weissman James B | DRNA | Common Stock | D | 3,4200 | 20.000 | 68 | 34.704 | ||||
| 2019-11-01 | 2019-10-31 | 4 | Weissman James B | DRNA | Employee Stock Option (Right to Buy) | D | 3,42 | -15.000 | 17.699 | |||||
| 2019-11-01 | 2019-10-31 | 4 | Weissman James B | DRNA | Common Stock | D | 18,0000 | -15.000 | -270 | 14.704 | ||||
| 2019-11-01 | 2019-10-31 | 4 | Weissman James B | DRNA | Common Stock | D | 3,4200 | 15.000 | 51 | 29.704 | ||||
| 2019-11-01 | 2019-10-31 | 4 | GREEN JOHN B | DRNA | Employee Stock Option (Right to Buy) | D | 5,45 | -12.500 | 252.500 | |||||
| 2019-11-01 | 2019-10-31 | 4 | GREEN JOHN B | DRNA | Common Stock | D | 18,0000 | -12.500 | -225 | 14.260 | ||||
| 2019-11-01 | 2019-10-31 | 4 | GREEN JOHN B | DRNA | Common Stock | D | 5,4500 | 12.500 | 68 | 26.760 | ||||
| 2019-10-18 | 2019-10-18 | 4 | Weissman James B | DRNA | Employee Stock Option (Right to Buy) | D | 3,42 | -4.104 | 60.000 | |||||
| 2019-10-18 | 2019-10-18 | 4 | Weissman James B | DRNA | Employee Stock Option (Right to Buy) | D | 3,42 | -800 | 0 | |||||
| 2019-10-18 | 2019-10-18 | 4 | Weissman James B | DRNA | Common Stock | D | 3,4200 | 4.104 | 14 | 14.704 | ||||
| 2019-10-18 | 2019-10-18 | 4 | Weissman James B | DRNA | Common Stock | D | 3,4200 | 800 | 3 | 10.600 | ||||
| 2019-09-19 | 2019-09-17 | 4 | GRAY PATRICK M. | DRNA | Director Stock Option (Right to Buy) | D | 14,32 | 25.000 | 25.000 | |||||
| 2019-08-23 | 2019-08-23 | 4 | Weissman James B | DRNA | Common Stock | D | 13,0676 | -14.680 | -192 | 9.800 | ||||
| 2019-07-01 | 2019-07-01 | 4 | Ciappenelli Robert D. | DRNA | Employee Stock Option (Right to Buy) | D | 15,61 | 300.000 | 300.000 | |||||
| 2019-06-21 | 2019-06-20 | 4 | Smith Cynthia | DRNA | Director Stock Option (right to buy) | D | 15,44 | 25.000 | 25.000 | |||||
| 2019-06-21 | 2019-06-20 | 4 | Kolchinsky Peter | DRNA | Director Stock Option (right to buy) | D | 15,44 | 25.000 | 25.000 | |||||
| 2019-06-21 | 2019-06-20 | 4 | Freed Martin I | DRNA | Director Stock Option (right to buy) | D | 15,44 | 25.000 | 25.000 | |||||
| 2019-06-21 | 2019-06-20 | 4 | BUCHI J KEVIN | DRNA | Director Stock Option (right to buy) | D | 15,44 | 33.000 | 33.000 | |||||
| 2019-06-21 | 2019-06-20 | 4 | HOFFMAN STEPHEN J | DRNA | Director Stock Option (right to buy) | D | 15,44 | 25.000 | 25.000 | |||||
| 2019-06-21 | 2019-06-20 | 4 | LANGER DENNIS | DRNA | Director Stock Option (right to buy) | D | 15,44 | 25.000 | 25.000 | |||||
| 2019-06-21 | 2019-06-20 | 4 | Protopapas Anna | DRNA | Director Stock Option (right to buy) | D | 15,44 | 25.000 | 25.000 | |||||
| 2019-06-21 | 2019-06-20 | 4 | Koppel Adam | DRNA | Director Stock Option (right to buy) | D | 15,44 | 25.000 | 25.000 | |||||
| 2019-06-21 | 2019-06-20 | 4 | KOZIN MARC D | DRNA | Director Stock Option (right to buy) | D | 15,44 | 25.000 | 25.000 | |||||
| 2019-05-31 | 2019-05-29 | 4 | Bain Capital Life Sciences Investors, LLC See footnotes | DRNA | Common Stock | I | 12,5000 | -1.600.000 | -20.000 | 7.330.237 | ||||
| 2019-04-04 | 2019-04-02 | 4 | Weissman James B | DRNA | Employee Stock Option (Right to Buy) | D | 3,42 | -15.000 | 32.699 | |||||
| 2019-04-04 | 2019-04-02 | 4 | Weissman James B | DRNA | Common Stock | D | 15,0000 | -15.000 | -225 | 24.480 | ||||
| 2019-04-04 | 2019-04-02 | 4 | Weissman James B | DRNA | Common Stock | D | 3,4200 | 15.000 | 51 | 39.480 | ||||
| 2019-03-29 | 2019-03-28 | 4 | BUCHI J KEVIN | DRNA | Director Stock Option (Right to Buy) | D | 14,13 | 8.000 | 8.000 | |||||
| 2019-01-25 | 2019-01-23 | 4 | KOZIN MARC D | DRNA | Director Stock Option (Right to Buy) | D | 10,31 | 25.000 | 25.000 | |||||
| 2019-01-25 | 2019-01-23 | 4 | Protopapas Anna | DRNA | Director Stock Option (Right to Buy) | D | 10,31 | 25.000 | 25.000 | |||||
| 2019-01-25 | 3 | KOZIN MARC D By Marc D. Kozin Revocable Trust | DRNA | Common Stock | I | 10.000 | ||||||||
| 2019-01-25 | 3 | KOZIN MARC D By Marc D. Kozin Revocable Trust | DRNA | Common Stock | I | 10.000 | ||||||||
| 2019-01-25 | 3 | KOZIN MARC D By Marc D. Kozin Revocable Trust | DRNA | Common Stock | I | 10.000 | ||||||||
| 2019-01-04 | 2019-01-02 | 4 | ROSSKAMP RALF | DRNA | Employee Stock Option (Right to Buy) | D | 11,77 | 180.000 | 180.000 | |||||
| 2019-01-04 | 2019-01-02 | 4 | FAMBROUGH DOUGLAS | DRNA | Employee Stock Option (Right to Buy) | D | 11,77 | 505.000 | 505.000 | |||||
| 2019-01-04 | 2019-01-02 | 4 | Brown Bob D | DRNA | Employee Stock Option (Right to Buy) | D | 11,77 | 180.000 | 180.000 | |||||
| 2019-01-04 | 2019-01-02 | 4 | Weissman James B | DRNA | Employee Stock Option (Right to Buy) | D | 11,77 | 180.000 | 180.000 | |||||
| 2019-01-04 | 2019-01-02 | 4 | GREEN JOHN B | DRNA | Employee Stock Option (Right to Buy) | D | 11,77 | 180.000 | 180.000 | |||||
| 2018-11-09 | 2018-11-08 | 4 | Kolchinsky Peter See Note | DRNA | Common Stock | I | 14,8599 | -107.920 | -1.604 | 2.456.669 | ||||
| 2018-11-09 | 2018-11-07 | 4 | Kolchinsky Peter See Note | DRNA | Common Stock | I | 14,7402 | -250.000 | -3.685 | 2.564.589 | ||||
| 2018-11-06 | 2018-11-06 | 4 | Kolchinsky Peter See Note | DRNA | Common Stock | I | 13,8434 | -263.300 | -3.645 | 2.814.589 | ||||
| 2018-11-06 | 2018-11-05 | 4 | Kolchinsky Peter See Note | DRNA | Common Stock | I | 12,8880 | -71.400 | -920 | 3.077.889 | ||||
| 2018-11-06 | 2018-11-02 | 4 | Kolchinsky Peter See Note | DRNA | Common Stock | I | 13,4926 | -175.700 | -2.371 | 3.149.289 | ||||
| 2018-11-06 | 2018-11-06 | 4 | Halak Brian K By DP VIII Associates, L.P. | DRNA | Common Stock | I | 14,1600 | -11 | -0 | 19.150 | ||||
| 2018-11-06 | 2018-11-06 | 4 | Halak Brian K By Domain Partners VIII, L.P. | DRNA | Common Stock | I | 14,1600 | -1.489 | -21 | 2.586.535 | ||||
| 2018-11-06 | 2018-11-06 | 4 | Halak Brian K By DP VIII Associates, L.P. | DRNA | Common Stock | I | 13,1800 | -761 | -10 | 19.161 | ||||
| 2018-11-06 | 2018-11-06 | 4 | Halak Brian K By Domain Partners VIII, L.P. | DRNA | Common Stock | I | 13,1800 | -102.067 | -1.345 | 2.588.024 | ||||
| 2018-11-06 | 2018-11-05 | 4 | Halak Brian K By DP VIII Associates, L.P. | DRNA | Common Stock | I | 12,9800 | -295 | -4 | 19.922 | ||||
| 2018-11-06 | 2018-11-05 | 4 | Halak Brian K By Domain Partners VIII, L.P. | DRNA | Common Stock | I | 12,9800 | -39.606 | -514 | 2.690.091 | ||||
| 2018-11-06 | 2018-11-02 | 4 | Halak Brian K By DP VIII Associates, L.P. | DRNA | Common Stock | I | 13,4700 | -1.412 | -19 | 20.217 | ||||
| 2018-11-06 | 2018-11-02 | 4 | Halak Brian K By Domain Partners VIII, L.P. | DRNA | Common Stock | I | 13,4700 | -189.359 | -2.551 | 2.729.697 | ||||
| 2018-11-05 | 2018-11-01 | 4/A | Halak Brian K By DP VIII Associates, L.P. | DRNA | Common Stock | I | 13,3700 | -1.408 | -19 | 21.629 | ||||
| 2018-11-05 | 2018-11-01 | 4/A | Halak Brian K By Domain Partners VIII, L.P. | DRNA | Common Stock | I | 13,3700 | -188.867 | -2.525 | 2.919.056 | ||||
| 2018-11-05 | 2018-10-31 | 4/A | Halak Brian K By DP VIII Associates, L.P. | DRNA | Common Stock | I | 13,6000 | -959 | -13 | 23.037 | ||||
| 2018-11-05 | 2018-10-31 | 4/A | Halak Brian K By Domain Partners VIII, L.P. | DRNA | Common Stock | I | 13,6000 | -128.670 | -1.750 | 3.107.923 | ||||
| 2018-11-05 | 2018-10-30 | 4/A | Halak Brian K By DP VIII Associates, L.P. | DRNA | Common Stock | I | 14,3100 | -678 | -10 | 23.996 | ||||
| 2018-11-05 | 2018-10-30 | 4/A | Halak Brian K By Domain Partners VIII, L.P. | DRNA | Common Stock | I | 14,3100 | -90.918 | -1.301 | 3.236.593 | ||||
| 2018-11-05 | 2018-10-30 | 4/A | Halak Brian K By DP VIII Associates, L.P. | DRNA | Common Stock | I | 13,6800 | -1.136 | -16 | 24.674 | ||||
| 2018-11-05 | 2018-10-30 | 4/A | Halak Brian K By Domain Partners VIII, L.P. | DRNA | Common Stock | I | 13,6800 | -152.364 | -2.084 | 3.327.511 | ||||
| 2018-11-01 | 2018-11-01 | 4 | Kolchinsky Peter See Note | DRNA | Common Stock | I | 13,3757 | -180.100 | -2.409 | 3.324.989 | ||||
| 2018-11-01 | 2018-10-31 | 4 | Kolchinsky Peter See Note | DRNA | Common Stock | I | 13,4619 | -178.400 | -2.402 | 3.505.089 | ||||
| 2018-11-01 | 2018-10-30 | 4 | Kolchinsky Peter See Note | DRNA | Common Stock | I | 13,8603 | -250.000 | -3.465 | 3.683.489 | ||||
| 2018-11-01 | 2018-11-01 | 4 | Halak Brian K By DP VIII Associates, L.P. | DRNA | Common Stock | I | 13,3700 | -1.408 | -19 | 21.629 | ||||
| 2018-11-01 | 2018-11-01 | 4 | Halak Brian K By Domain Partners VIII, L.P. | DRNA | Common Stock | I | 13,3700 | -188.167 | -2.516 | 2.919.056 | ||||
| 2018-11-01 | 2018-10-31 | 4 | Halak Brian K By DP VIII Associates, L.P. | DRNA | Common Stock | I | 13,6000 | -959 | -13 | 23.037 | ||||
| 2018-11-01 | 2018-10-31 | 4 | Halak Brian K By Domain Partners VIII, L.P. | DRNA | Common Stock | I | 13,6000 | -128.670 | -1.750 | 3.107.923 | ||||
| 2018-11-01 | 2018-10-30 | 4 | Halak Brian K By DP VIII Associates, L.P. | DRNA | Common Stock | I | 14,3100 | -678 | -10 | 23.996 | ||||
| 2018-11-01 | 2018-10-30 | 4 | Halak Brian K By Domain Partners VIII, L.P. | DRNA | Common Stock | I | 14,3100 | -90.918 | -1.301 | 3.236.593 | ||||
| 2018-11-01 | 2018-10-30 | 4 | Halak Brian K By DP VIII Associates, L.P. | DRNA | Common Stock | I | 13,6800 | -1.136 | -16 | 24.674 | ||||
| 2018-11-01 | 2018-10-30 | 4 | Halak Brian K By Domain Partners VIII, L.P. | DRNA | Common Stock | I | 13,6800 | -152.364 | -2.084 | 3.327.511 | ||||
| 2018-09-06 | 2018-09-05 | 4 | Weissman James B | DRNA | Employee Stock Option (Right to Buy) | D | 3,42 | -2.301 | 47.699 | |||||
| 2018-09-06 | 2018-09-05 | 4 | Weissman James B | DRNA | Common Stock | D | 17,5000 | -2.301 | -40 | 24.480 | ||||
| 2018-09-06 | 2018-09-05 | 4 | Weissman James B | DRNA | Common Stock | D | 3,4200 | 2.301 | 8 | 26.781 | ||||
| 2018-08-20 | 2018-08-17 | 4 | Weissman James B | DRNA | Employee Stock Option (Right to Buy) | D | 3,42 | -14.680 | 64.104 | |||||
| 2018-08-20 | 2018-08-17 | 4 | Weissman James B | DRNA | Common Stock | D | 3,4200 | 14.680 | 50 | 24.480 | ||||
| 2018-08-17 | 2018-08-15 | 4 | LANGER DENNIS | DRNA | Common Stock | D | 16,0000 | -14.531 | -232 | 29.064 | ||||
| 2018-08-17 | 2018-08-15 | 4 | LANGER DENNIS Langer Family Holdings, LLLP | DRNA | Common Stock | I | 16,0000 | -23.810 | -381 | 47.978 | ||||
| 2018-08-15 | 2018-08-13 | 4 | Smith Cynthia | DRNA | Director Stock Option (Right to Buy) | D | 14,76 | 25.000 | 25.000 | |||||
| 2018-08-15 | 2018-08-13 | 4 | BUCHI J KEVIN | DRNA | Director Stock Option (Right to Buy) | D | 14,76 | 25.000 | 25.000 | |||||
| 2018-06-26 | 2018-06-21 | 4 | Wise Bart W | DRNA | Employee Stock Option (Right to Buy) | D | 13,08 | 25.000 | 25.000 | |||||
| 2018-06-26 | 3 | Wise Bart W | DRNA | Common Stock | D | 11.294 | ||||||||
| 2018-06-26 | 3 | Wise Bart W | DRNA | Common Stock | D | 11.294 | ||||||||
| 2018-06-26 | 3 | Wise Bart W | DRNA | Common Stock | D | 11.294 | ||||||||
| 2018-06-25 | 2018-06-21 | 4 | Freed Martin I | DRNA | Director Stock Option (Right to Buy) | D | 13,08 | 25.000 | 25.000 | |||||
| 2018-06-25 | 2018-06-21 | 4 | LANGER DENNIS | DRNA | Director Stock Option (right to buy) | D | 13,08 | 25.000 | 25.000 | |||||
| 2018-06-25 | 2018-06-21 | 4 | Kolchinsky Peter | DRNA | Director Stock Option (right to buy) | D | 13,08 | 25.000 | 25.000 | |||||
| 2018-06-25 | 2018-06-21 | 4 | HOFFMAN STEPHEN J | DRNA | Director Stock Option (right to buy) | D | 13,08 | 25.000 | 25.000 | |||||
| 2018-06-25 | 2018-06-21 | 4 | MADDEN DAVID | DRNA | Director Stock Option (right to buy) | D | 13,08 | 33.000 | 33.000 | |||||
| 2018-06-25 | 2018-06-21 | 4 | Halak Brian K | DRNA | Stock Option (Right to Buy) | D | 13,08 | 25.000 | 25.000 | |||||
| 2018-06-25 | 2018-06-21 | 4 | Koppel Adam | DRNA | Director Stock Option (right to buy) | D | 13,08 | 25.000 | 25.000 | |||||
| 2018-06-11 | 2018-06-07 | 4 | Halak Brian K By DP VIII Associates, L.P. | DRNA | Warrant to Purchase Common Stock | I | 7,00 | -156 | 0 | |||||
| 2018-06-11 | 2018-06-07 | 4 | Halak Brian K By Domain Partners VIII, L.P. | DRNA | Warrant to Purchase Common Stock | I | 7,00 | -21.041 | 0 | |||||
| 2018-06-11 | 2018-06-07 | 4 | Halak Brian K By DP VIII Associates, L.P. | DRNA | Common Stock | I | 14,4500 | -76 | -1 | 25.810 | ||||
| 2018-06-11 | 2018-06-07 | 4 | Halak Brian K By Domain Partners VIII, L.P. | DRNA | Common Stock | I | 14,4500 | -10.195 | -147 | 3.479.875 | ||||
| 2018-06-11 | 2018-06-07 | 4 | Halak Brian K By DP VIII Associates, L.P. | DRNA | Common Stock | I | 7,0000 | 156 | 1 | 25.886 | ||||
| 2018-06-11 | 2018-06-07 | 4 | Halak Brian K By Domain Partners VIII, L.P. | DRNA | Common Stock | I | 7,0000 | 21.041 | 147 | 3.490.070 | ||||
| 2018-05-11 | 2018-05-09 | 4 | Brown Bob D | DRNA | Common Stock | D | 15,0000 | -9.669 | -145 | 9.670 | ||||
| 2018-05-11 | 2018-05-09 | 4 | Weissman James B | DRNA | Employee Stock Option (Right to Buy) | D | 3,42 | -10.000 | 50.000 | |||||
| 2018-05-11 | 2018-05-09 | 4 | Weissman James B | DRNA | Common Stock | D | 15,0000 | -10.000 | -150 | 9.800 | ||||
| 2018-05-11 | 2018-05-09 | 4 | Weissman James B | DRNA | Common Stock | D | 3,4200 | 10.000 | 34 | 19.800 | ||||
| 2018-04-24 | 2018-04-20 | 4 | Weissman James B | DRNA | Common Stock | D | 13,0000 | -8.965 | -117 | 9.800 | ||||
| 2018-03-27 | 2018-03-23 | 4 | Kolchinsky Peter See Note | DRNA | Common Stock | I | 11,0511 | -55.300 | -611 | 3.933.489 | ||||
| 2018-03-21 | 2018-03-19 | 4 | Weissman James B | DRNA | Common Stock | D | 13,0000 | -1.035 | -13 | 18.765 | ||||
| 2018-03-21 | 2018-03-21 | 4 | Kolchinsky Peter See Note | DRNA | Common Stock | I | 11,1727 | -36.224 | -405 | 3.988.789 | ||||
| 2018-03-21 | 2018-03-21 | 4 | Kolchinsky Peter See Note | DRNA | Common Stock | I | 11,1400 | -49.000 | -546 | 4.025.013 | ||||
| 2018-03-21 | 2018-03-21 | 4 | Kolchinsky Peter See Note | DRNA | Common Stock | I | 11,0718 | -31.145 | -345 | 4.074.013 | ||||
| 2018-03-21 | 2018-03-21 | 4 | Kolchinsky Peter See Note | DRNA | Common Stock | I | 11,2399 | -64.600 | -726 | 4.105.158 | ||||
| 2018-03-21 | 2018-03-20 | 4 | Kolchinsky Peter See Note | DRNA | Common Stock | I | 11,1648 | -67.985 | -759 | 4.169.758 | ||||
| 2018-03-21 | 2018-03-20 | 4 | Kolchinsky Peter See Note | DRNA | Common Stock | I | 11,1555 | -55.200 | -616 | 4.237.743 | ||||
| 2018-03-21 | 2018-03-20 | 4 | Kolchinsky Peter See Note | DRNA | Common Stock | I | 11,0000 | -50.000 | -550 | 4.292.943 | ||||
| 2018-03-21 | 2018-03-19 | 4 | Kolchinsky Peter See Note | DRNA | Common Stock | I | 12,4550 | -34.700 | -432 | 4.342.943 | ||||
| 2018-03-21 | 2018-03-19 | 4 | Kolchinsky Peter See Note | DRNA | Common Stock | I | 12,6308 | -84.670 | -1.069 | 4.377.643 | ||||
| 2018-01-30 | 2018-01-26 | 4 | LANGER DENNIS Langer Family Holdings, LLLP | DRNA | Stock Option (Right to Buy) | I | 3,42 | -360 | 0 | |||||
| 2018-01-30 | 2018-01-26 | 4 | LANGER DENNIS Langer Family Holdings, LLLP | DRNA | Common Stock | I | 3,4200 | 360 | 1 | 71.788 | ||||
| 2018-01-19 | 2018-01-18 | 4 | Kolchinsky Peter See Note | DRNA | Common Stock | I | 9,2271 | -59.700 | -551 | 4.462.313 | ||||
| 2018-01-19 | 2018-01-17 | 4 | Kolchinsky Peter See Note | DRNA | Common Stock | I | 9,3254 | -220.900 | -2.060 | 4.522.013 | ||||
| 2018-01-08 | 2018-01-04 | 4 | Brown Bob D | DRNA | Employee Stock Option (Right to Buy) | D | 9,30 | 105.000 | 105.000 | |||||
| 2018-01-08 | 2018-01-04 | 4 | FAMBROUGH DOUGLAS | DRNA | Employee Stock Option (Right to Buy) | D | 9,30 | 255.000 | 255.000 | |||||
| 2018-01-08 | 2018-01-04 | 4 | Weissman James B | DRNA | Employee Stock Option (Right to Buy) | D | 9,30 | 105.000 | 105.000 | |||||
| 2018-01-08 | 2018-01-04 | 4 | GREEN JOHN B | DRNA | Employee Stock Option (Right to Buy) | D | 9,30 | 105.000 | 105.000 | |||||
| 2018-01-08 | 2018-01-04 | 4 | ROSSKAMP RALF | DRNA | Employee Stock Option (Right to Buy) | D | 9,30 | 57.750 | 57.750 | |||||
| 2018-01-08 | 2018-01-05 | 4 | Kolchinsky Peter See Note | DRNA | Common Stock | I | 9,1461 | -18.100 | -166 | 4.742.913 | ||||
| 2018-01-08 | 2018-01-04 | 4 | Kolchinsky Peter See Note | DRNA | Common Stock | I | 9,1978 | -77.400 | -712 | 4.761.013 | ||||
| 2018-01-03 | 2018-01-03 | 4 | Kolchinsky Peter See Note | DRNA | Common Stock | I | 9,2533 | -59.100 | -547 | 4.838.413 | ||||
| 2018-01-03 | 2018-01-02 | 4 | Kolchinsky Peter See Note | DRNA | Common Stock | I | 9,4655 | -68.000 | -644 | 4.897.513 | ||||
| 2018-01-03 | 2017-12-29 | 4 | Kolchinsky Peter See Note | DRNA | Common Stock | I | 9,1288 | -23.100 | -211 | 4.965.513 | ||||
| 2018-01-03 | 2017-12-29 | 4 | Kolchinsky Peter See Note | DRNA | Common Stock | I | 9,1026 | -85.400 | -777 | 4.988.613 | ||||
| 2017-12-20 | 2017-12-18 | 4 | RA CAPITAL MANAGEMENT, LLC See Note | DRNA | Redeemable Convertible Preferred Stock | I | 3,1900 | -76.500 | -244 | 0 | ||||
| 2017-12-20 | 2017-12-18 | 4 | RA CAPITAL MANAGEMENT, LLC See Note | DRNA | Common Stock | I | 2.645.442 | 5.074.013 | ||||||
| 2017-12-20 | 2017-12-18 | 4 | Kolchinsky Peter See Note | DRNA | Redeemable Convertible Preferred Stock | I | 3,1900 | -76.500 | -244 | 0 | ||||
| 2017-12-20 | 2017-12-18 | 4 | Kolchinsky Peter See Note | DRNA | Common Stock | I | 2.645.442 | 5.074.013 | ||||||
| 2017-12-20 | 2017-12-18 | 4 | Domain Partners VIII, L.P. | DRNA | Redeemable Convertible Preferred Stock | D | 3,19 | -49.632 | 0 | |||||
| 2017-12-20 | 2017-12-18 | 4 | Domain Partners VIII, L.P. | DRNA | Common Stock | D | 37.890 | 3.469.029 | ||||||
| 2017-12-20 | 2017-12-18 | 4 | Domain Partners VIII, L.P. | DRNA | Common Stock | D | 3,1900 | 1.678.432 | 5.354 | 3.431.139 | ||||
| 2017-12-20 | 2017-12-18 | 4 | DP VIII Associates, L.P. | DRNA | Redeemable Convertible Preferred Stock | D | 3,19 | -368 | 0 | |||||
| 2017-12-20 | 2017-12-18 | 4 | DP VIII Associates, L.P. | DRNA | Common Stock | D | 282 | 25.730 | ||||||
| 2017-12-20 | 2017-12-18 | 4 | DP VIII Associates, L.P. | DRNA | Common Stock | D | 3,1900 | 12.444 | 40 | 25.448 | ||||
| 2017-12-19 | 2017-12-18 | 4 | Bain Capital Life Sciences Investors, LLC See footnotes | DRNA | Redeemable Convertible Preferred Stock | I | 3,1900 | -250.000 | -798 | 0 | ||||
| 2017-12-19 | 2017-12-18 | 4 | Bain Capital Life Sciences Investors, LLC See footnotes | DRNA | Common Stock | I | 190.849 | 8.930.237 | ||||||
| 2017-12-19 | 2017-12-18 | 4 | Bain Capital Life Sciences Investors, LLC See footnotes | DRNA | Common Stock | I | 8.454.388 | 8.739.388 | ||||||
| 2017-12-19 | 2017-12-18 | 4 | Bain Capital Life Sciences Investors, LLC See footnotes | DRNA | Common Stock | I | 7,0000 | 285.000 | 1.995 | 285.000 | ||||
| 2017-07-24 | 2017-07-18 | 4 | HOFFMAN STEPHEN J | DRNA | Director Stock Option (right to buy) | D | 3,42 | 25.000 | 25.000 | |||||
| 2017-07-20 | 2017-07-18 | 4 | Kolchinsky Peter | DRNA | Director Stock Option (right to buy) | D | 3,42 | 25.000 | 25.000 | |||||
| 2017-07-20 | 2017-07-18 | 4 | PEACOCK BRUCE | DRNA | Director Stock Option (right to buy) | D | 3,42 | 25.000 | 25.000 | |||||
| 2017-07-20 | 2017-07-18 | 4 | LANGER DENNIS | DRNA | Director Stock Option (right to buy) | D | 3,42 | 25.000 | 25.000 | |||||
| 2017-07-20 | 2017-07-18 | 4 | Freed Martin I | DRNA | Director Stock Option (Right to Buy) | D | 3,42 | 25.000 | 25.000 | |||||
| 2017-07-20 | 2017-07-18 | 4 | MADDEN DAVID | DRNA | Director Stock Option (right to buy) | D | 3,42 | 33.000 | 33.000 | |||||
| 2017-07-20 | 2017-07-18 | 4 | Koppel Adam | DRNA | Director Stock Option (right to buy) | D | 3,42 | 25.000 | 25.000 | |||||
| 2017-07-20 | 2017-07-18 | 4 | Halak Brian K | DRNA | Stock Option (Right to Buy) | D | 3,42 | 25.000 | 25.000 | |||||
| 2017-06-16 | 2017-06-15 | 4 | ROSSKAMP RALF | DRNA | Employee Stock Option (Right to Buy) | D | 2,91 | 250.000 | 250.000 | |||||
| 2017-04-13 | 2017-04-11 | 4 | Koppel Adam | DRNA | Employee Stock Option (Right to buy) | D | 3,47 | 25.000 | 25.000 | |||||
| 2017-04-13 | 2017-04-11 | 4 | RA CAPITAL MANAGEMENT, LLC See Note 1 | DRNA | Redeemable Convertible Preferred Stock | I | 3,19 | 100,0000 | 76.500 | 7.650 | 76.500 | |||
| 2017-04-12 | 2017-04-11 | 4 | DP VIII Associates, L.P. | DRNA | Redeemable Convertible Preferred Stock | D | 3,19 | 100,0000 | 368 | 37 | 368 | |||
| 2017-04-12 | 2017-04-11 | 4 | Domain Partners VIII, L.P. | DRNA | Redeemable Convertible Preferred Stock | D | 3,19 | 100,0000 | 49.632 | 4.963 | 49.632 | |||
| 2017-01-05 | 2017-01-03 | 4 | GREEN JOHN B | DRNA | Employee Stock Option (Right to Buy) | D | 2,97 | 75.000 | 75.000 | |||||
| 2017-01-05 | 2017-01-03 | 4 | FAMBROUGH DOUGLAS | DRNA | Employee Stock Option (Right to Buy) | D | 2,97 | 225.000 | 225.000 | |||||
| 2017-01-05 | 2017-01-03 | 4 | Brown Bob D | DRNA | Employee Stock Option (Right to Buy | D | 2,97 | 75.000 | 75.000 | |||||
| 2017-01-05 | 2017-01-03 | 4 | Weissman James B | DRNA | Employee Stock Option (Right to Buy) | D | 2,97 | 75.000 | 75.000 | |||||
| 2016-11-17 | 2016-11-16 | 4 | LANGER DENNIS Langer Family Holdings, LLLP | DRNA | Common Stock | I | 3,5200 | -23.766 | -84 | 71.428 | ||||
| 2016-11-16 | 2016-11-15 | 4 | FAMBROUGH DOUGLAS | DRNA | Common Stock | D | 3,6300 | 16.500 | 60 | 55.579 | ||||
| 2016-11-16 | 2016-11-14 | 4 | FAMBROUGH DOUGLAS | DRNA | Common Stock | D | 3,7800 | 16.600 | 63 | 39.079 | ||||
| 2016-06-16 | 2016-06-14 | 4 | Halak Brian K | DRNA | Stock Option (Right to Buy) | D | 3,26 | 15.000 | 15.000 | |||||
| 2016-06-15 | 2016-06-14 | 4 | PEACOCK BRUCE | DRNA | Director Stock Option (right to buy) | D | 3,26 | 15.000 | 15.000 | |||||
| 2016-06-15 | 2016-06-14 | 4 | HOFFMAN STEPHEN J | DRNA | Director Stock Option (right to buy) | D | 3,26 | 15.000 | 15.000 | |||||
| 2016-06-15 | 2016-06-14 | 4 | LANGER DENNIS | DRNA | Director Stock Option (right to buy) | D | 3,26 | 15.000 | 15.000 | |||||
| 2016-06-15 | 2016-06-14 | 4 | MADDEN DAVID | DRNA | Director Stock Option (right to buy) | D | 3,26 | 20.000 | 20.000 | |||||
| 2016-06-15 | 2016-06-14 | 4 | Kolchinsky Peter | DRNA | Director Stock Option (right to buy) | D | 3,26 | 15.000 | 15.000 | |||||
| 2016-06-15 | 2016-06-14 | 4 | Freed Martin I | DRNA | Employee Stock Option (Right to Buy) | D | 3,26 | 25.000 | 25.000 | |||||
| 2016-05-16 | 2016-05-12 | 4 | Weissman James B | DRNA | Common Stock | D | 3,2899 | 4.170 | 14 | 19.800 | ||||
| 2016-05-16 | 2016-05-12 | 4 | Weissman James B | DRNA | Common Stock | D | 3,2897 | 530 | 2 | 15.630 | ||||
| 2016-05-16 | 2016-05-12 | 4 | Weissman James B | DRNA | Common Stock | D | 3,2399 | 300 | 1 | 15.100 | ||||
| 2016-04-18 | 2016-04-14 | 4 | GREEN JOHN B | DRNA | Employee Stock Option (Right to Buy) | D | 5,45 | 265.000 | 265.000 | |||||
| 2016-02-05 | 2016-02-03 | 4 | LANGER DENNIS | DRNA | Employee Stock Option (Right to Buy) | D | 3,42 | -34.722 | 6.945 | |||||
| 2016-02-05 | 2016-02-03 | 4 | LANGER DENNIS | DRNA | Common Stock | D | 3,4200 | 34.722 | 119 | 43.595 | ||||
| 2016-01-12 | 2016-01-08 | 4 | FAMBROUGH DOUGLAS | DRNA | Employee Stock Option (Right to Buy) | D | 9,09 | 225.000 | 225.000 | |||||
| 2016-01-12 | 2016-01-08 | 4 | Ashburn Theodore | DRNA | Employee Stock Option (Right to Buy) | D | 9,09 | -75.000 | 75.000 | |||||
| 2016-01-12 | 2016-01-08 | 4 | Bhargava Pankaj | DRNA | Employee Stock Option (Right to Buy) | D | 9,09 | 75.000 | 75.000 | |||||
| 2016-01-12 | 2016-01-08 | 4 | Weissman James B | DRNA | Employee Stock Option (Right to Buy) | D | 9,09 | 75.000 | 75.000 | |||||
| 2016-01-12 | 2016-01-08 | 4 | Brown Bob D | DRNA | Employee Stock Option (Right to Buy) | D | 9,09 | 125.000 | 125.000 | |||||
| 2015-06-29 | 2015-06-25 | 4 | Halak Brian K | DRNA | Stock Option (Right to Buy) | D | 13,87 | 15.000 | 15.000 | |||||
| 2015-06-29 | 2015-06-25 | 4 | Kolchinsky Peter | DRNA | Director Stock Option (right to buy) | D | 13,87 | 15.000 | 15.000 | |||||
| 2015-06-29 | 2015-06-25 | 4 | HOFFMAN STEPHEN J | DRNA | Director Stock Option (right to buy) | D | 13,87 | 15.000 | 15.000 | |||||
| 2015-06-26 | 2015-06-25 | 4 | LANGER DENNIS | DRNA | Director Stock Option (right to buy) | D | 13,87 | 15.000 | 15.000 | |||||
| 2015-06-26 | 2015-06-25 | 4 | MADDEN DAVID | DRNA | Director Stock Option (right to buy) | D | 13,87 | 20.000 | 20.000 | |||||
| 2015-06-26 | 2015-06-25 | 4 | PEACOCK BRUCE | DRNA | Director Stock Option (right to buy) | D | 13,87 | 15.000 | 15.000 | |||||
| 2015-02-24 | 2015-02-20 | 4 | Skyline Venture Partners V LP | DRNA | Common Stock | I | 26,0200 | -37.532 | -977 | 1.719.671 | ||||
| 2015-01-13 | 2015-01-09 | 4 | Brown Bob D | DRNA | Employee Stock Option (Right to Buy) | D | 18,50 | 75.000 | 75.000 | |||||
| 2015-01-13 | 2015-01-09 | 4 | FAMBROUGH DOUGLAS | DRNA | Employee Stock Option (Right to Buy) | D | 18,50 | 225.000 | 225.000 | |||||
| 2015-01-13 | 2015-01-09 | 4 | Ashburn Theodore | DRNA | Employee Stock Option (Right to Buy) | D | 18,50 | 3.333 | 3.333 | |||||
| 2015-01-13 | 2015-01-09 | 4 | Dentzer James E | DRNA | Employee Stock Option (Right to Buy) | D | 18,50 | 75.000 | 75.000 | |||||
| 2015-01-13 | 2015-01-09 | 4 | Bhargava Pankaj | DRNA | Employee Stock Option (Right to Buy) | D | 18,50 | 56.250 | 56.250 | |||||
| 2015-01-13 | 2015-01-09 | 4 | Weissman James B | DRNA | Employee Stock Option (Right to Buy) | D | 18,50 | 75.000 | 75.000 | |||||
| 2014-12-19 | 2014-12-17 | 4 | FAMBROUGH DOUGLAS | DRNA | Employee Stock Option (Right to Buy) | D | 3,42 | -1.450 | 0 | |||||
| 2014-12-19 | 2014-12-17 | 4 | FAMBROUGH DOUGLAS | DRNA | Employee Stock Option (Right to Buy) | D | 3,42 | -1.050 | 0 | |||||
| 2014-12-19 | 2014-12-17 | 4 | FAMBROUGH DOUGLAS | DRNA | Common Stock | D | 3,4200 | 2.500 | 9 | 19.800 | ||||
| 2014-12-16 | 2014-12-15 | 4 | Ashburn Theodore | DRNA | Employee Stock Option (Right to Buy) | D | 13,08 | 115.000 | 115.000 | |||||
| 2014-12-16 | 2014-12-15 | 4 | Ashburn Theodore | DRNA | Employee Stock Option (Right to Buy) | D | 13,08 | 115.000 | 115.000 | |||||
| 2014-12-16 | 3 | Ashburn Theodore | DRNA | No securities are beneficially owned | D | 0 | ||||||||
| 2014-12-11 | 2014-12-09 | 4 | PEACOCK BRUCE | DRNA | Director Stock Option (right to buy) | D | 11,04 | 25.000 | 25.000 | |||||
| 2014-11-25 | 2014-11-25 | 4 | Flynn James E Through Deerfield Private Design International II, L.P. | DRNA | Common Stock | I | 11,5000 | -55.035 | -633 | 800.794 | ||||
| 2014-11-25 | 2014-11-25 | 4 | Flynn James E Through Deerfield Private Design Fund II, L.P. | DRNA | Common Stock | I | 11,5000 | -48.027 | -552 | 698.822 | ||||
| 2014-11-25 | 2014-11-25 | 4 | Flynn James E Through Deerfield Special Situations Fund, L.P. | DRNA | Common Stock | I | 11,5000 | -18.903 | -217 | 275.046 | ||||
| 2014-11-25 | 2014-11-24 | 4 | Flynn James E Through Deerfield Private Design International II, L.P. | DRNA | Common Stock | I | 11,5400 | -3.785 | -44 | 855.829 | ||||
| 2014-11-25 | 2014-11-24 | 4 | Flynn James E Through Deerfield Private Design Fund II, L.P. | DRNA | Common Stock | I | 11,5400 | -3.303 | -38 | 746.849 | ||||
| 2014-11-25 | 2014-11-24 | 4 | Flynn James E Through Deerfield Special Situations Fund, L.P. | DRNA | Common Stock | I | 11,5500 | -14.199 | -164 | 293.949 | ||||
| 2014-11-25 | 2014-11-24 | 4 | Flynn James E Through Deerfield Private Design International II, L.P. | DRNA | Common Stock | I | 11,5500 | -41.339 | -477 | 859.614 | ||||
| 2014-11-25 | 2014-11-24 | 4 | Flynn James E Through Deerfield Private Design Fund II, L.P. | DRNA | Common Stock | I | 11,5500 | -36.074 | -417 | 750.152 | ||||
| 2014-11-25 | 2014-11-24 | 4 | Flynn James E Through Deerfield Special Situations Fund, L.P. | DRNA | Common Stock | I | 11,5400 | -1.300 | -15 | 308.148 | ||||
| 2014-11-25 | 2014-11-21 | 4 | Flynn James E Through Deerfield Private Design International II, L.P. | DRNA | Common Stock | I | 11,0000 | -45.124 | -496 | 900.953 | ||||
| 2014-11-25 | 2014-11-21 | 4 | Flynn James E Through Deerfield Private Design Fund II, L.P. | DRNA | Common Stock | I | 11,0000 | -39.377 | -433 | 786.226 | ||||
| 2014-11-25 | 2014-11-21 | 4 | Flynn James E Through Deerfield Special Situations Fund, L.P. | DRNA | Common Stock | I | 11,0000 | -15.499 | -170 | 309.448 | ||||
| 2014-11-10 | 2014-11-07 | 4 | Flynn James E Through Deerfield Special Situations International Master Fund, L.P. | DRNA | Common Stock | I | 9,3300 | -30.100 | -281 | 0 | ||||
| 2014-11-10 | 2014-11-07 | 4 | Flynn James E Through Deerfield Special Situations International Master Fund, L.P. | DRNA | Common Stock | I | 9,2700 | -3.500 | -32 | 30.100 | ||||
| 2014-11-10 | 2014-11-07 | 4 | Flynn James E Through Deerfield Special Situations International Master Fund, L.P. | DRNA | Common Stock | I | 9,0000 | -180.564 | -1.625 | 33.600 | ||||
| 2014-10-15 | 2014-10-15 | 4 | Flynn James E Through Deerfield Special Situations International Master Fund, L.P. | DRNA | Common Stock | I | 10,0100 | -51.449 | -515 | 214.164 | ||||
| 2014-10-15 | 2014-10-14 | 4 | Flynn James E Through Deerfield Private Design International II, L.P. | DRNA | Common Stock | I | 11,0200 | -14.464 | -159 | 946.077 | ||||
| 2014-10-15 | 2014-10-14 | 4 | Flynn James E Through Deerfield Private Design Fund II, L.P. | DRNA | Common Stock | I | 11,0200 | -12.622 | -139 | 825.603 | ||||
| 2014-10-15 | 2014-10-14 | 4 | Flynn James E Through Deerfield Special Situations International Master Fund, L.P. | DRNA | Common Stock | I | 11,0200 | -4.061 | -45 | 265.613 | ||||
| 2014-10-15 | 2014-10-14 | 4 | Flynn James E Through Deerfield Special Situations Fund, L.P. | DRNA | Common Stock | I | 11,0200 | -4.968 | -55 | 324.947 | ||||
| 2014-10-15 | 2014-10-10 | 4 | Flynn James E Through Deerfield Private Design International II, L.P. | DRNA | Common Stock | I | 12,0020 | -246 | -3 | 960.541 | ||||
| 2014-10-15 | 2014-10-10 | 4 | Flynn James E Through Deerfield Private Design Fund II, L.P. | DRNA | Common Stock | I | 12,0020 | -215 | -3 | 838.225 | ||||
| 2014-10-15 | 2014-10-10 | 4 | Flynn James E Through Deerfield Special Situations International Master Fund, L.P. | DRNA | Common Stock | I | 12,0020 | -69 | -1 | 269.674 | ||||
| 2014-10-15 | 2014-10-10 | 4 | Flynn James E Through Deerfield Special Situations Fund, L.P. | DRNA | Common Stock | I | 12,0020 | -84 | -1 | 330 | ||||
| 2014-10-15 | 2014-10-10 | 4 | Flynn James E Through Deerfield Private Design International II, L.P. | DRNA | Common Stock | I | 12,1350 | -11.855 | -144 | 960.787 | ||||
| 2014-10-15 | 2014-10-10 | 4 | Flynn James E Through Deerfield Private Design Fund II, L.P. | DRNA | Common Stock | I | 12,1350 | -10.345 | -126 | 838.440 | ||||
| 2014-10-15 | 2014-10-10 | 4 | Flynn James E Through Deerfield Special Situations International Master Fund, L.P. | DRNA | Common Stock | I | 12,1350 | -3.328 | -40 | 269.743 | ||||
| 2014-10-15 | 2014-10-10 | 4 | Flynn James E Through Deerfield Special Situations Fund, L.P. | DRNA | Common Stock | I | 12,1350 | -4.072 | -49 | 329.999 | ||||
| 2014-06-24 | 2014-06-18 | 4 | HOFFMAN STEPHEN J | DRNA | Director Stock Option (right to buy) | D | 18,73 | 15.000 | 15.000 | |||||
| 2014-06-23 | 2014-06-18 | 4 | Kolchinsky Peter | DRNA | Director Stock Option (right to buy) | D | 18,73 | 15.000 | 15.000 | |||||
| 2014-06-23 | 2014-06-18 | 4 | Miles Vincent J | DRNA | Director Stock Option (right to buy) | D | 18,73 | 15.000 | 15.000 | |||||
| 2014-06-20 | 2014-06-18 | 4 | Halak Brian K | DRNA | Stock Option (Right to Buy) | D | 18,73 | 15.000 | 15.000 | |||||
| 2014-06-20 | 2014-06-18 | 4 | MADDEN DAVID | DRNA | Director Stock Option (right to buy) | D | 18,73 | 20.000 | 20.000 | |||||
| 2014-06-20 | 2014-06-18 | 4 | LANGER DENNIS | DRNA | Director Stock Option (right to buy) | D | 18,73 | 15.000 | 15.000 | |||||
| 2014-05-08 | 2014-04-16 | 4/A | Kolchinsky Peter | DRNA | Director Stock Option (right to buy) | D | 16,30 | 25.000 | 25.000 | |||||
| 2014-04-30 | 2014-04-16 | 4/A | Halak Brian K | DRNA | Stock Option (Right to Buy) | D | 16,30 | 25.000 | 25.000 | |||||
| 2014-04-21 | 2014-02-04 | 4/A | LANGER DENNIS Langer Family Holdings, LLLP | DRNA | Series C Preferred | I | -71.428 | 0 | ||||||
| 2014-04-21 | 2014-02-04 | 4/A | LANGER DENNIS Langer Family Holdings, LLLP | DRNA | Series B Preferred | I | -8.586 | 0 | ||||||
| 2014-04-21 | 2014-02-04 | 4/A | LANGER DENNIS Langer Family Holdings, LLLP | DRNA | Series A Preferred | I | -15.000 | 0 | ||||||
| 2014-04-21 | 2014-02-04 | 4/A | LANGER DENNIS Langer Family Holdings, LLLP | DRNA | Common Stock | I | 95.014 | 95.194 | ||||||
| 2014-04-21 | 2014-04-16 | 4 | RA CAPITAL MANAGEMENT, LLC See Footnotes | DRNA | Director Stock Option (right to buy) | I | 16,30 | 25.000 | 25.000 | |||||
| 2014-04-18 | 2014-04-16 | 4 | Halak Brian K | DRNA | Stock Option (Right to Buy) | D | 16,30 | 25.000 | 25.000 | |||||
| 2014-04-18 | 2014-04-16 | 4 | LANGER DENNIS | DRNA | Director Stock Option (right to buy) | D | 16,30 | 25.000 | 25.000 | |||||
| 2014-04-18 | 2014-04-16 | 4 | HOFFMAN STEPHEN J | DRNA | Director Stock Option (right to buy) | D | 16,30 | 25.000 | 25.000 | |||||
| 2014-04-18 | 2014-04-16 | 4 | FAMBROUGH DOUGLAS | DRNA | Employee Stock Option (right to buy) | D | 16,30 | 471.900 | 471.900 | |||||
| 2014-04-18 | 2014-04-16 | 4 | Miles Vincent J See footnotes | DRNA | Director Stock Option (right to buy | I | 16,30 | 25.000 | 25.000 | |||||
| 2014-04-18 | 2014-04-16 | 4 | MADDEN DAVID | DRNA | Director Stock Option (right to buy) | D | 16,30 | 30.000 | 30.000 | |||||
| 2014-04-18 | 2014-04-16 | 4 | Dentzer James E | DRNA | Employee Stock Option (right to buy) | D | 16,30 | 108.750 | 108.750 | |||||
| 2014-04-18 | 2014-04-16 | 4 | Brown Bob D | DRNA | Employee Stock Option (right to buy) | D | 16,30 | 165.050 | 165.050 | |||||
| 2014-04-18 | 2014-04-16 | 4 | Weissman James B | DRNA | Employee Stock Option (right to buy) | D | 16,30 | 111.800 | 111.800 | |||||
| 2014-04-18 | 2014-04-16 | 4 | Bhargava Pankaj | DRNA | Employee Stock Option (right to buy) | D | 16,30 | 264.808 | 264.808 | |||||
| 2014-04-11 | 2014-03-18 | 4 | Bain Capital Public Equity Management, LLC | DRNA | Common Stock | I | 38,6200 | -14.937 | -577 | 1.550.862 | ||||
| 2014-04-11 | 2014-03-18 | 4 | Bain Capital Public Equity Management, LLC | DRNA | Common Stock | I | 37,7500 | -250.000 | -9.438 | 1.565.799 | ||||
| 2014-04-11 | 2014-03-17 | 4 | Bain Capital Public Equity Management, LLC | DRNA | Common Stock | I | 36,5000 | -9.301 | -339 | 1.815.799 | ||||
| 2014-04-11 | 2014-03-14 | 4 | Bain Capital Public Equity Management, LLC | DRNA | Common Stock | I | 35,5000 | -200.000 | -7.100 | 1.825.100 | ||||
| 2014-04-11 | 2014-03-14 | 4 | Bain Capital Public Equity Management, LLC | DRNA | Common Stock | I | 35,3300 | -50.400 | -1.781 | 2.025.100 | ||||
| 2014-04-11 | 2014-03-12 | 4 | Bain Capital Public Equity Management, LLC | DRNA | Common Stock | I | 37,7700 | -1.500 | -57 | 2.075.500 | ||||
| 2014-04-11 | 2014-03-11 | 4 | Bain Capital Public Equity Management, LLC | DRNA | Common Stock | I | 38,3700 | -2.900 | -111 | 2.077.000 | ||||
| 2014-04-11 | 2014-03-11 | 4 | Bain Capital Public Equity Management, LLC | DRNA | Common Stock | I | 38,0000 | -257.100 | -9.770 | 2.079.900 | ||||
| 2014-04-03 | 3 | Bhargava Pankaj | DRNA | No securities are beneficially owned | D | 0 | ||||||||
| 2014-02-20 | 2014-01-29 | 4/A | LANGER DENNIS Langer Family Holdings, LLP | DRNA | Series C Preferred | I | -71.428 | 0 | ||||||
| 2014-02-20 | 2014-01-29 | 4/A | LANGER DENNIS Langer Family Holdings, LLP | DRNA | Series B Preferred | I | -8.586 | 0 | ||||||
| 2014-02-20 | 2014-01-29 | 4/A | LANGER DENNIS Langer Family Holdings, LLP | DRNA | Series A Preferred | I | -10.000 | 0 | ||||||
| 2014-02-20 | 2014-01-29 | 4/A | LANGER DENNIS Langer Family Holdings, LLP | DRNA | Common Stock | I | 90.014 | 90.014 | ||||||
| 2014-02-20 | 2014-01-27 | 4/A | LANGER DENNIS | DRNA | Employee Stock Option (right to buy) | D | 3,42 | -540 | 0 | |||||
| 2014-02-20 | 2014-01-27 | 4/A | LANGER DENNIS | DRNA | Employee Stock Option (right to buy) | D | 3,42 | -8.333 | 41.667 | |||||
| 2014-02-20 | 2014-01-27 | 4/A | LANGER DENNIS | DRNA | Common Stock | D | 3,4200 | 8.873 | 30 | 8.873 | ||||
| 2014-02-20 | 2013-09-24 | 4/A | LANGER DENNIS | DRNA | Employee Stock Option (right to buy) | D | 3,42 | 50.000 | 50.000 | |||||
| 2014-02-20 | 2014-01-29 | 4 | FAMBROUGH DOUGLAS | DRNA | Common Stock | D | 15,0000 | 5.000 | 75 | 17.300 | ||||
| 2014-02-20 | 2013-11-11 | 4 | FAMBROUGH DOUGLAS | DRNA | Employee Stock Option (right to buy) | D | 3,42 | -4.350 | 1.450 | |||||
| 2014-02-20 | 2013-11-11 | 4 | FAMBROUGH DOUGLAS | DRNA | Employee Stock Option (right to buy) | D | 3,42 | -4.950 | 1.050 | |||||
| 2014-02-20 | 2013-11-11 | 4 | FAMBROUGH DOUGLAS | DRNA | Common Stock | D | 3,4200 | 9.300 | 32 | 12.300 | ||||
| 2014-02-20 | 2013-09-24 | 4 | FAMBROUGH DOUGLAS | DRNA | Employee Stock Option (right to buy) | D | 3,42 | 281.250 | 281.250 | |||||
| 2014-02-20 | 2013-09-24 | 4 | FAMBROUGH DOUGLAS | DRNA | Employee Stock Option (right to buy) | D | 3,42 | 281.250 | 281.250 | |||||
| 2014-02-20 | 2014-01-29 | 4 | MADDEN DAVID | DRNA | Common Stock | D | 15,0000 | 7.500 | 112 | 120.011 | ||||
| 2014-02-20 | 2014-01-24 | 4 | MADDEN DAVID | DRNA | Employee Stock Option (right to buy) | D | 3,42 | -110.000 | 0 | |||||
| 2014-02-20 | 2014-01-24 | 4 | MADDEN DAVID | DRNA | Employee Stock Option (right to buy) | D | 3,42 | -1.311 | 0 | |||||
| 2014-02-20 | 2014-01-24 | 4 | MADDEN DAVID | DRNA | Employee Stock Option (right to buy) | D | 3,42 | -1.200 | 0 | |||||
| 2014-02-20 | 2014-01-24 | 4 | MADDEN DAVID | DRNA | Common Stock | D | 3,4200 | 112.511 | 385 | 112.511 | ||||
| 2014-02-20 | 2013-09-24 | 4 | MADDEN DAVID | DRNA | Employee Stock Option (right to buy) | D | 3,42 | 110.000 | 110.000 | |||||
| 2014-02-20 | 2014-01-29 | 4 | Weissman James B | DRNA | Common Stock | D | 15,0000 | 1.000 | 15 | 13.116 | ||||
| 2014-02-20 | 2014-01-27 | 4 | Weissman James B | DRNA | Employee Stock Option (right to buy) | D | 3,42 | -67 | 800 | |||||
| 2014-02-20 | 2014-01-27 | 4 | Weissman James B | DRNA | Employee Stock Option (right to buy) | D | 3,42 | -11.216 | 78.784 | |||||
| 2014-02-20 | 2014-01-27 | 4 | Weissman James B | DRNA | Common Stock | D | 3,2400 | 11.283 | 37 | 12.116 | ||||
| 2014-02-20 | 2013-11-11 | 4 | Weissman James B | DRNA | Employee Stock Option (right to buy) | D | 3,42 | -100 | 1.500 | |||||
| 2014-02-20 | 2013-11-11 | 4 | Weissman James B | DRNA | Employee Stock Option (right to buy) | D | 3,42 | -733 | 867 | |||||
| 2014-02-20 | 2013-11-05 | 4 | Weissman James B | DRNA | Common Stock | D | 3,4200 | 833 | 3 | 833 | ||||
| 2014-02-20 | 2013-09-24 | 4 | Weissman James B | DRNA | Employee Stock Option (right to buy) | D | 3,42 | 90.000 | 90.000 | |||||
| 2014-02-20 | 2013-09-24 | 4 | Weissman James B | DRNA | Employee Stock Option (right to buy) | D | 3,42 | 60.000 | 60.000 | |||||
| 2014-02-05 | 2014-02-04 | 4 | HOFFMAN STEPHEN J | DRNA | Common Stock Warrant (right to buy) | I | 7,00 | 21.697 | 21.697 | |||||
| 2014-02-05 | 2014-02-04 | 4 | HOFFMAN STEPHEN J | DRNA | Series C Preferred Stock Warrants | I | 7,00 | -21.697 | 0 | |||||
| 2014-02-05 | 2014-02-04 | 4 | HOFFMAN STEPHEN J | DRNA | Common Stock Warrant | I | 250,00 | 755 | 755 | |||||
| 2014-02-05 | 2014-02-04 | 4 | HOFFMAN STEPHEN J | DRNA | Series C Preferred Stock | I | -1.043.429 | 0 | ||||||
| 2014-02-05 | 2014-02-04 | 4 | HOFFMAN STEPHEN J | DRNA | Series B Preferred Stock | I | -179.322 | 0 | ||||||
| 2014-02-05 | 2014-02-04 | 4 | HOFFMAN STEPHEN J | DRNA | Series A Preferred Stock | I | -312.000 | 0 | ||||||
| 2014-02-05 | 2014-02-04 | 4 | HOFFMAN STEPHEN J | DRNA | Common Stock | I | 15,0000 | 200.000 | 3.000 | 1.734.751 | ||||
| 2014-02-05 | 2014-02-04 | 4 | HOFFMAN STEPHEN J | DRNA | Common Stock | I | 1.043.429 | 1.534.751 | ||||||
| 2014-02-05 | 2014-02-04 | 4 | HOFFMAN STEPHEN J | DRNA | Common Stock | I | 179.322 | 491.322 | ||||||
| 2014-02-05 | 2014-02-04 | 4 | HOFFMAN STEPHEN J | DRNA | Common Stock | I | 312.000 | 312.000 | ||||||
| 2014-02-05 | 2014-02-04 | 4 | RA CAPITAL MANAGEMENT, LLC | DRNA | Series C Preferred Stock, par value $0.0001 | D | -1.428.571 | 0 | ||||||
| 2014-02-05 | 2014-02-04 | 4 | RA CAPITAL MANAGEMENT, LLC See Footnotes | DRNA | Common Stock, par value $0.0001 per share | I | 15,0000 | 1.000.000 | 15.000 | 2.428.571 | ||||
| 2014-02-05 | 2014-02-04 | 4 | RA CAPITAL MANAGEMENT, LLC See Footnotes | DRNA | Common Stock, par value $0.0001 per share | I | 1.428.571 | 1.428.571 | ||||||
| 2014-02-05 | 2014-02-04 | 4 | Skyline Venture Partners V LP | DRNA | Common Stock Warrant (right to buy) | I | 7,00 | 21.697 | 21.697 | |||||
| 2014-02-05 | 2014-02-04 | 4 | Skyline Venture Partners V LP | DRNA | Series C Preferred Stock Warrants | I | 7,00 | -21.697 | 0 | |||||
| 2014-02-05 | 2014-02-04 | 4 | Skyline Venture Partners V LP | DRNA | Common Stock Warrant | I | 250,00 | 755 | 755 | |||||
| 2014-02-05 | 2014-02-04 | 4 | Skyline Venture Partners V LP | DRNA | Series C Preferred Stock | I | -1.043.429 | 0 | ||||||
| 2014-02-05 | 2014-02-04 | 4 | Skyline Venture Partners V LP | DRNA | Series B Preferred Stock | I | -179.322 | 0 | ||||||
| 2014-02-05 | 2014-02-04 | 4 | Skyline Venture Partners V LP | DRNA | Series A Preferred Stock | I | -312.000 | 0 | ||||||
| 2014-02-05 | 2014-02-04 | 4 | Skyline Venture Partners V LP | DRNA | Common Stock | I | 15,0000 | 200.000 | 3.000 | 1.734.751 | ||||
| 2014-02-05 | 2014-02-04 | 4 | Skyline Venture Partners V LP | DRNA | Common Stock | I | 1.043.429 | 1.534.751 | ||||||
| 2014-02-05 | 2014-02-04 | 4 | Skyline Venture Partners V LP | DRNA | Common Stock | I | 179.322 | 491.322 | ||||||
| 2014-02-05 | 2014-02-04 | 4 | Skyline Venture Partners V LP | DRNA | Common Stock | I | 312.000 | 312.000 | ||||||
| 2014-02-04 | 2014-02-04 | 4 | BLAIR JAMES C By DP VIII Associates, L.P. | DRNA | Warrant | I | 7,00 | 156 | 156 | |||||
| 2014-02-04 | 2014-02-04 | 4 | BLAIR JAMES C By DP VIII Associates, L.P. | DRNA | Warrant | I | 7,00 | -156 | 0 | |||||
| 2014-02-04 | 2014-02-04 | 4 | BLAIR JAMES C By DP VIII Associates, L.P. | DRNA | Series C Preferred Stock | I | -9.469 | 0 | ||||||
| 2014-02-04 | 2014-02-04 | 4 | BLAIR JAMES C By DP VIII Associates, L.P. | DRNA | Series B Preferred Stock | I | -3.535 | 0 | ||||||
| 2014-02-04 | 2014-02-04 | 4 | BLAIR JAMES C By Domain Partners VIII, L.P. | DRNA | Warrant | I | 7,00 | 21.041 | 21.041 | |||||
| 2014-02-04 | 2014-02-04 | 4 | BLAIR JAMES C By Domain Partners VIII, L.P. | DRNA | Warrant | I | 7,00 | -21.041 | 0 | |||||
| 2014-02-04 | 2014-02-04 | 4 | BLAIR JAMES C By Domain Partners VIII, L.P. | DRNA | Series C Preferred Stock | I | -1.276.243 | 0 | ||||||
| 2014-02-04 | 2014-02-04 | 4 | BLAIR JAMES C By Domain Partners VIII, L.P. | DRNA | Series B Preferred Stock | I | -476.464 | 0 | ||||||
| 2014-02-04 | 2014-02-04 | 4 | BLAIR JAMES C By DP VIII Associates, L.P. | DRNA | Common Stock | I | 13.004 | 13.004 | ||||||
| 2014-02-04 | 2014-02-04 | 4 | BLAIR JAMES C By Domain Partners VIII, L.P. | DRNA | Common Stock | I | 1.752.707 | 1.752.707 | ||||||
| 2014-02-04 | 2014-02-04 | 4 | DOVEY BRIAN H By DP VIII Associates, L.P. | DRNA | Warrant | I | 7,00 | 156 | 156 | |||||
| 2014-02-04 | 2014-02-04 | 4 | DOVEY BRIAN H By DP VIII Associates, L.P. | DRNA | Warrant | I | 7,00 | -156 | 0 | |||||
| 2014-02-04 | 2014-02-04 | 4 | DOVEY BRIAN H By DP VIII Associates, L.P. | DRNA | Series C Preferred Stock | I | -9.469 | 0 | ||||||
| 2014-02-04 | 2014-02-04 | 4 | DOVEY BRIAN H By DP VIII Associates, L.P. | DRNA | Series B Preferred Stock | I | -3.535 | 0 | ||||||
| 2014-02-04 | 2014-02-04 | 4 | DOVEY BRIAN H By Domain Partners VIII, L.P. | DRNA | Warrant | I | 7,00 | 21.041 | 21.041 | |||||
| 2014-02-04 | 2014-02-04 | 4 | DOVEY BRIAN H By Domain Partners VIII, L.P. | DRNA | Warrant | I | 7,00 | -21.041 | 0 | |||||
| 2014-02-04 | 2014-02-04 | 4 | DOVEY BRIAN H By Domain Partners VIII, L.P. | DRNA | Series C Preferred Stock | I | -1.276.243 | 0 | ||||||
| 2014-02-04 | 2014-02-04 | 4 | DOVEY BRIAN H By Domain Partners VIII, L.P. | DRNA | Series B Preferred Stock | I | -476.464 | 0 | ||||||
| 2014-02-04 | 2014-02-04 | 4 | DOVEY BRIAN H By DP VIII Associates, L.P. | DRNA | Common Stock | I | 13.004 | 13.004 | ||||||
| 2014-02-04 | 2014-02-04 | 4 | DOVEY BRIAN H By Domain Partners VIII, L.P. | DRNA | Common Stock | I | 1.752.707 | 1.752.707 | ||||||
| 2014-02-04 | 2014-02-04 | 4 | TREU JESSE I By DP VIII Associates, L.P. | DRNA | Warrant | I | 7,00 | 156 | 156 | |||||
| 2014-02-04 | 2014-02-04 | 4 | TREU JESSE I By DP VIII Associates, L.P. | DRNA | Warrant | I | 7,00 | -156 | 0 | |||||
| 2014-02-04 | 2014-02-04 | 4 | TREU JESSE I By DP VIII Associates, L.P. | DRNA | Series C Preferred Stock | I | -9.469 | 0 | ||||||
| 2014-02-04 | 2014-02-04 | 4 | TREU JESSE I By DP VIII Associates, L.P. | DRNA | Series B Preferred Stock | I | -3.535 | 0 | ||||||
| 2014-02-04 | 2014-02-04 | 4 | TREU JESSE I By Domain Partners VIII, L.P. | DRNA | Warrant | I | 7,00 | 21.041 | 21.041 | |||||
| 2014-02-04 | 2014-02-04 | 4 | TREU JESSE I By Domain Partners VIII, L.P. | DRNA | Warrant | I | 7,00 | -21.041 | 0 | |||||
| 2014-02-04 | 2014-02-04 | 4 | TREU JESSE I By Domain Partners VIII, L.P. | DRNA | Series C Preferred Stock | I | -1.276.243 | 0 | ||||||
| 2014-02-04 | 2014-02-04 | 4 | TREU JESSE I By Domain Partners VIII, L.P. | DRNA | Series B Preferred Stock | I | -476.464 | 0 | ||||||
| 2014-02-04 | 2014-02-04 | 4 | TREU JESSE I By DP VIII Associates, L.P. | DRNA | Common Stock | I | 13.004 | 13.004 | ||||||
| 2014-02-04 | 2014-02-04 | 4 | TREU JESSE I By Domain Partners VIII, L.P. | DRNA | Common Stock | I | 1.752.707 | 1.752.707 | ||||||
| 2014-02-04 | 2014-02-04 | 4 | SCHOEMAKER KATHLEEN K By DP VIII Associates, L.P. | DRNA | Warrant | I | 7,00 | 156 | 156 | |||||
| 2014-02-04 | 2014-02-04 | 4 | SCHOEMAKER KATHLEEN K By DP VIII Associates, L.P. | DRNA | Warrant | I | 7,00 | -156 | 0 | |||||
| 2014-02-04 | 2014-02-04 | 4 | SCHOEMAKER KATHLEEN K By DP VIII Associates, L.P. | DRNA | Series C Preferred Stock | I | -9.469 | 0 | ||||||
| 2014-02-04 | 2014-02-04 | 4 | SCHOEMAKER KATHLEEN K By DP VIII Associates, L.P. | DRNA | Series B Preferred Stock | I | -3.535 | 0 | ||||||
| 2014-02-04 | 2014-02-04 | 4 | SCHOEMAKER KATHLEEN K By Domain Partners VIII, L.P. | DRNA | Warrant | I | 7,00 | 21.041 | 21.041 | |||||
| 2014-02-04 | 2014-02-04 | 4 | SCHOEMAKER KATHLEEN K By Domain Partners VIII, L.P. | DRNA | Warrant | I | 7,00 | -21.041 | 0 | |||||
| 2014-02-04 | 2014-02-04 | 4 | SCHOEMAKER KATHLEEN K By Domain Partners VIII, L.P. | DRNA | Series C Preferred Stock | I | -1.276.243 | 0 | ||||||
| 2014-02-04 | 2014-02-04 | 4 | SCHOEMAKER KATHLEEN K By Domain Partners VIII, L.P. | DRNA | Series B Preferred Stock | I | -476.464 | 0 | ||||||
| 2014-02-04 | 2014-02-04 | 4 | SCHOEMAKER KATHLEEN K By DP VIII Associates, L.P. | DRNA | Common Stock | I | 13.004 | 13.004 | ||||||
| 2014-02-04 | 2014-02-04 | 4 | SCHOEMAKER KATHLEEN K By Domain Partners VIII, L.P. | DRNA | Common Stock | I | 1.752.707 | 1.752.707 | ||||||
| 2014-02-04 | 2014-02-04 | 4 | VITULLO NICOLE By DP VIII Associates, L.P. | DRNA | Warrant | I | 7,00 | 156 | 156 | |||||
| 2014-02-04 | 2014-02-04 | 4 | VITULLO NICOLE By DP VIII Associates, L.P. | DRNA | Warrant | I | 7,00 | -156 | 0 | |||||
| 2014-02-04 | 2014-02-04 | 4 | VITULLO NICOLE By DP VIII Associates, L.P. | DRNA | Series C Preferred Stock | I | -9.469 | 0 | ||||||
| 2014-02-04 | 2014-02-04 | 4 | VITULLO NICOLE By DP VIII Associates, L.P. | DRNA | Series B Preferred Stock | I | -3.535 | 0 | ||||||
| 2014-02-04 | 2014-02-04 | 4 | VITULLO NICOLE By Domain Partners VIII, L.P. | DRNA | Warrant | I | 7,00 | 21.041 | 21.041 | |||||
| 2014-02-04 | 2014-02-04 | 4 | VITULLO NICOLE By Domain Partners VIII, L.P. | DRNA | Warrant | I | 7,00 | -21.041 | 0 | |||||
| 2014-02-04 | 2014-02-04 | 4 | VITULLO NICOLE By Domain Partners VIII, L.P. | DRNA | Series C Preferred Stock | I | -1.276.243 | 0 | ||||||
| 2014-02-04 | 2014-02-04 | 4 | VITULLO NICOLE By Domain Partners VIII, L.P. | DRNA | Series B Preferred Stock | I | -476.464 | 0 | ||||||
| 2014-02-04 | 2014-02-04 | 4 | VITULLO NICOLE By DP VIII Associates, L.P. | DRNA | Common Stock | I | 13.004 | 13.004 | ||||||
| 2014-02-04 | 2014-02-04 | 4 | VITULLO NICOLE By Domain Partners VIII, L.P. | DRNA | Common Stock | I | 1.752.707 | 1.752.707 | ||||||
| 2014-02-04 | 2014-02-04 | 4 | Halak Brian K By DP VIII Associates, L.P. | DRNA | Warrant | I | 7,00 | 156 | 156 | |||||
| 2014-02-04 | 2014-02-04 | 4 | Halak Brian K By DP VIII Associates, L.P. | DRNA | Warrant | I | 7,00 | -156 | 0 | |||||
| 2014-02-04 | 2014-02-04 | 4 | Halak Brian K By DP VIII Associates, L.P. | DRNA | Series C Preferred Stock | I | -9.469 | 0 | ||||||
| 2014-02-04 | 2014-02-04 | 4 | Halak Brian K By DP VIII Associates, L.P. | DRNA | Series B Preferred Stock | I | -3.535 | 0 | ||||||
| 2014-02-04 | 2014-02-04 | 4 | Halak Brian K By Domain Partners VIII, L.P. | DRNA | Warrant | I | 7,00 | 21.041 | 21.041 | |||||
| 2014-02-04 | 2014-02-04 | 4 | Halak Brian K By Domain Partners VIII, L.P. | DRNA | Warrant | I | 7,00 | -21.041 | 0 | |||||
| 2014-02-04 | 2014-02-04 | 4 | Halak Brian K By Domain Partners VIII, L.P. | DRNA | Series C Preferred Stock | I | -1.276.243 | 0 | ||||||
| 2014-02-04 | 2014-02-04 | 4 | Halak Brian K By Domain Partners VIII, L.P. | DRNA | Series B Preferred Stock | I | -476.464 | 0 | ||||||
| 2014-02-04 | 2014-02-04 | 4 | Halak Brian K By DP VIII Associates, L.P. | DRNA | Common Stock | I | 13.004 | 13.004 | ||||||
| 2014-02-04 | 2014-02-04 | 4 | Halak Brian K By Domain Partners VIII, L.P. | DRNA | Common Stock | I | 1.752.707 | 1.752.707 | ||||||
| 2014-02-04 | 2014-02-04 | 4 | LANGER DENNIS Langer Family Holdings, LLP | DRNA | Series C Preferred | I | -71.428 | 0 | ||||||
| 2014-02-04 | 2014-02-04 | 4 | LANGER DENNIS Langer Family Holdings, LLP | DRNA | Series B Preferred | I | -8.586 | 0 | ||||||
| 2014-02-04 | 2014-02-04 | 4 | LANGER DENNIS Langer Family Holdings, LLP | DRNA | Series A Preferred | I | -10.000 | 0 | ||||||
| 2014-02-04 | 2014-02-04 | 4 | LANGER DENNIS Langer Family Holdings, LLP | DRNA | Common Stock | I | 90.014 | 90.194 | ||||||
| 2014-02-04 | 3 | Brookside Capital Trading Fund, L.P. | DRNA | Common Stock | I | 2.337.000 | ||||||||
| 2014-02-04 | 2014-02-04 | 4 | DP VIII Associates, L.P. | DRNA | Warrant | D | 7,00 | 156 | 156 | |||||
| 2014-02-04 | 2014-02-04 | 4 | DP VIII Associates, L.P. | DRNA | Warrant | D | 7,00 | -156 | 0 | |||||
| 2014-02-04 | 2014-02-04 | 4 | DP VIII Associates, L.P. | DRNA | Series C Preferred Stock | D | -9.469 | 0 | ||||||
| 2014-02-04 | 2014-02-04 | 4 | DP VIII Associates, L.P. | DRNA | Series B Preferred Stock | D | -3.535 | 0 | ||||||
| 2014-02-04 | 2014-02-04 | 4 | DP VIII Associates, L.P. | DRNA | Common Stock | D | 13.004 | 13.004 | ||||||
| 2014-02-04 | 2014-02-04 | 4 | Domain Partners VIII, L.P. | DRNA | Warrant | D | 7,00 | 21.041 | 21.041 | |||||
| 2014-02-04 | 2014-02-04 | 4 | Domain Partners VIII, L.P. | DRNA | Warrant | D | 7,00 | -21.041 | 0 | |||||
| 2014-02-04 | 2014-02-04 | 4 | Domain Partners VIII, L.P. | DRNA | Series C Preferred Stock | D | -1.276.243 | 0 | ||||||
| 2014-02-04 | 2014-02-04 | 4 | Domain Partners VIII, L.P. | DRNA | Series B Preferred Stock | D | -476.464 | 0 | ||||||
| 2014-02-04 | 2014-02-04 | 4 | Domain Partners VIII, L.P. | DRNA | Common Stock | D | 1.752.707 | 1.752.707 | ||||||
| 2014-02-04 | 2014-02-04 | 4 | Flynn James E Through Deerfield Private Design International II, L.P. | DRNA | Series C Preferred Stock | I | -572.142 | 0 | ||||||
| 2014-02-04 | 2014-02-04 | 4 | Flynn James E Through Deerfield Private Design Fund II, L.P. | DRNA | Series C Preferred Stock | I | -499.285 | 0 | ||||||
| 2014-02-04 | 2014-02-04 | 4 | Flynn James E Through Deerfield Special Situations International Master Fund, L.P. | DRNA | Series C Preferred Stock | I | -161.071 | 0 | ||||||
| 2014-02-04 | 2014-02-04 | 4 | Flynn James E Through Deerfield Special Situations Fund, L.P. | DRNA | Series C Preferred Stock | I | -196.071 | 0 | ||||||
| 2014-02-04 | 2014-02-04 | 4 | Flynn James E Through Deerfield Private Design International II, L.P. | DRNA | Common Stock | I | 15,0000 | 400.500 | 6.008 | 972.642 | ||||
| 2014-02-04 | 2014-02-04 | 4 | Flynn James E Through Deerfield Private Design Fund II, L.P. | DRNA | Common Stock | I | 15,0000 | 349.500 | 5.242 | 848.785 | ||||
| 2014-02-04 | 2014-02-04 | 4 | Flynn James E Through Deerfield Special Situations International Master Fund, L.P. | DRNA | Common Stock | I | 15,0000 | 112.000 | 1.680 | 273.071 | ||||
| 2014-02-04 | 2014-02-04 | 4 | Flynn James E Through Deerfield Special Situations Fund, L.P. | DRNA | Common Stock | I | 15,0000 | 138.000 | 2.070 | 334.071 | ||||
| 2014-02-04 | 2014-02-04 | 4 | Flynn James E Through Deerfield Private Design International II, L.P. | DRNA | Common Stock | I | 572.142 | 972.642 | ||||||
| 2014-02-04 | 2014-02-04 | 4 | Flynn James E Through Deerfield Private Design Fund II, L.P. | DRNA | Common Stock | I | 499.285 | 848.785 | ||||||
| 2014-02-04 | 2014-02-04 | 4 | Flynn James E Through Deerfield Special Situations International Master Fund, L.P. | DRNA | Common Stock | I | 161.071 | 273.071 | ||||||
| 2014-02-04 | 2014-02-04 | 4 | Flynn James E Through Deerfield Special Situations Fund, L.P. | DRNA | Common Stock | I | 196.071 | 334.071 | ||||||
| 2014-01-29 | 3 | FAMBROUGH DOUGLAS | DRNA | Common Stock | D | 12.300 | ||||||||
| 2014-01-29 | 3 | MADDEN DAVID | DRNA | Common Stock | D | 112.511 | ||||||||
| 2014-01-29 | 3 | LANGER DENNIS | DRNA | Common Stock | D | 8.873 | ||||||||
| 2014-01-29 | 3 | LANGER DENNIS Langer Family Holdings, LLP | DRNA | Common Stock | I | 180 | ||||||||
| 2014-01-29 | 3 | Miles Vincent J | DRNA | No securities are beneficially owned | D | 0 | ||||||||
| 2014-01-29 | 3 | Brown Bob D | DRNA | Common Stock | D | 19.339 | ||||||||
| 2014-01-29 | 3 | Weissman James B | DRNA | Common Stock | D | 12.116 |
