ISPC / iSpecimen Inc. - SEC-arkivering, Årsberetning, Fuldmagtserklæring

iSpecimen Inc.

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CIK 1558569
SEC Filings
All companies that sell securities in the United States must register with the Securities and Exchange Commission (SEC) and file reports on a regular basis. These reports include company annual reports (10K, 10Q), news updates (8K), investor presentations (found in 8Ks), insider trades (form 4), ownership reports (13D, and 13G), and reports related to the specific securities sold, such as registration statements and prospectus. This page shows recent SEC filings related to iSpecimen Inc.
SEC Filings (Chronological Order)
Denne side giver en komplet, kronologisk liste over SEC-arkiveringer, eksklusive ejerskabsregistreringer, som vi leverer andre steder.
June 4, 2026 EX-FILING FEES

CALCULATION OF FILING FEE TABLES iSpecimen Inc. Table 1: Newly Registered and Carry Forward Securities

Ex-Filing Fees CALCULATION OF FILING FEE TABLES S-3 iSpecimen Inc. Table 1: Newly Registered and Carry Forward Securities Line Item Type Security Type Security Class Title Notes Fee Calculation Rule Amount Registered Proposed Maximum Offering Price Per Unit Maximum Aggregate Offering Price Fee Rate Amount of Registration Fee Newly Registered Securities Fees to be Paid Equity Common Stock, $0.0001

June 4, 2026 S-3

As filed with the Securities and Exchange Commission on June 4, 2026

As filed with the Securities and Exchange Commission on June 4, 2026 Registration No.

June 1, 2026 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): May 29, 2026 iSpecimen Inc. (Exac

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): May 29, 2026 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of Incorporation) (Commission File Number

May 29, 2026 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): May 29, 2026 iSpecimen Inc. (Exac

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): May 29, 2026 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of Incorporation) (Commission File Number

May 18, 2026 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Quarterly Period Ended March 31, 2026 ☐ TRANSITION REPORT P

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Quarterly Period Ended March 31, 2026 ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File No. 001-40501 iSpecimen Inc. (

May 18, 2026 NT 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 12b-25 NOTIFICATION OF LATE FILING

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 12b-25 NOTIFICATION OF LATE FILING (Check one): ☐ Form 10-K ☐ Form 20-F ☐ Form 11-K ☒ Form 10-Q ☐ Form 10-D ☐ Form N-CEN ☐ Form N-CSR For Period Ended: March 31, 2026 ☐ Transition Report on Form 10-K ☐ Transition Report on Form 20-F ☐ Transition Report on Form 11-K ☐ Transition Report on Form 10-Q For the Transition Perio

May 18, 2026 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Definitive

May 13, 2026 EX-10.3

PLACEMENT AGENCY AGREEMENT

Exhibit 10.3 PLACEMENT AGENCY AGREEMENT May 7, 2026 PERSONAL AND CONFIDENTIAL iSpecimen Inc. 8 Cabot Rd., Suite 1800 Woburn, MA 01801 Attention: Katharyn Field, Chief Executive Officer Dear Ms. Field: This agreement (the “Agreement”) constitutes the agreement between E.F. Hutton & Co. (the “Placement Agent”) on one hand, and iSpecimen Inc., a company incorporated under the laws of Delaware (the “C

May 13, 2026 EX-4.1

iSPECIMEN INC.

Exhibit 4.1 iSPECIMEN INC. NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EF

May 13, 2026 EX-10.1

SECURITIES PURCHASE AGREEMENT

Exhibit 10.1 SECURITIES PURCHASE AGREEMENT This Securities Purchase Agreement (this “Agreement”) is entered into and made effective as of [], 2026, by and among iSpecimen Inc., a Delaware corporation (the “Company”), each purchaser identified on the signature pages hereto (each, including its successors and assigns, a “Purchaser” and collectively the “Purchasers”). RECITALS WHEREAS, subject to the

May 13, 2026 EX-99.1

iSpecimen Inc. Announces Pricing of Approximately $2.5 Million Private Placement May 8, 2026

Exhibit 99.1 iSpecimen Inc. Announces Pricing of Approximately $2.5 Million Private Placement May 8, 2026 WOBURN, Mass., May 08, 2026 (GLOBE NEWSWIRE) - iSpecimen Inc. (Nasdaq: ISPC) (“iSpecimen” or the “Company”), an online global marketplace that connects scientists requiring biospecimens for medical research with a network of healthcare specimen providers, today announced that it has priced a p

May 13, 2026 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): May 8, 2026 iSpecimen Inc. (Exact

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): May 8, 2026 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of Incorporation) (Commission File Number)

May 13, 2026 EX-10.2

REGISTRATION RIGHTS AGREEMENT

Exhibit 10.2 REGISTRATION RIGHTS AGREEMENT This Registration Rights Agreement (this “Agreement”) is made and entered into as of May 7, 2026 between iSpecimen Inc., a Delaware corporation (the “Company”), and each purchaser appearing on the signature page to the Purchase Agreement (as defined below) (each such purchaser, a “Purchaser” and, collectively, the “Purchasers”). WHEREAS, the Company and t

May 1, 2026 EX-99.1

iSpecimen Announces 1-for-40 Reverse Stock Split

Exhibit 99.1 iSpecimen Announces 1-for-40 Reverse Stock Split WOBURN, Mass., April 24, 2026 – iSpecimen Inc. (Nasdaq: ISPC) (“iSpecimen” or the “Company”), an online global marketplace that connects scientists requiring biospecimens for medical research with a network of healthcare specimen providers, announced today that it will effect a reverse stock split of its issued and outstanding shares of

May 1, 2026 EX-3.2

CERTIFICATE OF VALIDATION iSPECIMEN INC. Pursuant to Section 204 of the General Corporation Law of the State of Delaware

Exhibit 3.2 CERTIFICATE OF VALIDATION OF iSPECIMEN INC. Pursuant to Section 204 of the General Corporation Law of the State of Delaware iSpecimen Inc., a corporation organized and existing under the laws of the State of Delaware (the “Corporation”), does hereby certify as follows: 1. The name of the Corporation is iSpecimen Inc. The original certificate of incorporation of the Corporation was file

May 1, 2026 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): April 29, 2026 iSpecimen Inc. (Ex

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): April 29, 2026 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of Incorporation) (Commission File Numb

May 1, 2026 EX-3.1

FIFTH AMENDED AND RESTATED CERTIFICATE OF INCORPORATION iSPECIMEN INC. April 29, 2026

Exhibit 3.1 FIFTH AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF iSPECIMEN INC. April 29, 2026 iSpecimen Inc., a corporation organized and existing under the laws of the State of Delaware (the “Corporation”), DOES HEREBY CERTIFY AS FOLLOWS: 1. The name of the Corporation is “iSpecimen Inc.” The original certificate of incorporation of the Corporation was filed with the Secretary of State of

April 13, 2026 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): April 10, 2026 iSpecimen Inc. (Ex

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): April 10, 2026 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of Incorporation) (Commission File Numb

April 10, 2026 EX-99.1

iSpecimen achieves 85% Reduction in Human Biospecimen Shipping Time

Exhibit 99.1 FOR IMMEDIATE RELEASE iSpecimen achieves 85% Reduction in Human Biospecimen Shipping Time Woburn, MA — April 9, 2026 — iSpecimen, an online marketplace for human biospecimens, has implemented a streamlined shipping model that enables direct shipment of biospecimens from supplier sites to customers, both domestically and internationally. By reducing reliance on centralized hub processi

April 10, 2026 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): April 9, 2026 iSpecimen Inc. (Exa

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): April 9, 2026 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of Incorporation) (Commission File Numbe

April 1, 2026 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Fiscal Year Ended December 31, 2025 ☐ TRANSITION REPORT PURSUA

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Fiscal Year Ended December 31, 2025 ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File No. 001-40501 iSpecimen Inc. (Exact

March 31, 2026 NT 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 12b-25 NOTIFICATION OF LATE FILING

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 12b-25 NOTIFICATION OF LATE FILING (Check One): ☒ Form 10-K ☐ Form 20-F ☐ Form 11-K ☐ Form 10-Q ☐ Form 10-D ☐ Form N-SAR ☐ Form N-CSR For Period Ended: December 31, 2025 ☐ Transition Report on Form 10-K ☐ Transition Report on Form 20-F ☐ Transition Report on Form 11-K ☐ Transition Report on Form 10-K ☐ Transition Report o

March 13, 2026 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): March 13, 2026 iSpecimen Inc. (Ex

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): March 13, 2026 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of Incorporation) (Commission File Numb

March 3, 2026 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Definitive

February 23, 2026 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): February 17, 2026 iSpecimen Inc.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): February 17, 2026 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of Incorporation) (Commission File N

February 18, 2026 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): February 13, 2026 iSpecimen Inc.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): February 13, 2026 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of Incorporation) (Commission File N

February 6, 2026 EX-99.1

iSpecimen Announces Milestone 2: System Integration and Marketplace Activation Complete Live Production Marketplace Now Available

Exhibit 99.1 iSpecimen Announces Milestone 2: System Integration and Marketplace Activation Complete Live Production Marketplace Now Available Woburn, MA - February 6, 2026: iSpecimen Inc. (NASDAQ: ISPC) today announced the successful completion of Milestone 2, System Integration and Marketplace Activation, marking a pivotal step in the SalesStack digital transformation journey. The milestone deli

February 6, 2026 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): February 6, 2026 iSpecimen Inc. (

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): February 6, 2026 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of Incorporation) (Commission File Nu

February 6, 2026 EX-99.2

iSpecimen Achieves Rapid Procurement Milestone for Influenza Research

Exhibit 99.2 iSpecimen Achieves Rapid Procurement Milestone for Influenza Research Lexington, MA — February 6, 2026 — iSpecimen Inc. (NASDAQ: ISPC), a leading provider of human biospecimens for research, is proud to announce recent milestones that demonstrate the strength, responsiveness, and reliability of its site network. Over the past several months, iSpecimen has been actively supporting cust

February 3, 2026 424B3

101,000,000 Shares of Common Stock

PROSPECTUS Filed Pursuant to Rule 424(b)(3) Registration No. 333-292804 101,000,000 Shares of Common Stock This prospectus relates to the offer and resale of up to an aggregate of 101,000,000 shares of common stock, par value $0.0001 per share (“Common Stock” or ‘common stock”), of iSpecimen Inc., held by selling stockholders, consisting of the following: (i) up to 101,000,000 shares of common sto

January 28, 2026 CORRESP

iSpecimen Inc. 8 Cabot Road, Suite 1800 Woburn, WA 08101

iSpecimen Inc. 8 Cabot Road, Suite 1800 Woburn, WA 08101 January 28, 2026 VIA EDGAR U.S. Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Re: iSpecimen Inc. Request for Acceleration Registration Statement on Form S-3 File No. 333-292804 Ladies and Gentlemen: Pursuant to Rule 461 promulgated under the Securities Act of 1933, as amended (th

January 27, 2026 LETTER

LETTER

January 27, 2026 Katharyn Field Chief Executive Officer iSpecimen Inc. 8 Cabot Road, Suite 1800 Woburn, MA 01801 Re: iSpecimen Inc. Registration Statement on Form S-3 Filed January 20, 2026 File No. 333-292804 Dear Katharyn Field: This is to advise you that we have not reviewed and will not review your registration statement. Please refer to Rules 460 and 461 regarding requests for acceleration. W

January 27, 2026 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): January 23, 2026 iSpecimen Inc. (

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): January 23, 2026 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of Incorporation) (Commission File Nu

January 20, 2026 EX-FILING FEES

CALCULATION OF FILING FEE TABLES iSpecimen Inc. Table 1: Newly Registered and Carry Forward Securities

Ex-Filing Fees CALCULATION OF FILING FEE TABLES S-3 iSpecimen Inc. Table 1: Newly Registered and Carry Forward Securities Line Item Type Security Type Security Class Title Notes Fee Calculation Rule Amount Registered Proposed Maximum Offering Price Per Unit Maximum Aggregate Offering Price Fee Rate Amount of Registration Fee Newly Registered Securities Fees to be Paid Equity Common Stock, $0.0001

January 20, 2026 S-3

As filed with the Securities and Exchange Commission on January 16, 2026

As filed with the Securities and Exchange Commission on January 16, 2026 Registration No.

January 16, 2026 EX-3.1

AMENDED CERTIFICATE OF DESIGNATIONS, PREFERENCES AND RIGHTS OF THE SERIES C CONVERTIBLE PREFERRED STOCK ISPECIMEN INC. pursuant to section 151(g) of the delaware General Corporation law

Exhibit 3.1 AMENDED CERTIFICATE OF DESIGNATIONS, PREFERENCES AND RIGHTS OF THE SERIES C CONVERTIBLE PREFERRED STOCK OF ISPECIMEN INC. pursuant to section 151(g) of the delaware General Corporation law RECITALS WHEREAS, iSpecimen Inc., a Delaware corporation (the “Corporation”), previously filed on December 30, 2025 a Certificate of Designations, Preferences and Rights of the Series C Convertible P

January 16, 2026 8-K/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K/A (Amendment No. 1) CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): December 30,

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K/A (Amendment No. 1) CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): December 30, 2025 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of Incorporation

January 6, 2026 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Definitive

January 5, 2026 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): December 31, 2025 iSpecimen Inc.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): December 31, 2025 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of Incorporation) (Commission File N

January 5, 2026 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): December 31, 2025 iSpecimen Inc.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): December 31, 2025 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of Incorporation) (Commission File N

January 5, 2026 EX-10.1

CONSULTING AGREEMENT

Exhibit 10.1 CONSULTING AGREEMENT IR Agency LLC (the “Consultant” or “IR Agency”) is pleased to provide certain consulting services to Ispecimen Inc. (“you,” “Client” or “Company”) as more fully described in this agreement (the “Agreement”). This Agreement sets forth the terms and conditions pursuant to which Company engages Consultant to provide such services. 1. Consulting Services. (a) Commenci

January 2, 2026 EX-10.3

PLACEMENT AGENCY AGREEMENT

Exhibit 10.3 PLACEMENT AGENCY AGREEMENT December 30, 2025 PERSONAL AND CONFIDENTIAL iSpecimen Inc. 8 Cabot Rd., Suite 1800 Woburn, MA 01801 Attention: Katharyn Field, Chief Executive Officer Dear Ms. Field: This agreement (the “Agreement”) constitutes the agreement between E.F. Hutton & Co. (the “Placement Agent”) on one hand, and iSpecimen Inc., a company incorporated under the laws of Delaware (

January 2, 2026 EX-10.1

SECURITIES PURCHASE AGREEMENT

Exhibit 10.1 SECURITIES PURCHASE AGREEMENT This Securities Purchase Agreement (this “Agreement”) is entered into and made effective as of December 30, 2025, by and among iSpecimen Inc., a Delaware corporation (the “Company”), each purchaser identified on the signature pages hereto (each, including its successors and assigns, a “Purchaser” and collectively the “Purchasers”). RECITALS WHEREAS, subje

January 2, 2026 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): December 30, 2025 iSpecimen Inc.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): December 30, 2025 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of Incorporation) (Commission File N

January 2, 2026 424B3

1,559,828 Shares of Common Stock

PROSPECTUS Filed Pursuant to Rule 424(b)(3) Registration No. 333-289725 1,559,828 Shares of Common Stock This prospectus relates to the offer and resale of up to an aggregate of 1,559,828 shares of common stock, par value $0.0001 per share, of iSpecimen Inc., held by selling stockholders, consisting of the following: (i) 267,379 shares of common stock (the “Shares”) and (ii) 1,292,449 shares of co

January 2, 2026 EX-3.1

CERTIFICATE OF DESIGNATIONS, PREFERENCES AND RIGHTS OF THE SERIES C CONVERTIBLE PREFERRED STOCK ISPECIMEN INC. pursuant to section 151(g) of the delaware General Corporation law

Exhibit 3.1 CERTIFICATE OF DESIGNATIONS, PREFERENCES AND RIGHTS OF THE SERIES C CONVERTIBLE PREFERRED STOCK OF ISPECIMEN INC. pursuant to section 151(g) of the delaware General Corporation law The undersigned, Katharyn Field, the Chief Executive Officer of iSpecimen Inc. (the “Corporation”), a Delaware corporation, hereby does certify: That pursuant to the authority expressly conferred upon the Bo

January 2, 2026 EX-10.2

REGISTRATION RIGHTS AGREEMENT

Exhibit 10.2 REGISTRATION RIGHTS AGREEMENT This Registration Rights Agreement (this “Agreement”) is made and entered into as of December 30, 2025 between iSpecimen Inc., a Delaware corporation (the “Company”), and each purchaser appearing on the signature page to the Purchase Agreement (as defined below) (each such purchaser, a “Purchaser” and, collectively, the “Purchasers”). WHEREAS, the Company

December 19, 2025 S-1/A

As filed with the Securities and Exchange Commission on December 19, 2025

As filed with the Securities and Exchange Commission on December 19, 2025 Registration No.

December 1, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): November 28, 2025 iSpecimen Inc.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): November 28, 2025 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of Incorporation) (Commission File N

November 21, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): November 19, 2025 iSpecimen Inc.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): November 19, 2025 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of Incorporation) (Commission File N

November 21, 2025 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☒ Definitive

November 17, 2025 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Quarterly Period Ended September 30, 2025 ☐ TRANSITION REPO

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Quarterly Period Ended September 30, 2025 ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File No. 001-40501 iSpecimen In

November 14, 2025 NT 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 12b-25 NOTIFICATION OF LATE FILING

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 12b-25 NOTIFICATION OF LATE FILING (Check one): ☐ Form 10-K ☐ Form 20-F ☐ Form 11-K ☒ Form 10-Q ☐ Form 10-D ☐ Form N-CEN ☐ Form N-CSR For Period Ended: September 30, 2025 ☐ Transition Report on Form 10-K ☐ Transition Report on Form 20-F ☐ Transition Report on Form 11-K ☐ Transition Report on Form 10-Q For the Transition P

November 10, 2025 PRER14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. 1)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. 1) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☒ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e

November 7, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): November 7, 2025 iSpecimen Inc. (

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): November 7, 2025 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of Incorporation) (Commission File Nu

November 3, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): October 30, 2025 iSpecimen Inc. (

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): October 30, 2025 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of incorporation) (Commission File Nu

November 3, 2025 PRE 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☒ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Definitive

October 23, 2025 S-3

As filed with the Securities and Exchange Commission on October 23, 2025

As filed with the Securities and Exchange Commission on October 23, 2025 Registration No.

October 23, 2025 EX-FILING FEES

CALCULATION OF FILING FEE TABLES iSpecimen Inc. Table 1: Newly Registered and Carry Forward Securities

Ex-Filing Fees CALCULATION OF FILING FEE TABLES S-3 iSpecimen Inc. Table 1: Newly Registered and Carry Forward Securities Line Item Type Security Type Security Class Title Notes Fee Calculation Rule Amount Registered Proposed Maximum Offering Price Per Unit Maximum Aggregate Offering Price Fee Rate Amount of Registration Fee Newly Registered Securities Fees to be Paid Equity Common Stock (1) 457(o

October 14, 2025 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☒ Definitive

October 6, 2025 S-1/A

As filed with the Securities and Exchange Commission on October 6, 2025

As filed with the Securities and Exchange Commission on October 6, 2025 Registration No.

October 2, 2025 PRER14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION (Amendment No. 2) Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION (Amendment No. 2) Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☒ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e

September 8, 2025 PRER14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION (Amendment No. 1) Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION (Amendment No. 1) Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☒ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e

September 8, 2025 S-1/A

As filed with the Securities and Exchange Commission on September 8, 2025

As filed with the Securities and Exchange Commission on September 8, 2025 Registration No.

September 4, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): September 4, 2025 iSpecimen Inc.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): September 4, 2025 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of Incorporation) (Commission File N

September 4, 2025 EX-99.1

iSpecimen Approached by Crypto Currency Companies for $200 Million Treasury Discussions

Exhibit 99.1 iSpecimen Approached by Crypto Currency Companies for $200 Million Treasury Discussions Woburn, MA – September 4, 2025 – iSpecimen Inc. (NASDAQ: ISPC), (the “Company”), a technology-enabled company modernizing the way human biospecimens are sourced for scientific research, today announced an update on its major strategic initiative aimed at integrating digital assets into its business

August 25, 2025 S-1/A

As filed with the Securities and Exchange Commission on August 25, 2025

As filed with the Securities and Exchange Commission on August 25, 2025 Registration No.

August 21, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): August 21, 2025 iSpecimen Inc. (E

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): August 21, 2025 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of Incorporation) (Commission File Num

August 21, 2025 EX-99.1

iSpecimen Announces Completion of Milestone 1 in Digital Transformation Journey with Salestack Platform

Exhibit 99.1 iSpecimen Announces Completion of Milestone 1 in Digital Transformation Journey with Salestack Platform Woburn, MA – August 21, 2025 – iSpecimen Inc. (NASDAQ: ISPC), an online marketplace for human biospecimens, today announced the successful completion of Milestone 1 in its digital transformation program powered by Salestack Solutions. This critical achievement marks the installation

August 20, 2025 EX-FILING FEES

Filing Fee Table

Ex-Filing Fees CALCULATION OF FILING FEE TABLES S-1 iSpecimen Inc. Table 1: Newly Registered and Carry Forward Securities Line Item Type Security Type Security Class Title Notes Fee Calculation Rule Amount Registered Proposed Maximum Offering Price Per Unit Maximum Aggregate Offering Price Fee Rate Amount of Registration Fee Newly Registered Securities Fees to be Paid Equity Common Stock, $0.0001

August 20, 2025 S-1

As filed with the Securities and Exchange Commission on August 20, 2025

As filed with the Securities and Exchange Commission on August 20, 2025 Registration No.

August 14, 2025 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Quarterly Period Ended June 30, 2025 ☐ TRANSITION REPORT PU

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Quarterly Period Ended June 30, 2025 ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File No. 001-40501 iSpecimen Inc. (E

August 13, 2025 PRE 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☒ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Definitive

August 7, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): August 7, 2025 iSpecimen Inc. (Ex

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): August 7, 2025 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of Incorporation) (Commission File Numb

August 7, 2025 EX-99.1

iSpecimen to Establish $200M Corporate Treasury Built Around Solana Cryptocurrency with BlockArrow

Exhibit 99.1 iSpecimen to Establish $200M Corporate Treasury Built Around Solana Cryptocurrency with BlockArrow Woburn, MA – August 7, 2025 – iSpecimen Inc. (NASDAQ: ISPC), a technology-enabled company modernizing the way human biospecimens are sourced for scientific research, today announced a major strategic initiative aimed at integrating digital assets into its business model. The company is l

August 5, 2025 EX-10.3

Investor Relations Agreement by and between the Company and IR Agency LLC.

Exhibit 10.3 ADDENDUM TO CONSULTING AGREEMENT Dated August 1, 2025 This Addendum to Consulting Agreement (this “Addendum”) is entered into for the purpose of amending the Consulting Agreement between IR Agency LLC (the “Consultant” or “IR Agency”) and iSpecimen Inc. (“you,” the “Client” or the “Company”) dated as of July 25, 2025, to provide for the purchase of additional Services by the Company u

August 5, 2025 EX-10.2

Form of Registration Rights Agreement.

Exhibit 10.2 REGISTRATION RIGHTS AGREEMENT THIS REGISTRATION RIGHTS AGREEMENT (“Agreement”) is entered into as of July 31, 2025 by and among iSpecimen Inc., a Delaware corporation (the “Company”), and the purchasers from time to time party hereto (each, a “Purchaser” and collectively, the “Purchasers”). This Agreement is made pursuant to the Securities Purchase Agreement, dated as of the date here

August 5, 2025 EX-10.1

Form of Securities Purchase Agreement.

Exhibit 10.1 SECURITIES PURCHASE AGREEMENT This Securities Purchase Agreement (this “Agreement”) is dated as of July 31, 2025, between iSpecimen Inc., a Delaware corporation (the “Company”), and each of the purchasers identified on the signature pages hereto (each, including its successors and assigns, an “Purchaser” and collectively the “Purchasers”). RECITALS A. The Company and each Purchaser is

August 5, 2025 EX-4.1

Form of Pre-Funded Warrant.

Exhibit 4.1 NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGISTR

August 5, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): July 31, 2025 iSpecimen Inc. (Exa

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): July 31, 2025 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of Incorporation) (Commission File Numbe

August 5, 2025 EX-99.2

iSpecimen Inc. Announces Closing of Approximately $1.75 Million Private Placement Priced At-the-Market

Exhibit 99.2 iSpecimen Inc. Announces Closing of Approximately $1.75 Million Private Placement Priced At-the-Market WOBURN, Mass., Aug. 04, 2025 (GLOBE NEWSWIRE) - iSpecimen Inc. (Nasdaq: ISPC) (“iSpecimen” or the “Company”), an online global marketplace that connects scientists requiring biospecimens for medical research with a network of healthcare specimen providers, today announced that it clo

August 5, 2025 EX-99.1

iSpecimen Inc. Announces Pricing of Approximately $1.75 Million Private Placement Priced At-the-Market

Exhibit 99.1 iSpecimen Inc. Announces Pricing of Approximately $1.75 Million Private Placement Priced At-the-Market WOBURN, Mass., July 31, 2025 (GLOBE NEWSWIRE) - iSpecimen Inc. (Nasdaq: ISPC) (“iSpecimen” or the “Company”), an online global marketplace that connects scientists requiring biospecimens for medical research with a network of healthcare specimen providers, today announced that it ent

July 25, 2025 EX-99.1

iSpecimen Inc. Announces Pricing of $4 Million Underwritten Offering

Exhibit 99.1 iSpecimen Inc. Announces Pricing of $4 Million Underwritten Offering WOBURN, Mass., July 24, 2025 (GLOBE NEWSWIRE) - iSpecimen Inc. (Nasdaq: ISPC) (“iSpecimen” or the “Company”), an online global marketplace that connects scientists requiring biospecimens for medical research with a network of healthcare specimen providers, announced today the pricing of an underwritten public offerin

July 25, 2025 424B4

1,482,644 SHARES OF COMMON STOCK PRE-FUNDED WARRANTS TO PURCHASE 4,231,639 SHARES OF COMMON STOCK 4,231,639 SHARES OF COMMON STOCK ISSUABLE UPON THE EXERCISE OF THE PRE-FUNDED WARRANTS iSpecimen Inc.

PROSPECTUS Filed pursuant to Rule 424(b)(4) Registration No. 333-286958 1,482,644 SHARES OF COMMON STOCK PRE-FUNDED WARRANTS TO PURCHASE 4,231,639 SHARES OF COMMON STOCK 4,231,639 SHARES OF COMMON STOCK ISSUABLE UPON THE EXERCISE OF THE PRE-FUNDED WARRANTS iSpecimen Inc. We are offering on an underwritten basis 1,482,644 shares of our common stock, par value $0.0001 per share (the “Shares”) and 4,

July 25, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): July 23, 2025 iSpecimen Inc. (Exa

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): July 23, 2025 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of Incorporation) (Commission File Numbe

July 25, 2025 EX-99.2

iSpecimen Inc. Announces Closing of $4 Million Underwritten Offering

Exhibit 99.2 iSpecimen Inc. Announces Closing of $4 Million Underwritten Offering WOBURN, Mass., July 25, 2025 (GLOBE NEWSWIRE) - iSpecimen Inc. (Nasdaq: ISPC) (“iSpecimen” or the “Company”), an online global marketplace that connects scientists requiring biospecimens for medical research with a network of healthcare specimen providers, announced today the closing of its previously announced under

July 21, 2025 CORRESP

iSpecimen Inc. 8 Cabot Road, Suite 1800 Mt Woburn, WA 08101

iSpecimen Inc. 8 Cabot Road, Suite 1800 Mt Woburn, WA 08101 July 21, 2025 VIA EDGAR U.S. Securities and Exchange Commission Division of Corporation Finance Office of Industrial Applications and Services 100 F Street, N.E. Washington, D.C. 20549 Re: iSpecimen Inc. Request for Acceleration Registration Statement on Form S-1 File No. 333-286958 Ladies and Gentlemen: Pursuant to Rule 461 promulgated u

July 21, 2025 CORRESP

WestPark Capital, Inc. 1800 Century Park East, Suite 220 Los Angeles, CA 90067

WestPark Capital, Inc. 1800 Century Park East, Suite 220 Los Angeles, CA 90067 July 21, 2025 Via EDGAR U.S. Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Re: iSpecimen Inc. Registration Statement on Form S-1 File No. 333-286958 Acceleration Request Requested Date: Wednesday, July 23, 2025 Requested Time: 4:30 PM Eastern Time Ladies and

July 14, 2025 CORRESP

ISPECIMEN INC. 8 Cabot Road, Suite 1800 Woburn, MA 01801

ISPECIMEN INC. 8 Cabot Road, Suite 1800 Woburn, MA 01801 July 14, 2025 VIA EDGAR U.S. Securities and Exchange Commission 100 F Street, N.E. Washington, DC. 20549 Attn: Nicholas O’Leary/Margaret Sawicki Re: iSpecimen Inc. Withdrawal of Acceleration Request for Registration Statement on Form S-1 File No. 333-286958 Ladies and Gentlemen: Reference is made to our letter, dated July 10, 2025, in which

July 14, 2025 CORRESP

WestPark Capital, Inc. 1800 Century Park East, Suite 220 Los Angeles, CA 90067

WestPark Capital, Inc. 1800 Century Park East, Suite 220 Los Angeles, CA 90067 July 14, 2025 Via EDGAR U.S. Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Re: iSpecimen Inc. Registration Statement on Form S-1 File No. 333-286958 WITHDRAWAL OF ACCELERATION REQUEST Ladies and Gentlemen: Reference is made to our letter, filed as correspond

July 10, 2025 EX-3.1

Third Amended and Restated Bylaws of iSpecimen Inc.

Exhibit 3.1 THIRD AMENDED AND RESTATED BY-LAWS OF ISPECIMEN INC. (as amended through July 9, 2025) ARTICLE I OFFICES Section 1.01 Registered Office. The registered office of iSpecimen Inc. (the “Corporation”) will be fixed in the Certificate of Incorporation of the Corporation, as may be amended from time to time (the “Certificate of Incorporation”). Section 1.02 Other Offices. The Corporation may

July 10, 2025 CORRESP

WestPark Capital, Inc. 1800 Century Park East, Suite 220 Los Angeles, CA 90067

WestPark Capital, Inc. 1800 Century Park East, Suite 220 Los Angeles, CA 90067 July 10, 2025 Via EDGAR U.S. Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Re: iSpecimen Inc. Registration Statement on Form S-1 File No. 333-286958 Acceleration Request Requested Date: Monday, July 14, 2025 Requested Time: 4:30 PM Eastern Time Ladies and Ge

July 10, 2025 CORRESP

iSpecimen Inc. 8 Cabot Road, Suite 1800 Mt Woburn, WA 08101

iSpecimen Inc. 8 Cabot Road, Suite 1800 Mt Woburn, WA 08101 July 10, 2025 VIA EDGAR U.S. Securities and Exchange Commission Division of Corporation Finance Office of Industrial Applications and Services 100 F Street, N.E. Washington, D.C. 20549 Re: iSpecimen Inc. Request for Acceleration Registration Statement on Form S-1 File No. 333-286958 Ladies and Gentlemen: Pursuant to Rule 461 promulgated u

July 10, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): July 9, 2025 iSpecimen Inc. (Exac

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): July 9, 2025 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of Incorporation) (Commission File Number

July 8, 2025 S-1/A

As filed with the Securities and Exchange Commission on July 8, 2025.

As filed with the Securities and Exchange Commission on July 8, 2025. Registration No. 333-286958 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-1/A Amendment No. 4 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 8731 27-0480143 (State or other jurisdiction of incorporation or org

June 27, 2025 S-1/A

As filed with the Securities and Exchange Commission on June 27, 2025.

As filed with the Securities and Exchange Commission on June 27, 2025. Registration No. 333-286958 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-1/A Amendment No. 3 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 8731 27-0480143 (State or other jurisdiction of incorporation or or

June 27, 2025 CORRESP

1185 AVENUE OF THE AMERICAS | 31ST FLOOR | NEW YORK, NY | 10036 T (212) 930-9700 | F (212) 930-9725 | WWW.SRFC.LAW

June 27, 2025 U.S. Securities and Exchange Commission Division of Corporation Finance Office of Industrial Applications and Services 100 F Street, N.E. Washington, D.C. 20549 Attn: Mr. O’Leary / Ms. Sawicki Re: iSpecimen Inc. Amendment No. 2 to Registration Statement on Form S-1 Filed June 11, 2025 File No. 333-286958 Dear Mr. O’Leary and Ms. Sawicki: On behalf of iSpecimen Inc. (the “Company”), w

June 24, 2025 LETTER

LETTER

June 24, 2025 Robert Lim Chief Executive Officer iSpecimen Inc. 8 Cabot Road, Suite 1800 Woburn, MA 01801 Re: iSpecimen Inc. Amendment No. 2 to Registration Statement on Form S-1 Filed June 11, 2025 File No. 333-286958 Dear Robert Lim: We have reviewed your amended registration statement and have the following comment. Please respond to this letter by amending your registration statement and provi

June 24, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): June 18, 2025 iSpecimen Inc. (Exa

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): June 18, 2025 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of Incorporation) (Commission File Numbe

June 11, 2025 EX-10.45

Consulting Agreement by and between the Company and IR Agency LLC.

Exhibit 10.45 CONSULTING AGREEMENT IR Agency LLC (the “Consultant” or “IR Agency”) is pleased to provide certain consulting services to iSpecimen Inc. (“you,” “Client” or “Company”) as more fully described in this agreement (the “Agreement”). This Agreement sets forth the terms and conditions pursuant to which Company engages Consultant to provide such services. 1. Consulting Services. (a) Commenc

June 11, 2025 S-1/A

As filed with the Securities and Exchange Commission on June 11, 2025.

As filed with the Securities and Exchange Commission on June 11, 2025. Registration No. 333-286958 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-1/A Amendment No. 2 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 8731 27-0480143 (State or other jurisdiction of incorporation or or

June 11, 2025 EX-10.46

Definitive Software Purchase and Services Agreement by and between the Company and Sales Stack Solutions Corp., a British Columbia Company.

Exhibit 10.46 Definitive Service Agreement for the Development of the SalesStack This Definitive Software Purchase and Services Agreement (the “Agreement”) is made and entered into as of the Effective Date (defined in Section 1.3 below), by and between: iSpecimen Inc., a Delaware corporation with its principal place of business at 8 Cabot Road, Woburn MA 01801 (the “Purchaser”), AND Sales Stack So

June 11, 2025 CORRESP

June 11, 2025 Via EDGAR

June 11, 2025 Via EDGAR U.S. Securities and Exchange Commission Division of Corporation Finance Office of Industrial Applications and Services Attn: Mr. O’Leary and Ms. Sawicki Re: iSpecimen Inc. Amendment No. 1 to Registration Statement on Form S-1 Filed May 23, 2025 File No. 333-286958 Dear Mr. O’Leary and Ms. Sawicki: On behalf of iSpecimen Inc. (the “Company”), we have set forth below response

June 9, 2025 LETTER

LETTER

June 9, 2025 Robert Lim Chief Executive Officer iSpecimen Inc. 8 Cabot Road, Suite 1800 Woburn, MA 01801 Re: iSpecimen Inc. Amendment No. 1 to Registration Statement on Form S-1 Filed May 23, 2025 File No. 333-286958 Dear Robert Lim: We have reviewed your amended registration statement and have the following comment. Please respond to this letter by amending your registration statement and providi

June 5, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): June 4, 2025 iSpecimen Inc. (Exac

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): June 4, 2025 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of Incorporation) (Commission File Number

May 23, 2025 EX-FILING FEES

Filing Fee Table.

Exhibit 107 Calculation of Filing Fee Tables FORM S-1 (Form Type) ISPECIMEN INC. (Exact Name of Registrant as Specified in its Charter) Table 1: Newly Registered Securities Security Type Security Class Title Fee Calculation Rule Amount Registered Proposed Maximum Offering Price Per Share Maximum Aggregate Offering Price(1)(3) Fee Rate Amount of Registration Fee Fees to Be Paid Equity Common Stock,

May 23, 2025 S-1/A

As filed with the Securities and Exchange Commission on May 23, 2025.

As filed with the Securities and Exchange Commission on May 23, 2025. Registration No. 333-286958 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-1/A Amendment No. 1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 8731 27-0480143 (State or other jurisdiction of incorporation or org

May 23, 2025 EX-10.46

Form of Definitive Software Purchase and Services Agreement by and between the Company and Sales Stack Solutions Corp., a British Columbia Company.

Exhibit 10.46 Definitive Service Agreement for the Development of the SalesStack This Definitive Software Purchase and Services Agreement (the “Agreement”) is made and entered into as of the Effective Date (defined in Section 1.3 below), by and between: iSpecimen Inc., a Delaware corporation with its principal place of business at 8 Cabot Road, Woburn MA 01801 (the “Purchaser”), AND Sales Stack So

May 23, 2025 CORRESP

May 23, 2025 Via EDGAR

May 23, 2025 Via EDGAR U.S. Securities and Exchange Commission Division of Corporation Finance Office of Industrial Applications and Services 100 F Street, N.E. Washington, D.C. 20549 Attn: Mr. O’Leary / Ms. Sawicki Re: iSpecimen Inc. Registration Statement on Form S-1 Submitted May 2, 2025 File No. 333-286958 Dear Mr. O’Leary and Ms. Sawicki: On behalf of iSpecimen Inc. (the “Company”), we have s

May 19, 2025 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Quarterly Period Ended March 31, 2025 ☐ TRANSITION REPORT P

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Quarterly Period Ended March 31, 2025 ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File No. 001-40501 iSpecimen Inc. (

May 16, 2025 LETTER

LETTER

May 16, 2025 Robert Lim Chief Executive Officer iSpecimen Inc. 8 Cabot Road, Suite 1800 Woburn, MA 01801 Re: iSpecimen Inc. Registration Statement on Form S-1 Filed May 2, 2025 File No. 333-286958 Dear Robert Lim: We have conducted a limited review of your registration statement and have the following comments. Please respond to this letter by amending your registration statement and providing the

May 15, 2025 NT 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 12b-25 NOTIFICATION OF LATE FILING

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 12b-25 NOTIFICATION OF LATE FILING (Check one): ☐ Form 10-K ☐ Form 20-F ☐ Form 11-K ☒ Form 10-Q ☐ Form 10-D ☐ Form N-CEN ☐ Form N-CSR For Period Ended: March 31, 2025 ☐ Transition Report on Form 10-K ☐ Transition Report on Form 20-F ☐ Transition Report on Form 11-K ☐ Transition Report on Form 10-Q For the Transition Perio

May 2, 2025 EX-1.1

Form of Underwriting Agreement between the Company and WestPark Capital, Inc.

Exhibit 1.1 ISPECIMEN INC. UNDERWRITING AGREEMENT [*], 2025 WestPark Capital, Inc. 1800 Century Park East, Suite 220 Los Angeles, CA 90067 As Representative of the Several underwriters, if any, named in Schedule I hereto Ladies and Gentlemen: The undersigned, ISPECIMEN INC., a corporation formed under the laws of the State of Delaware (the “Company”), hereby confirms its agreement (this “Agreement

May 2, 2025 S-1

As filed with the Securities and Exchange Commission on May 2, 2025.

As filed with the Securities and Exchange Commission on May 2, 2025. Registration No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 8731 27-0480143 (State or other jurisdiction of incorporation or organization) (Primary Stand

May 2, 2025 EX-10.46

Form of Software Agreement by and between the Company and Sales Stack Solutions Corp., a British Columbia Company.

Exhibit 10.46 BETWEEN: iSpecimen Inc., a Delaware corporation, with its principal place of business at 8 Cabot Road, Woburn MA 01801 (the “Purchaser”) AND: Sales Stack Solutions Corp., a British Columbia Company, with a registered address at 25th Floor – 700 West Georgia Street, Vancouver B.C. V7Y 1K8 (the “Vendor”) WHEREAS: 1. The Purchaser has recently experienced technological challenges associ

May 2, 2025 EX-FILING FEES

Filing Fee Table.

Exhibit 107 Calculation of Filing Fee Tables FORM S-1 (Form Type) ISPECIMEN INC. (Exact Name of Registrant as Specified in its Charter) Table 1: Newly Registered Securities Security Type Security Class Title Fee Calculation Rule Amount Registered Proposed Maximum Offering Price Per Share Maximum Aggregate Offering Price(1)(3) Fee Rate Amount of Registration Fee Fees to Be Paid Equity Common Stock,

May 2, 2025 EX-10.45

Form of Consulting Agreement by and between the Company and IR Agency LLC.

Exhibit 10.45 CONSULTING AGREEMENT IR Agency LLC (the “Consultant” or “IR Agency”) is pleased to provide certain consulting services to iSpecimen Inc (“you,” “Client” or “Company”) as more fully described in this agreement (the “Agreement”). This Agreement sets forth the terms and conditions pursuant to which Company engages Consultant to provide such services. 1. Consulting Services. (a) Commenci

May 2, 2025 EX-4.5

Form of Pre-Funded Warrant for Investors in this Offering.

Exhibit 4.5 PRE-FUNDED COMMON STOCK PURCHASE WARRANT ISPECIMEN INC. Warrant Shares: Issue Date: , 2025 Initial Exercise Date: , 2025 THIS PRE-FUNDED COMMON STOCK PURCHASE WARRANT (the “Warrant”) certifies that, for value received, or its assigns (the “Holder”) is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter set forth, at any time on or after th

April 14, 2025 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2024 ☐ TRANSITION REPORT PURSUANT TO SECTI

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2024 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-40501 iSpecimen Inc. (Exact nam

March 26, 2025 NT 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 12b-25 NOTIFICATION OF LATE FILING

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 12b-25 NOTIFICATION OF LATE FILING (Check One): ☒ Form 10-K ☐ Form 20-F ☐ Form 11-K ☐ Form 10-Q ☐ Form 10-D ☐ Form N-SAR ☐ Form N-CSR For Period Ended: December 31, 2024 ☐ Transition Report on Form 10-K ☐ Transition Report on Form 20-F ☐ Transition Report on Form 11-K ☐ Transition Report on Form 10-K ☐ Transition Report o

March 11, 2025 EX-16.1

Letter from Wolf & Company, P.C., dated March 11, 2025.

Exhibit 16.1 March 11, 2025 Securities and Exchange Commission Washington, DC 20549 Commissioners: We have read iSpecimen Inc.’s statements included under Item 4.01 of its Form 8-K filed on March 11, 2025 and we agree with such statements concerning our firm. Boston, Massachusetts

March 11, 2025 8-K

Financial Statements and Exhibits, Changes in Registrant's Certifying Accountant

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): March 7, 2025 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of Incorporation) (Commission File Numbe

February 28, 2025 EX-10.1

Employment Agreement between iSpecimen Inc. and Katharyn Field, dated February 28, 2025

Exhibit 10.1 February 28th, 2025 Katharyn Field 22210 Woodset Lane Boca Raton, FL 33428 Dear Katie: I am pleased to confirm our offer to you of the position of President with iSpecimen Inc. (the “Company"), effective as of February 19, 2025 (your “Employment Date”). The purpose of this letter is to generally describe your employment with the Company and your agreement with the terms thereof. Job R

February 28, 2025 8-K/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K/A (Amendment No. 1) CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): February 19,

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K/A (Amendment No. 1) CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): February 19, 2025 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of Incorporation

February 24, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): February 19, 2025 iSpecimen Inc.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): February 19, 2025 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of Incorporation) (Commission File N

January 16, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): January 16, 2025 iSpecimen Inc. (

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): January 16, 2025 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of Incorporation) (Commission File Nu

January 16, 2025 EX-99.1

iSpecimen Secures Suppliers for COVID-style hMPV Outbreak

Exhibit 99.1 iSpecimen Secures Suppliers for COVID-style hMPV Outbreak WOBURN, Mass., Jan. 16, 2025 (Newsfile Corp.) - iSpecimen Inc. (NASDAQ: ISPC), a leading online marketplace for human biospecimens, has secured suppliers for the flu-like human metapneumovirus (hMPV). The virus has been causing hospitals in China to become overrun, raising the potential for another COVID-style pandemic. iSpecim

December 30, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): December 27, 2024 iSpecimen Inc.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): December 27, 2024 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of Incorporation) (Commission File N

December 20, 2024 EX-99.1

iSpecimen will serve as a Preferred Provider of Cancer Biospecimens

Exhibit 99.1 iSpecimen will serve as a Preferred Provider of Cancer Biospecimens Woburn, MA, Dec. 20, 2024 (GLOBE NEWSWIRE) - iSpecimen Inc. (Nasdaq: ISPC), a leading online marketplace for human biospecimens, today announced its strategic initiatives for 2025, expanding services to procure high demand cancer biospecimens, enhancing its ability to support groundbreaking cancer research worldwide.

December 20, 2024 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Other Events, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): December 13, 2024 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of Incorporation) (Commission File N

December 20, 2024 EX-10.1

Engagement Letter between iSpecimen Inc. and Yuying Liang Professional Corp., dated December 13, 2024 (incorporated by reference as Exhibit 10.1 to the Company’s Form 8-K filed with the SEC on December 20, 2024).

Exhibit 10.1 YUYING LIANG PROFESSIONAL CORP. Vancouver, British Columbia Canada Telephone +1 778 318 7278 Private and Confidential December 13, 2024 Ms. Katharyn Field Director iSpecimen Inc. 8 Cabot Road, Suite 1800 Woburn, MA 01801 United States Dear Board of Directors: We appreciate the opportunity to provide accounting services to iSpecimen Inc. the (“Company”) in connection with the bookkeepi

December 13, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): December 13, 2024 iSpecimen Inc.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): December 13, 2024 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of Incorporation) (Commission File N

December 13, 2024 EX-99.1

iSpecimen Reports Positive Results on Next Day Quote Program for Researchers and Providers

Exhibit 99.1 iSpecimen Reports Positive Results on Next Day Quote Program for Researchers and Providers WOBURN, Mass., December 13, 2024 — iSpecimen Inc. (Nasdaq: ISPC) (“iSpecimen” or the “Company”), an online global marketplace that connects scientists requiring biospecimens for medical research with a network of healthcare specimen providers, announced today positive results attributed to its N

December 12, 2024 EX-10.1

Form of Independent Contractor Agreement, dated December 9, 2024, by and between iSpecimen Inc. and 1513932 B.C. Ltd., the personal corporation of Mr. Robert Bradley Lim.

Exhibit 10.1 INDEPENDENT CONTRACTOR AGREEMENT This Independent Contractor Agreement (the “Agreement”) is made and entered into as of this December 9, 2024, by and between iSpecimen Inc., a Delaware corporation, and Robert Bradley Lim (the “Contractor”) through his personal corporation, 1513932 B.C. Ltd., a company incorporated under the laws of the Province of British Columbia, Canada. 1. Engageme

December 12, 2024 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): December 9, 2024 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of Incorporation) (Commission File Nu

December 12, 2024 EX-99.1

iSpecimen Appoints Robert Lim as CEO and Director

Exhibit 99.1 iSpecimen Appoints Robert Lim as CEO and Director WOBURN, Mass., December 12, 2024 — iSpecimen Inc. (Nasdaq: ISPC) (“iSpecimen” or the “Company”), an online global marketplace that connects scientists requiring biospecimens for medical research with a network of healthcare specimen providers, announced today that it has appointed Robert Lim as CEO and director. Mr. Lim is the principa

November 12, 2024 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): November 7, 2024 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of Incorporation) (Commission File Nu

November 7, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One)

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Quarterly Period Ended September 30, 2024 ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File No. 001-

October 31, 2024 424B4

132,814 SHARES OF COMMON STOCK        PRE-FUNDED WARRANTS TO PURCHASE 1,533,852 SHARES OF COMMON STOCK 1,533,852 SHARES OF COMMON STOCK ISSUABLE UPON THE EXERCISE OF THE PRE-FUNDED WARRANTS iSpecimen Inc.

TABLE OF CONTENTS  Filed pursuant to Rule 424(b)(4)  Registration No. 333-282736 PROSPECTUS 132,814 SHARES OF COMMON STOCK        PRE-FUNDED WARRANTS TO PURCHASE 1,533,852 SHARES OF COMMON STOCK 1,533,852 SHARES OF COMMON STOCK ISSUABLE UPON THE EXERCISE OF THE PRE-FUNDED WARRANTS iSpecimen Inc. We are offering on a best-efforts basis 132,814 shares of our common stock, par value $0.0001 per share

October 31, 2024 EX-10.3

Form of Investor Relations Agreement (incorporated by reference as Exhibit 10.3 to the Company’s Form 8-K filed with the SEC on October 31, 2024).

Exhibit 10.3 CONSULTING AGREEMENT IR Agency LLC (the “Consultant” or “IR Agency”) is pleased to provide certain consulting services to iSpecimen Inc. (“you,” the “Client” or the “Company”) as more fully described in this agreement (the “Agreement”). This Agreement sets forth the terms and conditions pursuant to which the Company engages the Consultant to provide such services. 1. Consulting Servic

October 31, 2024 EX-10.1

Form of Placement Agency Agreement (incorporated by reference as Exhibit 10.1 to the Company’s Form 8-K filed with the SEC on October 31, 2024).

Exhibit 10.1 WestPark Capital, Inc. 1800 Century Park East, Suite 220 Los Angeles, CA 90067 October 29, 2024 iSpecimen Inc. 8 Cabot Road Woburn, MA 01801 Attention: Tracy Curley Dear Ms. Curley: Subject to the terms and conditions of this letter agreement (the “Agreement”), between WestPark Capital, Inc., as lead placement agent (“Placement Agent”), and iSpecimen Inc., a company organized under th

October 31, 2024 EX-10.2

Form of Securities Purchase Agreement (incorporated by reference as Exhibit 10.2 to the Company’s Form 8-K filed with the SEC on October 31, 2024).

Exhibit 10.2 SECURITIES PURCHASE AGREEMENT This Securities Purchase Agreement (this “Agreement”) is dated as of October 29, 2024, between iSpecimen Inc., a Delaware corporation (the “Company”), and each purchaser identified on the signature pages hereto (each, including its successors and assigns, a “Purchaser” and collectively the “Purchasers”). WHEREAS, subject to the terms and conditions set fo

October 31, 2024 8-K

Regulation FD Disclosure, Entry into a Material Definitive Agreement, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): October 29, 2024 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of Incorporation) (Commission File Nu

October 31, 2024 EX-4.1

Form of Pre-Funded Warrant (incorporated by reference as Exhibit 4.1 to the Company’s Form 8-K filed with the SEC on October 31, 2024).

Exhibit 4.1 PRE-FUNDED COMMON STOCK PURCHASE WARRANT ISPECIMEN INC. Warrant Shares: Initial Exercise Date: , 2024 THIS PRE-FUNDED COMMON STOCK PURCHASE WARRANT (“Warrant”) certifies that, for value received, or its assigns (the “Holder”) is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter set forth, at any time on or after the date hereof (the “Ini

October 31, 2024 EX-99.1

iSpecimen Inc. Announces Pricing of $5 Million Public Offering of Common Stock and Pre-Funded Warrants

Exhibit 99.1 iSpecimen Inc. Announces Pricing of $5 Million Public Offering of Common Stock and Pre-Funded Warrants WOBURN, Mass., October 29, 2024 – iSpecimen Inc. (Nasdaq: ISPC) (“iSpecimen” or the “Company”), an online global marketplace that connects scientists requiring biospecimens for medical research with a network of healthcare specimen providers, announced today the pricing of its public

October 31, 2024 EX-99.2

iSpecimen Inc. Announces Closing of $5 Million Public Offering of Common Stock and Pre-Funded Warrants

Exhibit 99.2 iSpecimen Inc. Announces Closing of $5 Million Public Offering of Common Stock and Pre-Funded Warrants WOBURN, Mass., October 31, 2024 – iSpecimen Inc. (Nasdaq: ISPC) (“iSpecimen” or the “Company”), an online global marketplace that connects scientists requiring biospecimens for medical research with a network of healthcare specimen providers, announced today the closing of its previo

October 28, 2024 CORRESP

iSpecimen Inc. 8 Cabot Road, Suite 1800 Mt Woburn, WA 08101

iSpecimen Inc. 8 Cabot Road, Suite 1800 Mt Woburn, WA 08101 October 28, 2024 VIA EDGAR U.S. Securities and Exchange Commission Division of Corporation Finance Office of Industrial Applications and Services 100 F Street, N.E. Washington, D.C. 20549 Re: iSpecimen Inc. Request for Acceleration Registration Statement on Form S-1 File No. 333-282736 Ladies and Gentlemen: Pursuant to Rule 461 promulgate

October 28, 2024 CORRESP

WestPark Capital, Inc. 1800 Century Park East, Suite 220 Los Angeles, CA 90067

WestPark Capital, Inc. 1800 Century Park East, Suite 220 Los Angeles, CA 90067 October 28, 2024 VIA EDGAR United States Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, DC 20549 Re: iSpecimen Inc. Registration Statement on Form S-1 File No. 333-282736 REQUEST FOR ACCELERATION OF EFFECTIVENESS Requested Date:    Tuesday, October 29, 2024 Requested Ti

October 24, 2024 LETTER

LETTER

October 24, 2024 Tracy Curley Chief Executive Officer iSpecimen Inc. 8 Cabot Road, Suite 1800 Woburn, MA 01801 Re: iSpecimen Inc. Registration Statement on Form S-1 Filed October 18, 2024 File No. 333-282736 Dear Tracy Curley: This is to advise you that we have not reviewed and will not review your registration statement. Please refer to Rules 460 and 461 regarding requests for acceleration. We re

October 18, 2024 EX-10.46

Form of Securities Purchase Agreement for this offering.

Exhibit 10.46 SECURITIES PURCHASE AGREEMENT This Securities Purchase Agreement (this “Agreement”) is dated as of , 2024, between iSpecimen Inc., a Delaware corporation (the “Company”), and each purchaser identified on the signature pages hereto (each, including its successors and assigns, a “Purchaser” and collectively the “Purchasers”). WHEREAS, subject to the terms and conditions set forth in th

October 18, 2024 EX-10.47

Form of Consulting Agreement by and between the Company and IR Agency LLC.

Exhibit 10.47 CONSULTING AGREEMENT IR Agency LLC (the “Consultant” or “IR Agency”) is pleased to provide certain consulting services to Ispecimen inc (“you,” the “Client” or the “Company”) as more fully described in this agreement (the “Agreement”). This Agreement sets forth the terms and conditions pursuant to which the Company engages the Consultant to provide such services. 1. Consulting Servic

October 18, 2024 EX-4.4

Form of Pre-Funded Warrant for Investors in this Offering.

Exhibit 4.4 PRE-FUNDED COMMON STOCK PURCHASE WARRANT ISPECIMEN INC. Warrant Shares: Initial Exercise Date: , 2024 THIS PRE-FUNDED COMMON STOCK PURCHASE WARRANT (“Warrant”) certifies that, for value received, or its assigns (the “Holder”) is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter set forth, at any time on or after the date hereof (the “Ini

October 18, 2024 EX-FILING FEES

Filing Fee Table.

Exhibit 107 Calculation of Filing Fee Tables S-1 (Form Type) iSpecimen Inc. (Exact Name of Registrant as Specified in its Charter) Table 1: Newly Registered Securities Security Type Security Class Title Fee Calculation or Carry Forward Rule Amount Registered Proposed Maximum Offering Price Per Unit Maximum Aggregate Offering Price(1)(2) Fee Rate Amount of Registration Fee Fees to Be Paid Equity Co

October 18, 2024 EX-1.1

Form of Placement Agency Agreement between the Company and WestPark Capital, Inc.

Exhibit 1.1 WestPark Capital, Inc. 1800 Century Park East, Suite 220 Los Angeles, CA 90067 [ ] [ ], 2024 iSpecimen, Inc. 8 Cabot Road Woburn, MA 01801 Attention: Tracy Curley Dear Ms. Curley: Subject to the terms and conditions of this letter agreement (the “Agreement”), between WestPark Capital, Inc., as lead placement agent (“Placement Agent”), and iSpecimen, Inc., a company organized under the

October 18, 2024 S-1

As filed with the Securities and Exchange Commission on October 18, 2024.

TABLE OF CONTENTS As filed with the Securities and Exchange Commission on October 18, 2024.

October 2, 2024 8-K

Regulation FD Disclosure, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): July 25, 2024 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of Incorporation) (Commission File Numbe

September 25, 2024 EX-4.1

Senior Note, dated as of September 24, 2024 (incorporated by reference to Exhibit 4.1 of the Company’s Current Report on Form 8-K filed with the SEC on September 25, 2024)

Exhibit 4.1 THIS SECURITY HAS NOT BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT UNDER THE SECURITIES ACT OR PURSUANT TO AN AVAI

September 25, 2024 EX-10.1

Note Purchase Agreement, dated as of September 19, 2024 (incorporated by reference to Exhibit 10.1 of the Company’s Current Report on Form 8-K filed with the SEC on September 25, 2024)

Exhibit 10.1 NOTE PURCHASE AGREEMENT This Note Purchase Agreement (this “Agreement”) is dated as of September 18, 2024 between iSpecimen Inc., a Delaware corporation (the “Company”), and the purchaser identified on the signature page (including its successors and assigns, the “Investor”. WHEREAS, the Investor wishes to purchase from the Company, and the Company wishes to issue and sell to the Inve

September 25, 2024 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Entry into a Material Definitive Agreement, Financial Statements and Exhibits, Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): September 19, 2024 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of Incorporation) (Commission File

September 11, 2024 8-K

Regulation FD Disclosure, Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Material Modification to Rights of Security Holders, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): September 11, 2024 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of incorporation) (Commission File

September 11, 2024 EX-99.1

iSpecimen Announces 1-for-20 Reverse Stock Split

Exhibit 99.1 iSpecimen Announces 1-for-20 Reverse Stock Split WOBURN, Mass., September 11, 2024 – iSpecimen Inc. (Nasdaq: ISPC) (“iSpecimen” or the “Company”), an online global marketplace that connects scientists requiring biospecimens for medical research with a network of healthcare specimen providers, announced today that it will effect a reverse stock split of its issued and outstanding share

September 11, 2024 EX-3.1

Form of Certificate of Amendment to Fourth Amended and Restated Certificate of Incorporation (incorporated by reference to Exhibit 3.1 of the Company’s Current Report on Form 8-K filed with the SEC on September 11, 2024)

Exhibit 3.1 CERTIFICATE OF AMENDMENT OF FOURTH AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF iSPECIMEN INC. A DELAWARE CORPORATION PURSUANT TO SECTION 242 OF THE GENERAL CORPORATION LAW OF THE STATE OF DELAWARE iSpecimen Inc., a corporation duly organized and existing under the General Corporation Law of the State of Delaware (the “Corporation”), does hereby certify that: First: That the na

August 6, 2024 EX-99.1

iSpecimen Reports Second Quarter 2024 Results Revenue increased 76% year-over-year to approximately $2.86 million Brielan Smiechowski Named SVP of Sales and Business Development

Exhibit 99.1 iSpecimen Reports Second Quarter 2024 Results Revenue increased 76% year-over-year to approximately $2.86 million Brielan Smiechowski Named SVP of Sales and Business Development LEXINGTON, Mass., August 6, 2024 – iSpecimen Inc. (Nasdaq: ISPC) (“iSpecimen” or the “Company”), an online global marketplace that connects scientists requiring biospecimens for medical research with a network

August 6, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): August 6, 2024 iSpecimen Inc. (Ex

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): August 6, 2024 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of incorporation) (Commission File Numb

August 6, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One)

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Quarterly Period Ended June 30, 2024 ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File No. 001-40501

August 6, 2024 EX-99.2

August 2024 Investor Presentation Nasdaq: ISPC The Online Marketplace for Human Biospecimens Transforming Biospecimen Procurement

Exhibit 99.2 August 2024 Investor Presentation Nasdaq: ISPC The Online Marketplace for Human Biospecimens Transforming Biospecimen Procurement This presentation may contain forward - looking statements within the meaning of Section 27 A of the Securities Act of 1933 , as amended, and Section 21 E of the Securities Exchange Act of 1934 , as amended . Such forward - looking statements are characteri

July 22, 2024 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): July 17, 2024 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of incorporation) (Commission File Numbe

July 8, 2024 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): July 5, 2024 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of incorporation) (Commission File Number

July 3, 2024 EX-10.2

Notice of Lease Termination, dated June 28, 2024 (incorporated by reference to Exhibit 10.2 of the Company’s Current Report on Form 8-K filed with the SEC on July 3, 2024)

Exhibit 10.2 450 Bedford Street | Lexington, MA 02420 | 781-301-6700 June 28, 2024 TO: BEDFORD STREET LLC: NOTICE OF LEASE TERMINATION This Notice of Lease Termination (the “Notice”) is in reference to the Seventh Amendment to the Lease Agreement (“Seventh Amendment”) dated September 27, 2023, by and between iSpecimen Inc. (“Tenant”) and Bedford Street LLC (“Landlord”). Date of Notice: June 28, 20

July 3, 2024 EX-10.1

Commercial Lease, dated July 2, 2024, between the Company and Cummings Properties, LLC (incorporated by reference to Exhibit 10.1 of the Company’s Current Report on Form 8-K filed with the SEC on July 3, 2024)

Exhibit 10.1 CUMMINGS PROPERTIES, LLC COMMERCIAL LEASE Cummings Properties, LLC ("LESSOR") hereby leases to iSpecimen Inc. (a DE corp.), 450 Bedford Street, Suite 1010, Lexington, MA 02420 ("LESSEE"), the following premises, approximately 2,273 square feet (including 13% common area) at 8 Cabot Road, Suite 1800, Woburn, MA 01801 (“premises"), for an initial term of five years and two months commen

July 3, 2024 8-K

Entry into a Material Definitive Agreement, Termination of a Material Definitive Agreement, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): June 28, 2024 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of incorporation) (Commission File Numbe

June 10, 2024 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

TABLE OF CONTENTS UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant [X] Filed by a Party other than the Registrant [ ] Check the appropriate box: [ ] Preliminary Proxy Statement [ ] Confidential, for Use of the Commission Only (as permitted by Rule

June 10, 2024 ARS

ARS

Transforming Biospecimen Procurement An online marketplace for human biospecimens 2023 Annual Report UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.

May 28, 2024 PRER14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION (Amendment No. 1) Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

TABLE OF CONTENTS UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION (Amendment No. 1) Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant [X] Filed by a Party other than the Registrant [ ] Check the appropriate box: [X] Preliminary Proxy Statement [ ] Confidential, for Use of the Commission Only (as

May 17, 2024 8-K

Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): May 16, 2024 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of incorporation) (Commission File Number

May 7, 2024 EX-99.2

This presentation may contain forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. Such forward-looking statements are characterize

Exhibit 99.2 May 2024 Investor Presentation Nasdaq: ISPC The Online Marketplace for Human Biospecimens Transforming Biospecimen Procurement This presentation may contain forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. Such forward-looking statements are characterized by futur

May 7, 2024 EX-99.1

iSpecimen Reports First Quarter 2024 Results

Exhibit 99.1 iSpecimen Reports First Quarter 2024 Results LEXINGTON, Mass., May 7, 2024 – iSpecimen Inc. (Nasdaq: ISPC) (“iSpecimen” or the “Company”), an online global marketplace that connects scientists requiring biospecimens for medical research with a network of healthcare specimen providers, today reported its financial and operating results for the three-month period ended March 31, 2024. “

May 7, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One)

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Quarterly Period Ended March 31, 2024 ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File No. 001-4050

May 7, 2024 8-K

Regulation FD Disclosure, Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): May 7, 2024 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of incorporation) (Commission File Number)

April 11, 2024 8-K

Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of Listing

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): April 9, 2024 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of incorporation) (Commission File Numbe

March 28, 2024 PRE 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

TABLE OF CONTENTS UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant [X] Filed by a Party other than the Registrant [ ] Check the appropriate box: [X] Preliminary Proxy Statement [ ] Confidential, for Use of the Commission Only (as permitted by Rule

March 26, 2024 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): March 21, 2024 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of incorporation) (Commission File Numb

March 14, 2024 EX-99.1

iSpecimen Reports Full Year 2023 Results

Exhibit 99.1 iSpecimen Reports Full Year 2023 Results LEXINGTON, Mass., March 14 2024 – iSpecimen Inc. (Nasdaq: ISPC) (“iSpecimen” or the “Company”), an online global marketplace that connects scientists requiring biospecimens for medical research with a network of healthcare specimen providers, today reported its financial and operating results for the twelve-month period ended December 31, 2023.

March 14, 2024 EX-99.2

This presentation may contain forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. Such forward-looking statements are characterize

Exhibit 99.2 March 2024 Investor Presentation Nasdaq: ISPC The Online Marketplace for Human Biospecimens Transforming Biospecimen Procurement This presentation may contain forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. Such forward-looking statements are characterized by fut

March 14, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): March 14, 2024 iSpecimen Inc. (Ex

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): March 14, 2024 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of incorporation) (Commission File Numb

March 13, 2024 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period fromto Commission file number: 001-40501 iSpecime

March 13, 2024 EX-97.1

iSpecimen Inc. Executive Compensation Clawback Policy (Adopted on October 27, 2023).

Exhibit 97.1 ISPECIMEN INC. EXECUTIVE COMPENSATION CLAWBACK POLICY Adopted as of October 27, 2023 The Board of Directors (the “Board”) of iSpecimen Inc. (the “Company”) has adopted the following executive compensation clawback policy (this “Policy”). This Policy shall supplement any other clawback or compensation recovery policy or policies adopted by the Company or included in any agreement betwe

March 5, 2024 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): March 5, 2024 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of Incorporation) (Commission File Numbe

March 5, 2024 424B5

iSpecimen Inc. Up to $1,500,000 of Common Stock

TABLE OF CONTENTS  Filed Pursuant to Rule 424(b)(5)  Registration Statement 333-265976 PROSPECTUS SUPPLEMENT (To Prospectus dated July 12, 2022) iSpecimen Inc.

March 5, 2024 EX-10.1

At the Market Offering Agreement, dated March 5, 2024, between the Company and Rodman & Renshaw LLC

Exhibit 10.1 AT THE MARKET OFFERING AGREEMENT March 5, 2024 Rodman & Renshaw LLC 600 Lexington Avenue, 32nd Floor New York, NY 10022 Ladies and Gentlemen: iSpecimen Inc., a corporation organized under the laws of Delaware (the “Company”), confirms its agreement (this “Agreement”) with Rodman & Renshaw LLC (the “Manager”) as follows: 1.             Definitions. The terms that follow, when used in t

February 15, 2024 EX-10.1

Form of Warrant Repurchase and Termination Agreements between the Company and certain Warrant Holders

Exhibit 10.1 WARRANT REPURCHASE AND TERMINATION AGREEMENT This WARRANT REPURCHASE AND TERMINATION AGREEMENT (this “Agreement”), dated and effective as of , 2024 (the “Effective Date”), is entered into by and between (“Warrant Holder”), and iSpecimen Inc., a Delaware corporation (the “Company”). The Warrant Holder and the Company are sometimes each referred to herein as a “Party” and collectively a

February 15, 2024 8-K

Entry into a Material Definitive Agreement, Termination of a Material Definitive Agreement

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): February 13, 2024 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of Incorporation) (Commission File N

February 13, 2024 SC 13G/A

ISPC / iSpecimen Inc. / OBF Investments, LLC Passive Investment

SC 13G/A 1 tm61.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G/A Under the Securities Exchange Act of 1934 (Amendment No. 2)* iSpecimen Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 45032V108 (CUSIP Number) December 31, 2023 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant

December 21, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): December 15, 2023 iSpecimen Inc.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): December 15, 2023 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of Incorporation) (Commission File N

November 2, 2023 8-K

Regulation FD Disclosure, Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): November 2, 2023 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of incorporation) (Commission File Nu

November 2, 2023 EX-99.2

November 2023 Investor Presentation Nasdaq: ISPC The Online Marketplace for Human Biospecimens Transforming Biospecimen Procurement This presentation may contain forward - looking statements within the meaning of Section 27 A of the Securities Act of

Exhibit 99.2 November 2023 Investor Presentation Nasdaq: ISPC The Online Marketplace for Human Biospecimens Transforming Biospecimen Procurement This presentation may contain forward - looking statements within the meaning of Section 27 A of the Securities Act of 1933 , as amended, and Section 21 E of the Securities Exchange Act of 1934 , as amended . Such forward - looking statements are characte

November 2, 2023 EX-99.1

iSpecimen Reports Third Quarter 2023 Financial and Operating Results Sequential Quarterly Revenue Growth of 75% Driven by Enhanced Operational Efficiencies of iSpecimen Marketplace and Rollout of New Business Initiatives

Exhibit 99.1 iSpecimen Reports Third Quarter 2023 Financial and Operating Results Sequential Quarterly Revenue Growth of 75% Driven by Enhanced Operational Efficiencies of iSpecimen Marketplace and Rollout of New Business Initiatives LEXINGTON, Mass., November 2, 2023 – iSpecimen Inc. (Nasdaq: ISPC) (“iSpecimen” or the “Company”), an online global marketplace that connects scientists requiring bio

November 2, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One)

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Quarterly Period Ended September 30, 2023 ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File No. 001-

October 23, 2023 8-K

Regulation FD Disclosure, Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): October 23, 2023 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of incorporation) (Commission File Nu

October 23, 2023 EX-99.1

iSpecimen Preannounces Third Quarter 2023 Revenue Increase of 60-70% Sequentially Management to Host Third Quarter 2023 Conference Call on Thursday, November 2, 2023

Exhibit 99.1 iSpecimen Preannounces Third Quarter 2023 Revenue Increase of 60-70% Sequentially Management to Host Third Quarter 2023 Conference Call on Thursday, November 2, 2023 LEXINGTON, Mass., October 23, 2023 – iSpecimen Inc. (Nasdaq: ISPC) (“iSpecimen” or the “Company”), an online global marketplace that connects scientists requiring biospecimens for medical research with a network of health

October 10, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): October 9, 2023 iSpecimen Inc. (E

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): October 9, 2023 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of incorporation) (Commission File Num

September 6, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): September 6, 2023 iSpecimen Inc.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): September 6, 2023 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of incorporation) (Commission File N

September 6, 2023 EX-99.1

iSpecimen Announces Organizational Changes to Enhance Operational Efficiencies and Drive Profitability Company to Focus on Core Revenue Drivers, New Revenue Growth Opportunities from Recently Launched Sequencing Procurement Program and Expense Reduct

Exhibit 99.1 iSpecimen Announces Organizational Changes to Enhance Operational Efficiencies and Drive Profitability Company to Focus on Core Revenue Drivers, New Revenue Growth Opportunities from Recently Launched Sequencing Procurement Program and Expense Reductions LEXINGTON, Mass., September 6, 2023 – iSpecimen Inc. (Nasdaq: ISPC) (“iSpecimen” or the “Company”), an online global marketplace tha

August 2, 2023 EX-99.1

iSpecimen Reports Second Quarter 2023 Financial and Operating Results

Exhibit 99.1 iSpecimen Reports Second Quarter 2023 Financial and Operating Results LEXINGTON, Mass., August 2, 2023 – iSpecimen Inc. (Nasdaq: ISPC) (“iSpecimen” or the “Company”), an online global marketplace that connects scientists requiring biospecimens for medical research with a network of healthcare specimen providers, today reported its financial and operating results for the three and six

August 2, 2023 EX-99.2

August 2023 Investor Presentation Nasdaq: ISPC The Online Marketplace for Human Biospecimens Transforming Biospecimen Procurement

Exhibit 99.2 August 2023 Investor Presentation Nasdaq: ISPC The Online Marketplace for Human Biospecimens Transforming Biospecimen Procurement This presentation may contain forward - looking statements within the meaning of Section 27 A of the Securities Act of 1933 , as amended, and Section 21 E of the Securities Exchange Act of 1934 , as amended . Such forward - looking statements are characteri

August 2, 2023 8-K

Regulation FD Disclosure, Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): August 2, 2023 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of incorporation) (Commission File Numb

August 2, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One)

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Quarterly Period Ended June 30, 2023 ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File No. 001-40501

July 7, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): July 7, 2023 iSpecimen Inc. (Exac

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): July 7, 2023 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of Incorporation) (Commission File Number

May 25, 2023 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits, Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): May 24, 2023 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of Incorporation) (Commission File Number

May 25, 2023 EX-10.1

Amendment No. 1 to iSpecimen Inc. Second Amended and Restated 2021 Stock Incentive Plan

AMENDMENT NO. 1 TO iSPECIMEN INC. AMENDED AND RESTATED 2021 STOCK INCENTIVE PLAN WHEREAS, iSpecimen Inc. (the “Company”) has adopted the 2021 Stock Incentive Plan, effective June 16, 2021, which was amended and restated twice since adoption and the Second Amended and Restated 2021 Stock Incentive Plan was approved by the of holders of the Company’s common stock (“Common Stock”), $0.0001 par value

May 4, 2023 EX-99.1

iSpecimen Reports First Quarter 2023 Results - Quarterly Revenue Increased 17% Year-Over-Year -

Exhibit 99.1 iSpecimen Reports First Quarter 2023 Results - Quarterly Revenue Increased 17% Year-Over-Year - LEXINGTON, MA, May 4, 2023 – iSpecimen Inc. (Nasdaq: ISPC) (“iSpecimen” or the “Company”), an online global marketplace that connects scientists requiring biospecimens for medical research with a network of healthcare specimen providers, today reported its financial and operating results fo

May 4, 2023 EX-99.2

This presentation may contain forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. Such forward-looking statements are characterize

Exhibit 99.2 May 2023 Investor Presentation Transforming Biospecimen Procurement An online marketplace for human biospecimens This presentation may contain forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. Such forward-looking statements are characterized by future or condition

May 4, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One)

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Quarterly Period Ended March 31, 2023 ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File No. 001-4050

May 4, 2023 8-K

Regulation FD Disclosure, Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): May 4, 2023 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of incorporation) (Commission File Number)

April 17, 2023 SC 13D

ISPC / iSpecimen Inc / Ross Andrew L. - SC 13D Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. )* iSpecimen Inc. (Name of Issuer) Common Stock, par value $0.0001 (Title of Class of Securities) 45032V108 (CUSIP Number) Andrew L. Ross c/o iSpecimen Inc. 450 Bedford Street Lexington, MA 02420 (781) 301-6700 (Name, Address and Telephone Number of Person A

April 10, 2023 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

DEFA14A 1 tm232091d5defa14a.htm DEFA14A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant x Filed by a Party other than the Registrant ¨ Check the appropriate box: ¨ Preliminary Proxy Statement ¨ Confidential, for Use of the Commission Only (a

April 10, 2023 ARS

ARS

Transforming Biospecimen Procurement An online marketplace for human biospecimens 2022 Annual Report 450 Bedford Street | Lexington, MA 02420 | 781-301-6700 Dear Fellow Stockholders, It is an exciting time to be associated with iSpecimen.

April 10, 2023 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

TABLE OF CONTENTS UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant [X] Filed by a Party other than the Registrant [ ] Check the appropriate box: [ ] Preliminary Proxy Statement [ ] Confidential, for Use of the Commission Only (as permitted by Rule

March 31, 2023 EX-10.2

Second Amendment to First Amended and Restated Executive Employment Agreement, dated March 31, 2023, by and between Tracy Wilson Curley and iSpecimen Inc.

Exhibit 10.2 SECOND AMENDMENT TO first amended and restated executive employment agreement This is a contractual amendment to the First Amended and Restated Executive Employment Agreement between iSpecimen, Inc. (the “Company”) and TRACY WILSON CURLEY (the “Executive”), executed on October 24th, 2022, as previously amended by the First Amendment to the First Amended and Restated Executive Employme

March 31, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): March 31, 2023 iSpecimen Inc. (Ex

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): March 31, 2023 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or Other Jurisdiction of Incorporation) (Commission File Numb

March 31, 2023 EX-10.1

Amendment No. 1 to iSpecimen Inc. Second Amended and Restated 2021 Stock Incentive Plan (incorporated by reference to Exhibit 10.1 of the Company’s Current Report on Form 8-K filed with the SEC on May 25, 2023)

Exhibit 10.1 first AMENDMENT TO first amended and restated executive employment agreement This is a contractual amendment to the First Amended and Restated Executive Employment Agreement between iSpecimen, Inc. (the “Company”) and TRACY WILSON CURLEY (the “Executive”), executed on October 24th, 2022 (the “Agreement”). WHEREAS, the Company and Executive do now mutually desire to amend the Agreement

March 31, 2023 PRE 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

TABLE OF CONTENTS UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant [X] Filed by a Party other than the Registrant [ ] Check the appropriate box: [X] Preliminary Proxy Statement [ ] Confidential, for Use of the Commission Only (as permitted by Rule

March 30, 2023 10-K/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K/A (Amendment No. 1)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K/A (Amendment No. 1) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2022 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For The Transition Period FromTo Commission file number: 001-40501 iSpeci

March 21, 2023 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2022 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For The Transition Period FromTo Commission file number: 001-40501 iSpecimen Inc. (Exact name

March 14, 2023 EX-99.1

iSpecimen Reports Full Year 2022 Results - Reported Record Quarterly Revenue of $3.2 Million, Up 28% Year-Over-Year -

Exhibit 99.1 iSpecimen Reports Full Year 2022 Results - Reported Record Quarterly Revenue of $3.2 Million, Up 28% Year-Over-Year - LEXINGTON, MA, March 14, 2023 – iSpecimen Inc. (Nasdaq: ISPC) (“iSpecimen” or the “Company”), an online global marketplace that connects scientists in need of biospecimens for medical research with a network of healthcare specimen providers, today reported its financia

March 14, 2023 EX-99.2

CONNECT. INNOVATE. March 2023 Investor Presentation TRANSFORMING BIOSPECIMEN PROCUREMENT An online marketplace for human biospecimens

Exhibit 99.2 CONNECT. INNOVATE. March 2023 Investor Presentation TRANSFORMING BIOSPECIMEN PROCUREMENT An online marketplace for human biospecimens This presentation may contain forward - looking statements within the meaning of Section 27 A of the Securities Act of 1933 , as amended, and Section 21 E of the Securities Exchange Act of 1934 , as amended . Such forward - looking statements are charac

March 14, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): March 14, 2023 iSpecimen Inc. (Ex

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): March 14, 2023 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of incorporation) (Commission File Numb

February 13, 2023 SC 13G/A

ISPC / iSpecimen Inc. / OBF Investments, LLC Passive Investment

SC 13G/A 1 tm20.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G/A Under the Securities Exchange Act of 1934 (Amendment No. 1)* iSpecimen Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 45032V108 (CUSIP Number) December 31, 2022 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant

January 12, 2023 SC 13G/A

ISPC / iSpecimen Inc. / Empery Asset Management, LP - ISPECIMEN INC. Passive Investment

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* iSpecimen Inc. (Name of Issuer) Common Stock, par value $0.0001 (Title of Class of Securities) 45032V108 (CUSIP Number) December 31, 2022 (Date of event which requires filing of this statement) Check the appropriate box to designate the rule pursuant to which this Sch

January 10, 2023 EX-99.1

iSpecimen Names Tracy Curley as Chief Executive Officer Previously Appointed Interim CEO in September 2022

Exhibit 99.1 iSpecimen Names Tracy Curley as Chief Executive Officer - Previously Appointed Interim CEO in September 2022 - LEXINGTON, Mass. – January 10, 2023 – iSpecimen Inc. (Nasdaq: ISPC) (“iSpecimen” or the “Company”), an online global marketplace that connects scientists in need of biospecimens for medical research with a network of healthcare specimen providers, announced today that its Boa

January 10, 2023 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): January 9, 2023 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of incorporation) (Commission File Num

December 30, 2022 424B3

Prospectus Supplement No. 1 to Reoffer Prospectus iSpecimen Inc.

Filed Pursuant to Rule 424(b)(3) Registration No. 333-261701 Prospectus Supplement No. 1 to Reoffer Prospectus of iSpecimen Inc. Up to 734,152 shares of Common Stock under the iSpecimen Inc. 2010 Stock Incentive Plan, the iSpecimen Inc. 2013 Stock Incentive Plan and the iSpecimen Inc. Second Amended and Restated 2021 Stock Incentive Plan. This Prospectus Supplement, dated December 30, 2022 (this ?

December 27, 2022 SC 13G/A

ISPC / iSpecimen Inc. / Wolf James G. - SC 13G/A Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G/A (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO §240.13d-1(b), (c) AND (d) AND AMENDMENTS THERETO FILED PURSUANT §240.13d-2 (Amendment No. 1) iSPECIMEN INC. (Name of Issuer) Common Stock $.0001 Par Value (Title of Class of Securities) 45032V108 (CUSIP Number) December 23, 2022 (Date of

November 28, 2022 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): November 28, 2022 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of incorporation) (Commission File N

November 8, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One)

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Quarterly Period Ended September 30, 2022 ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File No. 001-

November 8, 2022 8-K

Regulation FD Disclosure, Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): November 8, 2022 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of incorporation) (Commission File Nu

November 8, 2022 EX-99.2

Investor Presentation, dated November 2022.

Exhibit 99.2 CONNECT. INNOVATE. TRANSFORMING PROCUREMENT BIOSPECIMEN An online marketplace for human biospecimens November 2022 Investor Presentation Forward-Looking Statements This presentation may contain forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. Such forward-looking

November 8, 2022 EX-99.1

iSpecimen Reports Third Quarter 2022 Financial and Operating Results - Reported Revenue of $2.6 Million, Comprised Of A Record 88% Non-COVID Revenue -

Exhibit 99.1 iSpecimen Reports Third Quarter 2022 Financial and Operating Results - Reported Revenue of $2.6 Million, Comprised Of A Record 88% Non-COVID Revenue - LEXINGTON, MA, November 8, 2022 ? iSpecimen Inc. (Nasdaq: ISPC) (?iSpecimen? or the ?Company?), an online global marketplace that connects scientists in need of biospecimens for medical research with a network of healthcare specimen pro

October 28, 2022 EX-10.1

First Amended and Restated Executive Employment Agreement, dated October 24, 2022, by and between Tracy Wilson Curley and iSpecimen Inc. (incorporated by reference to Exhibit 10.1 of the Company’s Form 8-K filed with the SEC on October 28, 2022).

Exhibit 10.1 iSpecimen, Inc. FIRST AMENDED AND RESTATED EXECUTIVE EMPLOYMENT AGREEMENT This Amended and Restated Executive Employment Agreement (the ?Agreement?) made as of this 24 day of October, 2022, between Tracy Wilson Curley (the ?Executive?), and iSpecimen, Inc., a Delaware corporation located at 450 Bedford St, Lexington, MA 02420 (the ?Company?). Whereas, the Board of Directors of the Com

October 28, 2022 EX-10.2

First Restated Noncompetition, Nonsolicitation, Nondisclosure and Inventions Agreement, dated October 24, 2022, by and between Tracy Wilson Curley and iSpecimen Inc. (incorporated by reference to Exhibit 10.2 of the Company’s Form 8-K filed with the SEC on October 28, 2022).

Exhibit 10.2 iSpecimen, Inc. FIRST RESTATED NONCOMPETITION, NONSOLICITATION, NONDISCLOSURE AND INVENTIONS AGREEMENT The undersigned, TRACY WILSON CURLEY, in consideration for and as a condition of employment as a senior executive officer (the ?Executive?) of iSpecimen, Inc. (the ?Company?), or for receiving stock or options, or any other form of compensation, salary, bonus, benefit or fringe benef

October 28, 2022 EX-10.4

First Restated Noncompetition, Nonsolicitation, Nondisclosure and Inventions Agreement, dated October 24, 2022, by and between Benjamin Bielak and iSpecimen Inc. (incorporated by reference to Exhibit 10.4 of the Company’s Form 8-K filed with the SEC on October 28, 2022).

Exhibit 10.4 iSpecimen, Inc. FIRST RESTATED NONCOMPETITION, NONSOLICITATION, NONDISCLOSURE AND INVENTIONS AGREEMENT The undersigned, BENJAMIN BIELAK, in consideration for and as a condition of employment as a senior executive officer (the ?Executive?) of iSpecimen, Inc. (the ?Company?), or for receiving stock or options, or any other form of compensation, salary, bonus, benefit or fringe benefits

October 28, 2022 EX-10.5

Separation Agreement, dated October 24, 2022, by and between Christopher Ianelli and iSpecimen Inc. (incorporated by reference to Exhibit 10.5 of the Company’s Form 8-K filed with the SEC on October 28, 2022).

Exhibit 10.5 October 24, 2022 Christopher Ianelli, MD, Ph.D. Re:??????Separation Agreement Dear Chris, This letter sets forth the substance of the separation agreement (the ?Agreement?) which ISPECIMEN INC. (the ?Company?) is offering to you to aid in your employment transition. Separation. Your last day of work with the Company and your employment termination date will be October 24, 2022 (the ?S

October 28, 2022 EX-10.3

First Amended and Restated Executive Employment Agreement, dated October 24, 2022, by and between Benjamin Bielak and iSpecimen Inc. (incorporated by reference to Exhibit 10.3 of the Company’s Form 8-K filed with the SEC on October 28, 2022).

Exhibit 10.3 iSpecimen, Inc. FIRST AMENDED AND RESTATED EXECUTIVE EMPLOYMENT AGREEMENT This Amended and Restated Executive Employment Agreement (the ?Agreement?) made as of this 24th day of October, 2022, between Benjamin Bielak (the ?Executive?), and iSpecimen, Inc., a Delaware corporation located at 450 Bedford St, Lexington, MA 02420 (the ?Company?). Whereas, the Board of Directors of the Compa

October 28, 2022 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): October 24, 2022 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or Other Jurisdiction of Incorporation) (Commission File Nu

October 28, 2022 EX-10.6

Separation Agreement effective October 24, 2022, by and between Jill Mullan and iSpecimen Inc. (incorporated by reference to Exhibit 10.6 of the Company’s Form 8-K filed with the SEC on October 28, 2022).

Exhibit 10.6 October 24, 2022 Jill Mullan Re:??????Separation Agreement Dear Jill, This letter sets forth the substance of the separation agreement (the ?Agreement?) which ISPECIMEN INC. (the ?Company?) is offering to you to aid in your employment transition. Separation. Your last day of work with the Company and your employment termination date will be October 24, 2022 (the ?Separation Date?). Th

September 28, 2022 SC 13G

ISPC / iSpecimen Inc. / Wolf James G. - SC 13G Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO §240.13d-1(b), (c) AND (d) AND AMENDMENTS THERETO FILED PURSUANT §240.13d-2 (Amendment No. ) iSPECIMEN INC. (Name of Issuer) Common Stock $.0001 Par Value (Title of Class of Securities) 45032V108 (CUSIP Number) September 23, 2022 (Date of Ev

September 22, 2022 EX-99.1

iSpecimen Names Chief Financial Officer, Tracy Curley, Interim CEO Current President and CEO, Christopher Ianelli, to Leave Company

EX-99.1 2 tm2226424d1ex99-1.htm EXHIBIT 99.1 Exhibit 99.1 iSpecimen Names Chief Financial Officer, Tracy Curley, Interim CEO - Current President and CEO, Christopher Ianelli, to Leave Company - LEXINGTON, Mass., September 22, 2022 – iSpecimen Inc. (Nasdaq: ISPC) (“iSpecimen” or the “Company”), an online global marketplace that connects scientists in need of biospecimens for medical research with a

September 22, 2022 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): September 19, 2022 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or Other Jurisdiction of Incorporation) (Commission File

August 5, 2022 424B3

iSpecimen Inc. 2,598,473 Shares of Common Stock

TABLE OF CONTENTS ?Filed Pursuant to Rule 424(b)(3)? ?Registration No. 333-266384? PROSPECTUS iSpecimen Inc. 2,598,473 Shares of Common Stock This prospectus relates to the resale by the selling stockholders named herein, or their respective transferees, pledgees, donees or other successors-in-interest, from time to time, of up to an aggregate of 2,598,473 shares of common stock, par value $0.0001

August 4, 2022 EX-99.1

iSpecimen Reports Second Quarter 2022 Financial and Operating Results - Enhanced iSpecimen Marketplace Platform® with Data Integration Capabilities to Simplify the Ingestion and Maintenance of Biospecimen Inventories for Providers -

Exhibit 99.1 iSpecimen Reports Second Quarter 2022 Financial and Operating Results - Enhanced iSpecimen Marketplace Platform? with Data Integration Capabilities to Simplify the Ingestion and Maintenance of Biospecimen Inventories for Providers - LEXINGTON, MA, August 4, 2022 ? iSpecimen Inc. (Nasdaq: ISPC) (?iSpecimen? or the ?Company?), an online global marketplace that connects scientists in nee

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