Zymeworks Inc.
US ˙ NasdaqGS ˙ US98985Y1082

SecurityZYME / Zymeworks Inc.
InstitutionJane Street Group, Llc
Latest Disclosed Ownership226,967 shares
Latest Disclosed Value $ 5,683,253
Jane Street Group, Llc reports 222.19% increase in ownership of ZYME / Zymeworks Inc.

On May 12, 2026 - Jane Street Group, Llc filed a 13F-HR form disclosing ownership of 226,967 shares of Zymeworks Inc. (US:ZYME) valued at $5,683,254 USD as of March 31, 2026. The entity filed a previous 13F-HR on February 12, 2026 disclosing 70,445 shares of Zymeworks Inc.. This represents a change in shares of 222.19% during the quarter. The current value of the position is $5,456,287 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-05-12 2026-03-31 13F ZYMEWORKS COM 98985Y108 226,967 156,522 222.19 5,683 206.53 0.0004
2026-02-12 2025-12-31 13F ZYMEWORKS COM 98985Y108 70,445 -74,761 -51.49 1,855 -25.24 0.0003
2025-11-14 2025-09-30 13F ZYMEWORKS COM 98985Y108 145,206 132,657 1,057.11 2,480 1,479.62 0.0004
2025-08-14 2025-06-30 13F ZYMEWORKS COM 98985Y108 12,549 -123,214 -90.76 157 -90.28 0.0000
2025-05-19 2025-03-31 13F/A-1 ZYMEWORKS COM 98985Y108 135,763 112,636 487.03 1,617 378.11 0.0004
2025-05-14 2025-03-31 13F ZYMEWORKS COM 98985Y108 135,763 112,636 1,617 0.0003
2025-02-14 2024-12-31 13F ZYMEWORKS COM 98985Y108 23,127 -57,199 -71.21 339 -66.47 0.0001
2024-11-15 2024-09-30 13F ZYMEWORKS COM 98985Y108 80,326 17,205 27.26 1,008 87.71 0.0002
2024-08-15 2024-06-30 13F ZYMEWORKS COM 98985Y108 63,121 27,056 75.02 537 41.69 0.0001
2024-05-16 2024-03-31 13F ZYMEWORKS COM 98985Y108 36,065 -10,705 -22.89 379 -21.86 0.0001
2024-02-15 2023-12-31 13F ZYMEWORKS COM 98985Y108 46,770 46,770 486 0.0001
2023-08-14 2023-06-30 13F ZYMEWORKS COM 98985Y108 0 -140,816 -100.00 0 -100.00
2023-05-16 2023-03-31 13F ZYMEWORKS COM 98985Y108 140,816 140,816 1,273 0.0005
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.