Vertex Pharmaceuticals Incorporated
US ˙ NasdaqGS ˙ US92532F1003

SecurityVRTX / Vertex Pharmaceuticals Incorporated
InstitutionWetherby Asset Management Inc
Latest Disclosed Ownership5,470 shares
Latest Disclosed Value $ 2,142,271
Wetherby Asset Management Inc reports 3.56% decrease in ownership of VRTX / Vertex Pharmaceuticals Incorporated

On November 14, 2025 - Wetherby Asset Management Inc filed a 13F-HR form disclosing ownership of 5,470 shares of Vertex Pharmaceuticals Incorporated (US:VRTX) valued at $2,142,271 USD as of September 30, 2025. The entity filed a previous 13F-HR on August 14, 2025 disclosing 5,672 shares of Vertex Pharmaceuticals Incorporated. This represents a change in shares of -3.56% during the quarter. The current value of the position is $2,444,160 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2025-11-14 2025-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 5,470 -202 -3.56 2,142 -15.17 0.0875
2025-08-14 2025-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 5,672 90 1.61 2,525 12.37 0.1124
2025-02-14 2024-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 5,582 -297 -5.05 2,248 -17.81 0.1078
2024-11-14 2024-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 5,879 -84 -1.41 2,734 -2.15 0.1250
2024-08-14 2024-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 5,963 30 0.51 2,795 12.66 0.1318
2024-05-15 2024-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 5,933 -13 -0.22 2,480 2.52 0.1182
2024-02-14 2023-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 5,946 14 0.24 2,419 17.31 0.1260
2023-11-14 2023-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 5,932 107 1.84 2,063 0.63 0.1170
2023-08-14 2023-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 5,825 -179 -2.98 2,050 8.36 0.1104
2023-05-12 2023-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 6,004 213 3.68 1,892 13.10 0.1107
2023-02-14 2022-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 5,791 43 0.75 1,672 0.48 0.1074
2022-11-14 2022-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 5,748 540 10.37 1,664 13.35 0.1173
2022-08-15 2022-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 5,208 -445 -7.87 1,468 -0.47 0.1002
2022-05-16 2022-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 5,653 425 8.13 1,475 28.48 0.0845
2022-02-14 2021-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 5,228 1,148 28.14 1,148 55.14 0.0645
2021-11-15 2021-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 4,080 -327 -7.42 740 -16.76 0.0457
2021-08-16 2021-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 4,407 -390 -8.13 889 -13.77 0.0542
2021-05-14 2021-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 4,797 -290 -5.70 1,031 -14.23 0.0786
2021-02-11 2020-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 5,087 4,662 1,096.94 1,202 936.21 0.0815
2020-12-16 2020-09-30 13F/A-01 VERTEX PHARMACEUTICALS COM 92532F100 5,179 -541 1,409 0.1292
2020-12-16 2020-09-30 13F/A-02 VERTEX PHARMACEUTICALS COM 92532F100 425 -5,295 -92.57 116 -93.02 0.3485
2020-11-13 2020-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 5,623 -97 1,530 97,321.4343
2020-08-14 2020-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 5,720 65 1.15 1,661 23.40 0.1574
2020-05-06 2020-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 5,655 449 8.62 1,346 18.07 0.1511
2020-01-28 2019-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 5,206 177 3.52 1,140 33.80 0.1123
2019-10-31 2019-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 5,029 260 5.45 852 -2.52 0.0890
2019-07-25 2019-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 4,769 83 1.77 874 1.39 0.0957
2019-07-25 2019-03-31 13F/A-1 VERTEX PHARMACEUTICALS COM 92532F100 4,686 137 3.01 862 14.32 0.1073
2019-05-09 2019-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 4,686 137 862
2019-01-30 2018-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 4,549 297 6.98 754 -8.05 0.1067
2018-11-07 2018-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 4,252 225 5.59 820 19.88 0.1013
2018-07-24 2018-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 4,027 -51 -1.25 684 2.86 0.0926
2018-05-04 2018-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 4,078 375 10.13 665 19.82 0.0918
2018-02-09 2017-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 3,703 62 1.70 555 0.18 0.0770
2017-11-13 2017-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 3,641 263 7.79 554 27.36 0.0824
2017-08-01 2017-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 3,378 193 6.06 435 25.00 0.0740
2017-04-27 2017-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 3,185 3,185 348 0.0626
2017-02-08 2016-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 0 -3,111 -100.00 0 -100.00
2016-11-14 2016-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 3,111 669 27.40 271 29.05 0.0548
2016-08-10 2016-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 2,442 -776 -24.11 210 -17.97 0.0466
2016-05-10 2016-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 3,218 -306 -8.68 256 -42.21 0.0603
2016-02-08 2015-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 3,524 -111 -3.05 443 17.20 0.1062
2015-11-12 2015-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 3,635 785 27.54 378 7.39 0.0968
2015-08-12 2015-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 2,850 325 12.87 352 18.52 0.0846
2015-05-08 2015-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 2,525 157 6.63 297 5.32 0.0723
2015-02-12 2014-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 2,368 367 18.34 282 25.33 0.0709
2014-11-03 2014-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 2,001 2,001 225 0.0627
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.