Vertex Pharmaceuticals Incorporated
US ˙ NasdaqGS ˙ US92532F1003

SecurityVRTX / Vertex Pharmaceuticals Incorporated
InstitutionStifel Financial Corp
Latest Disclosed Ownership161,052 shares
Latest Disclosed Value $ 71,917,053
Stifel Financial Corp reports 5.64% increase in ownership of VRTX / Vertex Pharmaceuticals Incorporated

On May 12, 2026 - Stifel Financial Corp filed a 13F-HR form disclosing ownership of 161,052 shares of Vertex Pharmaceuticals Incorporated (US:VRTX) valued at $71,916,160 USD as of March 31, 2026. The entity filed a previous 13F-HR on February 13, 2026 disclosing 152,447 shares of Vertex Pharmaceuticals Incorporated. This represents a change in shares of 5.64% during the quarter. The current value of the position is $68,985,014 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-05-12 2026-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 161,052 8,605 5.64 71,917 4.06 0.0155
2026-02-13 2025-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 152,447 9,918 6.96 69,113 23.81 0.0622
2025-11-12 2025-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 142,529 40,984 40.36 55,820 23.48 0.0510
2025-08-14 2025-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 101,545 -5,446 -5.09 45,207 -12.85 0.0440
2025-05-14 2025-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 106,991 -17,853 -14.30 51,872 3.18 0.0551
2025-02-13 2024-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 124,844 30,512 32.35 50,275 14.60 0.0524
2024-11-14 2024-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 94,332 -2,315 -2.40 43,872 -3.15 0.0460
2024-08-13 2024-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 96,647 -6,494 -6.30 45,300 5.07 0.0510
2024-05-14 2024-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 103,141 3,534 3.55 43,114 6.38 0.0491
2024-02-12 2023-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 99,607 11,191 12.66 40,529 31.82 0.0510
2023-11-13 2023-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 88,416 -4,231 -4.57 30,746 -5.70 0.0432
2023-08-14 2023-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 92,647 13,570 17.16 32,603 30.86 0.0446
2023-05-12 2023-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 79,077 9,314 13.35 24,915 23.67 0.0357
2023-02-13 2022-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 69,763 5,939 9.31 20,146 9.02 0.0302
2022-11-14 2022-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 63,824 -17,696 -21.71 18,479 -19.56 0.0303
2022-08-15 2022-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 81,520 -23 -0.03 22,972 7.95 0.0360
2022-05-13 2022-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 81,543 -14,790 -15.35 21,280 0.60 0.0290
2022-02-14 2021-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 96,333 -16,531 -14.65 21,154 3.33 0.0280
2021-11-15 2021-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 112,864 -8,043 -6.65 20,472 -16.02 0.0300
2021-08-13 2021-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 120,907 11,010 10.02 24,378 3.22 0.0365
2021-05-14 2021-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 109,897 19,099 21.03 23,617 10.06 0.0389
2021-02-12 2020-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 90,798 -12,145 -11.80 21,459 -23.40 0.0383
2020-11-16 2020-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 102,943 310 0.30 28,013 -5.98 0.0576
2020-08-14 2020-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 102,633 5,997 6.21 29,795 30.19 0.0685
2020-05-14 2020-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 96,636 23,620 32.35 22,885 43.41 0.0632
2020-02-13 2019-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 73,016 4,492 6.56 15,958 36.84 0.0332
2019-11-19 2019-09-30 13F/A-1 VERTEX PHARMACEUTICALS COM 92532F100 68,524 -3,489 -4.84 11,662 -11.24 0.0298
2019-11-13 2019-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 68,283 -3,730 11,621 6,514.1530
2019-08-14 2019-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 72,013 3,871 5.68 13,139 5.06 0.0339
2019-05-14 2019-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 68,142 1,256 1.88 12,506 13.52 0.0353
2019-02-13 2018-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 66,886 -5,167 -7.17 11,017 -20.90 0.0356
2018-11-13 2018-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 72,053 6,692 10.24 13,928 25.03 0.0399
2018-08-14 2018-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 65,361 -3,375 -4.91 11,140 -0.02 0.0342
2018-05-11 2018-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 68,736 2,092 3.14 11,142 11.93 0.0352
2018-02-14 2017-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 66,644 1,743 2.69 9,954 0.91 0.0316
2017-11-13 2017-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 64,901 9,685 17.54 9,864 38.71 0.0342
2017-08-14 2017-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 55,216 15,880 40.37 7,111 65.06 0.0264
2017-05-10 2017-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 39,336 9,349 31.18 4,308 95.02 0.0167
2017-02-16 2016-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 29,987 12,407 70.57 2,209 44.10 0.0094
2016-11-15 2016-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 17,580 -2,174 -11.01 1,533 -9.82 0.0069
2016-08-17 2016-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 19,754 -637 -3.12 1,700 4.87 0.0079
2016-05-16 2016-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 20,391 -2,675 -11.60 1,621 -44.16 0.0086
2016-03-21 2015-12-31 13F/A-2 VERTEX PHARMACEUTICALS COM 92532F100 23,066 16,208 236.34 2,903 306.01 0.0151
2016-02-26 2015-12-31 13F/A-1 VERTEX PHARMACEUTICALS COM 92532F100 22,621 -445 2,848 0.0149
2016-02-16 2015-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 12,472 1,302
2015-11-16 2015-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 6,858 -6,062 -46.92 715 -52.65 0.0040
2015-08-17 2015-06-30 13F/A-1 VERTEX PHARMACEUTICALS COM 92532F100 12,920 10,612 459.79 1,510 453.11 0.0078
2015-08-17 2015-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 3,281 403
2015-05-14 2015-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 2,308 -2,583 -52.81 273 -53.01 0.0015
2015-02-13 2014-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 4,891 -614 -11.15 581 -5.99 0.0032
2014-11-13 2014-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 5,505 2,304 71.98 618 103.96 0.0054
2014-08-14 2014-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 3,201 3,201 303 0.0027
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.