Vertex Pharmaceuticals Incorporated
US ˙ NasdaqGS ˙ US92532F1003

SecurityVRTX / Vertex Pharmaceuticals Incorporated
InstitutionState Street Corp
Latest Disclosed Ownership11,730,139 shares
Latest Disclosed Value $ 5,237,976,269
State Street Corp reports 0.35% increase in ownership of VRTX / Vertex Pharmaceuticals Incorporated

On May 15, 2026 - State Street Corp filed a 13F-HR form disclosing ownership of 11,730,139 shares of Vertex Pharmaceuticals Incorporated (US:VRTX) valued at $5,237,976,269 USD as of March 31, 2026. The entity filed a previous 13F-HR on February 13, 2026 disclosing 11,689,539 shares of Vertex Pharmaceuticals Incorporated. This represents a change in shares of 0.35% during the quarter. The current value of the position is $5,024,487,739 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-05-15 2026-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 11,730,139 40,600 0.35 5,237,976 -1.16 0.1808
2026-02-13 2025-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 11,689,539 83,539 0.72 5,299,569 16.59 0.1778
2025-11-14 2025-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 11,606,000 -169,227 -1.44 4,545,374 -13.29 0.1576
2025-08-14 2025-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 11,775,227 -13,430 -0.11 5,242,331 -8.28 0.1965
2025-05-15 2025-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 11,788,657 -190,748 -1.59 5,715,377 18.48 0.2355
2025-02-14 2024-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 11,979,405 163,156 1.38 4,823,869 -12.22 0.1903
2024-11-14 2024-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 11,816,249 90,173 0.77 5,495,501 -0.01 0.2236
2024-08-14 2024-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 11,726,076 -280,407 -2.34 5,496,246 9.51 0.2402
2024-05-15 2024-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 12,006,483 -77,335 -0.64 5,018,830 2.08 0.2243
2024-02-14 2023-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 12,083,818 44,272 0.37 4,916,785 17.44 0.2392
2023-11-14 2023-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 12,039,546 -292,047 -2.37 4,186,632 -3.53 0.2321
2023-08-14 2023-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 12,331,593 124,141 1.02 4,339,611 12.83 0.2279
2023-05-15 2023-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 12,207,452 -162,978 -1.32 3,846,198 7.67 0.2170
2023-05-15 2022-12-31 13F/A-99 VERTEX PHARMACEUTICALS COM 92532F100 12,370,430 75,639 0.62 3,572,333 0.35 0.2099
2023-05-15 2022-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 12,370,430 75,639 3,572,333 0.2099
2022-11-15 2022-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 12,294,791 30,742 0.25 3,559,834 3.01 0.2252
2022-08-15 2022-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 12,264,049 211,286 1.75 3,455,886 9.87 0.2071
2022-05-16 2022-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 12,052,763 -304,152 -2.46 3,145,410 15.91 0.1555
2022-02-14 2021-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 12,356,915 33,499 0.27 2,713,579 21.39 0.1287
2021-11-15 2021-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 12,323,416 617,593 5.28 2,235,344 -5.29 0.1181
2021-08-16 2021-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 11,705,823 530,785 4.75 2,360,245 -1.71 0.1244
2021-07-09 2021-03-31 13F/A-1 VERTEX PHARMACEUTICALS COM 92532F100 11,175,038 -261,026 -2.28 2,401,404 -11.15 0.1377
2021-05-17 2021-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 11,175,038 -261,026 2,401,404 0.1377
2021-02-16 2020-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 11,436,064 74,118 0.65 2,702,799 -12.58 0.1655
2020-11-10 2020-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 11,361,946 -306,299 -2.63 3,091,813 -8.73 0.2111
2020-08-14 2020-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 11,668,245 219,002 1.91 3,387,408 24.34 0.2463
2020-06-19 2020-03-31 13F/A-1 VERTEX PHARMACEUTICALS COM 92532F100 11,449,243 54,718 0.48 2,724,347 9.20 0.2383
2020-05-11 2020-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 11,449,243 54,718 2,724,347 239,252.5220
2020-02-06 2019-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 11,394,525 80,917 0.72 2,494,831 30.16 0.1709
2019-11-14 2019-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 11,313,608 -60,634 -0.53 1,916,751 -8.11 0.1429
2019-08-14 2019-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 11,374,242 -109,804 -0.96 2,085,808 -1.26 0.1555
2019-05-15 2019-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 11,484,046 643,769 5.94 2,112,490 17.60 0.1648
2019-02-12 2018-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 10,840,277 -53,978 -0.50 1,796,342 -14.45 0.1635
2018-11-09 2018-09-30 13F VERTEX PHARMACEUTICALS Common equity shares 92532F100 10,894,255 404,711 3.86 2,099,758 17.78 0.1613
2018-08-14 2018-06-30 13F VERTEX PHARMACEUTICALS Common equity shares 92532F100 10,489,544 455,166 4.54 1,782,803 9.01 0.1490
2018-05-15 2018-03-31 13F VERTEX PHARMACEUTICALS Common equity shares 92532F100 10,034,378 -941,685 -8.58 1,635,399 -0.58 0.1389
2018-02-14 2017-12-31 13F VERTEX PHARMACEUTICALS Common equity shares 92532F100 10,976,063 -242,464 -2.16 1,644,877 -3.56 0.1323
2017-11-14 2017-09-30 13F VERTEX PHARMACEUTICALS Common equity shares 92532F100 11,218,527 -140,623 -1.24 1,705,669 16.52 0.1472
2017-08-14 2017-06-30 13F VERTEX PHARMACEUTICALS Common equity shares 92532F100 11,359,150 -654,028 -5.44 1,463,846 11.43 0.1295
2017-05-15 2017-03-31 13F VERTEX PHARMACEUTICALS Common equity shares 92532F100 12,013,178 239,017 2.03 1,313,647 51.45 0.1172
2017-02-09 2016-12-31 13F VERTEX PHARMACEUTICALS Common equity shares 92532F100 11,774,161 308,574 2.69 867,393 -13.25 0.0816
2017-01-13 2016-09-30 13F/A-1 VERTEX PHARMACEUTICALS Common equity shares 92532F100 11,465,587 1,639,879 16.69 999,917 18.30 0.1008
2016-11-14 2016-09-30 13F VERTEX PHARMACEUTICALS Common equity shares 92532F100 8,779,211 765,638
2016-08-12 2016-06-30 13F VERTEX PHARMACEUTICALS Common equity shares 92532F100 9,825,708 35,700 0.36 845,214 8.61 0.0908
2016-05-20 2016-03-31 13F/A-1 VERTEX PHARMACEUTICALS Common equity shares 92532F100 9,790,008 -11,572 -0.12 778,214 -36.90 0.0841
2016-05-12 2016-03-31 13F VERTEX PHARMACEUTICALS Common equity shares 92532F100 9,790,008 778,214
2016-02-16 2015-12-31 13F VERTEX PHARMACEUTICALS Common equity shares 92532F100 9,801,580 130,364 1.35 1,233,325 22.46 0.1348
2015-11-16 2015-09-30 13F VERTEX PHARMACEUTICALS Common equity shares 92532F100 9,671,216 20,073 0.21 1,007,149 -15.49 0.1172
2015-08-13 2015-06-30 13F VERTEX PHARMACEUTICALS Common equity shares 92532F100 9,651,143 -301,592 -3.03 1,191,724 1.50 0.1274
2015-05-15 2015-03-31 13F VERTEX PHARMACEUTICALS Common equity shares 92532F100 9,952,735 -303,130 -2.96 1,174,137 -3.63 0.1205
2015-02-11 2014-12-31 13F VERTEX PHARMACEUTICALS Common equity shares 92532F100 10,255,865 502,104 5.15 1,218,401 11.22 0.1214
2014-11-12 2014-09-30 13F/A-1 VERTEX PHARMACEUTICALS Common equity shares 92532F100 9,753,761 -208,163 -2.09 1,095,450 16.14 0.1179
2014-11-10 2014-09-30 13F VERTEX PHARMACEUTICALS Common equity shares 92532F100 9,753,761 1,095,450
2014-08-12 2014-06-30 13F VERTEX PHARMACEUTICALS Common equity shares 92532F100 9,961,924 -132,443 -1.31 943,193 32.12 0.1019
2014-05-15 2014-03-31 13F/A-1 VERTEX PHARMACEUTICALS Common equity shares 92532F100 10,094,367 457,444 4.75 713,876 -0.30 0.0811
2014-05-13 2014-03-31 13F VERTEX PHARMACEUTICALS Common equity shares 92532F100 10,094,367 713,876
2014-02-06 2013-12-31 13F/A-1 VERTEX PHARMACEUTICALS Common equity shares 92532F100 9,636,923 365,348 3.94 716,028 1.86 0.0797
2014-02-06 2013-12-31 13F VERTEX PHARMACEUTICALS Common equity shares 92532F100 7,112,897 298,316
2013-11-12 2013-09-30 13F VERTEX PHARMACEUTICALS Common equity shares 92532F100 9,271,575 2,192,814 30.98 702,972 24.33 0.0866
2013-08-08 2013-06-30 13F VERTEX PHARMACEUTICALS Common equity shares 92532F100 7,078,761 7,078,761 565,387 0.0737
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.