Vertex Pharmaceuticals Incorporated
US ˙ NasdaqGS ˙ US92532F1003

SecurityVRTX / Vertex Pharmaceuticals Incorporated
InstitutionSignaturefd, Llc
Latest Disclosed Ownership5,526 shares
Latest Disclosed Value $ 2,467,780
Signaturefd, Llc reports 4.17% increase in ownership of VRTX / Vertex Pharmaceuticals Incorporated

On April 7, 2026 - Signaturefd, Llc filed a 13F-HR form disclosing ownership of 5,526 shares of Vertex Pharmaceuticals Incorporated (US:VRTX) valued at $2,467,580 USD as of March 31, 2026. The entity filed a previous 13F-HR on January 20, 2026 disclosing 5,305 shares of Vertex Pharmaceuticals Incorporated. This represents a change in shares of 4.17% during the quarter. The current value of the position is $2,469,183 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-04-07 2026-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 5,526 221 4.17 2,468 2.58 0.0378
2026-01-20 2025-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 5,305 202 3.96 2,405 20.37 0.0367
2025-10-21 2025-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 5,103 -197 -3.72 1,999 -15.30 0.0315
2025-07-16 2025-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 5,300 -405 -7.10 2,360 -14.68 0.0402
2025-05-02 2025-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 5,705 656 12.99 2,766 36.01 0.0523
2025-02-10 2024-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 5,049 -100 -1.94 2,033 -15.08 0.0385
2024-10-21 2024-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 5,149 55 1.08 2,395 0.29 0.0456
2024-07-29 2024-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 5,094 -190 -3.60 2,388 8.11 0.0485
2024-05-03 2024-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 5,284 388 7.92 2,209 10.84 0.0467
2024-02-01 2023-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 4,896 448 10.07 1,992 28.85 0.0460
2023-11-03 2023-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 4,448 308 7.44 1,547 6.18 0.0403
2023-08-01 2023-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 4,140 386 10.28 1,457 23.18 0.0372
2023-04-28 2023-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 3,754 272 7.81 1,183 17.61 0.0323
2023-01-30 2022-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 3,482 125 3.72 1,006 3.40 0.0294
2022-11-08 2022-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 3,357 388 13.07 972 16.13 0.0333
2022-08-10 2022-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 2,969 332 12.59 837 21.66 0.0285
2022-05-02 2022-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 2,637 330 14.30 688 35.70 0.0207
2022-01-25 2021-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 2,307 631 37.65 507 66.78 0.0156
2021-10-28 2021-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 1,676 -1,636 -49.40 304 -54.49 0.0105
2021-07-26 2021-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 3,312 3 0.09 668 -6.05 0.0266
2021-04-30 2021-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 3,309 264 8.67 711 -1.25 0.0314
2021-02-11 2020-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 3,045 1,044 52.17 720 32.11 0.0339
2020-11-03 2020-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 2,001 -36 -1.77 545 -7.78 0.0292
2020-07-30 2020-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 2,037 398 24.28 591 51.54 0.0357
2020-04-23 2020-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 1,639 270 19.72 390 30.00 0.0337
2020-02-05 2019-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 1,369 143 11.66 300 44.23 0.0222
2019-10-16 2019-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 1,226 210 20.67 208 11.83 0.0171
2019-07-31 2019-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 1,016 72 7.63 186 6.90 0.0161
2019-05-09 2019-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 944 -8 -0.84 174 10.13 0.0148
2019-02-13 2018-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 952 191 25.10 158 7.48 0.0147
2018-11-14 2018-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 761 22 2.98 147 16.67 0.0149
2018-08-14 2018-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 739 -62 -7.74 126 -3.82 0.0141
2018-05-08 2018-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 801 801 131 0.0154
2017-02-14 2016-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 0 -453 -100.00 0 -100.00
2016-11-14 2016-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 453 126 38.53 40 42.86 0.0058
2016-07-29 2016-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 327 22 7.21 28 16.67 0.0041
2016-05-12 2016-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 305 54 21.51 24 -25.00 0.0041
2016-01-22 2015-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 251 173 221.79 32 300.00 0.0062
2015-10-23 2015-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 78 68 680.00 8 700.00 0.0018
2015-07-15 2015-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 10 10 1 0.0002
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.