Vertex Pharmaceuticals Incorporated
US ˙ NasdaqGS ˙ US92532F1003

SecurityVRTX / Vertex Pharmaceuticals Incorporated
InstitutionSei Investments Co
Latest Disclosed Ownership364,023 shares
Latest Disclosed Value $ 165,032,691
Sei Investments Co reports 106.21% increase in ownership of VRTX / Vertex Pharmaceuticals Incorporated

On February 13, 2026 - Sei Investments Co filed a 13F-HR form disclosing ownership of 364,023 shares of Vertex Pharmaceuticals Incorporated (US:VRTX) valued at $165,033,467 USD as of December 31, 2025. The entity filed a previous 13F-HR on November 13, 2025 disclosing 176,527 shares of Vertex Pharmaceuticals Incorporated. This represents a change in shares of 106.21% during the quarter. The current value of the position is $155,925,612 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-02-13 2025-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 364,023 187,496 106.21 165,033 138.74 0.1629
2025-11-13 2025-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 176,527 -120,876 -40.64 69,127 -47.80 0.0743
2025-08-14 2025-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 297,403 3,621 1.23 132,413 -7.03 0.1535
2025-05-14 2025-03-31 13F/A-1 VERTEX PHARMACEUTICALS COM 92532F100 293,782 18,647 6.78 142,423 28.54 0.1833
2025-05-13 2025-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 281,144 6,009 116,619 0.1268
2025-02-11 2024-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 275,135 61,234 28.63 110,800 11.37 0.1423
2024-11-12 2024-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 213,901 1,044 0.49 99,488 -0.28 0.1292
2024-08-13 2024-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 212,857 -1,612 -0.75 99,772 11.29 0.1414
2024-05-07 2024-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 214,469 -144,885 -40.32 89,652 -38.69 0.1314
2024-02-14 2023-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 359,354 -39,864 -9.99 146,216 5.32 0.2347
2023-11-14 2023-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 399,218 297 0.07 138,825 -1.11 0.2495
2023-08-11 2023-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 398,921 140,471 54.35 140,384 72.39 0.2449
2023-05-12 2023-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 258,450 184,117 247.69 81,433 279.32 0.1513
2023-02-10 2022-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 74,333 -37,235 -33.37 21,469 -33.55 0.0477
2022-11-14 2022-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 111,568 23,129 26.15 32,306 28.61 0.0721
2022-08-15 2022-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 88,439 44,349 100.59 25,120 113.68 0.0542
2022-05-13 2022-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 44,090 9,761 28.43 11,756 57.25 0.0236
2022-02-14 2021-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 34,329 -1,291 -3.62 7,476 15.73 0.0140
2021-11-12 2021-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 35,620 -7,796 -17.96 6,460 -26.11 0.0136
2021-08-06 2021-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 43,416 -2,736 -5.93 8,743 -14.09 0.0194
2021-05-12 2021-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 46,152 -29,939 -39.35 10,177 -43.22 0.0256
2021-02-08 2020-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 76,091 -43,830 -36.55 17,924 -45.12 0.0463
2020-12-04 2020-09-30 13F/A-1 VERTEX PHARMACEUTICALS COM 92532F100 119,921 -2,789 -2.27 32,660 -8.13 0.0946
2020-11-06 2020-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 124,513 1,803 33,910 81,647.7405
2020-08-17 2020-06-30 13F/A-1 VERTEX PHARMACEUTICALS COM 92532F100 122,710 -13,450 -9.88 35,552 9.75 0.1103
2020-08-11 2020-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 133,908 -2,252 31,953 86,674.2134
2020-05-14 2020-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 136,160 -11,973 -8.08 32,395 -0.24 0.1190
2020-02-06 2019-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 148,133 -6,193 -4.01 32,472 23.73 0.0969
2019-11-12 2019-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 154,326 20,690 15.48 26,245 7.11 0.0671
2019-08-14 2019-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 133,636 -5,772 -4.14 24,502 -4.45 0.0800
2019-05-15 2019-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 139,408 4,602 3.41 25,643 0.57 0.0861
2019-02-13 2018-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 134,806 14,351 11.91 25,497 9.70 0.0908
2018-11-08 2018-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 120,455 -11,228 -8.53 23,242 3.84 0.0842
2018-08-03 2018-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 131,683 4,659 3.67 22,382 8.12 0.0761
2018-05-11 2018-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 127,024 -31,375 -19.81 20,702 -12.79 0.0794
2018-02-08 2017-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 158,399 35,880 29.29 23,739 27.44 0.0824
2017-11-06 2017-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 122,519 25,069 25.72 18,627 48.33 0.0662
2017-07-31 2017-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 97,450 31,434 47.62 12,558 73.98 0.0501
2017-05-05 2017-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 66,016 1,817 2.83 7,218 52.60 0.0316
2017-02-02 2016-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 64,199 -55,439 -46.34 4,730 -54.66 0.0229
2016-11-04 2016-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 119,638 36,970 44.72 10,433 46.72 0.0530
2016-08-11 2016-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 82,668 51,942 169.05 7,111 191.20 0.0426
2016-05-10 2016-03-31 13F/A-1 VERTEX PHARMACEUTICALS COM 92532F100 30,726 -97,848 -76.10 2,442 -84.91 0.0152
2016-02-03 2015-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 128,574 -12,913 -9.13 16,179 9.80 0.0986
2015-11-02 2015-09-30 13F/A-1 VERTEX PHARMACEUTICALS COM 92532F100 141,487 -27,265 -16.16 14,735 -29.29 0.1353
2015-10-30 2015-09-30 13F DIREXION SHS ETF TR COM 92532F100 141,487 14,735
2015-08-07 2015-06-30 13F/A-1 VERTEX PHARMACEUTICALS COM 92532F100 168,752 2,301 1.38 20,838 6.09 0.1884
2015-08-04 2015-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 168,752 2,301 20,838 0.1884
2015-05-14 2015-03-31 13F/A-1 VERTEX PHARMACEUTICALS COM 92532F100 166,451 96,806 139.00 19,641 137.35 0.1706
2015-05-01 2015-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 166,451 19,641
2015-02-10 2014-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 69,645 69,645 8,275 0.0731
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.