Vertex Pharmaceuticals Incorporated
US ˙ NasdaqGS ˙ US92532F1003

SecurityVRTX / Vertex Pharmaceuticals Incorporated
InstitutionSectoral Asset Management Inc
Latest Disclosed Ownership7,007 shares
Latest Disclosed Value $ 3,457,113
Sectoral Asset Management Inc reports 12.47% decrease in ownership of VRTX / Vertex Pharmaceuticals Incorporated

On May 15, 2026 - Sectoral Asset Management Inc filed a 13F-HR form disclosing ownership of 7,007 shares of Vertex Pharmaceuticals Incorporated (US:VRTX) valued at $3,128,906 USD as of March 31, 2026. The entity filed a previous 13F-HR on February 9, 2026 disclosing 8,005 shares of Vertex Pharmaceuticals Incorporated. This represents a change in shares of -12.47% during the quarter. The current value of the position is $3,095,272 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-05-15 2026-03-31 13F VERTEX PHARMA COM 92532F100 7,007 -998 -12.47 3,457 -4.74 2.8636
2026-02-09 2025-12-31 13F VERTEX PHARMA COM 92532F100 8,005 290 3.76 3,629 20.13 2.9091
2025-11-14 2025-09-30 13F VERTEX PHARMA COM 92532F100 7,715 770 11.09 3,022 -2.26 1.8650
2025-08-14 2025-06-30 13F VERTEX PHARMA COM 92532F100 6,945 2,220 46.98 3,092 34.98 2.0414
2025-05-15 2025-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 4,725 1,055 28.75 2,291 55.04 1.7830
2025-02-14 2024-12-31 13F VERTEX PHARMA COM 92532F100 3,670 -1,170 -24.17 1,478 -34.36 0.9864
2024-11-14 2024-09-30 13F VERTEX PHARMA COM 92532F100 4,840 -3,810 -44.05 2,251 -44.50 1.3296
2024-08-13 2024-06-30 13F VERTEX PHARMA COM 92532F100 8,650 1,440 19.97 4,054 34.55 1.6477
2024-05-14 2024-03-31 13F VERTEX PHARMACEUTICL COM 92532F100 7,210 -2,009 -21.79 3,014 -19.67 1.1848
2024-02-14 2023-12-31 13F VERTEX PHARMACEUTICL COM 92532F100 9,219 450 5.13 3,751 23.02 1.6153
2023-11-14 2023-09-30 13F VERTEX PHARMACEUTICL COMMON 92532F100 8,769 605 7.41 3,049 6.16 0.5938
2023-08-11 2023-06-30 13F VERTEX PHARMACEUTICL COM 92532F100 8,164 1,545 23.34 2,873 37.75 0.4790
2023-05-12 2023-03-31 13F VERTEX PHARMACEUTICL COM 92532F100 6,619 -400 -5.70 2,085 2.91 0.4008
2023-02-10 2022-12-31 13F VERTEX PHARMACEUTICL COM 92532F100 7,019 -899 -11.35 2,027 -11.64 0.3922
2022-11-10 2022-09-30 13F VERTEX PHARMACEUTICL COM 92532F100 7,918 -200 -2.46 2,293 0.22 0.4517
2022-08-15 2022-06-30 13F VERTEX PHARMACEUTICL COM 92532F100 8,118 837 11.50 2,288 20.42 0.4610
2022-05-10 2022-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 7,281 -490 -6.31 1,900 11.31 0.3373
2022-02-11 2021-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 7,771 -1,950 -20.06 1,707 -3.18 0.2569
2021-11-15 2021-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 9,721 0 0.00 1,763 -10.05 0.1466
2021-08-16 2021-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 9,721 -1,600 -14.13 1,960 -19.44 0.1586
2021-05-14 2021-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 11,321 -5,600 -33.09 2,433 -39.16 0.1844
2021-02-12 2020-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 16,921 7,050 71.42 3,999 48.88 0.2818
2020-11-13 2020-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 9,871 -4,800 -32.72 2,686 -36.93 0.2309
2020-08-13 2020-06-30 13F VERTEX PHARMACEUTICL COM 92532F100 14,671 -1,500 -9.28 4,259 10.68 0.3910
2020-05-13 2020-03-31 13F VERTEX PHARMACEUTICL COM 92532F100 16,171 100 0.62 3,848 9.35 0.7387
2020-02-12 2019-12-31 13F VERTEX PHARMACEUTICL COM 92532F100 16,071 1,900 13.41 3,519 46.56 0.5251
2019-11-14 2019-09-30 13F VERTEX PHARMACEUTICL COM 92532F100 14,171 -23,600 -62.48 2,401 -65.33 0.4142
2019-08-14 2019-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 37,771 17,500 86.33 6,926 85.73 0.8282
2019-05-14 2019-03-31 13F VERTEX PHARMACEUTICL COM 92532F100 20,271 -15,946 -44.03 3,729 -37.87 0.4485
2019-02-12 2018-12-31 13F VERTEX PHARMACEUTICL COMMON 92532F100 36,217 -40,629 -52.87 6,002 -59.48 0.8159
2018-11-14 2018-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 76,846 76,846 14,811 1.5724
2018-08-13 2018-06-30 13F VERTEX PHARMACEUTICALS COMMON 92532F100 0 -41,915 -100.00 0 -100.00
2018-05-15 2018-03-31 13F VERTEX PHARMACEUTICALS COMMON 92532F100 41,915 5,200 14.16 6,831 24.15 0.7490
2018-02-13 2017-12-31 13F VERTEX PHARMACEUTICALS COMMON 92532F100 36,715 2,715 7.99 5,502 6.44 0.6875
2017-11-14 2017-09-30 13F VERTEX PHARMACEUTICL COMMON 92532F100 34,000 34,000 5,169 0.6658
2017-02-10 2016-12-31 13F VERTEX PHARMACEUTICALS COMMON 92532F100 0 -217,874 -100.00 0 -100.00
2016-11-10 2016-09-30 13F VERTEX PHARMACEUTICALS COMMON 92532F100 217,874 -13,701 -5.92 19,001 -4.61 1.8652
2016-08-12 2016-06-30 13F VERTEX PHARMACEUTICL COMMON 92532F100 231,575 -664,904 -74.17 19,920 -72.05 2.0569
2016-05-13 2016-03-31 13F VERTEX PHARMACEUTICL COMMON 92532F100 896,479 208,279 30.26 71,261 -17.71 3.4456
2016-02-12 2015-12-31 13F VERTEX PHARMACEUTICALS COMMON 92532F100 688,200 -46,000 -6.27 86,596 13.26 3.6922
2015-11-13 2015-09-30 13F VERTEX PHARMACEUTICALS COMMON 92532F100 734,200 135,400 22.61 76,460 3.41 3.5027
2015-08-13 2015-06-30 13F VERTEX PHARMACEUTICALS COMMON 92532F100 598,800 89,200 17.50 73,940 22.99 3.0840
2015-05-14 2015-03-31 13F VERTEX PHARMACEUTICALS COMMON 92532F100 509,600 297,350 140.09 60,118 138.42 2.2828
2015-02-13 2014-12-31 13F VERTEX PHARMACEUTICALS COMMON 92532F100 212,250 -117,647 -35.66 25,215 -31.95 1.1310
2014-11-13 2014-09-30 13F VERTEX PHARMACEUTICL COM 92532F100 329,897 -749,567 -69.44 37,051 -63.75 1.5592
2014-08-14 2014-06-30 13F VERTEX PHARMACEUTICALS COMMON 92532F100 1,079,464 -197,277 -15.45 102,204 13.19 4.3305
2014-05-14 2014-03-31 13F VERTEX PHARMACEUTICL COMMON 92532F100 1,276,741 44,583 3.62 90,291 -1.37 3.7141
2014-02-12 2013-12-31 13F VERTEX PHARMACEUTICL COMMON 92532F100 1,232,158 -3,597 -0.29 91,549 -2.29 3.9480
2013-11-13 2013-09-30 13F VERTEX PHARMACEUTICL COMMON 92532F100 1,235,755 -1,290,259 -51.08 93,695 -53.67 4.5081
2013-08-12 2013-06-30 13F VERTEX PHARMACEUTICL COMMON 92532F100 2,526,014 2,526,014 202,233 5.9801
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.