Vertex Pharmaceuticals Incorporated
US ˙ NasdaqGS ˙ US92532F1003

SecurityVRTX / Vertex Pharmaceuticals Incorporated
InstitutionRobeco Institutional Asset Management B.V.
Latest Disclosed Ownership401,644 shares
Latest Disclosed Value $ 179,350,113
Robeco Institutional Asset Management B.V. reports 1.89% increase in ownership of VRTX / Vertex Pharmaceuticals Incorporated

On April 21, 2026 - Robeco Institutional Asset Management B.V. filed a 13F-HR form disclosing ownership of 401,644 shares of Vertex Pharmaceuticals Incorporated (US:VRTX) valued at $179,350,112 USD as of March 31, 2026. The entity filed a previous 13F-HR on January 23, 2026 disclosing 394,200 shares of Vertex Pharmaceuticals Incorporated. This represents a change in shares of 1.89% during the quarter. The current value of the position is $179,466,589 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-04-21 2026-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 401,644 7,444 1.89 179,350 0.36 0.2556
2026-01-23 2025-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 394,200 14,829 3.91 178,715 20.28 0.2545
2025-10-22 2025-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 379,371 49,980 15.17 148,577 1.32 0.2152
2025-07-18 2025-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 329,391 183,391 125.61 146,645 107.17 0.2371
2025-04-23 2025-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 146,000 -140,756 -49.09 70,784 -38.70 0.1375
2025-01-23 2024-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 286,756 -9,812 -3.31 115,477 -16.28 0.2189
2024-10-29 2024-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 296,568 -73,643 -19.89 137,928 -20.51 0.2740
2024-07-23 2024-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 370,211 -93,658 -20.19 173,525 -10.51 0.3734
2024-04-24 2024-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 463,869 6,045 1.32 193,902 4.09 0.4213
2024-02-14 2023-12-31 13F/A-1 VERTEX PHARMACEUTICALS COM 92532F100 457,824 24,887 5.75 186,284 23.74 0.4516
2024-02-08 2023-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 245,188 -187,749 458 0.0857
2023-10-24 2023-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 432,937 26,523 6.53 150,550 5.26 0.4023
2023-07-24 2023-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 406,414 -40,403 -9.04 143,021 1.59 0.3750
2023-05-04 2023-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 446,817 -25,140 -5.33 140,779 3.29 0.3838
2023-02-07 2022-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 471,957 132,927 39.21 136,292 38.84 0.3928
2022-12-01 2022-09-30 13F/A-1 VERTEX PHARMACEUTICALS COM 92532F100 339,030 85,003 33.46 98,162 37.14 0.3172
2022-10-27 2022-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 339,030 85,003 98,162 0.3130
2022-12-01 2022-06-30 13F/A-1 VERTEX PHARMACEUTICALS COM 92532F100 254,027 17,195 7.26 71,580 15.82 0.2224
2022-07-27 2022-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 254,027 17,195 71,580 0.2193
2022-12-01 2022-03-31 13F/A-1 VERTEX PHARMACEUTICALS COM 92532F100 236,832 38,514 19.42 61,805 41.91 0.1456
2022-04-26 2022-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 236,832 38,514 61,805 0.1438
2022-12-01 2021-12-31 13F/A-1 VERTEX PHARMACEUTICALS COM 92532F100 198,318 -4,637 -2.28 43,551 18.31 0.0927
2022-01-31 2021-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 198,318 -4,637 43,551 0.0915
2022-12-01 2021-09-30 13F/A-1 VERTEX PHARMACEUTICALS COM 92532F100 202,955 -132 -0.06 36,812 -10.11 0.0816
2021-10-20 2021-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 202,955 -132 36,812 0.0806
2022-12-01 2021-06-30 13F/A-1 VERTEX PHARMACEUTICALS COM 92532F100 203,087 26,595 15.07 40,950 7.97 0.0908
2021-07-28 2021-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 203,087 26,595 40,950 0.0895
2022-12-01 2021-03-31 13F/A-1 VERTEX PHARMACEUTICALS COM 92532F100 176,492 -112,005 -38.82 37,927 -44.38 0.0935
2021-04-23 2021-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 176,492 -112,005 37,927 0.0922
2022-12-01 2020-12-31 13F/A-1 VERTEX PHARMACEUTICALS COM 92532F100 288,497 -67,392 -18.94 68,184 -29.59 0.1792
2021-01-28 2020-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 288,497 -67,392 68,184 0.1770
2021-01-19 2020-09-30 13F/A-1 VERTEX PHARMACEUTICALS COM 92532F100 355,889 47,537 15.42 96,844 8.19 0.2993
2020-10-29 2020-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 355,889 47,537 96,844 299,085.7908
2021-01-19 2020-06-30 13F/A-1 VERTEX PHARMACEUTICALS COM 92532F100 308,352 228,379 285.57 89,517 370.42 0.3040
2020-07-20 2020-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 308,352 228,379 89,517 303,747.1479
2021-01-19 2020-03-31 13F/A-1 VERTEX PHARMACEUTICALS COM 92532F100 79,973 47,325 144.96 19,029 166.18 0.0763
2020-04-30 2020-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 79,973 47,325 19,029 76,272.5234
2021-01-19 2019-12-31 13F/A-1 VERTEX PHARMACEUTICALS COM 92532F100 32,648 3,938 13.72 7,149 47.01 0.0229
2020-02-06 2019-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 32,648 3,938 7,149 22,865.5267
2021-01-19 2019-09-30 13F/A-1 VERTEX PHARMACEUTICALS COM 92532F100 28,710 -8,982 -23.83 4,863 -29.66 0.0172
2019-10-17 2019-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 28,710 -8,982 4,863 17,144.0749
2021-01-19 2019-06-30 13F/A-1 VERTEX PHARMACEUTICALS COM 92532F100 37,692 -3,294 -8.04 6,914 -8.30 0.0244
2019-07-19 2019-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 37,692 -3,294 6,914 24,380.5725
2021-01-19 2019-03-31 13F/A-1 VERTEX PHARMACEUTICALS COM 92532F100 40,986 15,783 62.62 7,540 80.56 0.0277
2019-05-02 2019-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 40,986 15,783 7,540 27,684.1978
2021-01-19 2018-12-31 13F/A-1 VERTEX PHARMACEUTICALS COM 92532F100 25,203 -12,012 -32.28 4,176 -41.79 0.0188
2019-02-08 2018-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 25,203 -12,012 4,176 18,718.7131
2021-01-19 2018-09-30 13F/A-1 VERTEX PHARMACEUTICALS COM 92532F100 37,215 2,636 7.62 7,174 22.05 0.0284
2018-10-25 2018-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 36,997 2,418 7,132
2021-01-19 2018-06-30 13F/A-1 VERTEX PHARMACEUTICALS COM 92532F100 34,579 -2,049 -5.59 5,878 -1.51 0.0268
2018-08-03 2018-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 34,579 -2,049 5,878
2021-01-19 2018-03-31 13F/A-1 VERTEX PHARMACEUTICALS COM 92532F100 36,628 9,940 37.25 5,968 49.20 0.0280
2018-05-07 2018-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 36,628 9,940 5,968 27,909.5443
2021-01-19 2017-12-31 13F/A-1 VERTEX PHARMACEUTICALS COM 92532F100 26,688 11,016 70.29 4,000 67.93 0.0207
2018-01-25 2017-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 26,688 11,016 4,000
2021-01-19 2017-09-30 13F/A-1 VERTEX PHARMACEUTICALS COM 92532F100 15,672 39 0.25 2,382 18.33 0.0148
2017-10-17 2017-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 15,672 39 2,382 14,757.3256
2021-01-19 2017-06-30 13F/A-1 VERTEX PHARMACEUTICALS COM 92532F100 15,633 14,672 1,526.74 2,013 1,817.14 0.0130
2017-08-07 2017-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 15,633 14,672 2,013 13,106.2512
2021-01-19 2017-03-31 13F/A-1 VERTEX PHARMACEUTICALS COM 92532F100 961 0 0.00 105 47.89 0.0007
2017-05-15 2017-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 961 0 105 697.4037
2017-02-09 2016-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 961 0 0.00 71 -15.48 0.0006
2016-11-07 2016-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 961 -9,767 -91.04 84 -90.90 0.0006
2016-07-22 2016-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 10,728 0 0.00 923 8.21 0.0070
2016-05-16 2016-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 10,728 0 0.00 853 -36.81 0.0068
2016-02-08 2015-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 10,728 2,605 32.07 1,350 59.57 0.0115
2015-11-12 2015-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 8,123 0 0.00 846 -15.65 0.0064
2015-08-17 2015-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 8,123 7,660 1,654.43 1,003 1,723.64 0.0076
2015-04-24 2015-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 463 -6,223 -93.08 55 -93.07 0.0004
2015-02-12 2014-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 6,686 2,592 63.31 794 72.61 0.0057
2014-11-10 2014-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 4,094 724 21.48 460 44.20 0.0033
2014-08-13 2014-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 3,370 1,521 82.26 319 143.51 0.0023
2014-05-07 2014-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 1,849 542 41.47 131 35.05 0.0010
2014-02-04 2013-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 1,307 0 0.00 97 -2.02 0.0008
2013-11-12 2013-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 1,307 0 0.00 99 -4.81 0.0010
2013-08-27 2013-06-30 13F Vertex Pharmaceuticals COM 92532F100 1,307 1,307 104 0.0011
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.