Vertex Pharmaceuticals Incorporated
US ˙ NasdaqGS ˙ US92532F1003

SecurityVRTX / Vertex Pharmaceuticals Incorporated
InstitutionRhumbline Advisers
Latest Disclosed Ownership423,140 shares
Latest Disclosed Value $ 188,948,846
Rhumbline Advisers reports 1.88% decrease in ownership of VRTX / Vertex Pharmaceuticals Incorporated

On May 12, 2026 - Rhumbline Advisers filed a 13F-HR form disclosing ownership of 423,140 shares of Vertex Pharmaceuticals Incorporated (US:VRTX) valued at $188,948,936 USD as of March 31, 2026. The entity filed a previous 13F-HR on February 13, 2026 disclosing 431,262 shares of Vertex Pharmaceuticals Incorporated. This represents a change in shares of -1.88% during the quarter. The current value of the position is $189,071,646 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-05-12 2026-03-31 13F VERTEX PHARMACEUTICALS INC COM COM 92532F100 423,140 -8,122 -1.88 188,949 -3.36 0.1616
2026-02-13 2025-12-31 13F VERTEX PHARMACEUTICALS INC COM COM 92532F100 431,262 -16,666 -3.72 195,517 11.45 0.1581
2025-11-06 2025-09-30 13F VERTEX PHARMACEUTICALS INC COM COM 92532F100 447,928 -6,444 -1.42 175,426 -13.28 0.1409
2025-08-12 2025-06-30 13F VERTEX PHARMACEUTICALS INC COM COM 92532F100 454,372 3,341 0.74 202,286 -7.49 0.1732
2025-05-29 2025-03-31 13F/A-1 VERTEX PHARMACEUTICALS INC COM COM 92532F100 451,031 8,670 1.96 218,669 22.75 0.2045
2025-04-08 2025-03-31 13F VERTEX PHARMACEUTICALS INC COM COM 92532F100 451,031 8,670 218,669 0.2045
2025-05-29 2024-12-31 13F/A-1 VERTEX PHARMACEUTICALS INC COM COM 92532F100 442,361 -7,335 -1.63 178,139 -14.83 0.1594
2025-01-30 2024-12-31 13F VERTEX PHARMACEUTICALS INC COM COM 92532F100 442,361 -7,335 178,139 0.1594
2024-11-12 2024-09-30 13F VERTEX PHARMACEUTICALS INC COM COM 92532F100 449,696 -8,209 -1.79 209,145 -2.56 0.1887
2024-08-01 2024-06-30 13F VERTEX PHARMACEUTICALS INC COM COM 92532F100 457,905 -5,322 -1.15 214,629 10.84 0.2017
2024-05-09 2024-03-31 13F VERTEX PHARMACEUTICALS INC COM COM 92532F100 463,227 4,739 1.03 193,633 3.79 0.1860
2024-02-08 2023-12-31 13F VERTEX PHARMACEUTICALS INC COM COM 92532F100 458,488 -5,263 -1.13 186,554 15.68 0.1955
2023-11-09 2023-09-30 13F VERTEX PHARMACEUTICALS INC COM COM 92532F100 463,751 425 0.09 161,265 -1.09 0.1872
2023-08-08 2023-06-30 13F VERTEX PHARMACEUTICALS INC COM COM 92532F100 463,326 12,895 2.86 163,049 115,537.59 0.1826
2023-05-11 2023-03-31 13F VERTEX PHARMACEUTICALS INC COM COM 92532F100 450,431 23,694 5.55 142 -99.89 0.1751
2023-02-14 2022-12-31 13F VERTEX PHARMACEUTICALS INC COM COM 92532F100 426,737 18,554 4.55 123,233 4.27 0.1657
2022-11-10 2022-09-30 13F VERTEX PHARMACEUTICALS INC COM COM 92532F100 408,183 12,188 3.08 118,185 5.91 0.1761
2022-08-11 2022-06-30 13F VERTEX PHARMACEUTICALS INC COM COM 92532F100 395,995 16,679 4.40 111,587 12.73 0.1628
2022-05-12 2022-03-31 13F VERTEX PHARMACEUTICALS INC COM COM 92532F100 379,316 -12,950 -3.30 98,990 14.91 0.1274
2022-02-10 2021-12-31 13F VERTEX PHARMACEUTICALS INC COM COM 92532F100 392,266 6,992 1.81 86,142 23.26 0.1056
2021-11-12 2021-09-30 13F VERTEX PHARMACEUTICALS INC COM COM 92532F100 385,274 -15,482 -3.86 69,885 -13.51 0.0946
2021-08-05 2021-06-30 13F VERTEX PHARMACEUTICALS INC COM COM 92532F100 400,756 -105,890 -20.90 80,804 -25.78 0.1060
2021-05-06 2021-03-31 13F VERTEX PHARMACEUTICALS INC COM COM 92532F100 506,646 -15,606 -2.99 108,873 -11.79 0.1479
2021-02-10 2020-12-31 13F VERTEX PHARMACEUTICALS INC COM COM 92532F100 522,252 2,345 0.45 123,429 -12.76 0.1704
2020-11-12 2020-09-30 13F VERTEX PHARMACEUTICALS INC COM COM 92532F100 519,907 -12,657 -2.38 141,477 -8.49 0.2217
2020-08-13 2020-06-30 13F VERTEX PHARMACEUTICALS INC COM COM 92532F100 532,564 28,578 5.67 154,609 28.92 0.2582
2020-05-06 2020-03-31 13F VERTEX PHARMACEUTICALS INC COM COM 92532F100 503,986 2,341 0.47 119,923 9.18 0.2513
2020-02-05 2019-12-31 13F VERTEX PHARMACEUTICALS INC COM COM 92532F100 501,645 -9,394 -1.84 109,835 26.86 0.1837
2019-10-23 2019-09-30 13F VERTEX PHARMACEUTICALS INC COM COM 92532F100 511,039 24,490 5.03 86,580 -2.96 0.1582
2019-08-14 2019-06-30 13F VERTEX PHARMACEUTICALS INC COM COM 92532F100 486,549 5,764 1.20 89,223 0.89 0.1675
2019-05-01 2019-03-31 13F VERTEX PHARMACEUTICALS INC COM COM 92532F100 480,785 26,369 5.80 88,440 17.45 0.1713
2019-01-31 2018-12-31 13F VERTEX PHARMACEUTICALS INC COM COM 92532F100 454,416 6,412 1.43 75,301 -12.79 0.1639
2018-11-07 2018-09-30 13F VERTEX PHARMACEUTICALS INC COM COM 92532F100 448,004 -5,113 -1.13 86,348 12.12 0.1668
2018-08-06 2018-06-30 13F VERTEX PHARMACEUTICALS INC COM COM 92532F100 453,117 12,823 2.91 77,012 7.32 0.1553
2018-05-02 2018-03-31 13F VERTEX PHARMACEUTICALS INC COM COM 92532F100 440,294 -7,641 -1.71 71,759 6.90 0.1499
2018-02-09 2017-12-31 13F VERTEX PHARMACEUTICALS INC COM COM 92532F100 447,935 20,478 4.79 67,128 3.29 0.1363
2017-11-06 2017-09-30 13F VERTEX PHARMACEUTICALS INC COM COM 92532F100 427,457 6,137 1.46 64,991 19.70 0.1413
2017-08-02 2017-06-30 13F VERTEX PHARMACEUTICALS INC COM COM 92532F100 421,320 2,799 0.67 54,296 18.64 0.1239
2017-05-02 2017-03-31 13F VERTEX PHARMACEUTICALS INC COM COM 92532F100 418,521 2,759 0.66 45,765 49.42 0.1069
2017-01-27 2016-12-31 13F VERTEX PHARMACEUTICALS INC COM COM 92532F100 415,762 17,833 4.48 30,629 -11.74 0.0776
2016-11-08 2016-09-30 13F VERTEX PHARMACEUTICALS INC COM COM 92532F100 397,929 20,841 5.53 34,703 6.99 0.0956
2016-08-11 2016-06-30 13F VERTEX PHARMACEUTICALS INC COM COM 92532F100 377,088 16,406 4.55 32,437 13.14 0.0961
2016-05-02 2016-03-31 13F VERTEX PHARMACEUTICALS INC COM COM 92532F100 360,682 13,790 3.98 28,671 -34.31 0.0890
2016-02-03 2015-12-31 13F VERTEX PHARMACEUTICALS INC COM COM 92532F100 346,892 -1,083 -0.31 43,649 20.45 0.1405
2015-11-04 2015-09-30 13F VERTEX PHARMACEUTICALS INC COM COM 92532F100 347,975 4,261 1.24 36,238 -14.62 0.1233
2015-08-04 2015-06-30 13F VERTEX PHARMACEUTICALS INC COM COM 92532F100 343,714 -105 -0.03 42,442 4.64 0.1353
2015-05-12 2015-03-31 13F VERTEX PHARMACEUTICALS INC COM COM 92532F100 343,819 3,623 1.06 40,560 0.36 0.1170
2015-02-06 2014-12-31 13F VERTEX PHARMACEUTICALS INC COM COM 92532F100 340,196 -6,337 -1.83 40,415 3.84 0.1174
2014-11-12 2014-09-30 13F VERTEX PHARMACEUTICALS INC COM COM 92532F100 346,533 -15,156 -4.19 38,919 13.65 0.1169
2014-08-06 2014-06-30 13F VERTEX PHARMACEUTICALS INC COM COM 92532F100 361,689 4,678 1.31 34,245 35.63 0.1005
2014-05-06 2014-03-31 13F VERTEX PHARMACEUTICALS INC COM COM 92532F100 357,011 6,245 1.78 25,248 -3.12 0.0749
2014-02-03 2013-12-31 13F VERTEX PHARMACEUTICALS INC COM COM 92532F100 350,766 68,474 24.26 26,062 21.77 0.0769
2013-11-05 2013-09-30 13F VERTEX PHARMACEUTICALS INC COM COM 92532F100 282,292 -104,222 -26.96 21,403 -30.67 0.0663
2013-08-07 2013-06-30 13F VERTEX PHARMACEUTICALS INC COM COM 92532F100 386,514 386,514 30,871 0.0992
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.