Vertex Pharmaceuticals Incorporated
US ˙ NasdaqGS ˙ US92532F1003

SecurityVRTX / Vertex Pharmaceuticals Incorporated
InstitutionHilltop Holdings Inc.
Latest Disclosed Ownership671 shares
Latest Disclosed Value $ 299,628
Hilltop Holdings Inc. reports 77.74% decrease in ownership of VRTX / Vertex Pharmaceuticals Incorporated

On May 14, 2026 - Hilltop Holdings Inc. filed a 13F-HR form disclosing ownership of 671 shares of Vertex Pharmaceuticals Incorporated (US:VRTX) valued at $299,628 USD as of March 31, 2026. The entity filed a previous 13F-HR on February 17, 2026 disclosing 3,015 shares of Vertex Pharmaceuticals Incorporated. This represents a change in shares of -77.74% during the quarter. The current value of the position is $299,823 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date
Effective
Date
Form Security Class ID Avg Price
Paid (Est)
Reported
Shares
ΔShares ΔShares
(%)
Reported
Value
(x1000)
ΔValue
(%)
Alloc
(%)
ΔAlloc ΔAlloc (%) Cost Basis
(x1000)
Unrealized
Gain/Loss
(x1000)
2026-05-14 2026-03-31 13F Vertex Pharm COM 92532F100 671 -2,344 -77.74 300 -78.11 0.0199
2026-02-17 2025-12-31 13F Vertex Pharm COM 92532F100 3,015 -1,919 -38.89 1,367 -29.30 0.0809
2025-11-14 2025-09-30 13F Vertex Pharm COM 92532F100 4,934 757 18.12 1,932 3.93 0.1022
2025-08-14 2025-06-30 13F VERTEX PHARM COM 92532F100 4,177 542 14.91 1,860 5.51 0.1192
2025-05-15 2025-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 3,635 90 2.54 1,762 23.48 0.1106
2025-02-14 2024-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 3,545 402 12.79 1,428 -2.33 0.0901
2024-11-14 2024-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 3,143 2,459 359.50 1,462 356.56 0.0934
2024-08-14 2024-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 684 0 0.00 321 12.28 0.0370
2024-05-15 2024-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 684 2 0.29 286 2.89 0.0295
2024-02-12 2023-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 682 -10 -1.45 277 15.42 0.0315
2023-11-14 2023-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 692 -11 -1.56 241 -2.83 0.0281
2023-08-14 2023-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 703 -7 -0.99 247 10.76 0.0301
2023-05-15 2023-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 710 -2 -0.28 224 8.78 0.0294
2023-02-14 2022-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 712 0 0.00 206 -0.49 0.0263
2022-11-14 2022-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 712 712 206 0.0279
2021-08-16 2021-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 0 -1,509 -100.00 0 -100.00
2021-05-17 2021-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 1,509 1,509 324 0.0418
2020-11-16 2020-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 0 -757 -100.00 0 -100.00
2020-08-14 2020-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 757 757 220 0.0406
2019-02-14 2018-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 0 -1,534 -100.00 0 -100.00
2018-11-14 2018-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 1,534 1,534 296 0.0621
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.