Vertex Pharmaceuticals Incorporated
US ˙ NasdaqGS ˙ US92532F1003

SecurityVRTX / Vertex Pharmaceuticals Incorporated
InstitutionGuggenheim Capital Llc
Latest Disclosed Ownership100,386 shares
Latest Disclosed Value $ 44,826,364
Guggenheim Capital Llc reports 0.65% decrease in ownership of VRTX / Vertex Pharmaceuticals Incorporated

On May 15, 2026 - Guggenheim Capital Llc filed a 13F-HR form disclosing ownership of 100,386 shares of Vertex Pharmaceuticals Incorporated (US:VRTX) valued at $44,826,364 USD as of March 31, 2026. The entity filed a previous 13F-HR on February 17, 2026 disclosing 101,041 shares of Vertex Pharmaceuticals Incorporated. This represents a change in shares of -0.65% during the quarter. The current value of the position is $44,855,476 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-05-15 2026-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 100,386 -655 -0.65 44,826 -2.14 0.1732
2026-02-17 2025-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 101,041 -2,084 -2.02 45,808 13.42 0.3280
2025-11-13 2025-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 103,125 1,905 1.88 40,388 -10.38 0.2931
2025-08-13 2025-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 101,220 -783 -0.77 45,063 -8.88 0.3576
2025-05-14 2025-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 102,003 -33,692 -24.83 49,453 -9.50 0.4542
2025-02-13 2024-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 135,695 -3,596 -2.58 54,644 -15.65 0.4430
2024-11-13 2024-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 139,291 -20,396 -12.77 64,781 -13.45 0.4533
2024-08-14 2024-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 159,687 -6,014 -3.63 74,848 8.06 0.5307
2024-05-14 2024-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 165,701 -5,961 -3.47 69,265 -0.83 0.4880
2024-02-14 2023-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 171,662 9,784 6.04 69,848 24.08 0.5278
2023-11-14 2023-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 161,878 3,146 1.98 56,291 0.77 0.4840
2023-08-11 2023-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 158,732 -4,115 -2.53 55,859 8.87 0.4385
2023-05-11 2023-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 162,847 -6,112 -3.62 51,308 5.16 0.4319
2023-02-14 2022-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 168,959 -6,140 -3.51 48,792 -3.76 0.4286
2022-11-14 2022-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 175,099 -20,047 -10.27 50,699 -7.80 0.4643
2022-08-15 2022-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 195,146 -25,465 -11.54 54,990 -4.48 0.4341
2022-05-16 2022-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 220,611 8,939 4.22 57,572 23.86 0.3463
2022-02-14 2021-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 211,672 4,577 2.21 46,483 23.74 0.2425
2021-11-15 2021-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 207,095 -9,157 -4.23 37,565 -13.85 0.2255
2021-08-13 2021-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 216,252 12,343 6.05 43,604 -0.49 0.2567
2021-05-13 2021-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 203,909 -5,881 -2.80 43,818 -11.63 0.2877
2021-02-16 2020-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 209,790 17,699 9.21 49,583 -5.15 0.3109
2020-11-13 2020-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 192,091 -3,079 -1.58 52,273 -7.74 0.3783
2020-08-14 2020-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 195,170 3,640 1.90 56,660 24.32 0.4384
2020-06-02 2020-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 191,530 -21,965 -10.29 45,575 -2.50 0.4590
2020-02-20 2019-12-31 13F/A-1 VERTEX PHARMACEUTICALS COM 92532F100 213,495 -20,187 -8.64 46,744 18.07 0.3511
2020-02-14 2019-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 213,495 -20,187 46,744 277,042.3442
2020-02-20 2019-09-30 13F/A-1 VERTEX PHARMACEUTICALS COM 92532F100 233,682 -2,694 -1.14 39,590 -8.67 0.3164
2019-11-14 2019-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 233,682 -2,694 39,590 290,127.1327
2019-08-14 2019-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 236,376 -10,327 -4.19 43,347 -4.48 0.3527
2019-05-15 2019-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 246,703 12,245 5.22 45,380 16.80 0.3698
2019-02-14 2018-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 234,458 -24,893 -9.60 38,852 -22.28 0.3292
2018-11-14 2018-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 259,351 -3,346 -1.27 49,987 11.96 0.3257
2018-08-14 2018-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 262,697 -473,152 -64.30 44,648 -62.77 0.2980
2018-05-15 2018-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 735,849 -68,978 -8.57 119,928 -0.57 0.2925
2018-02-14 2017-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 804,827 376,093 87.72 120,611 85.03 0.2857
2017-11-14 2017-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 428,734 -68,817 -13.83 65,184 1.66 0.1531
2017-08-14 2017-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 497,551 -72,719 -12.75 64,119 2.83 0.1698
2017-05-15 2017-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 570,270 -44,889 -7.30 62,356 37.59 0.1690
2017-02-14 2016-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 615,159 114,038 22.76 45,320 3.70 0.1296
2016-11-14 2016-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 501,121 -1,949 -0.39 43,703 0.99 0.1360
2016-08-15 2016-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 503,070 -14,031 -2.71 43,274 5.28 0.1359
2016-05-16 2016-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 517,101 11,785 2.33 41,105 -35.35 0.1297
2016-02-16 2015-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 505,316 -7,417 -1.45 63,584 19.08 0.1850
2015-11-16 2015-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 512,733 -121,983 -19.22 53,397 -31.87 0.1643
2015-08-14 2015-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 634,716 29,031 4.79 78,376 9.69 0.1935
2015-05-18 2015-03-31 13F/A-1 VERTEX PHARMACEUTICALS COM 92532F100 605,685 90,152 17.49 71,454 16.67 0.1691
2015-05-15 2015-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 605,685 71,454
2015-02-17 2014-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 515,533 -400,094 -43.70 61,245 -40.44 0.1536
2014-11-14 2014-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 915,627 31,288 3.54 102,834 22.82 0.2481
2014-08-14 2014-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 884,339 -56,286 -5.98 83,730 25.87 0.2118
2014-05-16 2014-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 940,625 182,273 24.04 66,522 18.06 0.1892
2014-02-14 2013-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 758,352 67,328 9.74 56,345 7.54 0.1712
2013-11-14 2013-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 691,024 139,449 25.28 52,394 18.93 0.1881
2013-08-22 2013-06-30 13F/A-1 VERTEX PHARMACEUTICALS COM 92532F100 551,575 551,575 44,053 0.1853
2013-08-14 2013-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 551,575 44,053 0.1857
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.