Vertex Pharmaceuticals Incorporated
US ˙ NasdaqGS ˙ US92532F1003

SecurityVRTX / Vertex Pharmaceuticals Incorporated
InstitutionGeode Capital Management, Llc
Latest Disclosed Ownership6,139,621 shares
Latest Disclosed Value $ 2,730,054,399
Geode Capital Management, Llc reports 2.64% increase in ownership of VRTX / Vertex Pharmaceuticals Incorporated

On May 15, 2026 - Geode Capital Management, Llc filed a 13F-HR form disclosing ownership of 6,139,621 shares of Vertex Pharmaceuticals Incorporated (US:VRTX) valued at $2,741,586,361 USD as of March 31, 2026. The entity filed a previous 13F-HR on February 9, 2026 disclosing 5,981,905 shares of Vertex Pharmaceuticals Incorporated. This represents a change in shares of 2.64% during the quarter. The current value of the position is $2,743,366,851 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-05-15 2026-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 6,139,621 157,716 2.64 2,730,054 1.11 0.0908
2026-02-09 2025-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 5,981,905 8,160 0.14 2,700,208 15.95 0.1666
2025-11-12 2025-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 5,973,745 44,998 0.76 2,328,862 -11.35 0.1486
2025-08-08 2025-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 5,928,747 166,987 2.90 2,627,135 -5.61 0.1841
2025-05-13 2025-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 5,761,760 113,524 2.01 2,783,399 22.67 0.2188
2025-02-12 2024-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 5,648,236 -287,652 -4.85 2,269,073 -17.55 0.1758
2024-11-12 2024-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 5,935,888 -389,420 -6.16 2,752,100 -6.97 0.2229
2024-08-09 2024-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 6,325,308 512,272 8.81 2,958,270 22.03 0.2596
2024-05-13 2024-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 5,813,036 139,617 2.46 2,424,281 5.28 0.2242
2024-02-13 2023-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 5,673,419 77,445 1.38 2,302,799 18.57 0.2409
2023-11-13 2023-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 5,595,974 51,113 0.92 1,942,174 -0.23 0.2313
2023-08-11 2023-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 5,544,861 135,604 2.51 1,946,630 14.44 0.2287
2023-05-15 2023-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 5,409,257 26,538 0.49 1,700,938 109,567.18 0.2209
2023-02-13 2022-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 5,382,719 111,052 2.11 1,552 -99.90 0.2178
2022-11-14 2022-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 5,271,667 737,183 16.26 1,524,917 19.56 0.2313
2022-08-12 2022-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 4,534,484 204,253 4.72 1,275,406 13.16 0.1868
2022-05-13 2022-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 4,330,231 -25,989 -0.60 1,127,130 18.11 0.1407
2022-02-11 2021-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 4,356,220 53,868 1.25 954,276 22.61 0.1149
2021-11-12 2021-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 4,302,352 215,173 5.26 778,281 -5.30 0.1048
2021-08-13 2021-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 4,087,179 145,993 3.70 821,836 -2.70 0.1132
2021-05-12 2021-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 3,941,186 54,343 1.40 844,607 -7.81 0.1292
2021-02-12 2020-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 3,886,843 12,691 0.33 916,123 -12.92 0.1538
2020-11-13 2020-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 3,874,152 33,835 0.88 1,052,026 -5.45 0.2061
2020-08-13 2020-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 3,840,317 30,946 0.81 1,112,676 23.00 0.2380
2020-05-14 2020-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 3,809,371 237,183 6.64 904,584 15.92 0.2358
2020-02-20 2019-12-31 13F/A-1 VERTEX PHARMACEUTICALS COM 92532F100 3,572,188 115,110 3.33 780,339 33.46 0.1631
2020-02-13 2019-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 3,572,188 115,110 780,339 99,447.3635
2019-11-12 2019-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 3,457,078 108,297 3.23 584,679 -4.61 0.1364
2019-08-14 2019-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 3,348,781 113,284 3.50 612,936 3.18 0.1483
2019-05-14 2019-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 3,235,497 176,191 5.76 594,020 17.40 0.1539
2019-03-06 2018-12-31 13F/A-1 VERTEX PHARMACEUTICALS COM 92532F100 3,059,306 207,934 7.29 505,995 -7.74 0.1564
2019-02-13 2018-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 3,059,306 207,934 505,995
2018-11-13 2018-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 2,851,372 69,858 2.51 548,438 16.27 0.1545
2018-08-14 2018-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 2,781,514 48,459 1.77 471,712 6.17 0.1450
2018-05-15 2018-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 2,733,055 125,804 4.83 444,280 13.95 0.1447
2018-02-13 2017-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 2,607,251 105,683 4.22 389,878 2.71 0.1324
2017-11-14 2017-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 2,501,568 114,200 4.78 379,582 23.60 0.1401
2017-08-14 2017-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 2,387,368 47,547 2.03 307,115 20.21 0.1208
2017-06-21 2017-03-31 13F/A-1 VERTEX PHARMACEUTICALS INC COM COM 92532F100 2,339,821 191,154 8.90 255,483 61.60 0.1048
2017-05-12 2017-03-31 13F VERTEX PHARMACEUTICALS INC COM COM 92532F100 2,339,821 255,483
2017-02-14 2016-12-31 13F VERTEX PHARMACEUTICALS INC COM COM 92532F100 2,148,667 102,298 5.00 158,093 -11.27 0.0735
2016-11-10 2016-09-30 13F VERTEX PHARMACEUTICALS INC COM COM 92532F100 2,046,369 58,820 2.96 178,167 4.40 0.0897
2016-08-12 2016-06-30 13F VERTEX PHARMACEUTICALS INC COM COM 92532F100 1,987,549 1,362 0.07 170,663 8.32 0.0928
2016-05-13 2016-03-31 13F VERTEX PHARMACEUTICALS INC COM COM 92532F100 1,986,187 40,848 2.10 157,561 -35.50 0.0836
2016-02-12 2015-12-31 13F VERTEX PHARMACEUTICALS INC COM COM 92532F100 1,945,339 28,873 1.51 244,269 22.64 0.1392
2015-11-13 2015-09-30 13F VERTEX PHARMACEUTICALS INC COM COM 92532F100 1,916,466 15,534 0.82 199,183 -14.97 0.1208
2015-08-14 2015-06-30 13F VERTEX PHARMACEUTICALS INC COM COM 92532F100 1,900,932 -21,862 -1.14 234,261 3.43 0.1337
2015-05-14 2015-03-31 13F VERTEX PHARMACEUTICALS INC COM COM 92532F100 1,922,794 89,425 4.88 226,482 4.12 0.1295
2015-02-12 2014-12-31 13F VERTEX PHARMACEUTICALS INC COM COM 92532F100 1,833,369 88,144 5.05 217,527 11.12 0.1294
2014-11-14 2014-09-30 13F VERTEX PHARMACEUTICALS INC COM COM 92532F100 1,745,225 4,930 0.28 195,756 18.88 0.1269
2014-08-13 2014-06-30 13F VERTEX PHARMACEUTICALS INC COM COM 92532F100 1,740,295 -1,670 -0.10 164,673 33.73 0.1065
2014-05-14 2014-03-31 13F VERTEX PHARMACEUTICALS INC COM COM 92532F100 1,741,965 28,146 1.64 123,139 -3.27 0.0826
2014-02-14 2013-12-31 13F VERTEX PHARMACEUTICALS INC COM COM 92532F100 1,713,819 66,692 4.05 127,300 1.96 0.0883
2013-11-14 2013-09-30 13F VERTEX PHARMACEUTICALS INC COM COM 92532F100 1,647,127 740,697 81.72 124,854 72.48 0.1001
2013-08-14 2013-06-30 13F VERTEX PHARMACEUTICALS INC COM COM 92532F100 906,430 906,430 72,387 0.0636
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.