Vertex Pharmaceuticals Incorporated
US ˙ NasdaqGS ˙ US92532F1003

SecurityVRTX / Vertex Pharmaceuticals Incorporated
InstitutionFirst Trust Advisors Lp
Latest Disclosed Ownership306,461 shares
Latest Disclosed Value $ 136,846,970
First Trust Advisors Lp reports 52.25% increase in ownership of VRTX / Vertex Pharmaceuticals Incorporated

On May 13, 2026 - First Trust Advisors Lp filed a 13F-HR form disclosing ownership of 306,461 shares of Vertex Pharmaceuticals Incorporated (US:VRTX) valued at $136,847,095 USD as of March 31, 2026. The entity filed a previous 13F-HR on February 13, 2026 disclosing 201,290 shares of Vertex Pharmaceuticals Incorporated. This represents a change in shares of 52.25% during the quarter. The current value of the position is $135,376,082 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-05-13 2026-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 306,461 105,171 52.25 136,847 49.96 0.0978
2026-02-13 2025-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 201,290 13,129 6.98 91,257 23.84 0.0663
2025-11-12 2025-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 188,161 -99,731 -34.64 73,691 -42.50 0.0548
2025-08-13 2025-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 287,892 143,084 98.81 128,170 82.56 0.1031
2025-05-14 2025-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 144,808 -47,978 -24.89 70,206 -9.57 0.0622
2025-02-13 2024-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 192,786 -382,246 -66.47 77,635 -70.97 0.0684
2024-11-13 2024-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 575,032 371,691 182.79 267,436 180.59 0.2548
2024-08-13 2024-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 203,341 -27,856 -12.05 95,310 -1.38 0.0972
2024-05-13 2024-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 231,197 -503,638 -68.54 96,643 -67.68 0.0981
2024-02-13 2023-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 734,835 -63,531 -7.96 298,997 7.70 0.3263
2023-11-13 2023-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 798,366 508,389 175.32 277,624 172.06 0.3290
2023-08-14 2023-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 289,977 -42,809 -12.86 102,046 -2.68 0.1160
2023-05-15 2023-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 332,786 -17,185 -4.91 104,851 3.75 0.1211
2023-02-09 2022-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 349,971 -10,921 -3.03 101,065 -3.28 0.1202
2022-11-14 2022-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 360,892 -668,540 -64.94 104,492 -63.98 0.1355
2022-08-12 2022-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 1,029,432 588,620 133.53 290,084 152.16 0.3582
2022-05-13 2022-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 440,812 -80,615 -15.46 115,039 0.47 0.1177
2022-02-08 2021-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 521,427 30,756 6.27 114,505 28.65 0.1114
2021-11-15 2021-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 490,671 91,357 22.88 89,003 10.54 0.0957
2021-10-12 2021-06-30 13F/A-1 VERTEX PHARMACEUTICALS COM 92532F100 399,314 11,734 3.03 80,518 -3.32 0.0872
2021-08-16 2021-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 400,016 12,436 80,655 0.0832
2021-05-14 2021-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 387,580 -16,439 -4.07 83,287 -12.78 0.1009
2021-02-02 2020-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 404,019 -425,744 -51.31 95,486 -57.71 0.1265
2020-11-05 2020-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 829,763 17,708 2.18 225,795 -4.22 0.3617
2020-07-22 2020-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 812,055 316,633 63.91 235,748 99.98 0.4086
2020-05-06 2020-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 495,422 138,446 38.78 117,886 50.83 0.2671
2020-02-03 2019-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 356,976 -89,458 -20.04 78,160 3.34 0.1335
2019-11-04 2019-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 446,434 -221,798 -33.19 75,635 -38.28 0.1424
2019-07-30 2019-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 668,232 -69,332 -9.40 122,540 -9.68 0.2310
2019-06-19 2019-03-31 13F/A-1 VERTEX PHARMACEUTICALS COM 92532F100 737,564 29,086 4.11 135,675 15.56 0.2698
2019-05-09 2019-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 737,564 29,086 135,675
2019-02-07 2018-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 708,478 -9,977 -1.39 117,402 -15.22 0.2784
2018-10-25 2018-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 718,455 204,780 39.87 138,475 58.61 0.2578
2018-08-02 2018-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 513,675 36,704 7.70 87,304 12.31 0.1810
2018-04-23 2018-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 476,971 -65,461 -12.07 77,737 -4.37 0.1785
2018-02-08 2017-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 542,432 -12,589 -2.27 81,289 -3.67 0.1935
2017-10-24 2017-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 555,021 -91,518 -14.16 84,385 1.28 0.2171
2017-08-02 2017-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 646,539 243,153 60.28 83,319 88.89 0.2224
2017-05-02 2017-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 403,386 -13,906 -3.33 44,110 43.48 0.1222
2017-02-06 2016-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 417,292 57,019 15.83 30,742 -2.15 0.0915
2016-11-01 2016-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 360,273 -56,288 -13.51 31,419 -12.32 0.0938
2016-08-04 2016-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 416,561 -17,404 -4.01 35,833 3.88 0.1128
2016-05-10 2016-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 433,965 -545,760 -55.71 34,496 -72.02 0.1108
2016-05-04 2015-12-31 13F/A-1 VERTEX PHARMACEUTICALS COM 92532F100 979,725 -43,619 -4.26 123,279 15.68 0.3199
2016-02-03 2015-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 979,725 123,279
2015-11-05 2015-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 1,023,344 22,220 2.22 106,571 -13.79 0.3087
2015-08-04 2015-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 1,001,124 150,498 17.69 123,619 23.19 0.3208
2015-05-04 2015-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 850,626 -165,610 -16.30 100,348 -16.88 0.2947
2015-02-13 2014-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 1,016,236 133,010 15.06 120,729 21.71 0.4073
2014-11-12 2014-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 883,226 -102,926 -10.44 99,195 6.24 0.3902
2014-08-11 2014-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 986,152 198,579 25.21 93,369 67.64 0.3879
2014-05-12 2014-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 787,573 153,849 24.28 55,697 18.29 0.2448
2014-08-08 2013-12-31 13F/A-1 VERTEX PHARMACEUTICALS COM 92532F100 633,724 -26,782 -4.05 47,086 -5.98 0.2283
2014-02-13 2013-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 633,724 47,086
2013-11-12 2013-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 660,506 252,451 61.87 50,080 53.30 0.2715
2013-08-12 2013-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 408,055 408,055 32,669 0.2126
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.