Vertex Pharmaceuticals Incorporated
US ˙ NasdaqGS ˙ US92532F1003

SecurityVRTX / Vertex Pharmaceuticals Incorporated
InstitutionDimensional Fund Advisors Lp
Latest Disclosed Ownership989,342 shares
Latest Disclosed Value $ 441,758,953
Dimensional Fund Advisors Lp reports 4.62% increase in ownership of VRTX / Vertex Pharmaceuticals Incorporated

On May 7, 2026 - Dimensional Fund Advisors Lp filed a 13F-HR form disclosing ownership of 989,342 shares of Vertex Pharmaceuticals Incorporated (US:VRTX) valued at $441,780,777 USD as of March 31, 2026. The entity filed a previous 13F-HR on February 12, 2026 disclosing 945,660 shares of Vertex Pharmaceuticals Incorporated. This represents a change in shares of 4.62% during the quarter. The current value of the position is $442,067,686 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-05-07 2026-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 989,342 43,682 4.62 441,759 3.04 0.0198
2026-02-12 2025-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 945,660 162,074 20.68 428,726 39.69 0.0899
2025-11-12 2025-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 783,586 187,359 31.42 306,909 15.63 0.0659
2025-08-12 2025-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 596,227 -9,652 -1.59 265,417 -9.65 0.0615
2025-05-13 2025-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 605,879 -21,638 -3.45 293,780 16.26 0.0730
2025-02-13 2024-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 627,517 -20,291 -3.13 252,685 -16.13 0.0607
2024-11-07 2024-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 647,808 -15,149 -2.29 301,271 -3.06 0.0731
2024-08-09 2024-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 662,957 75,045 12.76 310,768 26.46 0.0812
2024-05-10 2024-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 587,912 2,696 0.46 245,753 3.20 0.0665
2024-02-07 2023-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 585,216 -7,179 -1.21 238,128 15.59 0.0695
2023-11-09 2023-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 592,395 -18,304 -3.00 206,013 -4.14 0.0676
2023-08-09 2023-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 610,699 -10,116 -1.63 214,903 9.87 0.0685
2023-05-12 2023-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 620,815 -159,687 -20.46 195,593 86,830.22 0.0659
2023-02-09 2022-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 780,502 -83,805 -9.70 225 -99.91 0.0666
2022-11-10 2022-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 864,307 -17,338 -1.97 250,265 0.74 0.0961
2022-08-12 2022-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 881,645 -71,529 -7.50 248,425 -0.12 0.0891
2022-05-13 2022-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 953,174 19,141 2.05 248,718 21.25 0.0766
2022-02-09 2021-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 934,033 229,487 32.57 205,133 60.50 0.0620
2021-11-12 2021-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 704,546 185,523 35.74 127,807 22.14 0.0412
2021-08-12 2021-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 519,023 49,412 10.52 104,638 3.63 0.0331
2021-05-14 2021-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 469,611 15,062 3.31 100,971 -6.00 0.0334
2021-03-08 2020-12-31 13F/A-2 VERTEX PHARMACEUTICALS COM 92532F100 454,549 18,974 4.36 107,419 -9.37 0.0388
2021-02-11 2020-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 454,549 18,974 107,419 38,794.0332
2020-11-12 2020-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 435,575 3,625 0.84 118,523 -5.47 0.0503
2020-08-13 2020-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 431,950 35,100 8.84 125,387 32.81 0.0551
2020-05-14 2020-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 396,850 22,425 5.99 94,412 15.16 0.0492
2020-02-14 2019-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 374,425 1,852 0.50 81,981 29.88 0.0299
2019-11-12 2019-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 372,573 1,056 0.28 63,120 -7.35 0.0245
2019-08-13 2019-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 371,517 6,005 1.64 68,126 1.33 0.0265
2019-08-12 2019-03-31 13F/A-2 VERTEX PHARMACEUTICALS COM 92532F100 365,512 40,427 12.44 67,233 24.83 0.0268
2019-05-10 2019-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 365,512 40,427 67,233
2019-02-26 2018-12-31 13F/A-1 VERTEX PHARMACEUTICALS COM 92532F100 325,085 11,848 3.78 53,860 -10.77 0.0244
2019-02-13 2018-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 325,085 11,848 53,860
2018-11-13 2018-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 313,237 -8,109 -2.52 60,364 10.62 0.0230
2018-08-10 2018-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 321,346 200 0.06 54,569 4.26 0.0218
2018-05-11 2018-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 321,146 8,640 2.76 52,340 11.75 0.0218
2018-02-12 2017-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 312,506 15,625 5.26 46,835 3.77 0.0194
2017-11-13 2017-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 296,881 14,066 4.97 45,134 23.84 0.0197
2017-08-11 2017-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 282,815 9,882 3.62 36,445 22.13 0.0168
2017-05-12 2017-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 272,933 5,496 2.06 29,842 51.46 0.0143
2017-02-09 2016-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 267,437 8,524 3.29 19,703 -12.73 0.0098
2016-11-10 2016-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 258,913 9,896 3.97 22,577 5.41 0.0122
2016-08-09 2016-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 249,017 810 0.33 21,419 8.57 0.0123
2016-05-13 2016-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 248,207 8,583 3.58 19,728 -34.57 0.0118
2016-02-10 2015-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 239,624 14,019 6.21 30,153 28.37 0.0188
2015-11-13 2015-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 225,605 -113 -0.05 23,489 -15.72 0.0154
2015-08-14 2015-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 225,718 -5,656 -2.44 27,871 2.09 0.0171
2015-05-14 2015-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 231,374 1,117 0.49 27,300 -0.20 0.0172
2015-02-06 2014-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 230,257 2,319 1.02 27,356 6.84 0.0180
2014-11-13 2014-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 227,938 2,163 0.96 25,604 19.80 0.0181
2014-08-08 2014-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 225,775 -523 -0.23 21,373 33.54 0.0149
2014-05-14 2014-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 226,298 2,655 1.19 16,005 -3.68 0.0120
2014-02-12 2013-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 223,643 16,274 7.85 16,616 5.69 0.0129
2013-11-13 2013-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 207,369 60,681 41.37 15,722 34.17 0.0136
2013-08-15 2013-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 146,688 146,688 11,718 0.0110
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.