Vertex Pharmaceuticals Incorporated
US ˙ NasdaqGS ˙ US92532F1003

SecurityVRTX / Vertex Pharmaceuticals Incorporated
InstitutionConning Inc.
Latest Disclosed Ownership1,167 shares
Latest Disclosed Value $ 521,112
Conning Inc. reports 16.64% decrease in ownership of VRTX / Vertex Pharmaceuticals Incorporated

On April 30, 2026 - Conning Inc. filed a 13F-HR form disclosing ownership of 1,167 shares of Vertex Pharmaceuticals Incorporated (US:VRTX) valued at $521,112 USD as of March 31, 2026. The entity filed a previous 13F-HR on February 5, 2026 disclosing 1,400 shares of Vertex Pharmaceuticals Incorporated. This represents a change in shares of -16.64% during the quarter. The current value of the position is $499,873 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-04-30 2026-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 1,167 -233 -16.64 521 -17.82 0.0173
2026-02-05 2025-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 1,400 -144 -9.33 635 4.97 0.0213
2025-10-28 2025-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 1,544 0 0.00 605 -12.08 0.0201
2025-07-24 2025-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 1,544 -42 -2.65 687 -10.55 0.0236
2025-04-29 2025-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 1,586 172 12.16 769 34.97 0.0269
2025-01-28 2024-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 1,414 -89 -5.92 569 -18.60 0.0200
2024-10-29 2024-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 1,503 -18 -1.18 699 -1.83 0.0231
2024-07-26 2024-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 1,521 33 2.22 713 14.65 0.0257
2024-04-26 2024-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 1,488 -40 -2.62 622 0.00 0.0204
2024-01-30 2023-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 1,528 10 0.66 622 17.84 0.0216
2023-10-26 2023-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 1,518 -20 -1.30 528 -2.59 0.0192
2023-07-21 2023-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 1,538 -235 -13.25 541 -3.05 0.0181
2023-04-27 2023-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 1,773 -20 -1.12 559 7.93 0.0187
2023-02-08 2022-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 1,793 -8 -0.44 518 -0.77 0.0168
2022-10-31 2022-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 1,801 -102 -5.36 521 -2.80 0.0185
2022-07-20 2022-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 1,903 -22 -1.14 536 6.77 0.0161
2022-05-02 2022-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 1,925 -170 -8.11 502 9.13 0.0137
2022-01-27 2021-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 2,095 -399 -16.00 460 1.77 0.0123
2021-11-05 2021-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 2,494 -590 -19.13 452 -27.33 0.0130
2021-07-29 2021-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 3,084 -303 -8.95 622 -14.56 0.0180
2021-04-23 2021-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 3,387 -300 -8.14 728 -16.42 0.0219
2021-01-28 2020-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 3,687 -15 -0.41 871 -13.51 0.0277
2020-10-21 2020-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 3,702 69 1.90 1,007 -4.55 0.0354
2020-08-07 2020-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 3,633 -254 -6.53 1,055 14.05 0.0392
2020-04-29 2020-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 3,887 7 0.18 925 8.82 0.0394
2020-01-29 2019-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 3,880 40 1.04 850 30.57 0.0279
2019-10-30 2019-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 3,840 0 0.00 651 -7.53 0.0225
2019-07-25 2019-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 3,840 -1,559 -28.88 704 -29.10 0.0233
2019-04-22 2019-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 5,399 -60 -1.10 993 9.72 0.0310
2019-01-29 2018-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 5,459 -490 -8.24 905 -21.10 0.0308
2018-10-26 2018-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 5,949 -180 -2.94 1,147 10.08 0.0340
2018-07-25 2018-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 6,129 -90 -1.45 1,042 2.76 0.0318
2018-05-03 2018-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 6,219 -110 -1.74 1,014 6.96 0.0326
2018-01-30 2017-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 6,329 -70 -1.09 948 -2.57 0.0313
2017-10-20 2017-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 6,399 -90 -1.39 973 16.39 0.0331
2017-08-03 2017-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 6,489 390 6.39 836 25.34 0.0304
2017-04-27 2017-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 6,099 -140 -2.24 667 45.00 0.0246
2017-02-02 2016-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 6,239 439 7.57 460 -9.09 0.0183
2016-10-25 2016-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 5,800 60 1.05 506 2.43 0.0202
2016-07-26 2016-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 5,740 20 0.35 494 8.57 0.0204
2016-04-26 2016-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 5,720 110 1.96 455 -35.55 0.0191
2016-02-04 2015-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 5,610 -320 -5.40 706 14.24 0.0302
2015-10-23 2015-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 5,930 -580 -8.91 618 -23.13 0.0271
2015-08-03 2015-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 6,510 -50 -0.76 804 3.88 0.0330
2015-04-24 2015-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 6,560 90 1.39 774 0.65 0.0329
2015-02-13 2014-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 6,470 -140 -2.12 769 3.64 0.0375
2014-11-07 2014-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 6,610 840 14.56 742 35.90 0.0389
2014-07-25 2014-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 5,770 490 9.28 546 46.38 0.0290
2014-04-25 2014-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 5,280 5,280 373 0.0219
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.