Axa S.a. closes position in VRTX / Vertex Pharmaceuticals Incorporated

Vertex Pharmaceuticals Incorporated

US ˙ NasdaqGS ˙ US92532F1003

Security	VRTX / Vertex Pharmaceuticals Incorporated
Institution	Axa S.a.
Latest Disclosed Ownership	0 shares
Latest Disclosed Value	$ 0

On November 14, 2025 - Axa S.a. filed a 13F-HR form disclosing ownership of 0 shares of Vertex Pharmaceuticals Incorporated (US:VRTX) valued at $0 USD as of September 30, 2025. The entity filed a previous 13F-HR on August 14, 2025 disclosing 171,270 shares of Vertex Pharmaceuticals Incorporated. The current value of the position is $0 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)

File Date	Effective Date	Form	Security	Class	ID	Reported Shares	ΔShares	ΔShares (%)	Reported Value (x1000)	ΔValue (%)	Alloc (%)
2025-11-14	2025-09-30	13F	VERTEX PHARMACEUTICALS	COM	92532F100	0		-100.00	0
2025-08-14	2025-06-30	13F	VERTEX PHARMACEUTICALS	COM	92532F100	171,270	10,477	6.52	76,249	-2.19	0.1522
2025-05-15	2025-03-31	13F	VERTEX PHARMACEUTICALS	COM	92532F100	160,793	20,003	14.21	77,956	37.50	0.2561
2025-02-14	2024-12-31	13F	VERTEX PHARMACEUTICALS	COM	92532F100	140,790	-3,620	-2.51	56,696	-15.58	0.1722
2024-11-14	2024-09-30	13F	VERTEX PHARMACEUTICALS	COM	92532F100	144,410	-48,927	-25.31	67,162	-25.89	0.1989
2025-02-25	2024-06-30	13F/A-1	VERTEX PHARMACEUTICALS	COM	92532F100	193,337	-36,554	-15.90	90,621	-5.70	0.2696
2024-08-14	2024-06-30	13F	VERTEX PHARMACEUTICALS	COM	92532F100	193,337	-36,554		90,621		0.2696
2024-05-15	2024-03-31	13F	VERTEX PHARMACEUTICALS	COM	92532F100	229,891	-43,470	-15.90	96,097	-13.60	0.2881
2024-07-16	2023-12-31	13F/A-1	VERTEX PHARMACEUTICALS	COM	92532F100	273,361	-12,314	-4.31	111,228	11.97	0.3586
2024-02-14	2023-12-31	13F	VERTEX PHARMACEUTICALS	COM	92532F100	273,361	-12,314		111,228		0.2178
2023-11-14	2023-09-30	13F	VERTEX PHARMACEUTICALS	COM	92532F100	285,675	10,329	3.75	99,341	2.52	0.3492
2023-08-14	2023-06-30	13F	VERTEX PHARMACEUTICALS	COM	92532F100	275,346	-28,607	-9.41	96,897	1.18	0.3220
2023-05-15	2023-03-31	13F	VERTEX PHARMACEUTICALS	COM	92532F100	303,953	-39,737	-11.56	95,766	-3.51	0.3294
2023-02-14	2022-12-31	13F	VERTEX PHARMACEUTICALS	COM	92532F100	343,690	66,193	23.85	99,251	23.53	0.3581
2023-02-14	2022-09-30	13F/A-1	Vertex Pharmaceuticals	COM	92532F100	277,497	43,581	18.63	80,346	21.89	0.3161
2022-11-14	2022-09-30	13F	Vertex Pharmaceuticals	COM	92532F100	277,497	43,581		80,346		0.3161
2023-02-14	2022-06-30	13F/A-1	Vertex Pharmaceuticals	COM	92532F100	233,916	-73,703	-23.96	65,915	-17.89	0.2443
2022-08-15	2022-06-30	13F	Vertex Pharmaceuticals	COM	92532F100	233,916	-73,703		65,916		0.2443
2023-02-14	2022-03-31	13F/A-1	Vertex Pharmaceuticals	COM	92532F100	307,619	-98,580	-24.27	80,279	-10.00	0.2282
2022-05-13	2022-03-31	13F	Vertex Pharmaceuticals	COM	92532F100	307,619	-98,580		80,279		0.2282
2022-02-14	2021-12-31	13F	Vertex Pharmaceuticals	COM	92532F100	406,199	-15,690	-3.72	89,201	16.56	0.2280
2021-11-15	2021-09-30	13F	Vertex Pharmaceuticals	COM	92532F100	421,889	198,955	89.24	76,526	70.25	0.2148
2021-08-13	2021-06-30	13F/A-1	Vertex Pharmaceuticals	COM	92532F100	222,934	-11,825	-5.04	44,950	-10.90	0.1267
2021-08-13	2021-06-30	13F	Vertex Pharmaceuticals	COM	92532F100	222,934	-11,825		44,950		0.0759
2021-05-14	2021-03-31	13F	Vertex Pharmaceuticals	COM	92532F100	234,759	-74,326	-24.05	50,447	-30.94	0.1536
2021-02-12	2020-12-31	13F	Vertex Pharmaceuticals	COM	92532F100	309,085	-30,879	-9.08	73,049	-21.04	0.2293
2021-02-11	2020-09-30	13F/A-1	Vertex Pharmaceuticals	COM	92532F100	339,964	-131,440	-27.88	92,511	-32.40	0.3344
2020-11-13	2020-09-30	13F	Vertex Pharmaceuticals	COM	92532F100	339,964	-131,440		92,511		184,666.6386
2021-02-12	2020-06-30	13F/A-1	VERTEX PHARMACEUTICALS	COM	92532F100	471,404	46,653	10.98	136,853	35.40	0.5392
2020-08-14	2020-06-30	13F	VERTEX PHARMACEUTICALS	COM	92532F100	471,404	46,653		136,853		539,699.7765
2021-02-12	2020-03-31	13F/A-2	VERTEX PHARMACEUTICALS	COM	92532F100	424,751	25,645	6.43	101,070	15.66	0.5052
2020-06-15	2020-03-31	13F/A-1	VERTEX PHARMACEUTICALS	COM	92532F100	424,751	0		101,070		0.5055
2020-05-15	2020-03-31	13F	VERTEX PHARMACEUTICALS	COM	92532F100	424,751	25,645		101,070		281,077.4083
2021-02-12	2019-12-31	13F/A-1	VERTEX PHARMACEUTICALS	COM	92532F100	399,106	108,147	37.17	87,384	77.27	0.3554
2020-02-18	2019-12-31	13F	VERTEX PHARMACEUTICALS	COM	92532F100	399,106	108,147		87,384		355,797.7704
2021-02-12	2019-09-30	13F/A-1	VERTEX PHARMACEUTICALS	COM	92532F100	290,959	-169,430	-36.80	49,294	-41.61	0.1962
2019-11-14	2019-09-30	13F	VERTEX PHARMACEUTICALS	COM	92532F100	290,959	-169,430		49,294		196,439.7282
2021-02-12	2019-06-30	13F/A-1	VERTEX PHARMACEUTICALS	COM	92532F100	460,389	-76,979	-14.33	84,426	-14.59	0.3295
2019-08-13	2019-06-30	13F	VERTEX PHARMACEUTICALS	COM	92532F100	460,389	-76,979		84,426		331,083.2618
2019-05-14	2019-03-31	13F	VERTEX PHARMACEUTICALS	COM	92532F100	537,368	-15,291	-2.77	98,849	7.94	0.3863
2019-02-13	2018-12-31	13F	VERTEX PHARMACEUTICALS	COM	92532F100	552,659	20,083	3.77	91,581	-10.78	0.3992
2018-11-08	2018-09-30	13F	VERTEX PHARMACEUTICALS	COM	92532F100	532,576	-271,505	-33.77	102,648	-24.89	0.3765
2018-08-13	2018-06-30	13F	VERTEX PHARMACEUTICALS	COM	92532F100	804,081	114,996	16.69	136,662	21.69	0.5238
2018-05-14	2018-03-31	13F	VERTEX PHARMACEUTICALS	COM	92532F100	689,085	426,971	162.90	112,307	185.91	0.4482
2018-02-13	2017-12-31	13F	VERTEX PHARMACEUTICALS	COM	92532F100	262,114	-12,084	-4.41	39,281	-5.78	0.1543
2017-12-01	2017-09-30	13F/A-1	VERTEX PHARMACEUTICALS	COM	92532F100	274,198	103,149	60.30	41,689	89.13	0.1796
2017-11-13	2017-09-30	13F	VERTEX PHARMACEUTICALS	COM	92532F100	274,198	103,149		41,689
2017-08-10	2017-06-30	13F	VERTEX PHARMACEUTICALS	COM	92532F100	171,049	-5,880	-3.32	22,043	13.93	0.1001
2017-05-11	2017-03-31	13F	VERTEX PHARMACEUTICALS	COM	92532F100	176,929	-325,859	-64.81	19,347	-47.77	0.0873
2017-02-13	2016-12-31	13F	VERTEX PHARMACEUTICALS	COM	92532F100	502,788	-64,804	-11.42	37,040	-25.17	0.1738
2016-11-10	2016-09-30	13F	VERTEX PHARMACEUTICALS	COM	92532F100	567,592	-62,583	-9.93	49,500	-8.68	0.2174
2016-08-11	2016-06-30	13F	VERTEX PHARMACEUTICALS	COM	92532F100	630,175	64,659	11.43	54,207	20.59	0.2415
2016-05-13	2016-03-31	13F	VERTEX PHARMACEUTICALS	COM	92532F100	565,516	-59,822	-9.57	44,953	-42.87	0.2017
2016-02-12	2015-12-31	13F	VERTEX PHARMACEUTICALS	COM	92532F100	625,338	19,985	3.30	78,686	24.82	0.3438
2015-11-13	2015-09-30	13F	VERTEX PHARMACEUTICALS	COM	92532F100	605,353	80,402	15.32	63,041	-2.75	0.2585
2015-08-13	2015-06-30	13F	VERTEX PHARMACEUTICALS	COM	92532F100	524,951	-3,342	-0.63	64,821	4.01	0.2595
2015-05-13	2015-03-31	13F	VERTEX PHARMACEUTICALS	COM	92532F100	528,293	59,444	12.68	62,323	11.89	0.2568
2015-02-13	2014-12-31	13F	VERTEX PHARMACEUTICALS	COM	92532F100	468,849	102,747	28.07	55,700	35.47	0.2234
2014-11-13	2014-09-30	13F	VERTEX PHARMACEUTICALS	COM	92532F100	366,102	7,747	2.16	41,116	21.18	0.1758
2014-08-13	2014-06-30	13F	VERTEX PHARMACEUTICALS	COM	92532F100	358,355	116,167	47.97	33,929	98.09	0.1412
2014-05-13	2014-03-31	13F	VERTEX PHARMACEUTICALS	COM	92532F100	242,188	12,613	5.49	17,128	0.42	0.0745
2014-02-13	2013-12-31	13F	VERTEX PHARMACEUTICALS	COM	92532F100	229,575	25,616	12.56	17,057	10.30	0.0764
2013-11-13	2013-09-30	13F	VERTEX PHARMACEUTICALS	COM	92532F100	203,959	37,862	22.80	15,464	16.57	0.0762
2013-08-12	2013-06-30	13F	VERTEX PHARMACEUTICALS	COM	92532F100	166,097	166,097		13,266		0.0705

Legend

Shares: The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value: The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price: The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class: This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred

Allocation (%): The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation: The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%): The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis: The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss: This is the market value of the position as of the effective date minus the cost basis.