Vertex Pharmaceuticals Incorporated
US ˙ NasdaqGS ˙ US92532F1003

SecurityVRTX / Vertex Pharmaceuticals Incorporated
InstitutionAssenagon Asset Management S.A.
Latest Disclosed Ownership537,248 shares
Latest Disclosed Value $ 239,902,722
Assenagon Asset Management S.A. reports 35.49% decrease in ownership of VRTX / Vertex Pharmaceuticals Incorporated

On April 20, 2026 - Assenagon Asset Management S.A. filed a 13F-HR form disclosing ownership of 537,248 shares of Vertex Pharmaceuticals Incorporated (US:VRTX) valued at $239,902,722 USD as of March 31, 2026. The entity filed a previous 13F-HR on January 9, 2026 disclosing 832,853 shares of Vertex Pharmaceuticals Incorporated. This represents a change in shares of -35.49% during the quarter. The current value of the position is $240,058,524 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-04-20 2026-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 537,248 -295,605 -35.49 239,903 -36.46 0.3642
2026-01-09 2025-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 832,853 69,150 9.05 377,582 26.24 0.5198
2025-10-07 2025-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 763,703 520,949 214.60 299,097 176.75 0.4090
2025-07-11 2025-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 242,754 34,614 16.63 108,074 7.10 0.1604
2025-04-15 2025-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 208,140 -631,532 -75.21 100,910 -70.16 0.1683
2025-01-14 2024-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 839,672 528,029 169.43 338,136 133.30 0.5454
2024-10-23 2024-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 311,643 215,448 223.97 144,939 221.46 0.2667
2024-07-18 2024-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 96,195 -226,893 -70.23 45,089 -66.61 0.1004
2024-04-24 2024-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 323,088 26,935 9.09 135,054 12.08 0.3197
2024-01-17 2023-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 296,153 93,922 46.44 120,502 71.35 0.3198
2023-11-06 2023-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 202,231 -182,487 -47.43 70,324 -48.06 0.2177
2023-07-25 2023-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 384,718 -234,078 -37.83 135,386 -30.56 0.4684
2023-04-18 2023-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 618,796 -120,191 -16.26 194,964 91,432.39 0.6920
2023-01-12 2022-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 738,987 76,752 11.59 213 -99.89 0.7697
2022-10-27 2022-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 662,235 146,237 28.34 191,744 31.87 0.7360
2022-07-27 2022-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 515,998 -292,556 -36.18 145,403 -31.09 0.5389
2022-04-25 2022-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 808,554 486,323 150.92 211,008 198.19 0.5862
2022-02-01 2021-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 322,231 252,752 363.78 70,762 461.47 0.2050
2021-10-19 2021-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 69,479 -166,649 -70.58 12,603 -73.53 0.0403
2021-07-15 2021-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 236,128 -37,631 -13.75 47,610 -19.07 0.1616
2021-04-26 2021-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 273,759 -324,687 -54.26 58,828 -58.41 0.2387
2021-02-01 2020-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 598,446 474,130 381.39 141,437 318.09 0.6161
2020-10-07 2020-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 124,316 -1,314 -1.05 33,829 -7.25 0.1898
2020-07-21 2020-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 125,630 -641,941 -83.63 36,472 -80.03 0.2339
2020-04-17 2020-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 767,571 498,163 184.91 182,644 209.63 1.4616
2020-01-17 2019-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 269,408 240,816 842.25 58,987 1,117.73 0.3710
2019-10-16 2019-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 28,592 19,333 208.80 4,844 185.28 0.0324
2019-08-12 2019-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 9,259 -59,305 -86.50 1,698 -86.54 0.0128
2019-04-26 2019-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 68,564 -315,198 -82.13 12,612 -80.17 0.1183
2019-01-23 2018-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 383,762 192,494 100.64 63,593 72.50 0.7204
2018-10-29 2018-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 191,268 -173,500 -47.56 36,865 -40.54 0.3639
2018-07-17 2018-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 364,768 212,481 139.53 61,996 149.78 0.7156
2018-04-30 2018-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 152,287 -6,287 -3.96 24,820 4.44 0.3234
2018-01-25 2017-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 158,574 -734,806 -82.25 23,764 -82.50 0.2446
2017-10-18 2017-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 893,380 883,998 9,422.28 135,829 11,134.82 1.2613
2017-07-19 2017-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 9,382 9,382 1,209 0.0262
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.