Vertex Pharmaceuticals Incorporated
US ˙ NasdaqGS ˙ US92532F1003

SecurityVRTX / Vertex Pharmaceuticals Incorporated
InstitutionAmeriprise Financial Inc
Latest Disclosed Ownership2,633,481 shares
Latest Disclosed Value $ 1,175,957,388
Ameriprise Financial Inc reports 16.33% increase in ownership of VRTX / Vertex Pharmaceuticals Incorporated

On May 15, 2026 - Ameriprise Financial Inc filed a 13F-HR form disclosing ownership of 2,633,481 shares of Vertex Pharmaceuticals Incorporated (US:VRTX) valued at $1,175,954,606 USD as of March 31, 2026. The entity filed a previous 13F-HR on February 17, 2026 disclosing 2,263,732 shares of Vertex Pharmaceuticals Incorporated. This represents a change in shares of 16.33% during the quarter. The current value of the position is $1,176,718,315 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-05-15 2026-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 2,633,481 369,749 16.33 1,175,957 14.58 0.0504
2026-02-17 2025-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 2,263,732 -13,195 -0.58 1,026,287 15.09 0.2319
2025-11-14 2025-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 2,276,927 95,565 4.38 891,744 -8.17 0.2048
2025-08-14 2025-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 2,181,362 -54,107 -2.42 971,134 -10.40 0.2394
2025-05-14 2025-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 2,235,469 219,946 10.91 1,083,818 33.54 0.2926
2025-02-14 2024-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 2,015,523 143,713 7.68 811,635 -6.77 0.2082
2024-11-14 2024-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 1,871,810 -182,971 -8.90 870,554 -9.61 0.2233
2024-08-14 2024-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 2,054,781 -170,526 -7.66 963,130 3.55 0.2606
2024-05-15 2024-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 2,225,307 -284,722 -11.34 930,112 -8.93 0.2560
2024-02-14 2023-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 2,510,029 -427,783 -14.56 1,021,332 -0.04 0.3058
2023-11-14 2023-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 2,937,812 -86,031 -2.85 1,021,733 -3.99 0.3354
2023-08-14 2023-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 3,023,843 -366,017 -10.80 1,064,140 -0.36 0.3336
2023-05-22 2023-03-31 13F/A-1 VERTEX PHARMACEUTICALS COM 92532F100 3,389,860 -188,787 -5.28 1,068,025 3.35 0.3502
2023-05-15 2023-03-31 13F VERRA MOBILITY COM 92532F100 3,389,860 -188,787 1,068,025 0.0646
2023-02-14 2022-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 3,578,647 -463,346 -11.46 1,033,438 -11.71 0.3542
2022-11-14 2022-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 4,041,993 -520,956 -11.42 1,170,552 -8.94 0.4329
2022-08-15 2022-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 4,562,949 -384,414 -7.77 1,285,499 -0.36 0.4483
2022-05-16 2022-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 4,947,363 524,167 11.85 1,290,137 33.12 0.3807
2022-02-14 2021-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 4,423,196 1,034,106 30.51 969,171 57.66 0.2680
2021-11-15 2021-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 3,389,090 650,315 23.74 614,704 11.32 0.1964
2021-08-16 2021-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 2,738,775 820,708 42.79 552,201 33.98 0.1707
2021-05-17 2021-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 1,918,067 1,100,467 134.60 412,162 113.34 0.1370
2021-02-12 2020-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 817,600 -22,268 -2.65 193,192 -15.42 0.0685
2020-11-16 2020-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 839,868 -444,227 -34.59 228,416 -38.73 0.0929
2020-08-14 2020-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 1,284,095 -888,799 -40.90 372,781 -27.90 0.1597
2020-05-15 2020-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 2,172,894 -236,171 -9.80 517,046 -1.94 0.2714
2020-02-14 2019-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 2,409,065 30,299 1.27 527,300 30.85 0.2192
2019-11-14 2019-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 2,378,766 -62,955 -2.58 402,981 -10.00 0.1806
2019-08-14 2019-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 2,441,721 78,258 3.31 447,757 3.02 0.2006
2019-05-15 2019-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 2,363,463 -1,986,539 -45.67 434,625 -39.69 0.1999
2019-02-14 2018-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 4,350,002 -1,393,382 -24.26 720,666 -34.81 0.3604
2018-11-14 2018-09-30 13F VERTEX PHARMACEUTICA COM 92532F100 5,743,384 -82,081 -1.41 1,105,476 11.93 0.3865
2018-08-14 2018-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 5,825,465 220,446 3.93 987,636 8.12 0.4370
2018-05-14 2018-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 5,605,019 349,639 6.65 913,500 16.09 0.4133
2018-02-12 2017-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 5,255,380 -176,700 -3.25 786,892 -4.72 0.3589
2017-11-07 2017-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 5,432,080 -973,672 -15.20 825,872 0.04 0.3931
2017-08-10 2017-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 6,405,752 -1,832,449 -22.24 825,512 -8.39 0.4132
2017-05-05 2017-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 8,238,201 -468,434 -5.38 901,084 40.47 0.4662
2017-02-03 2016-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 8,706,635 11,204 0.13 641,475 -15.41 0.3503
2016-11-08 2016-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 8,695,431 -328,644 -3.64 758,327 -2.30 0.4248
2016-08-08 2016-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 9,024,075 -379,072 -4.03 776,208 3.85 0.4549
2016-05-12 2016-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 9,403,147 -187,047 -1.95 747,465 -38.06 0.4460
2016-02-11 2015-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 9,590,194 -571,203 -5.62 1,206,754 14.06 0.7084
2015-11-12 2015-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 10,161,397 286,836 2.90 1,058,033 -13.22 0.6553
2015-08-13 2015-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 9,874,561 -81,333 -0.82 1,219,257 3.81 0.6940
2015-05-14 2015-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 9,955,894 642,075 6.89 1,174,524 6.15 0.6741
2015-02-13 2014-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 9,313,819 -184,044 -1.94 1,106,467 3.73 0.6448
2014-11-14 2014-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 9,497,863 2,419,288 34.18 1,066,708 59.16 0.6418
2014-08-13 2014-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 7,078,575 -1,047,185 -12.89 670,196 16.63 0.3954
2014-05-14 2014-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 8,125,760 334,295 4.29 574,654 -0.74 0.3451
2014-02-14 2013-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 7,791,465 1,833,313 30.77 578,909 28.15 0.3507
2013-11-14 2013-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 5,958,152 1,375,662 30.02 451,746 23.41 0.2963
2013-08-14 2013-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 4,582,490 4,582,490 366,059 0.2534
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.