Vertex Pharmaceuticals Incorporated
US ˙ NasdaqGS ˙ US92532F1003

SecurityVRTX / Vertex Pharmaceuticals Incorporated
InstitutionAlliancebernstein L.p.
Latest Disclosed Ownership3,910,786 shares
Latest Disclosed Value $ 1,772,993,941
Alliancebernstein L.p. reports 13.03% decrease in ownership of VRTX / Vertex Pharmaceuticals Incorporated

On May 15, 2026 - Alliancebernstein L.p. filed a 13F-HR form disclosing ownership of 3,910,786 shares of Vertex Pharmaceuticals Incorporated (US:VRTX) valued at $1,746,322,380 USD as of March 31, 2026. The entity filed a previous 13F-HR on February 17, 2026 disclosing 4,496,482 shares of Vertex Pharmaceuticals Incorporated. This represents a change in shares of -13.03% during the quarter. The current value of the position is $1,675,146,075 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-05-15 2026-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 3,910,786 -585,696 -13.03 1,772,994 -13.03 0.4797
2026-02-17 2025-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 4,496,482 -26,104 -0.58 2,038,525 15.09 0.6437
2025-11-14 2025-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 4,522,586 144,266 3.30 1,771,226 -9.13 0.5578
2025-08-14 2025-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 4,378,320 424,808 10.75 1,949,228 1.69 0.6358
2025-05-15 2025-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 3,953,512 33,492 0.85 1,916,742 21.42 0.6935
2025-02-12 2024-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 3,920,020 -3,452,747 -46.83 1,578,592 -53.96 0.5357
2024-11-14 2024-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 7,372,767 151,695 2.10 3,428,926 1.31 1.1517
2024-08-14 2024-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 7,221,072 123,791 1.74 3,384,661 14.09 1.1803
2024-05-14 2024-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 7,097,281 57,543 0.82 2,966,734 3.57 1.0498
2024-02-14 2023-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 7,039,738 -486,718 -6.47 2,864,399 9.44 1.1022
2023-11-14 2023-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 7,526,456 -8,578 -0.11 2,617,250 -1.30 1.1133
2023-08-15 2023-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 7,535,034 -838,239 -10.01 2,651,654 0.51 1.0822
2023-05-15 2023-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 8,373,273 -696,307 -7.68 2,638,167 0.73 1.1304
2023-02-15 2022-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 9,069,580 -75,936 -0.83 2,619,113 -1.09 1.1787
2022-11-15 2022-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 9,145,516 -154,714 -1.66 2,647,993 1.04 1.2820
2022-08-15 2022-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 9,300,230 -1,254,811 -11.89 2,620,712 -4.86 1.1970
2022-05-13 2022-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 10,555,041 111,270 1.07 2,754,549 20.10 1.0630
2022-02-14 2021-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 10,443,771 1,374,923 15.16 2,293,452 39.42 0.8108
2021-11-10 2021-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 9,068,848 2,690,416 42.18 1,644,998 27.91 0.6490
2021-07-30 2021-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 6,378,432 -1,480,175 -18.84 1,286,083 -23.84 0.5163
2021-05-06 2021-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 7,858,607 -83,154 -1.05 1,688,736 -10.03 0.7405
2021-02-08 2020-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 7,941,761 1,342,210 20.34 1,876,956 4.52 0.8857
2020-11-12 2020-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 6,599,551 813,580 14.06 1,795,870 6.91 0.9665
2020-08-13 2020-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 5,785,971 -407,880 -6.59 1,679,725 13.97 0.9871
2020-05-14 2020-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 6,193,851 -167,782 -2.64 1,473,827 5.81 1.0566
2020-02-18 2019-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 6,361,633 580,418 10.04 1,392,880 42.21 0.7915
2019-11-14 2019-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 5,781,215 686,812 13.48 979,453 4.84 0.6098
2019-08-14 2019-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 5,094,403 1,777,171 53.57 934,212 53.10 0.5804
2019-05-14 2019-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 3,317,232 386,502 13.19 610,205 25.65 0.3972
2019-02-13 2018-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 2,930,730 2,394,289 446.33 485,651 369.71 0.3606
2018-11-08 2018-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 536,441 40,336 8.13 103,394 22.62 0.0675
2018-08-13 2018-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 496,105 29,847 6.40 84,318 10.96 0.0587
2018-05-14 2018-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 466,258 -5,020 -1.07 75,991 7.60 0.0549
2018-02-13 2017-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 471,278 -7,016 -1.47 70,626 -2.88 0.0505
2017-11-13 2017-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 478,294 34,642 7.81 72,720 27.19 0.0545
2017-08-10 2017-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 443,652 4,164 0.95 57,173 18.97 0.0442
2017-05-11 2017-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 439,488 -14,469 -3.19 48,058 43.70 0.0383
2017-02-13 2016-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 453,957 -12,092 -2.59 33,443 -17.72 0.0279
2016-11-10 2016-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 466,049 1,358 0.29 40,644 1.68 0.0343
2016-08-11 2016-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 464,691 7,491 1.64 39,973 9.99 0.0344
2016-05-13 2016-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 457,200 -3,775 -0.82 36,343 -37.34 0.0309
2016-02-16 2015-12-31 13F/A-1 VERTEX PHARMACEUTICALS COM 92532F100 460,975 -1,999 -0.43 58,004 20.31 0.0494
2016-02-12 2015-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 460,975 48,006
2015-11-13 2015-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 462,974 -5,942 -1.27 48,214 -16.73 0.0414
2015-08-14 2015-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 468,916 -92,272 -16.44 57,902 -12.54 0.0478
2015-05-13 2015-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 561,188 -71,004 -11.23 66,203 -11.85 0.0537
2015-02-13 2014-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 632,192 -68,841 -9.82 75,104 -4.61 0.0624
2014-11-13 2014-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 701,033 -677,587 -49.15 78,733 -39.68 0.0663
2014-08-13 2014-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 1,378,620 -1,266,303 -47.88 130,528 -30.22 0.1100
2014-05-13 2014-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 2,644,923 227,282 9.40 187,049 4.13 0.1616
2014-02-13 2013-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 2,417,641 428,030 21.51 179,631 19.08 0.1606
2013-11-14 2013-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 1,989,611 -491,244 -19.80 150,852 -23.87 0.1490
2013-08-13 2013-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 2,480,855 2,480,855 198,146 0.2103
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.