Vertex Pharmaceuticals Incorporated
US ˙ NasdaqGS ˙ US92532F1003

SecurityVRTX / Vertex Pharmaceuticals Incorporated
InstitutionAdage Capital Partners Gp, L.l.c.
ManagerPhil Gross, Robert Atchinson
Latest Disclosed Ownership251,990 shares
Latest Disclosed Value $ 112,523,615
Adage Capital Partners Gp, L.l.c. reports 7.52% decrease in ownership of VRTX / Vertex Pharmaceuticals Incorporated

On May 15, 2026 - Adage Capital Partners Gp, L.l.c. filed a 13F-HR form disclosing ownership of 251,990 shares of Vertex Pharmaceuticals Incorporated (US:VRTX) valued at $112,523,615 USD as of March 31, 2026. The entity filed a previous 13F-HR on February 17, 2026 disclosing 272,474 shares of Vertex Pharmaceuticals Incorporated. This represents a change in shares of -7.52% during the quarter. The current value of the position is $112,596,692 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-05-15 2026-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 251,990 -20,484 -7.52 112,524 -8.91 0.1735
2026-02-17 2025-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 272,474 -210,021 -43.53 123,529 -34.63 0.1870
2025-11-14 2025-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 482,495 304,303 170.77 188,964 138.20 0.2993
2025-08-14 2025-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 178,192 -311,475 -63.61 79,331 -66.58 0.1337
2025-05-15 2025-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 489,667 280,428 134.02 237,400 181.75 0.4397
2025-02-14 2024-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 209,239 -137,116 -39.59 84,261 -47.69 0.1473
2024-11-14 2024-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 346,355 11,194 3.34 161,083 2.54 0.2844
2024-08-14 2024-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 335,161 -15,095 -4.31 157,097 7.30 0.2909
2024-05-15 2024-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 350,256 50,066 16.68 146,411 19.87 0.2764
2024-02-14 2023-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 300,190 186 0.06 122,144 17.08 0.2529
2023-11-14 2023-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 300,004 -6,029 -1.97 104,323 -3.13 0.2366
2023-08-14 2023-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 306,033 -32,357 -9.56 107,696 1.01 0.2340
2023-05-15 2023-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 338,390 158,500 88.11 106,617 105.24 0.2391
2023-02-14 2022-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 179,890 -157,273 -46.65 51,949 -46.79 0.1243
2022-11-14 2022-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 337,163 -234,867 -41.06 97,622 -39.44 0.2421
2022-08-15 2022-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 572,030 -221,260 -27.89 161,192 -22.14 0.3695
2022-05-16 2022-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 793,290 572,400 259.13 207,025 326.79 0.3931
2022-02-14 2021-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 220,890 46,930 26.98 48,507 53.72 0.0873
2021-11-15 2021-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 173,960 -164,980 -48.68 31,555 -53.83 0.0621
2021-08-16 2021-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 338,940 -548,800 -61.82 68,340 -64.18 0.1338
2021-05-17 2021-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 887,740 205,600 30.14 190,766 18.33 0.3895
2021-02-16 2020-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 682,140 391,150 134.42 161,217 103.60 0.3515
2020-11-16 2020-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 290,990 -108,662 -27.19 79,184 -31.75 0.1982
2020-08-14 2020-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 399,652 -511,300 -56.13 116,023 -46.47 0.2971
2020-05-15 2020-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 910,952 101,251 12.50 216,761 22.27 0.6474
2020-02-14 2019-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 809,701 -62,800 -7.20 177,284 19.93 0.4354
2019-11-14 2019-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 872,501 219,360 33.59 147,819 23.42 0.3630
2019-08-14 2019-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 653,141 208,900 47.02 119,773 46.57 0.2982
2019-05-15 2019-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 444,241 11,729 2.71 81,718 14.02 0.2043
2019-02-14 2018-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 432,512 36,500 9.22 71,672 -6.10 0.1986
2018-11-14 2018-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 396,012 -464,892 -54.00 76,327 -47.84 0.1703
2018-08-14 2018-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 860,904 200,223 30.31 146,319 35.89 0.3350
2018-05-15 2018-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 660,681 -698,600 -51.39 107,678 -47.14 0.2506
2018-02-14 2017-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 1,359,281 323,100 31.18 203,702 29.30 0.4606
2017-11-14 2017-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 1,036,181 71,200 7.38 157,541 26.68 0.3828
2017-08-14 2017-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 964,981 600,319 164.62 124,357 211.86 0.3043
2017-05-15 2017-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 364,662 110,535 43.50 39,876 112.99 0.1005
2017-02-14 2016-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 254,127 -321,900 -55.88 18,722 -62.73 0.0511
2016-11-14 2016-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 576,027 -119,800 -17.22 50,235 -16.07 0.1384
2016-08-15 2016-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 695,827 -327,549 -32.01 59,855 -26.42 0.1633
2016-05-16 2016-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 1,023,376 -390,400 -27.61 81,348 -54.27 0.2206
2016-02-16 2015-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 1,413,776 515,000 57.30 177,895 90.06 0.4662
2015-11-16 2015-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 898,776 -11,000 -1.21 93,599 -16.68 0.2598
2015-08-14 2015-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 909,776 -520,808 -36.41 112,339 -33.44 0.2801
2015-05-15 2015-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 1,430,584 -664,548 -31.72 168,766 -32.20 0.4114
2015-02-17 2014-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 2,095,132 -496,545 -19.16 248,902 -14.49 0.6089
2014-11-14 2014-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 2,591,677 -375,690 -12.66 291,071 3.60 0.7192
2014-08-14 2014-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 2,967,367 1,309,893 79.03 280,950 139.68 0.7261
2014-05-15 2014-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 1,657,474 -2,149,587 -56.46 117,217 -58.56 0.3201
2014-02-14 2013-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 3,807,061 945,000 33.02 282,865 30.35 0.7491
2013-11-14 2013-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 2,862,061 -209,213 -6.81 217,001 -11.75 0.6239
2013-08-14 2013-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 3,071,274 1,306,900 74.07 245,886 153.52 0.7580
2013-07-12 2013-03-31 13F/A-1 VERTEX PHARMACEUTICALS COM 92532F100 1,764,374 1,764,374 96,988 0.3205
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.