Praxis Precision Medicines, Inc.
US ˙ NasdaqGS ˙ US74006W2070

SecurityPRAX / Praxis Precision Medicines, Inc.
InstitutionState Street Corp
Latest Disclosed Ownership875,352 shares
Ownership 1.92%
State Street Corp ownership in PRAX / Praxis Precision Medicines, Inc.

2022-10-11 - State Street Corp has filed an SC 13G/A form with the Securities and Exchange Commission (SEC) disclosing ownership of 875,352 shares of Praxis Precision Medicines, Inc. (US:PRAX). This represents 1.92 percent ownership of the company. In their previous filing dated 2022-07-11 , State Street Corp had reported owning 5,098,669 shares, indicating a decrease of -82.83 percent.

Institutional Ownership: 13D/G Filings

This table shows a history of the 13D/G filings made by the investor and/or investor group. Note that the share values in this table are not directly comparable to any numbers shown in the 13F table (if any).

File
Date		Effective
Date		Form Prev
Shares		 Latest
Shares		 ΔShares
(Percent)		 Ownership
(Percent)		 ΔOwnership
(Percent)
2022-10-11 2022-10-11 13G/A 5,098,669 875,352 -82.83 1.92 -82.86
2022-07-11 2022-07-11 13G 5,098,669 11.20

Important Note: One of the primary uses of the 13D/G filings is to evaluate the ability of a firm to control a company (ie, the "beneficial ownership"). To that end, firms are required to report not just direct holdings in companies, but indirect holdings that they control. For investment firms, these indirect holdings can include shares in funds they manage, advisory accounts, and in the case of activist campaigns, pledged votes. Therefore, share counts listed in 13D/G filings can differ significantly than share counts listed in 13F filings.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-05-15 2026-03-31 13F PRAXIS PRECISION MEDICINES I COM NEW 74006W207 884,238 2,023 0.23 284,893 9.56 0.0098
2026-02-13 2025-12-31 13F PRAXIS PRECISION MEDICINES I COM NEW 74006W207 882,215 -24,893 -2.74 260,024 440.86 0.0087
2025-11-14 2025-09-30 13F PRAXIS PRECISION MEDICINES I COM NEW 74006W207 907,108 209,015 29.94 48,077 63.78 0.0017
2025-08-14 2025-06-30 13F PRAXIS PRECISION MEDICINES I COM NEW 74006W207 698,093 -38,946 -5.28 29,355 5.17 0.0011
2025-05-15 2025-03-31 13F PRAXIS PRECISION MEDICINES I COM NEW 74006W207 737,039 -31,616 -4.11 27,912 -52.82 0.0012
2025-02-14 2024-12-31 13F PRAXIS PRECISION MEDICINES I COM NEW 74006W207 768,655 -20,969 -2.66 59,156 30.20 0.0023
2024-11-14 2024-09-30 13F PRAXIS PRECISION MEDICINES I COM NEW 74006W207 789,624 -29,518 -3.60 45,435 34.11 0.0018
2024-08-14 2024-06-30 13F PRAXIS PRECISION MEDICINES I COM NEW 74006W207 819,142 774,634 1,740.44 33,880 1,147.85 0.0015
2024-05-15 2024-03-31 13F PRAXIS PRECISION MEDICINES I COM NEW 74006W207 44,508 13,800 44.94 2,716 296.93 0.0001
2024-02-14 2023-12-31 13F PRAXIS PRECISION MEDICINES I COM NEW 74006W207 30,708 -175,847 -85.13 684 93.77 0.0000
2023-11-14 2023-09-30 13F PRAXIS PRECISION MEDICINES I COM 74006W108 206,555 -4,050 -1.92 353 45.87 0.0000
2023-08-14 2023-06-30 13F PRAXIS PRECISION MEDICINES I COM 74006W108 210,605 -757,965 -78.26 242 -69.09 0.0000
2023-05-15 2023-03-31 13F PRAXIS PRECISION MEDICINES I COM 74006W108 968,570 82,777 9.34 784 -62.86 0.0000
2023-05-15 2022-12-31 13F/A-99 PRAXIS PRECISION MEDICINES I COM 74006W108 885,793 10,441 1.19 2,108 6.09 0.0001
2023-05-15 2022-12-31 13F PRAXIS PRECISION MEDICINES I COM 74006W108 885,793 10,441 2,108 0.0001
2022-11-15 2022-09-30 13F PRAXIS PRECISION MEDICINES I COM 74006W108 875,352 -4,223,317 -82.83 1,987 -84.09 0.0001
2022-08-15 2022-06-30 13F PRAXIS PRECISION MEDICINES I COM 74006W108 5,098,669 3,705,283 265.92 12,492 -12.19 0.0007
2022-05-16 2022-03-31 13F PRAXIS PRECISION MEDICINES I COM 74006W108 1,393,386 125,571 9.90 14,226 -43.04 0.0007
2022-02-14 2021-12-31 13F PRAXIS PRECISION MEDICINES I COM 74006W108 1,267,815 759,911 149.62 24,976 165.96 0.0012
2021-11-15 2021-09-30 13F PRAXIS PRECISION MEDICINES I COM 74006W108 507,904 156,591 44.57 9,391 46.23 0.0005
2021-08-16 2021-06-30 13F PRAXIS PRECISION MEDICINES I COM 74006W108 351,313 -378,844 -51.89 6,422 -73.15 0.0003
2021-07-09 2021-03-31 13F/A-1 PRAXIS PRECISION MEDICINES I COM 74006W108 730,157 559,388 327.57 23,920 154.58 0.0014
2021-05-17 2021-03-31 13F PRAXIS PRECISION MEDICINES I COM 74006W108 730,157 559,388 23,920 0.0014
2021-02-16 2020-12-31 13F PRAXIS PRECISION MEDICINES I COM 74006W108 170,769 170,769 9,396 0.0006
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.