Praxis Precision Medicines, Inc.
US ˙ NasdaqGS ˙ US74006W2070

SecurityPRAX / Praxis Precision Medicines, Inc.
InstitutionMorgan Stanley
Latest Disclosed Ownership617,980 shares
Ownership 2.90%
Morgan Stanley ownership in PRAX / Praxis Precision Medicines, Inc.

2025-11-07 - Morgan Stanley has filed an SCHEDULE 13G/A form with the Securities and Exchange Commission (SEC) disclosing ownership of 617,980 shares of Praxis Precision Medicines, Inc. (US:PRAX). This represents 2.9 percent ownership of the company. In their previous filing dated 2025-02-05 , Morgan Stanley had reported owning 1,157,140 shares, indicating a decrease of -46.59 percent.

Institutional Ownership: 13D/G Filings

This table shows a history of the 13D/G filings made by the investor and/or investor group. Note that the share values in this table are not directly comparable to any numbers shown in the 13F table (if any).

File
Date		Effective
Date		Form Prev
Shares		 Latest
Shares		 ΔShares
(Percent)		 Ownership
(Percent)		 ΔOwnership
(Percent)
2025-11-07 2025-11-07 13G/A 1,157,140 617,980 -46.59 2.90 -53.23
2025-02-05 2025-02-05 13G 1,157,140 6.20

Important Note: One of the primary uses of the 13D/G filings is to evaluate the ability of a firm to control a company (ie, the "beneficial ownership"). To that end, firms are required to report not just direct holdings in companies, but indirect holdings that they control. For investment firms, these indirect holdings can include shares in funds they manage, advisory accounts, and in the case of activist campaigns, pledged votes. Therefore, share counts listed in 13D/G filings can differ significantly than share counts listed in 13F filings.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-05-15 2026-03-31 13F PRAXIS PRECISION MEDICINES I COM NEW 74006W207 833,491 -56,398 -6.34 268,543 2.39 0.0162
2026-05-27 2025-12-31 13F/A-1 PRAXIS PRECISION MEDICINES I COM NEW 74006W207 889,889 246,394 38.29 262,286 669.05 0.0157
2026-02-13 2025-12-31 13F PRAXIS PRECISION MEDICINES I COM NEW 74006W207 889,889 246,394 262,286 0.0157
2026-05-27 2025-09-30 13F/A-1 PRAXIS PRECISION MEDICINES I COM NEW 74006W207 643,495 -582,844 -47.53 34,105 -33.86 0.0021
2025-11-14 2025-09-30 13F PRAXIS PRECISION MEDICINES I COM NEW 74006W207 643,495 -582,844 34,105 0.0021
2025-08-15 2025-06-30 13F PRAXIS PRECISION MEDICINES I COM NEW 74006W207 1,226,339 12,670 1.04 51,568 12.20 0.0034
2025-05-15 2025-03-31 13F PRAXIS PRECISION MEDICINES I COM NEW 74006W207 1,213,669 50,143 4.31 45,962 -48.67 0.0033
2025-05-15 2024-12-31 13F/A-1 PRAXIS PRECISION MEDICINES I COM NEW 74006W207 1,163,526 1,083,026 1,345.37 89,545 1,833.60 0.0063
2025-02-14 2024-12-31 13F PRAXIS PRECISION MEDICINES I COM NEW 74006W207 1,163,526 1,083,026 89,545 0.0063
2025-05-14 2024-09-30 13F/A-2 PRAXIS PRECISION MEDICINES I COM NEW 74006W207 80,500 -103,819 -56.33 4,632 -39.25 0.0003
2025-02-14 2024-09-30 13F/A-1 PRAXIS PRECISION MEDICINES I COM NEW 74006W207 80,500 -103,819 4,632 0.0003
2024-11-14 2024-09-30 13F PRAXIS PRECISION MEDICINES I COM NEW 74006W207 80,500 -103,819 4,632 0.0003
2025-05-14 2024-06-30 13F/A-2 PRAXIS PRECISION MEDICINES I COM NEW 74006W207 184,319 84,183 84.07 7,623 24.76 0.0006
2024-10-17 2024-06-30 13F/A-1 PRAXIS PRECISION MEDICINES I COM NEW 74006W207 184,319 84,183 7,623 0.0006
2024-08-14 2024-06-30 13F PRAXIS PRECISION MEDICINES I COM NEW 74006W207 184,319 84,183 7,623 0.0006
2024-10-17 2024-03-31 13F/A-2 PRAXIS PRECISION MEDICINES I COM NEW 74006W207 100,136 83,203 491.37 6,110 1,520.69 0.0005
2024-08-16 2024-03-31 13F/A-1 PRAXIS PRECISION MEDICINES I COM NEW 74006W207 100,136 83,203 6,110 0.0001
2024-05-15 2024-03-31 13F PRAXIS PRECISION MEDICINES I COM NEW 74006W207 100,136 83,203 6,110 0.0005
2024-08-16 2023-12-31 13F/A-1 PRAXIS PRECISION MEDICINES I COM NEW 74006W207 16,933 -273,280 -94.17 377 -23.99 0.0000
2024-02-13 2023-12-31 13F PRAXIS PRECISION MEDICINES I COM NEW 74006W207 16,933 -273,280 377 0.0000
2023-11-15 2023-09-30 13F PRAXIS PRECISION MEDICINES I COM 74006W108 290,213 47,217 19.43 496 77.78 0.0001
2023-08-14 2023-06-30 13F PRAXIS PRECISION MEDICINES I COM 74006W108 242,996 -585,538 -70.67 279 -58.36 0.0000
2023-05-15 2023-03-31 13F PRAXIS PRECISION MEDICINES I COM 74006W108 828,534 646,477 355.10 670 54.73 0.0001
2023-02-14 2022-12-31 13F PRAXIS PRECISION MEDICINES I COM 74006W108 182,057 -92,816 -33.77 433 -30.61 0.0000
2022-11-14 2022-09-30 13F PRAXIS PRECISION MEDICINES I COM 74006W108 274,873 -252,350 -47.86 624 -51.63 0.0001
2022-10-27 2022-06-30 13F/A-1 PRAXIS PRECISION MEDICINES I COM 74006W108 527,223 455,125 631.26 1,290 75.03 0.0002
2022-08-15 2022-06-30 13F PRAXIS PRECISION MEDICINES I COM 74006W108 527,223 455,125 1,290 0.0000
2022-10-27 2022-03-31 13F/A-1 PRAXIS PRECISION MEDICINES I COM 74006W108 72,098 51,807 255.32 737 84.25 0.0001
2022-05-13 2022-03-31 13F PRAXIS PRECISION MEDICINES I COM 74006W108 72,098 51,807 737 0.0001
2022-02-14 2021-12-31 13F PRAXIS PRECISION MEDICINES I COM 74006W108 20,291 5,807 40.09 400 49.81 0.0000
2021-11-15 2021-09-30 13F PRAXIS PRECISION MEDICINES I COM 74006W108 14,484 -85,533 -85.52 267 -85.40 0.0000
2021-08-23 2021-06-30 13F/A-1 PRAXIS PRECISION MEDICINES I COM 74006W108 100,017 95,608 2,168.47 1,829 1,170.14 0.0002
2021-08-16 2021-06-30 13F PRAXIS PRECISION MEDICINES I COM 74006W108 100,017 95,608 1,829 0.0001
2021-05-17 2021-03-31 13F PRAXIS PRECISION MEDICINES I COM 74006W108 4,409 -9,922 -69.23 144 -81.73 0.0000
2021-02-16 2020-12-31 13F PRAXIS PRECISION MEDICINES I COM 74006W108 14,331 14,331 788 0.0001
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.