Puma Biotechnology, Inc.
US ˙ NasdaqGS ˙ US74587V1070

SecurityPBYI / Puma Biotechnology, Inc.
InstitutionSei Investments Co
Latest Disclosed Ownership429,925 shares
Latest Disclosed Value $ 2,558,037
Sei Investments Co reports 23.81% increase in ownership of PBYI / Puma Biotechnology, Inc.

On February 13, 2026 - Sei Investments Co filed a 13F-HR form disclosing ownership of 429,925 shares of Puma Biotechnology, Inc. (US:PBYI) valued at $2,558,054 USD as of December 31, 2025. The entity filed a previous 13F-HR on November 13, 2025 disclosing 347,234 shares of Puma Biotechnology, Inc.. This represents a change in shares of 23.81% during the quarter. The current value of the position is $3,022,373 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-02-13 2025-12-31 13F PUMA BIOTECHNOLOGY COM 74587V107 429,925 82,691 23.81 2,558 38.80 0.0025
2025-11-13 2025-09-30 13F PUMA BIOTECHNOLOGY COM 74587V107 347,234 0 0.00 1,844 54.87 0.0020
2025-08-14 2025-06-30 13F PUMA BIOTECHNOLOGY COM 74587V107 347,234 -445 -0.13 1,191 15.65 0.0014
2025-05-14 2025-03-31 13F/A-1 PUMA BIOTECHNOLOGY COM 74587V107 347,679 36,018 11.56 1,029 8.32 0.0013
2025-05-13 2025-03-31 13F PUMA BIOTECHNOLOGY COM 74587V107 311,661 0 950 0.0010
2025-02-11 2024-12-31 13F PUMA BIOTECHNOLOGY COM 74587V107 311,661 23,179 8.03 951 29.25 0.0012
2024-11-12 2024-09-30 13F PUMA BIOTECHNOLOGY COM 74587V107 288,482 -1,055 -0.36 736 -22.06 0.0010
2024-08-13 2024-06-30 13F PUMA BIOTECHNOLOGY COM 74587V107 289,537 -140 -0.05 944 -38.57 0.0013
2024-05-07 2024-03-31 13F PUMA BIOTECHNOLOGY COM 74587V107 289,677 -2,191 -0.75 1,535 21.54 0.0022
2024-02-14 2023-12-31 13F PUMA BIOTECHNOLOGY COM 74587V107 291,868 6,211 2.17 1,264 68.18 0.0020
2023-11-14 2023-09-30 13F PUMA BIOTECHNOLOGY COM 74587V107 285,657 59 0.02 751 -25.50 0.0013
2023-08-11 2023-06-30 13F PUMA BIOTECHNOLOGY COM 74587V107 285,598 -462 -0.16 1,008 14.16 0.0018
2023-05-12 2023-03-31 13F PUMA BIOTECHNOLOGY COM 74587V107 286,060 -105 -0.04 884 -27.02 0.0016
2023-02-10 2022-12-31 13F PUMA BIOTECHNOLOGY COM 74587V107 286,165 914 0.32 1,210 78.99 0.0027
2022-11-14 2022-09-30 13F PUMA BIOTECHNOLOGY COM 74587V107 285,251 1,311 0.46 676 -16.23 0.0015
2022-08-15 2022-06-30 13F PUMA BIOTECHNOLOGY COM 74587V107 283,940 -1,674 -0.59 807 -1.71 0.0017
2022-05-13 2022-03-31 13F PUMA BIOTECHNOLOGY COM 74587V107 285,614 1,541 0.54 821 -4.87 0.0017
2022-02-14 2021-12-31 13F PUMA BIOTECHNOLOGY COM 74587V107 284,073 12,150 4.47 863 -54.67 0.0016
2021-11-12 2021-09-30 13F PUMA BIOTECHNOLOGY COM 74587V107 271,923 43,215 18.90 1,904 -9.20 0.0040
2021-08-06 2021-06-30 13F PUMA BIOTECHNOLOGY COM 74587V107 228,708 76,077 49.84 2,097 41.59 0.0046
2021-05-12 2021-03-31 13F PUMA BIOTECHNOLOGY COM 74587V107 152,631 -501 -0.33 1,481 -5.55 0.0037
2021-02-08 2020-12-31 13F PUMA BIOTECHNOLOGY COM 74587V107 153,132 -25,276 -14.17 1,568 -12.84 0.0041
2020-12-04 2020-09-30 13F/A-1 PUMA BIOTECHNOLOGY COM 74587V107 178,408 28,232 18.80 1,799 14.88 0.0052
2020-11-06 2020-09-30 13F PUMA BIOTECHNOLOGY COM 74587V107 178,408 28,232 1,799 4,331.5920
2020-08-17 2020-06-30 13F/A-1 PUMA BIOTECHNOLOGY COM 74587V107 150,176 832 0.56 1,566 24.29 0.0049
2020-08-11 2020-06-30 13F PUMA BIOTECHNOLOGY COM 74587V107 151,207 1,863 1,322 3,585.9954
2020-05-14 2020-03-31 13F PUMA BIOTECHNOLOGY COM 74587V107 149,344 -1,936 -1.28 1,260 -4.69 0.0046
2020-02-06 2019-12-31 13F PUMA BIOTECHNOLOGY COM 74587V107 151,280 42,173 38.65 1,322 12.70 0.0039
2019-11-12 2019-09-30 13F PUMA BIOTECHNOLOGY COM 74587V107 109,107 96,089 738.12 1,173 615.24 0.0030
2019-08-14 2019-06-30 13F PUMA BIOTECHNOLOGY COM 74587V107 13,018 -26,272 -66.87 164 -89.19 0.0005
2019-05-15 2019-03-31 13F PUMA BIOTECHNOLOGY COM 74587V107 39,290 24,021 157.32 1,517 363.91 0.0051
2019-02-13 2018-12-31 13F PUMA BIOTECHNOLOGY COM 74587V107 15,269 14,513 1,919.71 327 861.76 0.0012
2018-11-08 2018-09-30 13F PUMA BIOTECHNOLOGY COM 74587V107 756 -12,293 -94.21 34 -95.59 0.0001
2018-08-03 2018-06-30 13F PUMA BIOTECHNOLOGY COM 74587V107 13,049 -4,398 -25.21 771 -35.05 0.0026
2018-05-11 2018-03-31 13F PUMA BIOTECHNOLOGY COM 74587V107 17,447 872 5.26 1,187 -27.53 0.0046
2018-02-08 2017-12-31 13F PUMA BIOTECHNOLOGY COM 74587V107 16,575 14,435 674.53 1,638 539.84 0.0057
2017-11-06 2017-09-30 13F PUMA BIOTECHNOLOGY COM 74587V107 2,140 2,140 256 0.0009
2016-05-10 2016-03-31 13F/A-1 DIREXION SHS ETF TR COM 74587V107 0 0 0 0.0000
2016-02-03 2015-12-31 13F DIREXION SHS ETF TR COM 74587V107 0 -502 -100.00 0 -100.00
2015-11-02 2015-09-30 13F/A-1 PUMA BIOTECHNOLOGY COM 74587V107 502 -2,865 -85.09 38 -90.33 0.0003
2015-10-30 2015-09-30 13F DIREXION SHS ETF TR COM 74587V107 502 38
2015-08-07 2015-06-30 13F/A-1 PUMA BIOTECHNOLOGY COM 74587V107 3,367 -750 -18.22 393 -59.57 0.0036
2015-08-04 2015-06-30 13F PUMA BIOTECHNOLOGY COM 74587V107 3,367 -750 393 0.0036
2015-05-14 2015-03-31 13F/A-1 PUMA BIOTECHNOLOGY COM 74587V107 4,117 685 19.96 972 49.77 0.0084
2015-05-01 2015-03-31 13F PUMA BIOTECHNOLOGY COM 74587V107 4,117 972
2015-02-10 2014-12-31 13F PUMA BIOTECHNOLOGY COM 74587V107 3,432 3,432 649 0.0057
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.