OPKO Health, Inc.
US ˙ NasdaqGS ˙ US68375N1037

SecurityOPK / OPKO Health, Inc.
InstitutionFirst Manhattan Co
Latest Disclosed Ownership52,150 shares
Latest Disclosed Value $ 59,451
First Manhattan Co reports 0.77% increase in ownership of OPK / OPKO Health, Inc.

On May 15, 2026 - First Manhattan Co filed a 13F-HR form disclosing ownership of 52,150 shares of OPKO Health, Inc. (US:OPK) valued at $59,451 USD as of March 31, 2026. The entity filed a previous 13F-HR on February 17, 2026 disclosing 51,750 shares of OPKO Health, Inc.. This represents a change in shares of 0.77% during the quarter. The current value of the position is $76,139 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-05-15 2026-03-31 13F OPKO HEALTH COM 68375N103 52,150 400 0.77 59 -9.23 0.0002
2026-02-17 2025-12-31 13F OPKO HEALTH COM 68375N103 51,750 0 0.00 65 -18.75 0.0002
2025-11-14 2025-09-30 13F OPKO HEALTH COM 68375N103 51,750 0 0.00 80 17.65 0.0002
2025-08-14 2025-06-30 13F OPKO HEALTH COM 68375N103 51,750 0 0.00 68 -20.00 0.0002
2025-05-15 2025-03-31 13F OPKO HEALTH COM 68375N103 51,750 0 0.00 86 11.84 0.0003
2025-02-14 2024-12-31 13F OPKO HEALTH COM 68375N103 51,750 0 0.00 76 -1.30 0.0002
2024-11-14 2024-09-30 13F OPKO HEALTH COM 68375N103 51,750 -4,000 -7.17 77 11.59 0.0002
2024-08-15 2024-06-30 13F/A-1 OPKO HEALTH COM 68375N103 55,750 -34,775 -38.41 70 -36.11 0.0002
2024-08-14 2024-06-30 13F OPKO HEALTH COM 68375N103 55,750 -34,775 70 0.0002
2024-05-15 2024-03-31 13F OPKO HEALTH COM 68375N103 90,525 50,000 123.38 109 77.05 0.0004
2024-02-13 2023-12-31 13F OPKO HEALTH COM 68375N103 40,525 36,525 913.12 61 916.67 0.0002
2023-11-14 2023-09-30 13F OPKO HEALTH COM 68375N103 4,000 -6,000 -60.00 6 -71.43 0.0000
2023-08-14 2023-06-30 13F OPKO HEALTH COM 68375N103 10,000 0 0.00 22 50.00 0.0001
2023-05-15 2023-03-31 13F OPKO HEALTH COM 68375N103 10,000 -2,000 -16.67 15 -6.67 0.0001
2023-02-14 2022-12-31 13F OPKO HEALTH COM 68375N103 12,000 6,000 100.00 15 36.36 0.0001
2022-11-14 2022-09-30 13F OPKO HEALTH COM 68375N103 6,000 -6,000 -50.00 11 -63.33 0.0000
2022-08-15 2022-06-30 13F OPKO HEALTH COM 68375N103 12,000 -9,500 -44.19 30 -58.90 0.0001
2022-05-16 2022-03-31 13F OPKO HEALTH COM 68375N103 21,500 0 0.00 73 -29.13 0.0002
2022-02-14 2021-12-31 13F OPKO HEALTH COM 68375N103 21,500 -13,000 -37.68 103 -17.60 0.0003
2021-11-15 2021-09-30 13F OPKO HEALTH COM 68375N103 34,500 0 0.00 125 -10.07 0.0005
2021-08-16 2021-06-30 13F OPKO HEALTH COM 68375N103 34,500 -6,250 -15.34 139 -20.11 0.0005
2021-05-14 2021-03-31 13F OPKO HEALTH COM 68375N103 40,750 -23,950 -37.02 174 -31.76 0.0008
2021-02-16 2020-12-31 13F OPKO HEALTH COM 68375N103 64,700 0 0.00 255 7.14 0.0012
2020-11-12 2020-09-30 13F OPKO HEALTH COMMON 68375N103 64,700 0 0.00 238 8.18 0.0012
2020-08-14 2020-06-30 13F OPKO HEALTH COMMON 68375N103 64,700 0 0.00 220 155.81 0.0013
2020-05-06 2020-03-31 13F OPKO HEALTH COMMON 68375N103 64,700 -5,000 -7.17 86 -15.69 0.0006
2020-02-13 2019-12-31 13F OPKO HEALTH COMMON 68375N103 69,700 0 0.00 102 -29.66 0.0005
2019-11-13 2019-09-30 13F OPKO HEALTH COMMON 68375N103 69,700 -200 -0.29 145 -14.71 0.0008
2019-08-16 2019-06-30 13F OPKO HEALTH COMMON 68375N103 69,900 200 0.29 170 -6.08 0.0009
2019-04-12 2019-03-31 13F OPKO HEALTH COMMON 68375N103 69,700 -2,716,663 -97.50 181 -97.84 0.0010
2019-01-30 2018-12-31 13F OPKO HEALTH COMMON 68375N103 2,786,363 -1,504,350 -35.06 8,386 -43.51 0.0522
2018-10-15 2018-09-30 13F OPKO HEALTH COMMON 68375N103 4,290,713 4,200,663 4,664.81 14,845 3,409.46 0.0791
2018-08-01 2018-06-30 13F OPKO HEALTH COMMON 68375N103 90,050 -2,500 -2.70 423 44.37 0.0024
2018-04-20 2018-03-31 13F OPKO HEALTH COMMON 68375N103 92,550 0 0.00 293 -35.32 0.0017
2018-01-22 2017-12-31 13F OPKO HEALTH COMMON 68375N103 92,550 -6,000 -6.09 453 -32.99 0.0025
2017-10-25 2017-09-30 13F OPKO HEALTH COMMON 68375N103 98,550 23,550 31.40 676 37.12 0.0039
2017-08-10 2017-06-30 13F/A-2 OPKO HEALTH COMMON 68375N103 75,000 11,600 18.30 493 -2.76 0.0029
2017-08-01 2017-06-30 13F/A-1 OPKO HEALTH COMMON 68375N103 75,000 0 493 0.0029
2017-07-28 2017-06-30 13F OPKO HEALTH COMMON 68375N103 75,000 11,600 493
2017-04-25 2017-03-31 13F/A-1 OPKO HEALTH COMMON 68375N103 63,400 41,050 183.67 507 144.93 0.0030
2017-04-24 2017-03-31 13F OPKO HEALTH COMMON 68375N103 20,000 211
2017-01-25 2016-12-31 13F OPKO HEALTH COMMON 68375N103 22,350 2,350 11.75 207 -1.90 0.0013
2016-10-20 2016-09-30 13F OPKO HEALTH COMMON 68375N103 20,000 6,000 42.86 211 62.31 0.0013
2016-07-14 2016-06-30 13F OPKO HEALTH COMMON 68375N103 14,000 0 0.00 130 -10.34 0.0008
2016-04-22 2016-03-31 13F OPKO HEALTH COMMON 68375N103 14,000 0 0.00 145 3.57 0.0009
2016-01-20 2015-12-31 13F OPKO HEALTH COMMON 68375N103 14,000 0 0.00 140 19.66 0.0009
2015-10-26 2015-09-30 13F OPKO HEALTH COMMON 68375N103 14,000 0 0.00 117 -48.00 0.0008
2015-07-17 2015-06-30 13F OPKO HEALTH COMMON 68375N103 14,000 -2,750 -16.42 225 -5.06 0.0013
2015-04-30 2015-03-31 13F OPKO HEALTH COMMON 68375N103 16,750 -8,750 -34.31 237 -6.69 0.0014
2015-01-20 2014-12-31 13F OPKO HEALTH COMMON 68375N103 25,500 0 0.00 254 17.05 0.0014
2014-10-23 2014-09-30 13F OPKO HEALTH COMMON 68375N103 25,500 0 0.00 217 -3.56 0.0013
2014-08-14 2014-06-30 13F/A-1 OPKO HEALTH COMMON 68375N103 25,500 7,500 41.67 225 34.73 0.0014
2014-05-16 2014-03-31 13F OPKO HEALTH COMMON 68375N103 18,000 -5,000 -21.74 167 -13.92 0.0011
2014-02-04 2013-12-31 13F OPKO HEALTH COMMON 68375N103 23,000 -16,000 -41.03 194 -43.44 0.0013
2013-10-29 2013-09-30 13F OPKO HEALTH COMMON 68375N103 39,000 -1,000 -2.50 343 12.83 0.0024
2013-08-13 2013-06-30 13F OPKO HEALTH COMMON 68375N103 40,000 40,000 304 0.0021
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.