OPKO Health, Inc.
US ˙ NasdaqGS ˙ US68375N1037

SecurityOPK / OPKO Health, Inc.
InstitutionDimensional Fund Advisors Lp
Latest Disclosed Ownership1,560,000 shares
Latest Disclosed Value $ 1,777,117
Dimensional Fund Advisors Lp reports 3.18% decrease in ownership of OPK / OPKO Health, Inc.

On May 7, 2026 - Dimensional Fund Advisors Lp filed a 13F-HR form disclosing ownership of 1,560,000 shares of OPKO Health, Inc. (US:OPK) valued at $1,778,400 USD as of March 31, 2026. The entity filed a previous 13F-HR on February 12, 2026 disclosing 1,611,318 shares of OPKO Health, Inc.. This represents a change in shares of -3.18% during the quarter. The current value of the position is $2,246,400 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-05-07 2026-03-31 13F OPKO HEALTH COM 68375N103 1,560,000 -51,318 -3.18 1,777 -12.51 0.0001
2026-02-12 2025-12-31 13F OPKO HEALTH COM 68375N103 1,611,318 -56,050 -3.36 2,031 -21.34 0.0004
2025-11-12 2025-09-30 13F OPKO HEALTH COM 68375N103 1,667,368 -262,315 -13.59 2,582 1.37 0.0006
2025-08-12 2025-06-30 13F OPKO HEALTH COM 68375N103 1,929,683 -292,829 -13.18 2,547 -30.98 0.0006
2025-05-13 2025-03-31 13F OPKO HEALTH COM 68375N103 2,222,512 -46,154 -2.03 3,690 10.68 0.0009
2025-02-13 2024-12-31 13F OPKO HEALTH COM 68375N103 2,268,666 -59,914 -2.57 3,335 -3.92 0.0008
2024-11-07 2024-09-30 13F OPKO HEALTH COM 68375N103 2,328,580 -325,955 -12.28 3,471 4.58 0.0008
2024-08-09 2024-06-30 13F OPKO HEALTH COM 68375N103 2,654,535 -266,901 -9.14 3,319 -5.34 0.0009
2024-05-10 2024-03-31 13F OPKO HEALTH COM 68375N103 2,921,436 -527,626 -15.30 3,506 -32.73 0.0009
2024-02-07 2023-12-31 13F OPKO HEALTH COM 68375N103 3,449,062 -864,430 -20.04 5,210 -24.47 0.0015
2023-11-09 2023-09-30 13F OPKO HEALTH COM 68375N103 4,313,492 559,202 14.90 6,899 -15.26 0.0023
2023-08-09 2023-06-30 13F OPKO HEALTH COM 68375N103 3,754,290 -3,125,757 -45.43 8,141 -18.94 0.0026
2023-05-12 2023-03-31 13F OPKO HEALTH COM 68375N103 6,880,047 -2,076,763 -23.19 10,043 91,190.91 0.0034
2023-02-09 2022-12-31 13F OPKO HEALTH COM 68375N103 8,956,810 -1,866,831 -17.25 11 -99.95 0.0033
2022-11-10 2022-09-30 13F OPKO HEALTH COM 68375N103 10,823,641 1,744,961 19.22 20,456 -10.94 0.0079
2022-08-12 2022-06-30 13F OPKO HEALTH COM 68375N103 9,078,680 1,894,266 26.37 22,970 -7.07 0.0082
2022-05-13 2022-03-31 13F OPKO HEALTH COM 68375N103 7,184,414 3,037,320 73.24 24,717 23.91 0.0076
2022-02-09 2021-12-31 13F OPKO HEALTH COM 68375N103 4,147,094 -326,001 -7.29 19,948 22.18 0.0060
2021-11-12 2021-09-30 13F OPKO HEALTH COM 68375N103 4,473,095 -2,759,184 -38.15 16,327 -44.26 0.0053
2021-08-12 2021-06-30 13F OPKO HEALTH COM 68375N103 7,232,279 -160,278 -2.17 29,292 -7.42 0.0093
2021-05-14 2021-03-31 13F OPKO HEALTH COM 68375N103 7,392,557 1,779,991 31.71 31,639 42.70 0.0105
2021-03-08 2020-12-31 13F/A-2 OPKO HEALTH COM 68375N103 5,612,566 530,660 10.44 22,172 18.30 0.0080
2021-02-11 2020-12-31 13F OPKO HEALTH COM 68375N103 5,612,566 530,660 22,172 8,007.3479
2020-11-12 2020-09-30 13F OPKO HEALTH COM 68375N103 5,081,906 -25,773 -0.50 18,742 7.71 0.0079
2020-08-13 2020-06-30 13F OPKO HEALTH COM 68375N103 5,107,679 702,861 15.96 17,400 194.77 0.0076
2020-05-14 2020-03-31 13F OPKO HEALTH COM 68375N103 4,404,818 -14,815 -0.34 5,903 -9.14 0.0031
2020-02-14 2019-12-31 13F OPKO HEALTH COM 68375N103 4,419,633 -279,751 -5.95 6,497 -33.85 0.0024
2019-11-12 2019-09-30 13F OPKO HEALTH COM 68375N103 4,699,384 135,032 2.96 9,822 -11.79 0.0038
2019-08-13 2019-06-30 13F OPKO HEALTH COM 68375N103 4,564,352 234,610 5.42 11,135 -1.46 0.0043
2019-08-12 2019-03-31 13F/A-2 OPKO HEALTH COM 68375N103 4,329,742 166,578 4.00 11,300 -9.84 0.0045
2019-05-10 2019-03-31 13F OPKO HEALTH COM 68375N103 4,329,742 166,578 11,300
2019-02-26 2018-12-31 13F/A-1 OPKO HEALTH COM 68375N103 4,163,164 -277,620 -6.25 12,533 -18.42 0.0057
2019-02-13 2018-12-31 13F OPKO HEALTH COM 68375N103 4,163,164 -277,620 12,533
2018-11-13 2018-09-30 13F OPKO HEALTH COM 68375N103 4,440,784 897,406 25.33 15,363 -7.76 0.0058
2018-08-10 2018-06-30 13F OPKO HEALTH COM 68375N103 3,543,378 -34,036 -0.95 16,655 46.87 0.0066
2018-05-11 2018-03-31 13F OPKO HEALTH COM 68375N103 3,577,414 -130,675 -3.52 11,340 -37.59 0.0047
2018-02-12 2017-12-31 13F OPKO HEALTH COM 68375N103 3,708,089 -295,554 -7.38 18,170 -33.85 0.0075
2017-11-13 2017-09-30 13F OPKO HEALTH COM 68375N103 4,003,643 2,241,103 127.15 27,466 136.82 0.0120
2017-08-11 2017-06-30 13F OPKO HEALTH COM 68375N103 1,762,540 141,412 8.72 11,598 -10.56 0.0054
2017-05-12 2017-03-31 13F OPKO HEALTH COM 68375N103 1,621,128 31,225 1.96 12,968 -12.44 0.0062
2017-02-09 2016-12-31 13F OPKO HEALTH COM 68375N103 1,589,903 30,851 1.98 14,811 -10.30 0.0074
2016-11-10 2016-09-30 13F OPKO HEALTH COM 68375N103 1,559,052 81,840 5.54 16,511 19.67 0.0089
2016-08-09 2016-06-30 13F OPKO HEALTH COM 68375N103 1,477,212 440,700 42.52 13,797 28.17 0.0079
2016-05-13 2016-03-31 13F OPKO HEALTH COM 68375N103 1,036,512 134,837 14.95 10,765 18.78 0.0064
2016-02-10 2015-12-31 13F OPKO HEALTH COM 68375N103 901,675 -1,522,215 -62.80 9,063 -55.54 0.0056
2015-11-13 2015-09-30 13F OPKO HEALTH COM 68375N103 2,423,890 1,115,985 85.33 20,386 -3.05 0.0134
2015-08-14 2015-06-30 13F OPKO HEALTH COM 68375N103 1,307,905 56,512 4.52 21,027 18.55 0.0129
2015-05-14 2015-03-31 13F OPKO HEALTH COM 68375N103 1,251,393 78,082 6.65 17,737 51.34 0.0112
2015-02-06 2014-12-31 13F OPKO HEALTH COM 68375N103 1,173,311 44,406 3.93 11,720 21.97 0.0077
2014-11-13 2014-09-30 13F OPKO HEALTH COM 68375N103 1,128,905 -79,996 -6.62 9,609 -10.10 0.0068
2014-08-08 2014-06-30 13F OPKO HEALTH COM 68375N103 1,208,901 -238,622 -16.48 10,689 -20.75 0.0074
2014-05-14 2014-03-31 13F OPKO HEALTH COM 68375N103 1,447,523 -417,206 -22.37 13,488 -14.30 0.0101
2014-02-12 2013-12-31 13F OPKO HEALTH COM 68375N103 1,864,729 560,584 42.98 15,739 37.00 0.0123
2013-11-13 2013-09-30 13F OPKO HEALTH COM 68375N103 1,304,145 -273,192 -17.32 11,488 2.57 0.0099
2013-08-15 2013-06-30 13F OPKO HEALTH COM 68375N103 1,577,337 1,577,337 11,200 0.0105
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.