Natera, Inc.
US ˙ NasdaqGS ˙ US6323071042

SecurityNTRA / Natera, Inc.
InstitutionD. E. Shaw & Co., Inc.
ManagerDE Shaw
Latest Disclosed Ownership491,336 shares
Latest Disclosed Value $ 98,262,287
D. E. Shaw & Co., Inc. reports 11.25% decrease in ownership of NTRA / Natera, Inc.

On May 15, 2026 - D. E. Shaw & Co., Inc. filed a 13F-HR form disclosing ownership of 491,336 shares of Natera, Inc. (US:NTRA) valued at $98,262,287 USD as of March 31, 2026. The entity filed a previous 13F-HR on February 17, 2026 disclosing 553,607 shares of Natera, Inc.. This represents a change in shares of -11.25% during the quarter. The current value of the position is $104,089,532 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-05-15 2026-03-31 13F NATERA COM 632307104 491,336 -62,271 -11.25 98,262 -22.52 0.0434
2026-02-17 2025-12-31 13F NATERA COM 632307104 553,607 421,450 318.90 126,826 496.18 0.0695
2025-11-14 2025-09-30 13F NATERA COM 632307104 132,157 -41,643 -23.96 21,273 -27.55 0.0120
2025-08-14 2025-06-30 13F NATERA COM 632307104 173,800 -69,298 -28.51 29,362 -14.59 0.0208
2025-05-15 2025-03-31 13F NATERA COM 632307104 243,098 -563,235 -69.85 34,376 -73.07 0.0306
2025-02-14 2024-12-31 13F NATERA COM 632307104 806,333 -230,527 -22.23 127,643 -3.03 0.0937
2024-11-14 2024-09-30 13F NATERA COM 632307104 1,036,860 -108,502 -9.47 131,629 6.13 0.1130
2024-08-14 2024-06-30 13F NATERA COM 632307104 1,145,362 303,905 36.12 124,031 61.17 0.1160
2024-05-15 2024-03-31 13F NATERA COM 632307104 841,457 156,142 22.78 76,960 79.27 0.0659
2024-02-14 2023-12-31 13F NATERA COM 632307104 685,315 -28,664 -4.01 42,928 35.88 0.0375
2023-11-14 2023-09-30 13F NATERA COM 632307104 713,979 -388,368 -35.23 31,594 -41.10 0.0330
2023-08-14 2023-06-30 13F NATERA COM 632307104 1,102,347 -364,629 -24.86 53,640 -34.14 0.0548
2023-05-15 2023-03-31 13F NATERA COM 632307104 1,466,976 -61,590 -4.03 81,447 32.64 0.0872
2023-02-14 2022-12-31 13F NATERA COM 632307104 1,528,566 -53,493 -3.38 61,402 -11.43 0.0679
2022-11-14 2022-09-30 13F NATERA COM 632307104 1,582,059 -190,008 -10.72 69,326 10.39 0.0828
2022-08-15 2022-06-30 13F NATERA COM 632307104 1,772,067 356,710 25.20 62,802 9.07 0.0736
2022-05-16 2022-03-31 13F NATERA COM 632307104 1,415,357 1,271,074 880.96 57,577 327.29 0.0539
2022-02-14 2021-12-31 13F NATERA COM 632307104 144,283 -303,941 -67.81 13,475 -73.02 0.0112
2021-11-15 2021-09-30 13F NATERA COM 632307104 448,224 -358,348 -44.43 49,950 -45.45 0.0451
2021-08-16 2021-06-30 13F NATERA COM 632307104 806,572 -230,797 -22.25 91,570 -13.07 0.0790
2021-05-17 2021-03-31 13F NATERA COM 632307104 1,037,369 359,073 52.94 105,334 56.04 0.1017
2021-02-16 2020-12-31 13F NATERA COM 632307104 678,296 47,025 7.45 67,504 48.03 0.0604
2020-11-16 2020-09-30 13F NATERA COM 632307104 631,271 70,088 12.49 45,603 62.98 0.0467
2020-08-14 2020-06-30 13F NATERA COM 632307104 561,183 372,838 197.95 27,981 397.53 0.0333
2020-05-15 2020-03-31 13F NATERA COM 632307104 188,345 188,345 5,624 0.0088
2019-11-14 2019-09-30 13F NATERA COM 632307104 0 -32,309 -100.00 0 -100.00
2019-08-14 2019-06-30 13F NATERA COM 632307104 32,309 -137,729 -81.00 891 -74.59 0.0011
2019-05-15 2019-03-31 13F NATERA COM 632307104 170,038 55,086 47.92 3,506 118.44 0.0045
2019-02-14 2018-12-31 13F NATERA COM 632307104 114,952 -51,732 -31.04 1,605 -59.77 0.0022
2018-11-14 2018-09-30 13F NATERA COM 632307104 166,684 -37,429 -18.34 3,990 3.88 0.0048
2018-08-14 2018-06-30 13F NATERA COM 632307104 204,113 -111,836 -35.40 3,841 31.14 0.0050
2018-05-15 2018-03-31 13F NATERA COM 632307104 315,949 -12,560 -3.82 2,929 -0.81 0.0040
2018-02-14 2017-12-31 13F NATERA COM 632307104 328,509 53,944 19.65 2,953 -16.56 0.0041
2017-11-14 2017-09-30 13F NATERA COM 632307104 274,565 108,261 65.10 3,539 95.96 0.0054
2017-08-14 2017-06-30 13F NATERA COM 632307104 166,304 47,069 39.48 1,806 70.86 0.0030
2017-05-15 2017-03-31 13F NATERA COM 632307104 119,235 -84,199 -41.39 1,057 -55.63 0.0019
2017-02-14 2016-12-31 13F NATERA COM 632307104 203,434 156,251 331.16 2,382 354.58 0.0040
2016-11-14 2016-09-30 13F NATERA COM 632307104 47,183 8,391 21.63 524 11.97 0.0009
2016-08-15 2016-06-30 13F NATERA COM 632307104 38,792 -2,510 -6.08 468 19.08 0.0009
2016-05-16 2016-03-31 13F NATERA COM 632307104 41,302 41,302 393 0.0007
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.