Lakefront Biotherapeutics NV - Depositary Receipt (Common Stock)
US ˙ NasdaqGS ˙ US36315X1019

SecurityLKFT / Lakefront Biotherapeutics NV - Depositary Receipt (Common Stock)
InstitutionRenaissance Technologies Llc
ManagerJames Simons
Latest Disclosed Ownership315,400 shares
Latest Disclosed Value $ 9,462,000
Renaissance Technologies Llc reports 1.55% increase in ownership of LKFT / Lakefront Biotherapeutics NV - Depositary Receipt (Common Stock)

On May 14, 2026 - Renaissance Technologies Llc filed a 13F-HR form disclosing ownership of 315,400 shares of Lakefront Biotherapeutics NV - Depositary Receipt (Common Stock) (US:LKFT) valued at $9,462,000 USD as of March 31, 2026. The entity filed a previous 13F-HR on February 12, 2026 disclosing 310,600 shares of Lakefront Biotherapeutics NV - Depositary Receipt (Common Stock). This represents a change in shares of 1.55% during the quarter. The current value of the position is $8,834,354 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-05-14 2026-03-31 13F GALAPAGOS SPON ADR 36315X101 315,400 4,800 1.55 9,462 -6.83 0.0148
2026-02-12 2025-12-31 13F GALAPAGOS SPON ADR 36315X101 310,600 -45,600 -12.80 10,157 -17.69 0.0158
2025-11-13 2025-09-30 13F GALAPAGOS SPON ADR 36315X101 356,200 -108,500 -23.35 12,339 -5.14 0.0163
2025-08-13 2025-06-30 13F GALAPAGOS SPON ADR 36315X101 464,700 133,900 40.48 13,007 56.53 0.0173
2025-05-14 2025-03-31 13F GALAPAGOS SPON ADR 36315X101 330,800 34,700 11.72 8,310 2.05 0.0126
2025-02-13 2024-12-31 13F GALAPAGOS SPON ADR 36315X101 296,100 4,421 1.52 8,143 -3.04 0.0121
2024-11-13 2024-09-30 13F GALAPAGOS SPON ADR 36315X101 291,679 20,879 7.71 8,397 25.14 0.0126
2024-08-09 2024-06-30 13F GALAPAGOS SPON ADR 36315X101 270,800 4,300 1.61 6,710 83,775.00 0.0114
2024-05-13 2024-03-31 13F GALAPAGOS SPON ADR 36315X101 266,500 3,300 1.25 9 -20.00 0.0135
2024-02-13 2023-12-31 13F GALAPAGOS SPON ADR 36315X101 263,200 -18,600 -6.60 11 11.11 0.0166
2023-11-14 2023-09-30 13F GALAPAGOS SPON ADR 36315X101 281,800 -26,100 -8.48 10 -25.00 0.0166
2023-08-11 2023-06-30 13F GALAPAGOS SPON ADR 36315X101 307,900 -50,500 -14.09 13 -7.69 0.0180
2023-05-12 2023-03-31 13F GALAPAGOS SPON ADR 36315X101 358,400 22,020 6.55 14 -7.14 0.0184
2023-02-13 2022-12-31 13F GALAPAGOS SPON ADR 36315X101 336,380 37,780 12.65 15 -99.89 0.0204
2022-11-14 2022-09-30 13F GALAPAGOS SPON ADR 36315X101 298,600 50,300 20.26 12,732 -8.11 0.0180
2022-08-12 2022-06-30 13F GALAPAGOS SPON ADR 36315X101 248,300 163,800 193.85 13,855 164.36 0.0164
2022-05-13 2022-03-31 13F GALAPAGOS SPON ADR 36315X101 84,500 27,900 49.29 5,241 67.98 0.0062
2022-02-11 2021-12-31 13F GALAPAGOS SPON ADR 36315X101 56,600 5,700 11.20 3,120 16.50 0.0039
2021-11-12 2021-09-30 13F GALAPAGOS SPON ADR 36315X101 50,900 40,700 399.02 2,678 280.94 0.0035
2021-08-13 2021-06-30 13F GALAPAGOS SPON ADR 36315X101 10,200 -500 -4.67 703 -14.79 0.0009
2021-05-13 2021-03-31 13F GALAPAGOS SPON ADR 36315X101 10,700 -64,210 -85.72 825 -88.87 0.0010
2021-02-10 2020-12-31 13F GALAPAGOS SPON ADR 36315X101 74,910 -105,090 -58.38 7,415 -70.97 0.0081
2020-11-13 2020-09-30 13F GALAPAGOS SPON ADR 36315X101 180,000 -81,200 -31.09 25,544 -50.43 0.0255
2020-08-13 2020-06-30 13F GALAPAGOS SPON ADR 36315X101 261,200 26,008 11.06 51,532 11.83 0.0445
2020-05-14 2020-03-31 13F GALAPAGOS SPON ADR 36315X101 235,192 233,792 16,699.43 46,079 15,789.31 0.0448
2020-02-13 2019-12-31 13F GALAPAGOS SPON ADR 36315X101 1,400 1,400 -99.40 290 -99.37 0.0002
2019-11-13 2019-09-30 13F GALAPAGOS SPON ADR 36315X101 0 -30,500 -100.00 0 -100.00
2019-08-12 2019-06-30 13F GALAPAGOS SPON ADR 36315X101 30,500 -22,600 -42.56 3,932 -37.13 0.0035
2019-05-14 2019-03-31 13F GALAPAGOS SPON ADR 36315X101 53,100 -8,600 -13.94 6,254 10.49 0.0057
2019-02-12 2018-12-31 13F GALAPAGOS SPON ADR 36315X101 61,700 -60,600 -49.55 5,660 -58.84 0.0062
2018-11-13 2018-09-30 13F GALAPAGOS SPON ADR 36315X101 122,300 -52,730 -30.13 13,750 -14.78 0.0141
2018-08-13 2018-06-30 13F/A-1 GALAPAGOS SPON ADR 36315X101 175,030 -52,070 -22.93 16,134 -28.78 0.0176
2018-08-13 2018-06-30 13F GALAPAGOS SPON ADR 36315X101 227,100 22,655
2018-05-14 2018-03-31 13F GALAPAGOS SPON ADR 36315X101 227,100 -8,100 -3.44 22,655 2.73 0.0248
2018-02-13 2017-12-31 13F GALAPAGOS SPON ADR 36315X101 235,200 -31,300 -11.74 22,052 -18.68 0.0243
2017-11-13 2017-09-30 13F GALAPAGOS SPON ADR 36315X101 266,500 -198,800 -42.73 27,116 -23.84 0.0319
2017-08-11 2017-06-30 13F GALAPAGOS SPON ADR 36315X101 465,300 154,100 49.52 35,605 32.75 0.0454
2017-05-12 2017-03-31 13F GALAPAGOS SPON ADR 36315X101 311,200 105,700 51.44 26,822 103.34 0.0375
2017-02-13 2016-12-31 13F GALAPAGOS SPON ADR 36315X101 205,500 65,300 46.58 13,191 45.52 0.0209
2016-11-14 2016-09-30 13F GALAPAGOS SPON ADR 36315X101 140,200 132,100 1,630.86 9,065 1,918.93 0.0160
2016-08-12 2016-06-30 13F GALAPAGOS SPON ADR 36315X101 8,100 8,100 -94.22 449 -95.05 0.0009
2016-05-13 2016-03-31 13F GALAPAGOS SPON ADR 36315X101 0 -37,900 -100.00 0 -100.00
2016-02-11 2015-12-31 13F GALAPAGOS SPON ADR 36315X101 37,900 37,900 2,383 0.0052
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.