Krystal Biotech, Inc.
US ˙ NasdaqGS ˙ US5011471027

SecurityKRYS / Krystal Biotech, Inc.
InstitutionDimensional Fund Advisors Lp
Latest Disclosed Ownership468,990 shares
Latest Disclosed Value $ 121,130,310
Dimensional Fund Advisors Lp reports 4.86% decrease in ownership of KRYS / Krystal Biotech, Inc.

On May 7, 2026 - Dimensional Fund Advisors Lp filed a 13F-HR form disclosing ownership of 468,990 shares of Krystal Biotech, Inc. (US:KRYS) valued at $121,149,497 USD as of March 31, 2026. The entity filed a previous 13F-HR on February 12, 2026 disclosing 492,968 shares of Krystal Biotech, Inc.. This represents a change in shares of -4.86% during the quarter. The current value of the position is $141,550,562 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-05-07 2026-03-31 13F KRYSTAL BIOTECH COM 501147102 468,990 -23,978 -4.86 121,130 -0.34 0.0054
2026-02-12 2025-12-31 13F KRYSTAL BIOTECH COM 501147102 492,968 -40,996 -7.68 121,538 28.94 0.0255
2025-11-12 2025-09-30 13F KRYSTAL BIOTECH COM 501147102 533,964 28,075 5.55 94,261 35.55 0.0202
2025-08-12 2025-06-30 13F KRYSTAL BIOTECH COM 501147102 505,889 -28,030 -5.25 69,542 -27.76 0.0161
2025-05-13 2025-03-31 13F KRYSTAL BIOTECH COM 501147102 533,919 -54,680 -9.29 96,270 4.40 0.0239
2025-02-13 2024-12-31 13F KRYSTAL BIOTECH COM 501147102 588,599 -11,662 -1.94 92,214 -15.60 0.0221
2024-11-07 2024-09-30 13F KRYSTAL BIOTECH COM 501147102 600,261 19,809 3.41 109,260 2.50 0.0265
2024-08-09 2024-06-30 13F KRYSTAL BIOTECH COM 501147102 580,452 7,537 1.32 106,593 4.57 0.0278
2024-05-10 2024-03-31 13F KRYSTAL BIOTECH COM 501147102 572,915 22,109 4.01 101,939 49.17 0.0276
2024-02-07 2023-12-31 13F KRYSTAL BIOTECH COM 501147102 550,806 30,169 5.79 68,337 13.15 0.0200
2023-11-09 2023-09-30 13F KRYSTAL BIOTECH COM 501147102 520,637 34,040 7.00 60,396 5.73 0.0198
2023-08-09 2023-06-30 13F KRYSTAL BIOTECH COM 501147102 486,597 24,507 5.30 57,125 54.41 0.0182
2023-05-12 2023-03-31 13F KRYSTAL BIOTECH COM 501147102 462,090 72,805 18.70 36,994 123,213.33 0.0125
2023-02-09 2022-12-31 13F KRYSTAL BIOTECH COM 501147102 389,285 30,448 8.49 31 -99.88 0.0091
2022-11-10 2022-09-30 13F KRYSTAL BIOTECH COM 501147102 358,837 82,914 30.05 25,012 38.07 0.0096
2022-08-12 2022-06-30 13F KRYSTAL BIOTECH COM 501147102 275,923 13,460 5.13 18,116 3.73 0.0065
2022-05-13 2022-03-31 13F KRYSTAL BIOTECH COM 501147102 262,463 111,822 74.23 17,465 65.73 0.0054
2022-02-09 2021-12-31 13F KRYSTAL BIOTECH COM 501147102 150,641 -13,223 -8.07 10,538 23.15 0.0032
2021-11-12 2021-09-30 13F KRYSTAL BIOTECH COM 501147102 163,864 -49,848 -23.32 8,557 -41.12 0.0028
2021-08-12 2021-06-30 13F KRYSTAL BIOTECH COM 501147102 213,712 68,380 47.05 14,533 29.85 0.0046
2021-05-14 2021-03-31 13F KRYSTAL BIOTECH COM 501147102 145,332 76,988 112.65 11,192 172.91 0.0037
2021-03-08 2020-12-31 13F/A-2 KRYSTAL BIOTECH COM 501147102 68,344 21,390 45.56 4,101 103.02 0.0015
2021-02-11 2020-12-31 13F KRYSTAL BIOTECH COM 501147102 68,344 21,390 4,101 1,481.0632
2020-11-12 2020-09-30 13F KRYSTAL BIOTECH COM 501147102 46,954 11,096 30.94 2,020 36.03 0.0009
2020-08-13 2020-06-30 13F KRYSTAL BIOTECH COM 501147102 35,858 35,858 1,485 0.0007
2020-02-14 2019-12-31 13F KRYSTAL BIOTECH COM 501147102 0 -14,270 -100.00 0 -100.00
2019-11-12 2019-09-30 13F KRYSTAL BIOTECH COM 501147102 14,270 14,270 496 0.0002
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.